Coronary artery calcium and cardiovascular risk in diabetes.

abstract：BACKGROUND:Tissue proportions of long chain n-6 [especially arachidonic acid (AA)] and n-3 fatty acids [FA; eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) acids], or some ratio of these may be markers of risk for coronary heart disease (CHD). The purpose of this paper is to evaluate the published associatio...

journal_title：Atherosclerosis

authors： Harris WS,Poston WC,Haddock CK

更新日期：2007-07-01 00:00:00

abstract：:The serum concentrations of testosterone, androstenedione, oestradiol and total low polar oestrogens, mainly oestradiol and oestrone, were measured in 26 healthy male subjects. The subjects were divided into two groups each of them with low (less than 1.04 mmol/l) and high (greater than 1.56 mmol/l) levels of serum HD...

journal_title：Atherosclerosis

authors： Nordøy A,Aakvaag A,Thelle D

更新日期：1979-12-01 00:00:00

abstract：BACKGROUND AND AIMS:Little is known about the role of liver enzymes as predictors of non-liver-related morbidity and mortality. The ideal cardiovascular health (CVH) score proposed by the American Heart Association (AHA) can be used to predict mortality and morbidity. We investigated the association of the CVH score wi...

journal_title：Atherosclerosis

authors： Mazidi M,Katsiki N,Mikhailidis DP,Banach M

更新日期：2019-05-01 00:00:00

abstract：:Oxidized low-density lipoprotein (oxLDL) exhibits many atherogenic effects, including the promotion of monocyte recruitment to the arterial endothelium and the induction of scavenger receptor expression. However, while atherosclerosis involves chronic inflammation within the arterial intima, it is unclear whether oxLD...

journal_title：Atherosclerosis

authors： Kavanagh IC,Symes CE,Renaudin P,Nova E,Mesa MD,Boukouvalas G,Leake DS,Yaqoob P

更新日期：2003-06-01 00:00:00

abstract：OBJECTIVE:Interruption of the enterohepatic circulation of bile acids induces hepatic bile acid synthesis, increases hepatic cholesterol demand, and increases clearance of apoB-containing lipoproteins in plasma. Based on these effects, bile acid sequestrants have been used for many years to treat hypercholesterolemia a...

journal_title：Atherosclerosis

authors： Lan T,Haywood J,Dawson PA

更新日期：2013-08-01 00:00:00

abstract：:Free radical mediated oxidation of apoB lipoproteins in the arterial intima appears to contribute to atherogenicity of the entrapped particles. A plausible pathogenic mechanism for oxidation is the one induced by heme leaking from erythrocytes that is then carried into the arterial wall by its high affinity for lipopr...

journal_title：Atherosclerosis

authors： Fernandez AZ,López F,Tablante A,Romano E,Hurt-Camejo E,Camejo G,Apitz-Castro R

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND AND AIMS:Oxidative modification of lipoproteins is a crucial step in atherosclerosis development. Isotopic-reinforced polyunsaturated fatty acids (D-PUFAs) are more resistant to reactive oxygen species-initiated chain reaction of lipid peroxidation than regular hydrogenated (H-)PUFAs. We aimed at investigati...

journal_title：Atherosclerosis

authors： Berbée JFP,Mol IM,Milne GL,Pollock E,Hoeke G,Lütjohann D,Monaco C,Rensen PCN,van der Ploeg LHT,Shchepinov MS

更新日期：2017-09-01 00:00:00

abstract：:Familial hypobetalipoproteinemia is an autosomal co-dominant disorder, which in a minority of cases is due to a truncation producing mutation in the apoB gene. We have identified an apoB mutation in a 40-year old hypobetalipoproteinemic man with Type II diabetes mellitus. Immunoblotting of plasma revealed a major band...

journal_title：Atherosclerosis

authors： Pulai JI,Latour MA,Kwok PY,Schonfeld G

更新日期：1998-02-01 00:00:00

abstract：:Forty patients with NIDDM and hyperlipoproteinemia were selected for a 12-week double-blind placebo-controlled trial to study the effects of metformin on lipoprotein concentration and composition. A significant decrease occurred in VLDL-apo B and all lipid components of VLDL, indicating a decreased number of circulati...

journal_title：Atherosclerosis

authors： Schneider J,Erren T,Zöfel P,Kaffarnik H

更新日期：1990-05-01 00:00:00

abstract：:Previous studies in mouse models showed that 12/15lipoxygenase (12/15LO) gene disruption diminishes atherosclerosis. Pharmacologic suppression of thromboxane (Tx) A(2) biosynthesis or blockade of its receptor also reduces the development of the disease in the same models. We tested the hypothesis that simultaneous gen...

journal_title：Atherosclerosis

authors： Tang L,Ding T,Praticò D

更新日期：2008-08-01 00:00:00

abstract：:Five out of 15 homozygotes and 41 out of 527 heterozygotes of familial hypercholesterolemia (FH) died during the past 10 years. Sudden death or heart failure was the cause of death in each of the 5 deceased homozygotes. Twenty heterozygotes died of myocardial infarction, 9 of sudden death, and 1 died after AC bypass s...

journal_title：Atherosclerosis

authors： Mabuchi H,Miyamoto S,Ueda K,Oota M,Takegoshi T,Wakasugi T,Takeda R

更新日期：1986-07-01 00:00:00

abstract：:Laying and genetically defective non-laying hens were evaluated for plasma lipid and plasma peroxidation levels. The non-layers developed extreme hyperlipidemia as well as greatly increased levels of lipid peroxidation. It was concluded that the concurrent presence of lipid peroxidation products must be considered whe...

journal_title：Atherosclerosis

authors： Smith T,Toda T,Kummerow FA

更新日期：1985-10-01 00:00:00

abstract：OBJECTIVE:We examined the risk of cardiovascular disease, stroke, ischaemic heart disease, and diabetes with the metabolic syndrome according to the new harmonised definition and its components using a national longitudinal data set from an Asian population. METHODS:Data of 9791 men and women aged 20+ from 1998 and 20...

journal_title：Atherosclerosis

authors： Khang YH,Cho SI,Kim HR

更新日期：2010-12-01 00:00:00

abstract：OBJECTIVE:Bone marrow cell therapy contributes to collateral formation through the secretion of angiogenic factors by progenitor cells and muscle cells per se, thereby presenting a novel option for patients with critical limb ischemia. However, some cases are refractory to this therapy due to graft failure. Therefore, ...

journal_title：Atherosclerosis

authors： Ishii M,Numaguchi Y,Okumura K,Kubota R,Ma X,Murakami R,Naruse K,Murohara T

更新日期：2009-09-01 00:00:00

abstract：:Even when administered at a comparatively low level, dietary cholesterol produces significant changes in the properties of plasma lipoproteins in rats, particularly the d less than or equal to 1.006 g/ml fraction (VLDL). The occurrence of these changes is promoted by dietary casein. To test the hypothesis that these d...

journal_title：Atherosclerosis

authors： Eklund A,Sjöblom L,Ostlund-Lindqvist AM

更新日期：1986-11-01 00:00:00

abstract：:Chronic renal failure markedly accelerates atherogenesis in apolipoprotein E-deficient (apoE(-/-)) mice. To study the putative role of receptor for advanced glycation end products (RAGE) in development of uremic atherosclerosis, apoE(-/-) mice received intraperitoneal injections thrice weekly of a neutralizing murine ...

journal_title：Atherosclerosis

authors： Bro S,Flyvbjerg A,Binder CJ,Bang CA,Denner L,Olgaard K,Nielsen LB

更新日期：2008-12-01 00:00:00

abstract：:Oxidation of low density lipoproteins (LDL) is considered a key event in the pathogenesis of atherosclerotic lesions. Disturbed generation of coagulatory and anticoagulatory factors by endothelial cells contributes to thrombosis and the progression of atherosclerosis in coronary arteries. In this study, the effects of...

journal_title：Atherosclerosis

authors： Gräfe M,Auch-Schwelk W,Hertel H,Terbeek D,Steinheider G,Loebe M,Fleck E

更新日期：1998-03-01 00:00:00

abstract：:Despite numerous studies, the precise role of dietary n-6 polyunsaturated fatty acids in the pathogenesis of atherosclerosis remains controversial. It has been shown that feeding an n-6-enriched diet resulted in decreased atherosclerosis in African green monkeys and was associated with a reduction in LDL levels. Howev...

journal_title：Atherosclerosis

authors： George J,Mulkins M,Casey S,Schatzman R,Sigal E,Harats D

更新日期：2000-06-01 00:00:00

abstract：:Long-term dietary omega-3 fatty acids improve coronary endothelial function in CAD patients, heart transplant recipients and diabetics. This study assessed whether short term omega-3 fatty acids affect radial artery function in CAD patients. A high resolution A-mode echotracking device (NIUS 02) was used to measure co...

journal_title：Atherosclerosis

authors： Kothny W,Angerer P,Störk S,von Schacky C

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:Previous studies have found polymorphisms of the HDL receptor, SR-BI, to be associated with plasma HDL-C in women, but not men, suggesting a modifying role of estrogen. We examined whether the association between SR-BI genotypes and HDL-C is modified by use of unopposed estrogen in community-dwelling postmen...

journal_title：Atherosclerosis

authors： Richard E,von Muhlen D,Barrett-Connor E,Alcaraz J,Davis R,McCarthy JJ

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND:Diabetic patients are characterised by poorer prognosis and more cardiovascular complications compared with non-diabetic patients, which may be due to metabolic abnormalities and atherosclerotic plaque characteristics. METHODS:Patients with unstable angina pectoris were enrolled in the study and divided int...

journal_title：Atherosclerosis

authors： Feng T,Yundai C,Lian C,Zhijun S,Changfu L,Jun G,Hongbin L

更新日期：2010-12-01 00:00:00

abstract：:In type 2 diabetics, the progression of atherosclerosis is more rapid than the general population and 80% of these patients will die of an atherosclerotic event. Since in these patients hyperglycemia per se confers increased risk for cardiovascular disease (CVD), the presence of even borderline-high-risk LDL-C signals...

journal_title：Atherosclerosis

authors： Baliarsingh S,Beg ZH,Ahmad J

更新日期：2005-10-01 00:00:00

abstract：INTRODUCTION:Although cardiovascular events are known to cluster in families it is unclear the extent to which atherosclerosis per se is genetically determined. The aim of this study was to assess the heritability of carotid intima media thickness (IMT) measurements, a surrogate marker of early atherosclerosis, using a...

journal_title：Atherosclerosis

authors： Swan L,Birnie DH,Inglis G,Connell JM,Hillis WS

更新日期：2003-01-01 00:00:00

abstract：:This study was aimed to test the hypothesis that noninvasive assessment of carotid plaques can be achieved by high-resolution micro-ultrasound imaging in apolipoprotein-E knockout (apoE-KO) mice. Forty-two male apoE-KO mice were fed a high-fat diet and atherosclerotic lesions in the left common carotid artery were ind...

journal_title：Atherosclerosis

authors： Ni M,Zhang M,Ding SF,Chen WQ,Zhang Y

更新日期：2008-03-01 00:00:00

abstract：:In the abdominal aortas of young mash-fed swine, intimal cell masses (pads, cushions) are located predominantly away from blood vessel orifices. They are found scattered throughout the aorta but nevertheless have a definite pattern of distribution. In the distal one half of the abdominal aorta, they are more frequent ...

journal_title：Atherosclerosis

authors： Scott RF,Thomas WA,Lee WM,Reiner JM,Florentin RA

更新日期：1979-11-01 00:00:00

abstract：OBJECTIVE:Genomewide association studies (GWAS), conventional association studies and the characterization of families with ApoA5 deficiency have shown that variation in the apolipoprotein A5 (APOA5) gene is associated with plasma triglyceride levels. The aim of this study was to determine the frequency of rare variant...

journal_title：Atherosclerosis

authors： Evans D,Aberle J,Beil FU

更新日期：2011-12-01 00:00:00

abstract：:We investigated the possibility that established atherosclerosis and xanthomas in mature WHHL rabbits could be suppressed or even regressed when their serum cholesterol levels were kept extremely low. Ten-month-old WHHL rabbits were divided into 3 groups, i.e. control rabbits, sacrificed at age 10 months, and placebo ...

journal_title：Atherosclerosis

authors： Shiomi M,Ito T,Watanabe Y,Tsujita Y,Kuroda M,Arai M,Fukami M,Fukushige J,Tamura A

更新日期：1990-07-01 00:00:00

abstract：:The fatty acid composition of adipose tissue from 4114 men and women across 22 districts of Scotland is described. A biopsy of subcutaneous adipose tissue was obtained from the upper arm using a skin biopsy punch. Overall the proportion of saturated fatty acids was lower in women and those of monounsaturated and polyu...

journal_title：Atherosclerosis

authors： Tavendale R,Lee AJ,Smith WC,Tunstall-Pedoe H

更新日期：1992-06-01 00:00:00

abstract：BACKGROUND:CD163 is a new potential scavenger receptor of Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) which elicits diverse biologic actions involved in atherosclerosis. We have analyzed the importance of TWEAK-CD163 interaction in atherosclerosis. METHODS:TWEAK and CD163 interaction was studied in cu...

journal_title：Atherosclerosis

authors： Moreno JA,Muñoz-García B,Martín-Ventura JL,Madrigal-Matute J,Orbe J,Páramo JA,Ortega L,Egido J,Blanco-Colio LM

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:Evidence suggests that delayed re-endothelialization is responsible for in-stent thrombosis. Probucol inhibits neointimal thickening in animals via enhanced re-endothelialization and is the only oral drug that consistently inhibits restenosis after coronary angioplasty in humans. Here, we examined the effect...

journal_title：Atherosclerosis

authors： Tanous D,Bräsen JH,Choy K,Wu BJ,Kathir K,Lau A,Celermajer DS,Stocker R

更新日期：2006-12-01 00:00:00