von Willebrand factor and soluble E-selectin in the prediction of cardiovascular disease progression in hyperlipidaemia.

abstract：:We have used DNA and protein polymorphisms for the third complement component (C3) to assess the potential of DNA markers in the diagnosis and study of familial hypercholesterolaemia (FH), and to confirm the reported linkage between FH and C3. The inheritance of FH and the C3 gene has been studied in 10 families by co...

journal_title：Atherosclerosis

authors： Humphries SE,Donald JA,McFadden JJ,Shull S,Williamson R,Jowett NI,Galton DJ,Julsrud JO,Berg K,Heiberg A

更新日期：1984-09-01 00:00:00

abstract：:Apolipoprotein B (apoB) release from activated washed human platelets was measured by enzyme-linked immunosorbent assay (ELISA) using monospecific rabbit antibodies to human low density lipoprotein (LDL). Activation of platelets with thrombin, Ca2+-ionophore A23187 or stable analogue of prostaglandin endoperoxides U46...

journal_title：Atherosclerosis

authors： Preobrazhensky SN,Podrez EA,Tsibulsky VP,Fuki IV,Mazurov AV,Repin VS,Smirnov VN

更新日期：1986-09-01 00:00:00

abstract：:To study the association of alcohol consumption and lipid-based cardiovascular risk factors among middle-age women, cross-sectional analysis among 274 middle-aged healthy women with different drinking habits and a follow-up analysis of alcoholic women during abstinence was performed. Serum total cholesterol, low and h...

journal_title：Atherosclerosis

authors： Sillanaukee P,Koivula T,Jokela H,Pitkäjärvi T,Seppä K

更新日期：2000-10-01 00:00:00

abstract：:Cytosolic Phospholipase A(2) (cPLA(2)) has been implicated in receptor-mediated release of arachidonic acid from membrane phospholipids, the limiting step in prostacyclin and other eicosanoid production. Its activity is controlled by Ca(++) levels and enzymatically regulated phosphorylation. The purpose of this study ...

journal_title：Atherosclerosis

authors： Gudmundsdóttir IJ,Halldórsson H,Magnúsdóttir K,Thorgeirsson G

更新日期：2001-05-01 00:00:00

abstract：:Low density lipoproteins (LDL) isolated by ultracentrifugation induce cytotoxic changes in cultured human endothelial cells (EC) and fibroblasts if the ratio between LDL cholesterol and the final protein concentration of the culture medium exceeds 0.10-0.12 mmol/g protein. In order to investigate if reactive oxygen sp...

journal_title：Atherosclerosis

authors： Evensen SA,Galdal KS,Nilsen E

更新日期：1983-10-01 00:00:00

abstract：:Human serum paraoxonase 1 (PON1) is associated with high-density lipoprotein, and inhibits oxidative modification of low-density lipoprotein in vitro. Therefore, PON1 is supposed to protect against atherosclerosis in vivo. In this study, we investigated the direct effect of Sp1 on PON1 transcription in HepG2 cells usi...

journal_title：Atherosclerosis

authors： Osaki F,Ikeda Y,Suehiro T,Ota K,Tsuzura S,Arii K,Kumon Y,Hashimoto K

更新日期：2004-10-01 00:00:00

abstract：:Hypercholesterolemia impairs endothelial function. However, the production/release of nitric oxide from the hypercholesterolemic aorta is reported to be enhanced rather than impaired in animal studies. L-arginine improves endothelial function in hypercholesterolemic subjects. The goal of the present study was to inves...

journal_title：Atherosclerosis

authors： Kawano H,Motoyama T,Hirai N,Kugiyama K,Yasue H,Ogawa H

更新日期：2002-04-01 00:00:00

abstract：:Extensive research has been carried out in recent years to discover the potential risk factors contributing to cardiac allograft atherogenesis. Injury to endothelial cells has been regarded as an important early mechanism in the development of transplant atherosclerosis; it leads to the manifestation of epicardial and...

journal_title：Atherosclerosis

authors： Liu Z,Wildhirt SM,Weismüller S,Schulze C,Conrad N,Reichart B

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:Astaxanthin has been reported to improve dyslipidemia and metabolic syndrome in animals, but such effects in humans are not well known. METHODS:Placebo-controlled astaxanthin administration at doses of 0, 6, 12, 18 mg/day for 12 weeks was randomly allocated to 61 non-obese subjects with fasting serum trigly...

journal_title：Atherosclerosis

authors： Yoshida H,Yanai H,Ito K,Tomono Y,Koikeda T,Tsukahara H,Tada N

更新日期：2010-04-01 00:00:00

abstract：:The defects in the internal elastic lamina (IEL) have been proposed to be important for the migration of smooth muscle cells into the intima during atherosclerosis. We investigated the association of a genetic factor--apolipoprotein E (apoE) genotype--with the number of gaps in the IEL of the artery wall in 123 consec...

journal_title：Atherosclerosis

authors： Ilveskoski E,Järvinen O,Sisto T,Karhunen PJ,Laippala P,Lehtimäki T

更新日期：2000-11-01 00:00:00

abstract：OBJECTIVE:Blood glucose fluctuations have been found to be relevant to the progression of atherosclerosis in patients with type 2 diabetes and to be more detrimental for the development of atherosclerosis than the sustained hyperglycemia. We aim at evaluating the effect of blunted daily acute glucose fluctuations by DP...

journal_title：Atherosclerosis

authors： Barbieri M,Rizzo MR,Marfella R,Boccardi V,Esposito A,Pansini A,Paolisso G

更新日期：2013-04-01 00:00:00

abstract：:Familial dysbetalipoproteinemia is characterized by hyperlipidemia, increases in beta-migrating, very low density lipoproteins (beta-VLDL), and homozygosity for apolipoprotein E2 (apo E2). In this study, 3 patients with familial dysbetalipoproteinemia were treated with lovastatin, and kinetics for apolipoprotein B (ap...

journal_title：Atherosclerosis

authors： Vega GL,East C,Grundy SM

更新日期：1988-03-01 00:00:00

abstract：:Human serum paraoxonase (PON1) is an HDL-associated enzyme involved in the protection of lipoproteins from oxidation. A polymorphism at position 192 (Gln/Arg) influences its activity in a substrate-dependent manner. The aim of the present study was to evaluate, in vivo, the contribution of the PON1-192 polymorphism to...

journal_title：Atherosclerosis

authors： Gnasso A,Motti C,Irace C,Di Gennaro I,Pujia A,Leto E,Ciamei M,Crivaro A,Bernardini S,Federici G,Cortese C

更新日期：2002-10-01 00:00:00

abstract：:Neopterin is released from human monocyte-derived macrophages upon stimulation with interferon-gamma and is a sensitive indicator for cellular immune activation. Furthermore, reactive oxygen species (ROS) are produced in case of immune activation and inflammation. In a cross-sectional approach, plasma concentrations o...

journal_title：Atherosclerosis

authors： Murr C,Winklhofer-Roob BM,Schroecksnadel K,Maritschnegg M,Mangge H,Böhm BO,Winkelmann BR,März W,Fuchs D

更新日期：2009-02-01 00:00:00

abstract：:Tranilast (N(3,4-dimethoxycinnamoyl)anthranilic acid), an agent which in cell culture inhibits transforming growth factor-beta (TGF-beta) secretion and antagonises the effects of TGF-beta and platelet-derived growth factor (PDGF) on cell migration and proliferation, has been reported to reduce the incidence of resteno...

journal_title：Atherosclerosis

authors： Ward MR,Sasahara T,Agrotis A,Dilley RJ,Jennings GL,Bobik A

更新日期：1998-04-01 00:00:00

abstract：:Plasma apo B and apo A-I were determined in 477 subjects (206 males and 271 females) by laser immuno-nephelometry. Measurements of VLDL- + LDL-cholesterol, HDL-cholesterol and triglycerides were done simultaneously. VLDL- + LDL-cholesterol and apo B values were similar in males and females and increased with age. HDL-...

journal_title：Atherosclerosis

authors： Dedonder-Decoopman E,Fievet-Desreumaux C,Campos E,Moulin S,Dewailly P,Sezille G,Jaillard J

更新日期：1980-12-01 00:00:00

abstract：:Exercise affects lipoprotein metabolism and apolipoprotein E (Apo E) genotype may alter changes in lipoprotein subclasses that occur with exercise. The present study examined the effects of Apo E genotype (APOE) on the response of lipoprotein subclass concentrations to long-term exercise. A prospective longitudinal st...

journal_title：Atherosclerosis

authors： Seip RL,Otvos J,Bilbie C,Tsongalis GJ,Miles M,Zoeller R,Visich P,Gordon P,Angelopoulos TJ,Pescatello L,Moyna N,Thompson PD

更新日期：2006-09-01 00:00:00

abstract：:The present study is the first work to evaluate thrombin-, ADP-, and collagen-induced platelet aggregation in laboratory rats receiving alimentation with the parenterally-administered lipid emulsion, Lipofundin-S, in doses sufficient to induce early atherosclerotic changes in the aorta. The aggregometry parameters of ...

journal_title：Atherosclerosis

authors： Saladino CF,Fox RL,Yeh Q,Karpowicz F,Feffer SE,Jonas EA

更新日期：1987-07-01 00:00:00

abstract：:In monocyte-derived macrophages from both normal and familial hypercholesterolaemic (FH) subjects, degradation of low density lipoprotein (LDL) through non-saturable pathways produced the same fall in 3-hydroxy-3-methylglutaryl-CoA reductase activity as receptor-mediated degradation of acetylated LDL, yet did not lead...

journal_title：Atherosclerosis

authors： Knight BL,Soutar AK,Patel DD

更新日期：1987-04-01 00:00:00

abstract：:Fractional esterification rate of cholesterol in high density lipoprotein (HDL) (FER[HDL]) can predict the size distribution and physicochemical characteristics of HDL in plasma. In the present study, we investigated the correlation of FER(HDL) with the particle size of low density lipoprotein (LDL) (LDL-size) in 111 ...

journal_title：Atherosclerosis

authors： Ohta T,Saku K,Takata K,Nagata N,Maung KK,Matsuda I

更新日期：1997-12-01 00:00:00

abstract：OBJECTIVE:Recent data suggest the involvement of dectin-1 in atherosclerosis through regulation of local reactive oxygen species production. The aim of the current study was to assess the effect of dectin-1 deficiency on atherosclerotic plaque development. METHODS:Using immunohistochemistry dectin-1 expression was obs...

journal_title：Atherosclerosis

authors： Szilagyi K,Gijbels MJ,van der Velden S,Heinsbroek SE,Kraal G,de Winther MP,van den Berg TK

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND AND AIMS:Inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9) reduces atherogenic lipoproteins and could lead to reduction of cardiovascular (CV) events. However, it is unclear whether blood PCSK9 levels predict future CV events. We performed a meta-analysis of all longitudinal studies to dete...

journal_title：Atherosclerosis

authors： Vlachopoulos C,Terentes-Printzios D,Georgiopoulos G,Skoumas I,Koutagiar I,Ioakeimidis N,Stefanadis C,Tousoulis D

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVE:Previous investigations have revealed an association between the ABO locus/blood group and total cholesterol and inflammatory biomarker levels. We aimed to test the statistical association of ABO locus variants with lipid profiles and levels of thirteen inflammatory markers in a Taiwanese population. METHODS...

journal_title：Atherosclerosis

authors： Teng MS,Hsu LA,Wu S,Chou HH,Chang CJ,Sun YZ,Juan SH,Ko YL

更新日期：2013-06-01 00:00:00

abstract：OBJECTIVE:To explore the cardiovascular disease (CVD) risk in prehypertensive subjects and evaluate whether high blood pressure (BP) is associated with insulin resistance (IR) and β-cell dysfunction. METHODS:A total of 2949 people aged 20-94 years old were selected in Fujian province of China. We assessed CVD risk usi...

journal_title：Atherosclerosis

authors： Chen G,Lai X,Jiang Q,Chen F,Chen N,Huang H,Liang J,Li L,Wen J,Lin L,Yao J

更新日期：2011-07-01 00:00:00

abstract：OBJECTIVE:Significant sex differences exist in cardiovascular diseases. Although an impact of gonadal hormones is presumed, it is largely unknown whether sexually dimorphic gene expression also plays a role and whether cells themselves show intrinsic sex differences. METHODS:We performed whole genome expression analys...

journal_title：Atherosclerosis

authors： Lorenz M,Koschate J,Kaufmann K,Kreye C,Mertens M,Kuebler WM,Baumann G,Gossing G,Marki A,Zakrzewicz A,Miéville C,Benn A,Horbelt D,Wratil PR,Stangl K,Stangl V

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Circulating endotoxin levels are associated with atherosclerosis. Moreover, ethnic differences in pro-inflammatory markers may be associated with ethnic differences in atherosclerotic and cardiovascular (CVD) and coronary heart disease (CHD) risk. OBJECTIVE AND METHODS:To investigate ethnic differences in c...

journal_title：Atherosclerosis

authors： Miller MA,McTernan PG,Harte AL,Silva NF,Strazzullo P,Alberti KG,Kumar S,Cappuccio FP

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:Recent failures of clinical trials promoting HDL-elevating therapies have prompted research groups to focus on its functional activity in disease. Endothelial effects of HDL can be measured with in vitro cell assays. The reproducibility and biological relevance of these assays have not been explored both in ...

journal_title：Atherosclerosis

authors： O'Neill F,McLoughlin E,Riwanto M,Manz J,Adler A,Sutill E,Khan T,Haywood R,Kay CW,D'Aiuto F,Charakida M,Landmesser U,Deanfield J

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVE:To assess whether plasma IGFBP-2 is independently associated with components of the lipoprotein-lipid profile and to suggest a cutoff value that could identify subjects with the features of the metabolic syndrome. METHODS:In this cross-sectional study, 379 Caucasian men from the general population and coveri...

journal_title：Atherosclerosis

authors： Carter S,Li Z,Lemieux I,Alméras N,Tremblay A,Bergeron J,Poirier P,Deshaies Y,Després JP,Picard F

更新日期：2014-12-01 00:00:00

abstract：:Altered activity of matrix metalloproteinases (MMPs) is implicated in the vascular remodeling of hypertension. We examined whether increased MMP-2 expression/activity plays a role in the vascular remodeling and dysfunction found in the two-kidney, one-clip (2K-1C) hypertension. Sham operated or 2K-1C hypertension rats...

journal_title：Atherosclerosis

authors： Castro MM,Rizzi E,Figueiredo-Lopes L,Fernandes K,Bendhack LM,Pitol DL,Gerlach RF,Tanus-Santos JE

更新日期：2008-06-01 00:00:00

abstract：:Advanced glycation end-products (AGEs), a group of carbohydrate-derived compounds formed by non-enzymatic glycation and oxidation, are markedly elevated in end-stage renal disease (ESRD) and may be related to both inflammation and oxidative stress. The cellular effects of AGE are largely mediated by their interaction ...

journal_title：Atherosclerosis

authors： Rodríguez-Ayala E,Anderstam B,Suliman ME,Seeberger A,Heimbürger O,Lindholm B,Stenvinkel P

更新日期：2005-06-01 00:00:00