Soluble endoglin, hypercholesterolemia and endothelial dysfunction.


:A soluble form of endoglin (sEng) is known to be an extracellular domain of the full-length membrane endoglin, which is elevated during various pathological conditions related to vascular endothelium. In the current review, we tried to summarize a possible role of soluble endoglin in cardiovascular pathologies, focusing on its relation to endothelial dysfunction and cholesterol levels. We discussed sEng as a proposed biomarker of cardiovascular disease progression, cardiovascular disease treatment and endothelial dysfunction. We also addressed a potential interaction of sEng with TGF-β/eNOS or BMP-9 signaling. We suggest soluble endoglin levels to be monitored, because they reflect the progression/treatment efficacy of cardiovascular diseases related to endothelial dysfunction and hypercholesterolemia. A possible role of soluble endoglin as an inducer of endothelial dysfunction however remains to be elucidated.






Rathouska J,Jezkova K,Nemeckova I,Nachtigal P




Has Abstract


2015-12-01 00:00:00














  • Rapid and substantial lowering of human serum cholesterol by mevinolin (MK-803), an inhibitor of hydroxymethylglutaryl-coenzyme A reductase.

    abstract::Mevinolin (MK-803) is a potent inhibitor of HMG-CoA reductase. After a placebo run-in period, mevinolin 5,15 or 50 mg, or placebo was given twice daily for 7-11 days under double -blind conditions ot 4 groups of 6 normocholesterolemic male volunteers. After 7 days, mean serum cholesterol fell 14%, 25% and 24% on 5, 15...


    pub_type: 临床试验,杂志文章


    authors: Tobert JA,Hitzenberger G,Kukovetz WR,Holmes IB,Jones KH

    更新日期:1982-01-01 00:00:00

  • Apolipoprotein E genotype affects plasma lipid response to atorvastatin in a gender specific manner.

    abstract::The response to therapy with hypolipidemic agents shows considerable individual variation. These differences may be due to the interaction of environmental and genetic factors that affect drug bioavailability, receptor function or ligand structure. Our objective was to assess the effect of apolipoprotein (apo) E genot...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Pedro-Botet J,Schaefer EJ,Bakker-Arkema RG,Black DM,Stein EM,Corella D,Ordovas JM

    更新日期:2001-09-01 00:00:00

  • Mediterranean diet and carotid atherosclerosis in the Northern Manhattan Study.

    abstract:OBJECTIVE:Adherence to a Mediterranean-style diet (MeDi) may protect against clinical vascular events by reducing atherosclerosis, but data is limited. This is the first observational study of the association between MeDi adherence and carotid plaque thickness and area. METHODS:The study included 1374 participants of ...


    pub_type: 杂志文章


    authors: Gardener H,Wright CB,Cabral D,Scarmeas N,Gu Y,Cheung K,Elkind MS,Sacco RL,Rundek T

    更新日期:2014-06-01 00:00:00

  • Effects of soy protein and casein in low cholesterol diets on plasma lipoproteins in normolipidemic subjects.

    abstract::Dietary plant proteins may lower plasma cholesterol and LDL concentrations in hypercholesterolemic patients when substituted for animal proteins, particularly in diets with low cholesterol and saturated fat content. Plant protein diets appear, however, to be without effect on plasma lipoprotein levels in normal subjec...


    pub_type: 杂志文章


    authors: Meinertz H,Faergeman O,Nilausen K,Chapman MJ,Goldstein S,Laplaud PM

    更新日期:1988-07-01 00:00:00

  • Sex differences in risk factors, etiology, and short-term outcome of cerebral infarction in young patients.

    abstract::Investigations to date have demonstrated that the underlying etiology, causes and burden of stroke may be different for women and men. However, data regarding sex differences among young cerebral ischemic stroke patients remains scarce. We conducted this study in 669 young Chinese adults with acute ischemic stroke as ...


    pub_type: 杂志文章


    authors: Zhang B,Pu S,Zhang W,Yang N,Shen G,Yin J,Yi Y,Gao Q,Gao C

    更新日期:2011-06-01 00:00:00

  • Changes in aortic endothelial gene expressions and relaxation responses following chronic short-term insulin treatment in diabetic rats.

    abstract::The purpose of the present study was to examine the relationship between the changes in the expressions of several mRNAs and changes in endothelial function in streptozotocin-induced diabetic and chronic short-term insulin-treated rats. Aortas from later-stage (10 week) diabetics, but not those from their insulin-trea...


    pub_type: 杂志文章


    authors: Kobayashi T,Oishi K,Hayashi Y,Matsumoto T,Kamata K

    更新日期:2006-03-01 00:00:00

  • Incremental diagnostic value of epicardial adipose tissue for the detection of functionally relevant coronary artery disease.

    abstract:BACKGROUND AND AIM:To determine the incremental diagnostic value of epicardial adipose tissue (EAT) volume in addition to the coronary artery calcium (CAC) score for detecting hemodynamic significant coronary artery disease (CAD). METHODS AND RESULTS:122 patients (mean age 61 ± 10 years, 61% male) without a previous c...


    pub_type: 杂志文章


    authors: Romijn MA,Danad I,Bakkum MJ,Stuijfzand WJ,Tulevski II,Somsen GA,Lammertsma AA,van Kuijk C,van de Ven PM,Min JK,Leipsic J,van Rossum AC,Raijmakers PG,Knaapen P

    更新日期:2015-09-01 00:00:00

  • Two new large deletions in the low density lipoprotein receptor (LDLR) gene not revealed by PCR-based molecular diagnosis of familial hypercholesterolemia.

    abstract::In the French Canadian population six mutations appear to be responsible for about 85% of FH cases. Two of these mutations are large deletions. The most prevalent deletion is a >15 kb deletion of the promoter and first exon; the second, a 5 kb deletion that removes exons 2 and 3. The high frequency of these deletions ...


    pub_type: 杂志文章


    authors: Bernier L,Boulet L,Roy M,Dufour R,Larivière F,Davignon J

    更新日期:2008-03-01 00:00:00

  • Failure of exogenous apoprotein E-3 to enhance cholesterol egress from J-774 murine macrophages in culture.

    abstract::HDL has been shown to enhance the removal of cholesterol from cultured fibroblasts, smooth muscle cells and macrophages, but fails to stimulate cholesterol removal from J-774 macrophages. Since J-774 macrophages do not synthesize or secrete apolipoprotein E, the effect of exogenous apolipoprotein E on HDL-mediated cel...


    pub_type: 杂志文章


    authors: Granot E,Eisenberg S

    更新日期:1995-04-07 00:00:00

  • The genetic effect of the apoprotein AV gene on the serum triglyceride level in Japanese.

    abstract::The newly identified apoprotein AV (apoAV) gene was suggested to have a significant effect on triglyceride (TG) metabolism in Caucasians. We studied the genetic effect of this gene on serum TG in a Japanese population. Participants (481 male and 412 female) were recruited at a health examination. A T/C single nucleoti...


    pub_type: 杂志文章


    authors: Nabika T,Nasreen S,Kobayashi S,Masuda J

    更新日期:2002-12-01 00:00:00

  • Effects of ADP and epinephrine on macaque and human platelets. Implications for studies on human atherosclerosis.

    abstract::The ranges for near-threshold ADP concentrations for the aggregation of macaque and human citrated platelets overlapped. The minimum concentrations of epinephrine, 0.05 microM to 1.0 microM, that at least doubled the aggregation response at threshold ADP concentrations were comparable for macaque and human citrated pl...


    pub_type: 杂志文章


    authors: Beatty CH,Howard CF Jr,Caruso V

    更新日期:1986-05-01 00:00:00

  • A monocyte chemoattractant protein-1 gene polymorphism is associated with occult ischemia in a high-risk asymptomatic population.

    abstract::Monocyte chemoattractant protein-1 (MCP-1) recruits monocytes into atherosclerotic plaques. A single nucleotide polymorphism in the MCP-1 gene promoter (-2578A>G) results in greater production of MCP-1 protein. We examined the association of this polymorphism with occult coronary artery disease (CAD) and its interacti...


    pub_type: 临床试验,杂志文章


    authors: Kim MP,Wahl LM,Yanek LR,Becker DM,Becker LC

    更新日期:2007-08-01 00:00:00

  • Lipoprotein particle profiles compared with standard lipids in association with coronary artery calcification in the general Japanese population.

    abstract:OBJECTIVE:The utility of lipoprotein particle profiles measured by nuclear magnetic resonance (NMR) spectroscopy beyond standard serum lipids remains inconclusive. Furthermore, few studies have compared NMR measurements with standard lipids in association with coronary artery calcification (CAC) in Japanese, where the ...


    pub_type: 杂志文章


    authors: Hisamatsu T,Fujiyoshi A,Miura K,Ohkubo T,Kadota A,Kadowaki S,Kadowaki T,Yamamoto T,Miyagawa N,Zaid M,Torii S,Takashima N,Murakami Y,Okamura T,Horie M,Ueshima H,SESSA Research Group.

    更新日期:2014-10-01 00:00:00

  • Probucol inhibits in-stent thrombosis and neointimal hyperplasia by promoting re-endothelialization.

    abstract:BACKGROUND:Evidence suggests that delayed re-endothelialization is responsible for in-stent thrombosis. Probucol inhibits neointimal thickening in animals via enhanced re-endothelialization and is the only oral drug that consistently inhibits restenosis after coronary angioplasty in humans. Here, we examined the effect...


    pub_type: 杂志文章


    authors: Tanous D,Bräsen JH,Choy K,Wu BJ,Kathir K,Lau A,Celermajer DS,Stocker R

    更新日期:2006-12-01 00:00:00

  • LXR agonism improves TNF-α-induced endothelial dysfunction in the absence of its cholesterol-modulating effects.

    abstract::Stimulation of the liver X receptor (LXR) is associated with anti-inflammatory and vascular-protective effects under hyperlipemic conditions. We examined whether LXR stimulation influences TNF-α-induced endothelial dysfunction under normolipemic conditions. Endothelium-dependent vasorelaxation of aortic rings was dete...


    pub_type: 杂志文章


    authors: Spillmann F,Van Linthout S,Miteva K,Lorenz M,Stangl V,Schultheiss HP,Tschöpe C

    更新日期:2014-01-01 00:00:00

  • Decreased concentration of high density lipoprotein cholesterol in schizophrenic patients treated with phenothiazines.

    abstract::In chronic schizophrenic patients treated with phenothiazines (Chlorpromazine, Levomepromazine, Perphenazine) for long periods (average = 8 years), high density lipoprotein cholesterol (HDL-C) levels were significantly lower (P less than 0.001) compared with normal controls. The HDL subfractions showed that HDL3-C was...


    pub_type: 杂志文章


    authors: Sasaki J,Kumagae G,Sata T,Kuramitsu M,Arakawa K

    更新日期:1984-05-01 00:00:00

  • Hematoporphyrin binding to cultured aortic smooth muscle cells from spontaneously atherosclerotic turkey.

    abstract::Porphyrins are known to be accumulated in vivo by tumors and atherosclerotic plaques. We studied the interaction of cultured aortic smooth muscle cells (SMC) from spontaneously atherosclerotic Broad Breasted White Turkeys (BBWT) with free hematoporphyrin (Hp) and low density lipoprotein (LDL)-Hp complexes. A significa...


    pub_type: 杂志文章


    authors: Scannapieco G,Pagnan A,Pauletto P,Mattiello A,Biffanti S,Jori G,Dal Palù C

    更新日期:1988-08-01 00:00:00

  • Association of ischemia-modified albumin and melatonin in patients with ST-elevation myocardial infarction.

    abstract:INTRODUCTION:It has been proposed that reactive oxygen species (ROS) generated during myocardial ischemia-reperfusion modify the N-terminus of serum albumin resulting in ischemia-modified albumin (IMA) formation. Likewise, several recent publications provide evidence that melatonin, a circadian endogenously produced in...


    pub_type: 杂志文章


    authors: Dominguez-Rodriguez A,Abreu-Gonzalez P,Garcia-Gonzalez MJ,Samimi-Fard S,Reiter RJ,Kaski JC

    更新日期:2008-07-01 00:00:00

  • Topology of protease activities reflects atherothrombotic plaque complexity.

    abstract::The pathological remodeling of the arterial wall in atherosclerosis involves protease activities, which play a major role in complications, through plaque rupture. Here, we investigated the release of active proteases by human carotid plaques in relation to (1) the degree of lesion complexity and (2) their compartment...


    pub_type: 杂志文章


    authors: Leclercq A,Houard X,Loyau S,Philippe M,Sebbag U,Meilhac O,Michel JB

    更新日期:2007-03-01 00:00:00

  • Angiotensin converting enzyme 2 and atherosclerosis.

    abstract::Angiotensin converting enzyme 2 (ACE2) is a homolog of angiotensin converting enzyme (ACE) which generates angiotensin II from angiotensin I. ACE, its product angiotensin II and the downstream angiotensin type I receptor are important components of the renin-angiotensin system (RAS). Angiotensin II, the most important...


    pub_type: 杂志文章,评审


    authors: Wang Y,Tikellis C,Thomas MC,Golledge J

    更新日期:2013-01-01 00:00:00

  • Genome-wide linkage analysis of carotid artery traits in exceptionally long-lived families.

    abstract:BACKGROUND AND AIMS:Atherosclerosis develops with age and is partially controlled by genetics. Research to date has identified common variants with small effects on atherosclerosis related traits. We aimed to use family-based genome-wide linkage analysis to identify chromosomal regions potentially harboring rare varian...


    pub_type: 杂志文章,多中心研究


    authors: Kuipers AL,Wojczynski MK,Barinas-Mitchell E,Minster RL,Wang L,Feitosa MF,Kulminski A,Thyagarajan B,Lee JH,Province MA,Newman AB,Zmuda JM,Long-Life Family Study.

    更新日期:2019-12-01 00:00:00

  • Race and sex-based disparities associated with carotid endarterectomy in the Atherosclerosis Risk in Communities (ARIC) study.

    abstract:BACKGROUND AND AIMS:The indications for carotid endarterectomy (CEA) are well established. The aim of the current study was to investigate sex and race-based disparities in the incidence of CEA after adjusting for carotid artery stenosis risk factors. METHODS:We conducted a prospective cohort analysis of 14,492 black ...


    pub_type: 杂志文章


    authors: Hicks CW,Daya NR,Black JH 3rd,Matsushita K,Selvin E

    更新日期:2020-01-01 00:00:00

  • Plasma MR-proANP levels are associated with carotid intima-media thickness in the general community: the KORA F4 study.

    abstract:OBJECTIVE:Subjects with metabolic syndrome (MetS) and individuals with type 2 diabetes are at high risk for vascular complications. Hormones acting on vascular endothelium may be involved in the atherogenic process associated with metabolic disorders. The objective of this study was to determine the correlation of pro-...


    pub_type: 杂志文章


    authors: Then C,Kowall B,Lechner A,Meisinger C,Heier M,Koenig W,Peters A,Thiery J,Rathmann W,Seissler J

    更新日期:2013-10-01 00:00:00

  • Focal differences in bioenergetic metabolism of atherosclerosis-susceptible and -resistant pigeon aortas.

    abstract::To test the hypothesis of altered energy production in aortic sites predisposed to lesion formation, both coupled oxidative phosphorylation (evaluated from P/O ratios) and control of the energy-linked (ATP) NADH transhydrogenase were examined in muscular cushions at the celiac artery bifurcation. Comparisons were made...


    pub_type: 杂志文章


    authors: Hajjar DP,Smith SC

    更新日期:1980-06-01 00:00:00

  • Carotid atherosclerosis in chronic renal failure-the central role of increased plaque burden.

    abstract::Studies on carotid artery atherosclerosis have been performed in order to understand the high risk for cardiovascular disease in chronic renal failure (CRF). The purpose of this study was to evaluate the extent and nature of carotid artery atherosclerosis in patients with CRF. Of the 135 patients with CRF (52 +/- 11 y...


    pub_type: 杂志文章


    authors: Leskinen Y,Lehtimäki T,Loimaala A,Lautamatti V,Kallio T,Huhtala H,Salenius JP,Saha H

    更新日期:2003-12-01 00:00:00

  • BMP-2 promotes phosphate uptake, phenotypic modulation, and calcification of human vascular smooth muscle cells.

    abstract::Vascular calcification is associated with increased risk of cardiovascular events that are the most common cause of death in patients with end-stage renal disease. Clinical and experimental studies indicate that hyperphosphatemia is a risk factor for vascular calcification and cardiovascular mortality in these patient...


    pub_type: 杂志文章


    authors: Li X,Yang HY,Giachelli CM

    更新日期:2008-08-01 00:00:00

  • MicroRNA-27a/b regulates cellular cholesterol efflux, influx and esterification/hydrolysis in THP-1 macrophages.

    abstract:RATIONALE:Macrophage cholesterol homeostasis maintenance is the result of a balance between influx, endogenous synthesis, esterification/hydrolysis and efflux. Excessive accumulation of cholesterol leads to foam cell formation, which is the major pathology of atherosclerosis. Previous studies have shown that miR-27 (mi...


    pub_type: 杂志文章


    authors: Zhang M,Wu JF,Chen WJ,Tang SL,Mo ZC,Tang YY,Li Y,Wang JL,Liu XY,Peng J,Chen K,He PP,Lv YC,Ouyang XP,Yao F,Tang DP,Cayabyab FS,Zhang DW,Zheng XL,Tian GP,Tang CK

    更新日期:2014-05-01 00:00:00

  • ACAT inhibitor pactimibe sulfate (CS-505) reduces and stabilizes atherosclerotic lesions by cholesterol-lowering and direct effects in apolipoprotein E-deficient mice.

    abstract::The objective of the present study was to determine whether a novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, pactimibe sulfate (CS-505), could reduce atherosclerotic lesions beyond and independent of the reduction achieved by cholesterol lowering alone from two different types of lesions. (1) Early lesio...


    pub_type: 杂志文章


    authors: Terasaka N,Miyazaki A,Kasanuki N,Ito K,Ubukata N,Koieyama T,Kitayama K,Tanimoto T,Maeda N,Inaba T

    更新日期:2007-02-01 00:00:00

  • Expression of tissue transglutaminase and elafin in human coronary artery: implication for plaque instability.

    abstract:BACKGROUND:the extracellular matrix (ECM) is an important determinant of plaque instability. Since tissue transglutaminase (tTG) and elafin act as stabilizing factors, they might play a crucial role in the pathogenesis of acute coronary syndrome. We examined their expression in human coronary arteries and the regulatio...


    pub_type: 杂志文章


    authors: Sumi Y,Inoue N,Azumi H,Seno T,Okuda M,Hirata K,Kawashima S,Hayashi Y,Itoh H,Yokoyama M

    更新日期:2002-01-01 00:00:00

  • Simvastatin-induced decrease in the transfer of cholesterol esters from high density lipoproteins to very low and low density lipoproteins in normolipidemic subjects.

    abstract::Hyperlipidemic patients often have an accelerated esterified cholesterol transfer (ECT) from high density lipoproteins (HDL) to very low (VLDL) and low density lipoproteins (LDL). We investigated the effect of simvastatin on ECT in twelve normolipidemic subjects. After 6 weeks of simvastatin administration, ECT was de...


    pub_type: 杂志文章


    authors: Ahnadi CE,Berthezène F,Ponsin G

    更新日期:1993-03-01 00:00:00