Abstract：
INTRODUCTION:Although the combination of statins with n-3 fatty acids seems to be beneficial under the lipid profile aspect, there is little information about the interaction of these two compounds on oxidative stress. OBJECTIVE:Evaluate the interaction between statins and n-3 fatty acids on oxidative stress in women, using a 2² factorial design. METHODS:Forty-three women participated in this crossover design. They were separated into two groups in which 20 were under statin treatment for more than 6 months, and 23 were normolipidemic. Within each group, half of the patients received capsules containing 2.4 g/day of a mixture of EPA and DHA for 6 weeks, while the other half received a mixture of soya and corn oil. After a period of 90 days of washout, the groups were switched, and received the supplementation for 6 weeks more. RESULTS:Statins reduced serum LDL and increased SOD expression. n-3 fatty acids increased the plasma malondialdehyde and SOD activity but reduced catalase expression (p<0.05). The interaction involving statins and n-3 fatty acids was nearly significant to the serum triacylglycerol reduction (p=0.054). CONCLUSION:Combining statins and n-3 fatty acids is an excellent strategy to reduce plasma cholesterol and triacylglycerol concentration in women. However, n-3 fatty acids increased the oxidative stress and the pleiotropic effect of statins seemed to be not enough to counterbalance this result. Our data also suggested that the mechanism by which n-3 fatty acids interfere in oxidative stress can be associated with antioxidant enzymes expression and activity.
journal_name
Atherosclerosisjournal_title
Atherosclerosisauthors
Carrepeiro MM,Rogero MM,Bertolami MC,Botelho PB,Castro N,Castro IAdoi
10.1016/j.atherosclerosis.2010.12.013subject
Has Abstractpub_date
2011-07-01 00:00:00pages
171-8issue
1eissn
0021-9150issn
1879-1484pii
S0021-9150(10)01033-6journal_volume
217pub_type
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