当前位置： SCI文献检索 > ATHEROSCLEROSIS期刊下所有文献 > Polymorphisms in the CC-chemokine receptor-2 (CCR2) and -5 (CCR5) genes and risk of coronary heart disease among US women.

Polymorphisms in the CC-chemokine receptor-2 (CCR2) and -5 (CCR5) genes and risk of coronary heart disease among US women.

Abstract：

OBJECTIVE:Genetic variation in CC-chemokine receptor-2 (CCR2) and -5 (CCR5), and their common haplotypes, acting through inflammatory responses, may affect atherosclerosis and risk of coronary heart disease (CHD). METHOD AND RESULTS:We examined seven common variants in the CCR2 and CCR5 loci and risk of CHD among women in the Nurses' Health Study. During 8 years of follow-up, we documented 248 incident cases of nonfatal myocardial infarction and fatal CHD, and matched controls 2:1 based on age and smoking. The distribution of alleles was similar between cases and controls. The haplotype-specific odds ratios (ORs) were not statistically significant nor was the globally-adjusted p-value (p=0.61). However, there was a statistically significant association for CCR5-Delta32 and A58755G (rs2856758) between cases and controls comparing age of onset <55 and >or=55 years. For Delta32, the OR for having the variant was 0.12 (0.02-0.76) for age <55, and 1.14 (0.69-1.88) for age >or=55 years (p, interaction=0.04). The CCR5-Delta32 was in linkage disequilibrium with 58755G, and a similar association was observed for having the 58755G. CONCLUSIONS:In this population, CCR2-CCR5 haplotypes were not associated with risk of CHD. However, our data suggest a strong inverse association for certain CCR5 variants and early age of CHD onset.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Pai JK,Kraft P,Cannuscio CC,Manson JE,Rexrode KM,Albert CM,Hunter D,Rimm EB

doi

10.1016/j.atherosclerosis.2005.06.041

keywords:

subject

Has Abstract

pub_date

2006-05-01 00:00:00

pages

132-9

issue

1

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(05)00449-1

journal_volume

186

pub_type

杂志文章

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