Soluble endoglin, hypercholesterolemia and endothelial dysfunction.

Abstract:

:A soluble form of endoglin (sEng) is known to be an extracellular domain of the full-length membrane endoglin, which is elevated during various pathological conditions related to vascular endothelium. In the current review, we tried to summarize a possible role of soluble endoglin in cardiovascular pathologies, focusing on its relation to endothelial dysfunction and cholesterol levels. We discussed sEng as a proposed biomarker of cardiovascular disease progression, cardiovascular disease treatment and endothelial dysfunction. We also addressed a potential interaction of sEng with TGF-β/eNOS or BMP-9 signaling. We suggest soluble endoglin levels to be monitored, because they reflect the progression/treatment efficacy of cardiovascular diseases related to endothelial dysfunction and hypercholesterolemia. A possible role of soluble endoglin as an inducer of endothelial dysfunction however remains to be elucidated.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Rathouska J,Jezkova K,Nemeckova I,Nachtigal P

doi

10.1016/j.atherosclerosis.2015.10.003

subject

Has Abstract

pub_date

2015-12-01 00:00:00

pages

383-8

issue

2

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(15)30150-7

journal_volume

243

pub_type

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