当前位置： SCI文献检索 > ATHEROSCLEROSIS期刊下所有文献 > Daily supplementation with aged garlic extract, but not raw garlic, protects low density lipoprotein against in vitro oxidation.

Daily supplementation with aged garlic extract, but not raw garlic, protects low density lipoprotein against in vitro oxidation.

Abstract：

:The oxidation of low density lipoprotein (LDL) is believed to be an important process in the development and progression of atherosclerosis. In this study, human subjects were supplemented daily with one of: 6 g raw garlic; 2.4 g aged garlic extract (AGE); or 0.8 g DL-alpha-tocopherol acetate for 7 days to determine the effect on the susceptibility of LDL particles to Cu2+-mediated oxidation. LDL isolated from subjects given either alpha-tocopherol or AGE, but not raw garlic, was significantly more resistant to oxidation than LDL isolated from subjects receiving no supplements. These results suggest that if antioxidants are proven to be antiatherogenic, AGE may be useful in preventing atherosclerotic disease.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Munday JS,James KA,Fray LM,Kirkwood SW,Thompson KG

doi

10.1016/s0021-9150(98)00293-7

keywords:

subject

Has Abstract

pub_date

1999-04-01 00:00:00

pages

399-404

issue

2

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(98)00293-7

journal_volume

143

pub_type

临床试验,杂志文章,随机对照试验

相关文献

ATHEROSCLEROSIS文献大全
  • Increased levels of asymmetric dimethylarginine in populations at risk for atherosclerotic disease. Effects of pravastatin.

    abstract：:The aim of the present study was to investigate plasma levels of asymmetric dimethylarginine (ADMA), an important endogenous inhibitor of nitric oxide synthase, in populations at high risk for atherosclerosis as compared to healthy controls, and furthermore to evaluate the effect of cholesterol lowering therapy in ind...

    journal_title：Atherosclerosis

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0021-9150(02)00206-x

    authors： Eid HM,Eritsland J,Larsen J,Arnesen H,Seljeflot I

    更新日期：2003-02-01 00:00:00

  • Tissue plasminogen activator on admission is an important predictor of 30-day mortality in patients with acute myocardial infarction undergoing primary angioplasty.

    abstract：:Tissue plasminogen activator (tPA) is emerging as an important risk factor for coronary heart disease, but the association between tPA concentration and mortality in acute myocardial infarction (AMI) remains uncertain. We studied the relationship between tPA antigen level on admission and 30-day mortality in 226 conse...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2006.11.005

    authors： Lee CW,Ahn JM,Park DW,Kim YH,Hong MK,Song JK,Kim JJ,Park SW,Chi HS,Park SJ

    更新日期：2008-01-01 00:00:00

  • The Crataegus extract WS 1442 inhibits balloon catheter-induced intimal hyperplasia in the rat carotid artery by directly influencing PDGFR-beta.

    abstract：OBJECTIVE:Effective systemic drugs against restenosis upon percutaneous transluminal coronary angioplasty (PTCA) are largely lacking. Polyphenols have been suggested to ameliorate post-angioplasty restenosis. Hawthorn (Crataegus spp.) extracts, which are among the most frequently used herbal medicinal products against ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2010.04.003

    authors： Fürst R,Zirrgiebel U,Totzke F,Zahler S,Vollmar AM,Koch E

    更新日期：2010-08-01 00:00:00

  • Effect of KC-9432, a new hypolipidemic compound, on high density lipoprotein cholesterol in rats.

    abstract：:KC-9432 (a new hypolipidemic compound, alpha-[p-(p-chlorobenzoyl) phenoxy-alpha-cyclohexyl acetic acid ethyl ester) was studied in rats for its effect on plasma lipid and lipoprotein levels. KC-9432 was particularly effective in hyperlipidemia in rats fed with a diet containing 2% cholesterol and 1% sodium cholate. Th...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(80)90097-0

    authors： Seri K,Sato R,Hamazaki Y,Yamamoto T,Ishiyama N

    更新日期：1980-09-01 00:00:00

  • Primary biliary cirrhosis, hyperlipidemia, and atherosclerotic risk: a systematic review.

    abstract：:Primary Biliary Cirrhosis (PBC) is a chronic, progressive liver disease associated with markedly elevated serum lipids, but it is not clear if PBC is associated with accelerated atherosclerosis. The present systematic review examined the relationship of PBC to atherosclerotic risk. The lipid abnormalities in PBC are c...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,评审

    doi：10.1016/j.atherosclerosis.2006.11.036

    authors： Sorokin A,Brown JL,Thompson PD

    更新日期：2007-10-01 00:00:00

  • Nonalcoholic fatty liver disease and advanced fibrosis are associated with left ventricular diastolic dysfunction.

    abstract：BACKGROUND AND AIMS:Nonalcoholic fatty liver disease (NAFLD) may be associated with a wide spectrum of cardiac abnormalities, which share many metabolic risk factors. This study aimed to evaluate whether NAFLD is associated with left ventricular (LV) diastolic dysfunction independent of other classical risk factors. M...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2018.03.027

    authors： Chung GE,Lee JH,Lee H,Kim MK,Yim JY,Choi SY,Kim YJ,Yoon JH,Kim D

    更新日期：2018-05-01 00:00:00

  • Triglyceride-rich lipoproteins from apolipoprotein E3/2 subjects with hypertriglyceridemia enhance cholesteryl ester synthesis in human macrophages.

    abstract：:The ability of triglyceride (TG)-rich lipoproteins from apolipoprotein (apo) E2 heterozygote, apo E3/2 which is relatively common, to stimulate cholesteryl ester synthesis in human monocyte-derived macrophages was studied to clarify the atherogenicity of apo E3/2. Twenty-three subjects were randomly sampled from our h...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(96)06026-1

    authors： Saito M,Eto M,Makino I

    更新日期：1997-02-28 00:00:00

  • Dietary fat and hormonal influences on lipoprotein fluidity and composition in premenopausal women.

    abstract：:LDL and HDL became more fluid when health, free-living, premenopausal women were fed reduced fat diets with higher proportions of polyunsaturated fatty acids. Lipoproteins were isolated from plasma of 31 female subjects fed one of two sets of diets from typical U.S.A. foods with P/S ratios of 0.3 or 1.0. All subjects ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(91)90206-i

    authors： Berlin E,Judd JT,Nair PP,Jones DY,Taylor PR

    更新日期：1991-02-01 00:00:00

  • Fractional esterification rate of cholesterol in high density lipoprotein (HDL) can predict the particle size of low density lipoprotein and HDL in patients with coronary heart disease.

    abstract：:Fractional esterification rate of cholesterol in high density lipoprotein (HDL) (FER[HDL]) can predict the size distribution and physicochemical characteristics of HDL in plasma. In the present study, we investigated the correlation of FER(HDL) with the particle size of low density lipoprotein (LDL) (LDL-size) in 111 ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(97)00163-9

    authors： Ohta T,Saku K,Takata K,Nagata N,Maung KK,Matsuda I

    更新日期：1997-12-01 00:00:00

  • Enhanced synthesis of collagen and total protein by smooth muscle cells from atherosclerotic rabbit aortas in culture.

    abstract：:Protein synthesis in smooth muscle cells from normal and atherosclerotic rabbit aortas was studied. Cultures of cells from the third passage were incubated with [3H]proline and the synthesis rates of collagen and total protein measured from the radioactivities incorporated into protein-bound hydroxyproline and proline...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(80)90089-1

    authors： Pietilä K,Nikkari T

    更新日期：1980-09-01 00:00:00

  • The Carnitine-butyrobetaine-trimethylamine-N-oxide pathway and its association with cardiovascular mortality in patients with carotid atherosclerosis.

    abstract：BACKGROUND AND PURPOSE:γ-butyrobetaine (γBB) is a metabolite from dietary Carnitine, involved in the gut microbiota-dependent conversion from Carnitine to the pro-atherogenic metabolite trimethylamine-N-oxide (TMAO). Orally ingested γBB has a pro-atherogenic effect in experimental studies, but γBB has not been studied ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2016.01.033

    authors： Skagen K,Trøseid M,Ueland T,Holm S,Abbas A,Gregersen I,Kummen M,Bjerkeli V,Reier-Nilsen F,Russell D,Svardal A,Karlsen TH,Aukrust P,Berge RK,Hov JE,Halvorsen B,Skjelland M

    更新日期：2016-04-01 00:00:00

  • Hyperglycaemia is associated with impaired vasa vasorum neovascularization and accelerated atherosclerosis in apolipoprotein-E deficient mice.

    abstract：OBJECTIVE:A direct correlation between blood glucose levels and the microvascular complications of diabetes is well established. However, the effects of hyperglycaemia on the vasa vasorum, a microvascular network which surrounds and supplies the walls of large arteries, is not known. The objective of this study is to i...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2013.01.018

    authors： Veerman KJ,Venegas-Pino DE,Shi Y,Khan MI,Gerstein HC,Werstuck GH

    更新日期：2013-04-01 00:00:00

  • Platelet-derived MIF: a novel platelet chemokine with distinct recruitment properties.

    abstract：OBJECTIVE:Macrophage migration inhibitory factor (MIF) is an inflammatory cytokine with chemokine-like functions that plays a role in several inflammatory diseases including atherosclerosis. We recently demonstrated that in addition to macrophages and endothelial cells, platelets are a source of MIF. However, the funct...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2014.12.039

    authors： Wirtz TH,Tillmann S,Strüßmann T,Kraemer S,Heemskerk JW,Grottke O,Gawaz M,von Hundelshausen P,Bernhagen J

    更新日期：2015-03-01 00:00:00

  • Usefulness of lipoprotein ratios in assessing carotid atherosclerosis in Japanese type 2 diabetic patients.

    abstract：OBJECTIVE:It is indicated that total/HDL cholesterol and LDL/HDL cholesterol ratios have more predictive power for cardiovascular disease compared to classic lipid parameters. However, there have been few reports about the usefulness of these indices for the assessment of early stage atherosclerosis in Japanese type 2 ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2010.10.035

    authors： Katakami N,Kaneto H,Osonoi T,Saitou M,Takahara M,Sakamoto F,Yamamoto K,Yasuda T,Matsuoka TA,Matsuhisa M,Yamasaki Y,Shimomura I

    更新日期：2011-02-01 00:00:00

  • Metabolic syndrome and urinary cGMP excretion in general population.

    abstract：:To examine the relationship between metabolic syndrome and endothelial dysfunction, we investigated cross-sectionally the correlation between metabolic risk factors and urinary excretion of cyclic guanosine 3',5'-monophosphate (cGMP), a second messenger of nitric oxide (NO), in 1541 Japanese men and women aged 40-79 y...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.atherosclerosis.2006.02.032

    authors： Cui R,Iso H,Pi J,Kumagai Y,Yamagishi K,Tanigawa T,Shimamoto T

    更新日期：2007-02-01 00:00:00

  • Possible involvement of p44/p42 MAP kinase in retinoic acid-stimulated vascular endothelial growth factor release in aortic smooth muscle cells.

    abstract：:Retinoic acid modulates cell growth and differentiation of the vascular system. Vascular endothelial growth factor (VEGF) is known as a vascular permeability factor and a potent mitogen for vascular endothelial cells. In the present study, we investigated whether retinoic acid induces VEGF release in aortic smooth mus...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2004.05.002

    authors： Tanabe K,Hirade K,Ishisaki A,Shu E,Suga H,Kitajima Y,Katagiri Y,Dohi S,Kozawa O

    更新日期：2004-08-01 00:00:00

  • Lipid-lowering therapy with fluvastatin inhibits oxidative modification of low density lipoprotein and improves vascular endothelial function in hypercholesterolemic patients.

    abstract：:This prospective randomized trial was designed to elucidate clinically the effect of fluvastatin on inhibiting oxidation of the low density lipoprotein (LDL) and improving the vascular endothelial function as well as its lipid-lowering effects, in comparison with pravastatin. Of 64 consecutive dyslipidemic patients, 4...

    journal_title：Atherosclerosis

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0021-9150(01)00585-8

    authors： Inoue T,Hayashi M,Takayanagi K,Morooka S

    更新日期：2002-02-01 00:00:00

  • Cationic peptides neutralize Ox-LDL, prevent its uptake by macrophages, and attenuate inflammatory response.

    abstract：OBJECTIVE:Apolipoprotein A1 (ApoA1) and apolipoprotein E (ApoE) mimetic peptides have attracted attention due to their ability to reduce atherosclerosis and exhibit antioxidant, anti-inflammatory, and hypolipidemic properties. In this study, we tested whether three distinct and unrelated cationic peptides would inhibit...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2014.06.020

    authors： Aluganti Narasimhulu C,Selvarajan K,Brown M,Parthasarathy S

    更新日期：2014-09-01 00:00:00

  • Quantitative morphologic study of intimal thickening at the human carotid bifurcation: I. Axial and circumferential distribution of maximum intimal thickening in asymptomatic, uncomplicated plaques.

    abstract：:The spatial distribution of intimal thickening was determined for each of 42 carotid bifurcations removed at autopsy from patients with no clinical or anatomic evidence of cerebrovascular disease. Both right and left specimens were available for six of the individuals. Each bifurcation was removed intact and included ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(94)90015-9

    authors： Masawa N,Glagov S,Zarins CK

    更新日期：1994-06-01 00:00:00

  • Administration of natural astaxanthin increases serum HDL-cholesterol and adiponectin in subjects with mild hyperlipidemia.

    abstract：BACKGROUND:Astaxanthin has been reported to improve dyslipidemia and metabolic syndrome in animals, but such effects in humans are not well known. METHODS:Placebo-controlled astaxanthin administration at doses of 0, 6, 12, 18 mg/day for 12 weeks was randomly allocated to 61 non-obese subjects with fasting serum trigly...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.atherosclerosis.2009.10.012

    authors： Yoshida H,Yanai H,Ito K,Tomono Y,Koikeda T,Tsukahara H,Tada N

    更新日期：2010-04-01 00:00:00

  • Hydrogen-rich saline prevents neointima formation after carotid balloon injury by suppressing ROS and the TNF-α/NF-κB pathway.

    abstract：BACKGROUND:Reactive oxygen species (ROS) play a pivotal role in neointima hyperplasia after balloon injury. Molecular hydrogen has emerged as a novel antioxidant and has been proven effective in treating many diseases. OBJECTIVES:We aimed to determine the mechanism by which hydrogen affects neointima formation. METHO...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2011.11.002

    authors： Qin ZX,Yu P,Qian DH,Song MB,Tan H,Yu Y,Li W,Wang H,Liu J,Wang Q,Sun XJ,Jiang H,Zhu JK,Lu W,Huang L

    更新日期：2012-02-01 00:00:00

  • Prevention of oxLDL uptake leads to decreased atherosclerosis in hematopoietic NPC1-deficient Ldlr-/- mice.

    abstract：BACKGROUND AND AIMS:Atherosclerosis is a chronic inflammatory disease of medium and large vessels and is typically characterized by the predominant accumulation of low-density lipoprotein (LDL)-cholesterol inside macrophages that reside in the vessel walls. Previous studies clearly demonstrated an association specifica...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2016.10.038

    authors： Jeurissen MLJ,Walenbergh SMA,Houben T,Gijbels MJJ,Li J,Hendrikx T,Oligschlaeger Y,van Gorp PJ,Binder CJ,Donners MMPC,Shiri-Sverdlov R

    更新日期：2016-12-01 00:00:00

  • Pregnancy-associated plasma protein-A (PAPP-A) and cardiovascular risk.

    abstract：:The search for markers to improve risk prediction for individuals at risk of developing serious cardiovascular events is ongoing. New markers of coronary artery disease progression have been identified in recent years, among which, circulating levels of pregnancy-associated plasma protein-A (PAPP-A) offer an interesti...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,评审

    doi：10.1016/j.atherosclerosis.2008.07.042

    authors： Consuegra-Sanchez L,Fredericks S,Kaski JC

    更新日期：2009-04-01 00:00:00

  • Bradykinin stimulates endothelial cell fatty acid oxidation by CaMKK-dependent activation of AMPK.

    abstract：:Endothelial cell lipotoxicity mediated by accumulation of free fatty acids is an early event in the pathogenesis of atherosclerosis. The energy-sensor AMP-activated protein kinase (AMPK) is a key regulator of endothelial cell lipid metabolism. To test the hypothesis that bradykinin (BK) regulates AMPK and fatty acid o...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2007.12.003

    authors： Mount PF,Lane N,Venkatesan S,Steinberg GR,Fraser SA,Kemp BE,Power DA

    更新日期：2008-09-01 00:00:00

  • Quantification of epicardial and peri-coronary fat using cardiac computed tomography; reproducibility and relation with obesity and metabolic syndrome in patients suspected of coronary artery disease.

    abstract：OBJECTIVE:Adipose tissue surrounding coronary arteries may contribute to the development of coronary atherosclerosis given its localisation and potential for local production of inflammatory cytokines. We compared various measurements for quantifying epicardial adipose tissue (EAT) and peri-coronary fat using cardiac C...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2007.08.016

    authors： Gorter PM,van Lindert AS,de Vos AM,Meijs MF,van der Graaf Y,Doevendans PA,Prokop M,Visseren FL

    更新日期：2008-04-01 00:00:00

  • Aspirin inhibits monocyte chemoattractant protein-1 and interleukin-8 expression in TNF-alpha stimulated human umbilical vein endothelial cells.

    abstract：:Atherosclerosis and its complications such as stroke, myocardial infraction and peripheral vascular disease, remain the major causes of morbidity and mortality in the world. Studies have showed that chemokines and adhesion molecules are involved in causing atherosclerosis by promoting directed migration of inflammator...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2004.01.024

    authors： Yang YY,Hu CJ,Chang SM,Tai TY,Leu SJ

    更新日期：2004-06-01 00:00:00

  • The HMG-CoA reductase inhibitor rosuvastatin inhibits plasminogen activator inhibitor-1 expression and secretion in human adipocytes.

    abstract：:Human preadipocytes and adipocytes are known to produce the proatherogenic factor PAI-1 and proinflammatory cytokines, and obesity was found to be state of increased adipose production of these factors. In the present study, we investigated the effect of rosuvastatin on the regulation of PAI-1 gene expression in human...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2007.06.005

    authors： Laumen H,Skurk T,Hauner H

    更新日期：2008-02-01 00:00:00

  • Age and sex mediated changes in epicardial fat adipokines.

    abstract：:Aging, which is an independent risk factor for heart disease, alters body fat mass and its function. Epicardial fat plays an important physiological and pathophysiological role on cardiac structure and function. This study investigated if aging altered the abundance of epicardial (EF) and abdominal fat (AF) derived me...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2010.06.044

    authors： Fei J,Cook C,Blough E,Santanam N

    更新日期：2010-10-01 00:00:00

  • Involvement of potassium channels in the protective effect of 17beta-estradiol on hypercholesterolemic rabbit carotid artery.

    abstract：:The involvement of endothelium-derived hyperpolarizing factor (EDHF) in the protective effect of 17beta-estradiol was investigated on the phenylephrine-precontracted carotid artery from cholesterol fed rabbits. Animals were fed for 8 weeks as follows: control group, standard chow; (control+estradiol) group, standard c...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(99)00450-5

    authors： Ghanam K,Ea-Kim L,Javellaud J,Oudart N

    更新日期：2000-09-01 00:00:00

  • Sex hormone levels and subclinical atherosclerosis in postmenopausal women: the Multi-Ethnic Study of Atherosclerosis.

    abstract：:We examined cross-sectional associations between sex hormones and carotid artery intimal-medial thickness (cIMT) and coronary artery calcium in women in the Multi-Ethnic Study of Atherosclerosis. Serum testosterone, estradiol, sex hormone binding globulin (SHBG), and dehydroepiandrosterone levels were measured in 1947...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.atherosclerosis.2008.08.037

    authors： Ouyang P,Vaidya D,Dobs A,Golden SH,Szklo M,Heckbert SR,Kopp P,Gapstur SM

    更新日期：2009-05-01 00:00:00