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Beta-very low density lipoproteins in cholesterol-fed rabbits are of hepatic origin.

Abstract：

:When rabbits are fed a cholesterol-rich diet they accumulate beta-migrating very low density lipoprotein (beta-VLDL) in their plasma. beta-VLDL are cholesteryl ester-rich lipoproteins which contain apolipoproteins B and E. There are 2 forms of apolipoprotein B in beta-VLDL. About 90% of apolipoprotein B is present as a 320 000-dalton protein and the remainder is present as a 210 000-dalton protein. These apolipoproteins are tissue specific. Lipoproteins secreted by perfused rabbit livers contain only the 320 000-dalton apolipoprotein B while lipoproteins secreted by the intestine contain only the 210 000-dalton apolipoprotein B. The tissue specificity of apolipoprotein B shows that beta-VLDL is largely of hepatic origin and that only a small fraction is of intestinal origin. The composition of VLDL secreted from the livers of cholesterol-fed rabbits is similar to that of plasma beta-VLDL. Both are cholesteryl ester-rich, in contrast to plasma and perfusate VLDL from normal rabbits which are both triglyceride-rich. This indicates that the cholesteryl ester-rich hepatic VLDL is a direct precursor for plasma beta-VLDL.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Kroon PA,Thompson GM,Chao YS

doi

10.1016/0021-9150(85)90007-3

subject

Has Abstract

pub_date

1985-09-01 00:00:00

pages

323-9

issue

3

eissn

0021-9150

issn

1879-1484

pii

0021-9150(85)90007-3

journal_volume

56

pub_type

杂志文章

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