当前位置： SCI文献检索 > ATHEROSCLEROSIS期刊下所有文献 > Variation of apolipoprotein B as a possible cause of decreased low density lipoprotein clearance and hypercholesterolemia.

Variation of apolipoprotein B as a possible cause of decreased low density lipoprotein clearance and hypercholesterolemia.

Abstract：

:The fractional catabolic rate (FCR) for low density lipoprotein (LDL) apolipoprotein B (apo B) was studied to explore the variations in apo B as a possible cause of hypercholesterolemia. The FCR of radioiodine labelled autologous LDL and homologous LDL isolated from a normocholesterolemic subject were compared in forty-nine type II hypercholesterolemic males and females with the mean plasma concentration of total cholesterol of 7.78 mmol/l, LDL-cholesterol 5.41 mmol/l and triglycerides 2.09 mmol/l. In most patients the autologous LDL was catabolized at an equal rate and sometimes even faster than the homologous LDL. However, twelve out of forty-nine patients catabolized homologous LDL 0.8-19.3% faster than autologous LDL and several apo B polymorphisms were determined. No apo B-3500 or apo B-3531 mutations were detected. Patients with XbaI -/- (absence of cutting site) had lower total, IDL and LDL cholesterol and LDL apoB than the other genotypes. Patients with EcoRI +/+ (presence of cutting site) had higher total, VLDL and LDL cholesterol and slower FCR for autologous LDL, and their VLDL was richer in cholesterol than that of patients with the EcoRI +/-. The MspI and ins/del polymorphisms were not associated with variations in the measured parameters. The apo E 4 was associated with higher VLDL and IDL cholesterol, higher triglycerides and LDL apo B than E 3/3. Overall, the determined apo B polymorphisms were not related to the slow clearance of autologous LDL among the 12 patients, in whom autologous LDL was cleared at a slower rate than homologous LDL. In conclusion, hypercholesterolemia can be due to particle-related slow clearance of LDL in some patients. However, this is not a common cause of hypercholesterolemia.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Korhonen T,Savolainen MJ,Kesäniemi YA

doi

10.1016/s0021-9150(99)00106-9

keywords:

subject

Has Abstract

pub_date

1999-09-01 00:00:00

pages

1-10

issue

1

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(99)00106-9

journal_volume

146

pub_type

临床试验,杂志文章

相关文献

ATHEROSCLEROSIS文献大全
  • Calculation of LDL apoB.

    abstract：OBJECTIVES:This study tests the validity of the Hattori formula to calculate LDL apoB based on plasma lipids and total apoB. METHODS:In 2178 patients in a tertiary care lipid clinic, LDL apoB calculated as suggested by Hattori et al. was compared to directly measured LDL apoB isolated by ultracentrifugation. RESULTS:...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2014.03.012

    authors： Sniderman AD,Tremblay AJ,De Graaf J,Couture P

    更新日期：2014-06-01 00:00:00

  • Impaired carotid and femoral viscoelastic properties and elevated intima-media thickness in peripheral vascular disease.

    abstract：BACKGROUND:We undertook a study to determine whether peripheral vascular disease of the lower extremity (PVD) per se affects the arterial viscoelastic properties and intima-media thickness (IMT) of the carotid and femoral arteries. METHODS:Thirty-five patients with PVD, 35 age- and gender-matched control subjects were...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(02)00042-4

    authors： Cheng KS,Tiwari A,Baker CR,Morris R,Hamilton G,Seifalian AM

    更新日期：2002-09-01 00:00:00

  • Body fat distribution and cardiovascular risk in middle-aged people in southern Italy.

    abstract：:Skinfold thickness, % body fat content, body mass index, systolic and diastolic blood pressure, plasma glucose, serum cholesterol and triglycerides have been measured in 132 middle-aged men (mean age 39.8 +/- 9.9, range 20-59 yr) and in 114 middle-aged women (mean age 39.1 +/- 9.3, range 20-59 yr). Anthropometric data...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(86)90077-8

    authors： Contaldo F,Di Biase G,Panico S,Trevisan M,Farinaro E,Mancini M

    更新日期：1986-08-01 00:00:00

  • Beta-very low density lipoproteins in cholesterol-fed rabbits are of hepatic origin.

    abstract：:When rabbits are fed a cholesterol-rich diet they accumulate beta-migrating very low density lipoprotein (beta-VLDL) in their plasma. beta-VLDL are cholesteryl ester-rich lipoproteins which contain apolipoproteins B and E. There are 2 forms of apolipoprotein B in beta-VLDL. About 90% of apolipoprotein B is present as ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(85)90007-3

    authors： Kroon PA,Thompson GM,Chao YS

    更新日期：1985-09-01 00:00:00

  • Serum selenium and coronary heart disease risk factors in southern Italian men.

    abstract：:The association between serum selenium concentration and a number of coronary heart disease risk factors is studied in 364 males from southern Italy participating in the Olivetti Heart Study. Selenium correlates positively and significantly with serum cholesterol (r = 0.120; P = 0.022), and this positive association p...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(91)90015-u

    authors： Jossa F,Trevisan M,Krogh V,Farinaro E,Giumetti D,Fusco G,Galasso R,Panico S,Frascatore S,Mellone C

    更新日期：1991-04-01 00:00:00

  • "Low dose" colestipol in children, adolescents and young adults with familial hypercholesterolemia.

    abstract：:The effect of colestipol on plasma lipids and lipoproteins was studied in children, adolescents and young adults with familial hypercholesterolemia. O.125 g or 0.25 g/kg body weight were given in randomized sequence for period of 4 weeks. Total cholesterol was lowered by 13 and 18% with the smaller and larger dose , r...

    journal_title：Atherosclerosis

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0021-9150(82)90077-6

    authors： Schlierf G,Mrozik K,Heuck CC,Middelhoff G,Oster P,Riesen W,Schellenberg B

    更新日期：1982-01-01 00:00:00

  • Tissue-specific expression pattern of human endothelial lipase in transgenic mice.

    abstract：:Endothelial lipase (EL), a new member of the triacylglycerol lipase gene family, is a key enzyme in HDL metabolism. The EL expression pattern in humans was reported to be unique and complementary to that documented for lipoprotein lipase. The regulatory elements responsible for the tissue-specific EL expression are no...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2005.01.027

    authors： Broedl UC,Jin W,Marchadier D,Secreto A,Rader DJ

    更新日期：2005-08-01 00:00:00

  • Incomplete dominance of type III hyperlipoproteinemia is associated with the rare apolipoprotein E2 (Arg136-->Ser) variant in multigenerational pedigree studies.

    abstract：:In the process of screening apolipoprotein (apo) E genotypes in a population of subjects with lipid abnormalities, we have identified five subjects (one homozygote and four heterozygotes) with an abnormal 109 base pairs band following apo E restriction isotyping of amplified DNA with the restriction endonuclease CfoI....

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(95)06745-0

    authors： Pocovi M,Cenarro A,Civeira F,Myers RH,Casao E,Esteban M,Ordovas JM

    更新日期：1996-04-26 00:00:00

  • Nonalcoholic fatty liver disease and advanced fibrosis are associated with left ventricular diastolic dysfunction.

    abstract：BACKGROUND AND AIMS:Nonalcoholic fatty liver disease (NAFLD) may be associated with a wide spectrum of cardiac abnormalities, which share many metabolic risk factors. This study aimed to evaluate whether NAFLD is associated with left ventricular (LV) diastolic dysfunction independent of other classical risk factors. M...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2018.03.027

    authors： Chung GE,Lee JH,Lee H,Kim MK,Yim JY,Choi SY,Kim YJ,Yoon JH,Kim D

    更新日期：2018-05-01 00:00:00

  • Evaluation of cholesterol lowering treatment of patients with familial hypercholesterolemia: a large cross-sectional study in The Netherlands.

    abstract：BACKGROUND:Heterozygous familial hypercholesterolemia (heFH) is a common autosomal dominant hereditary disorder caused by mutations in the LDL-receptor gene that lead to elevated plasma levels of low-density lipoprotein-cholesterol (LDL-c). Robust lowering of LDL-c levels is essential for risk reduction of premature ca...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2009.09.014

    authors： Pijlman AH,Huijgen R,Verhagen SN,Imholz BP,Liem AH,Kastelein JJ,Abbink EJ,Stalenhoef AF,Visseren FL

    更新日期：2010-03-01 00:00:00

  • Stroke with polyvascular atherothrombotic disease.

    abstract：OBJECTIVE:To study the influence of polyvascular atherothrombotic disease on stroke patient prognosis, its relation with inflammatory markers, and to analyze the progression of atherothrombotic disease. METHODS:MITICO is a multi-centered prospective observational study recruiting non-anticoagulated ischemic stroke pat...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.atherosclerosis.2009.07.041

    authors： Blanco M,Sobrino T,Montaner J,Medrano V,Jiménez C,Masjuán J,Gómez-Escalonilla C,de Luis P,Arboix A,Castillo J,MITICO Study.

    更新日期：2010-02-01 00:00:00

  • Glucose tolerance, plasma insulin, HDL cholesterol and obesity: 12-year follow-up and development of coronary heart disease in Edinburgh men.

    abstract：:The insulin response to a standard oral glucose tolerance test (OGTT) and other anthropometric and biochemical risk factors for coronary heart disease (CHD) were measured in a random sample of 107 Edinburgh men, who were initially studied in 1976 when they were 40 and who were reexamined in 1988-89. Fasting glucose an...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(92)90188-m

    authors： Hargreaves AD,Logan RL,Elton RA,Buchanan KD,Oliver MF,Riemersma RA

    更新日期：1992-05-01 00:00:00

  • Expression of tissue transglutaminase and elafin in human coronary artery: implication for plaque instability.

    abstract：BACKGROUND:the extracellular matrix (ECM) is an important determinant of plaque instability. Since tissue transglutaminase (tTG) and elafin act as stabilizing factors, they might play a crucial role in the pathogenesis of acute coronary syndrome. We examined their expression in human coronary arteries and the regulatio...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(01)00542-1

    authors： Sumi Y,Inoue N,Azumi H,Seno T,Okuda M,Hirata K,Kawashima S,Hayashi Y,Itoh H,Yokoyama M

    更新日期：2002-01-01 00:00:00

  • Detection of rupture-prone atherosclerotic plaques by time-resolved laser-induced fluorescence spectroscopy.

    abstract：OBJECTIVE:Plaque with dense inflammatory cells, including macrophages, thin fibrous cap and superficial necrotic/lipid core is thought to be prone-to-rupture. We report a time-resolved laser-induced fluorescence spectroscopy (TR-LIFS) technique for detection of such markers of plaque vulnerability in human plaques. ME...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2008.08.035

    authors： Marcu L,Jo JA,Fang Q,Papaioannou T,Reil T,Qiao JH,Baker JD,Freischlag JA,Fishbein MC

    更新日期：2009-05-01 00:00:00

  • beta-very low density lipoprotein enhances inducible nitric oxide synthase expression in cytokine-stimulated vascular smooth muscle cells.

    abstract：:beta-very low-density lipoprotein (beta-VLDL), a collective term for VLDL and chylomicron remnants, has recently shown to potently promote the development of atherosclerosis. However, the effects of beta-VLDL on the accumulation of nitric oxide (NO) and the expression of inducible NO synthase (iNOS) in vascular smooth...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(01)00727-4

    authors： Takahashi M,Takahashi S,Shimpo M,Naito A,Ogata Y,Kobayashi E,Ikeda U,Shimada K

    更新日期：2002-06-01 00:00:00

  • FH-Freiburg: a novel missense mutation (C317Y) in growth factor repeat A of the low density lipoprotein receptor gene in a German patient with homozygous familial hypercholesterolemia.

    abstract：:We describe the characterization of a novel mutation in the low density lipoprotein receptor (LDL-R) gene in a patient with true homozygous familial hypercholesterolemia (FH). The combined use of denaturing gradient gel electrophoresis (DGGE) and sequencing of genomic DNA revealed a guanine to adenine base substitutio...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(99)00415-3

    authors： Nauck MS,Scharnagl H,Nissen H,Schürmann C,Matern D,Nauck MA,Wieland H,März W

    更新日期：2000-08-01 00:00:00

  • Association between self-reported physical activity and vascular reactivity in postmenopausal women.

    abstract：:Short-term exercise training has been associated with improved endothelial-dependent vasodilation, but the impact of long-term habitual physical activity on vascular reactivity is not established. We studied the correlation between self-reported, habitual physical activity and vasoreactivity in non-smoking, non-diabet...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(01)00529-9

    authors： McKechnie R,Rubenfire M,Mosca L

    更新日期：2001-12-01 00:00:00

  • Micro-ultrasound imaging assessment of carotid plaque characteristics in apolipoprotein-E knockout mice.

    abstract：:This study was aimed to test the hypothesis that noninvasive assessment of carotid plaques can be achieved by high-resolution micro-ultrasound imaging in apolipoprotein-E knockout (apoE-KO) mice. Forty-two male apoE-KO mice were fed a high-fat diet and atherosclerotic lesions in the left common carotid artery were ind...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2007.07.039

    authors： Ni M,Zhang M,Ding SF,Chen WQ,Zhang Y

    更新日期：2008-03-01 00:00:00

  • Risk of myocardial infarction in patients with rhinosinusitis.

    abstract：:Research has indicated that inflammation promote all phases of atherosclerosis. The current study tested the hypothesis that rhinosinusitis is a risk marker for myocardial infarction (MI). Data on the general population were obtained from the Taiwan Longitudinal Health Insurance Database 2005 (LHID2005). The study coh...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2012.10.058

    authors： Hao WR,Lin HW,Chao PZ,Wu CW,Yen TH,Liu JC,Liou TH

    更新日期：2013-01-01 00:00:00

  • Sex hormones and high density lipoproteins in healthy males.

    abstract：:The serum concentrations of testosterone, androstenedione, oestradiol and total low polar oestrogens, mainly oestradiol and oestrone, were measured in 26 healthy male subjects. The subjects were divided into two groups each of them with low (less than 1.04 mmol/l) and high (greater than 1.56 mmol/l) levels of serum HD...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(79)90067-4

    authors： Nordøy A,Aakvaag A,Thelle D

    更新日期：1979-12-01 00:00:00

  • The NLRP3 inflammasome and the emerging role of colchicine to inhibit atherosclerosis-associated inflammation.

    abstract：:Atherosclerosis is considered a chronic inflammatory disease of the arterial wall. Recently, compelling evidence has arisen for the role of monocytes and neutrophils and a particular protein complex that resides within these cells - the NLRP3 inflammasome - in atherosclerosis-associated inflammation. It is now also kn...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,评审

    doi：10.1016/j.atherosclerosis.2017.12.027

    authors： Martínez GJ,Celermajer DS,Patel S

    更新日期：2018-02-01 00:00:00

  • Age-associated ultrastructural changes in the aortic intima of rats with diet-induced hypercholesterolemia.

    abstract：:The ultrastructure of the aortic intima and serum lipid levels in Fischer 344 rats were examined at the ages of 12, 18 and 24 months after feeding the animals an atherogenic diet (2% cholesterol, 0.25% sodium cholate, 5% beef fat) for 6 months. Structural changes in the intima were noticeable only at the age of 24 mon...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(89)90114-7

    authors： Nakamura H,Izumiyama N,Nakamura K,Ohtsubo K

    更新日期：1989-10-01 00:00:00

  • Plasma proprotein convertase subtilisin-kexin type 9 does not change during 24h insulin infusion in healthy subjects and type 2 diabetic patients.

    abstract：PURPOSE:Proprotein convertase subtilisin-kexin type 9 (PCSK9) promotes low density lipoprotein (LDL) receptor degradation, thereby providing a key pathway for LDL metabolism. PCSK9 mRNA expression may be upregulated by insulin in murine models. Here we examined effects of exogenous hyperinsulinemia on plasma PCSK9 leve...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2010.10.028

    authors： Kappelle PJ,Lambert G,Dullaart RP

    更新日期：2011-02-01 00:00:00

  • A single injection of gain-of-function mutant PCSK9 adeno-associated virus vector induces cardiovascular calcification in mice with no genetic modification.

    abstract：BACKGROUND AND AIMS:Studying atherosclerotic calcification in vivo requires mouse models with genetic modifications. Previous studies showed that injection of recombinant adeno-associated virus vector (AAV) encoding a gain-of-function mutant PCSK9 into mice promotes atherosclerosis. We aimed to study cardiovascular cal...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2016.06.011

    authors： Goettsch C,Hutcheson JD,Hagita S,Rogers MA,Creager MD,Pham T,Choi J,Mlynarchik AK,Pieper B,Kjolby M,Aikawa M,Aikawa E

    更新日期：2016-08-01 00:00:00

  • Effect of n-3 fatty acids and statins on oxidative stress in statin-treated hypercholestorelemic and normocholesterolemic women.

    abstract：INTRODUCTION:Although the combination of statins with n-3 fatty acids seems to be beneficial under the lipid profile aspect, there is little information about the interaction of these two compounds on oxidative stress. OBJECTIVE:Evaluate the interaction between statins and n-3 fatty acids on oxidative stress in women,...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.atherosclerosis.2010.12.013

    authors： Carrepeiro MM,Rogero MM,Bertolami MC,Botelho PB,Castro N,Castro IA

    更新日期：2011-07-01 00:00:00

  • Localization of atherosclerotic lesions in the bifurcation of the main left coronary artery.

    abstract：:The detailed distribution of atherosclerotic lesions in the branching region of the left main coronary artery in man was studied. Tissue cubes of the hearts, containing the left coronary arteries, were removed, and 1.5-mm-thick parallel and consecutive slices were cut perpendicular to the main coronary artery. Histolo...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(83)90071-0

    authors： Grøttum P,Svindland A,Walløe L

    更新日期：1983-04-01 00:00:00

  • The influence of apoE-deficiency and LDL-receptor-deficiency on the HDL subpopulation profile in mice and in humans.

    abstract：OBJECTIVE:As apoE(-/-) and LDL-Receptor(-/-) mice are commonly used in atherosclerosis research; our objective was to point out the differences in HDL metabolism between mice and humans regarding the roles of apoE and LDLR. METHODS:We examined HDL particles obtained from wild type (WT), LDLR(-/-), and apoE(-/-) mice, ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2013.11.080

    authors： Tani M,Matera R,Horvath KV,Hasan TS,Schaefer EJ,Asztalos BF

    更新日期：2014-03-01 00:00:00

  • High plasma insulin is associated with lower LDL cholesterol in elderly individuals.

    abstract：:To investigate possible relationships between plasma low density lipoprotein (LDL) cholesterol and fasting plasma insulin in the elderly, cross-sectional random samples of age cohorts (65, 75, 80 and 85 years, n = 1188, M/F 38/62 percent) were studied in the neighbouring cities of Helsinki and Vantaa, Finland. Plasma ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(95)05733-1

    authors： Strandberg TE,Tilvis RS,Lindberg O,Valvanne J,Sairanen S,Ehnholm C,Tuomilehto J

    更新日期：1996-04-05 00:00:00

  • Platelet membrane collagen receptor glycoprotein VI polymorphism is associated with coronary thrombosis and fatal myocardial infarction in middle-aged men.

    abstract：:Glycoprotein VI is a platelet collagen receptor binding to subendothelial collagen after a rupture of an atherosclerotic plaque. The GPVI gene is polymorphic with several SNPs and the T13254C polymorphism predicting amino acid substitution (serine to proline) has been associated with the risk of MI in a preliminary st...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2004.03.021

    authors： Ollikainen E,Mikkelsson J,Perola M,Penttilä A,Karhunen PJ

    更新日期：2004-09-01 00:00:00

  • Relationship of serum ferritin concentrations with metabolic cardiovascular risk factors in men without evidence for coronary artery disease.

    abstract：:Elevated serum ferritin concentrations between 200 and 500 microg/l have been found to be a strong risk factor for acute myocardial infarction in Finnish men, but the reason for this association is still uncertain. In the Finnish population ferritin concentrations correlated with factors of insulin resistance syndrome...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(96)05994-1

    authors： Halle M,König D,Berg A,Keul J,Baumstark MW

    更新日期：1997-02-10 00:00:00