LDL-induced cytotoxicity and its inhibition by anti-oxidant treatment in cultured human endothelial cells and fibroblasts.

abstract：:Two preparations active in reducing hepatic cholesterolgenesis in vitro were demonstrated in human milk. These appear to affect the cholesterol synthetic pathway at different loci. One inhibits the synthesis before the formation of mevalonic acid and has been isolated and subsequently identified as uric acid. The othe...

journal_title：Atherosclerosis

authors： Ward PC,McCarthy RD,Kilara A

更新日期：1982-02-01 00:00:00

abstract：OBJECTIVE:Although many studies have reported that elevated serum triglycerides to high-density lipoprotein cholesterol (TG-HDL) ratios constitute a risk for insulin resistance and increased arterial stiffness, no study has clarified as yet the association, in terms of the TG-HDL ratio, between diabetes and increased a...

journal_title：Atherosclerosis

authors： Shimizu Y,Nakazato M,Sekita T,Kadota K,Yamasaki H,Takamura N,Aoyagi K,Maeda T

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Moderate red wine has been shown to reduce cardiovascular disease (CVD) risk, however the effects on certain CVD risk factors are unclear. In this study we have investigated the effects of dealcoholised red wine (DRW) and full-complement red wine (RW) on several cardiovascular risk factors in mildly hypercho...

journal_title：Atherosclerosis

authors： Naissides M,Mamo JC,James AP,Pal S

更新日期：2006-04-01 00:00:00

abstract：:Cytosolic Phospholipase A(2) (cPLA(2)) has been implicated in receptor-mediated release of arachidonic acid from membrane phospholipids, the limiting step in prostacyclin and other eicosanoid production. Its activity is controlled by Ca(++) levels and enzymatically regulated phosphorylation. The purpose of this study ...

journal_title：Atherosclerosis

authors： Gudmundsdóttir IJ,Halldórsson H,Magnúsdóttir K,Thorgeirsson G

更新日期：2001-05-01 00:00:00

abstract：OBJECTIVE:Given the role of estrogen in the regulation of lipid metabolism, we screened for functional polymorphisms in the estrogen receptor alpha (ER*), and examined for their influence on serum cholesterol. METHODS AND RESULTS:We identified a novel C>T polymorphism (ERNE-145), with a minor allele frequency of 41%. ...

journal_title：Atherosclerosis

authors： Figtree GA,Grieve SM,Speller B,Geiger MJ,Robinson BG,Channon KM,Ragoussis J,Collins P,Watkins H

更新日期：2008-08-01 00:00:00

abstract：:Berberine, an alkaloid isolated from Chinese medicinal herbs, long been known for its anti-microbial activity and used to treat various infectious disorders in traditional Chinese medicine. In the present study, we have tested the hypothesis that berberine could inhibit vascular smooth muscle cell (VSMC) proliferation...

journal_title：Atherosclerosis

authors： Lee S,Lim HJ,Park HY,Lee KS,Park JH,Jang Y

更新日期：2006-05-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) is known to be a secretory product of activated macrophages. TNF-alpha activates endothelial cells, stimulates angiogenesis and induces proliferation of smooth muscle cells (SMCs). Therefore, TNF-alpha has been suggested to be actively involved in the inflammatory events associa...

journal_title：Atherosclerosis

authors： Lei X,Buja LM

更新日期：1996-08-23 00:00:00

abstract：BACKGROUND:Toll like receptors (TLR) have been recognized for their role in atherosclerotic lesion development and progression. Endogenous TLR ligands that are also expressed in atherosclerotic tissues have been shown to promote atherosclerosis in mice. Since repetitive stimulation of TLR induces an attenuated inflamma...

journal_title：Atherosclerosis

authors： Schoneveld AH,Hoefer I,Sluijter JP,Laman JD,de Kleijn DP,Pasterkamp G

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVE:P2X(7) receptor (P2X(7)R), upon its stimulation with extracellular ATP, modulates several inflammatory responses in different cell types. No information is available on its presence in human adipocytes and its potential involvement in the chronic inflammation associated with metabolic syndrome (MS). Therefore...

journal_title：Atherosclerosis

authors： Madec S,Rossi C,Chiarugi M,Santini E,Salvati A,Ferrannini E,Solini A

更新日期：2011-12-01 00:00:00

abstract：:Low density lipoprotein (LDL) and high density lipoprotein (HDL3) were tested for their ability to induce inositol phospholipid turnover and inositol phosphate production in bovine aortic endothelial cells (BAEC). The production of inositol phosphates following hydrolysis of the phosphoinositides was demonstrated by t...

journal_title：Atherosclerosis

authors： Myers DE,Fidge NH,Stanton H,Larkins RG

更新日期：1992-01-01 00:00:00

abstract：:Familial ligand-defective apolipoprotein (apo) B-100 (FDB) is an autosomal codominant disorder which may give rise to hypercholesterolaemia. It is caused by the substitution of glutamine for arginine at codon 3500 of the apo B gene (apo B R3500Q), resulting in decreased binding of low density lipoprotein (LDL) to the ...

journal_title：Atherosclerosis

authors： Wenham PR,Henderson BG,Penney MD,Ashby JP,Rae PW,Walker SW

更新日期：1997-03-21 00:00:00

abstract：:The efflux of cholesterol from cells and its incorporation into HDL is believed to be the initial step in reverse cholesterol transport. This report addresses the question of whether there is a relationship between the ability of serum to promote efflux of cholesterol from cells in culture and the severity of coronary...

journal_title：Atherosclerosis

authors： Mikkola TS,Anthony MS,Clarkson TB,St Clair RW

更新日期：2003-09-01 00:00:00

abstract：OBJECTIVE:To investigate the statin eligibility and the predictabilities for cardiovascular disease between AHA/ACC and ATPIII guidelines, comparing those results to concomitant coronary artery calcium scores (CACS) in a large cohort of Korean individuals who met statin-eligibility criteria. METHODS:Among 19,920 parti...

journal_title：Atherosclerosis

authors： Rhee EJ,Park SE,Oh HG,Park CY,Oh KW,Park SW,Blankstein R,Plutzky J,Lee WY

更新日期：2015-05-01 00:00:00

abstract：:Exercise affects lipoprotein metabolism and apolipoprotein E (Apo E) genotype may alter changes in lipoprotein subclasses that occur with exercise. The present study examined the effects of Apo E genotype (APOE) on the response of lipoprotein subclass concentrations to long-term exercise. A prospective longitudinal st...

journal_title：Atherosclerosis

authors： Seip RL,Otvos J,Bilbie C,Tsongalis GJ,Miles M,Zoeller R,Visich P,Gordon P,Angelopoulos TJ,Pescatello L,Moyna N,Thompson PD

更新日期：2006-09-01 00:00:00

abstract：OBJECTIVE:Genomewide association studies (GWAS), conventional association studies and the characterization of families with ApoA5 deficiency have shown that variation in the apolipoprotein A5 (APOA5) gene is associated with plasma triglyceride levels. The aim of this study was to determine the frequency of rare variant...

journal_title：Atherosclerosis

authors： Evans D,Aberle J,Beil FU

更新日期：2011-12-01 00:00:00

abstract：:Modified lipoproteins induce autoimmune responses including the synthesis of autoantibodies with pro-inflammatory characteristics. Circulating modified lipoprotein autoantibodies combine with circulating antigens and form immune complexes (IC). We now report the results of a study investigating the role of circulating...

journal_title：Atherosclerosis

authors： Lopes-Virella MF,McHenry MB,Lipsitz S,Yim E,Wilson PF,Lackland DT,Lyons T,Jenkins AJ,Virella G,DCCT\/EDIC Research Group.

更新日期：2007-02-01 00:00:00

abstract：:Oxidative stress is associated with atherosclerosis. Familial combined hyperlipidemia (FCH) is considered as a human model of primary dyslipidemia and atherosclerosis frequently associated with insulin resistance (IR), but there are few data on its possible relation to oxidative stress. The objective of this study was...

journal_title：Atherosclerosis

authors： Martinez-Hervas S,Fandos M,Real JT,Espinosa O,Chaves FJ,Saez GT,Salvador A,Cerdá C,Carmena R,Ascaso JF

更新日期：2008-08-01 00:00:00

abstract：:In type 2 diabetics, the progression of atherosclerosis is more rapid than the general population and 80% of these patients will die of an atherosclerotic event. Since in these patients hyperglycemia per se confers increased risk for cardiovascular disease (CVD), the presence of even borderline-high-risk LDL-C signals...

journal_title：Atherosclerosis

authors： Baliarsingh S,Beg ZH,Ahmad J

更新日期：2005-10-01 00:00:00

abstract：OBJECTIVE:Recent studies have demonstrated that palmitic acid (PA) could regulate endothelial progenitor cells (EPCs) function (migration, proliferation, survival and angiogenesis) via various signal pathways, but the effect of PA on EPCs apoptosis and associated mechanisms are still elusive. METHODS:The human EPCs we...

journal_title：Atherosclerosis

authors： Jiang H,Liang C,Liu X,Jiang Q,He Z,Wu J,Pan X,Ren Y,Fan M,Li M,Wu Z

更新日期：2010-05-01 00:00:00

abstract：AIMS:Transition metal ions have been implicated in atherosclerosis. The goal of this study was to investigate whether metal ion levels were higher in people with diabetes, in view of their increased risk of aggravated atherosclerosis. METHODS AND RESULTS:Absolute concentrations of iron, copper, zinc and calcium, and p...

journal_title：Atherosclerosis

authors： Stadler N,Heeneman S,Vöö S,Stanley N,Giles GI,Gang BP,Croft KD,Mori TA,Vacata V,Daemen MJ,Waltenberger J,Davies MJ

更新日期：2012-06-01 00:00:00

abstract：:In previous works, it has been evidenced that lipoperoxidative injury to macrophages caused by oxidatively modified low-density lipoprotein (O-LDL) plays an important role in foam cell formation, and that PSK, a protein bound polysaccharide extracted from the class Basidiomycetes Coriolus Versicolor, can protect macro...

journal_title：Atherosclerosis

authors： Yuan C,Mei Z,Liu S,Yi L

更新日期：1996-08-02 00:00:00

abstract：OBJECTIVE:Elevated leukocyte count is a classic marker of systemic inflammation. This study examined whether the leukocyte count is associated with incidence of coronary events (CE) and stroke during a long follow-up period. METHODS:A total of 17,131 men and 2932 women, aged 27-61 years, without history of cardiovascu...

journal_title：Atherosclerosis

authors： Li C,Engström G,Hedblad B

更新日期：2010-04-01 00:00:00

abstract：:The spatial distribution of intimal thickening was determined for each of 42 carotid bifurcations removed at autopsy from patients with no clinical or anatomic evidence of cerebrovascular disease. Both right and left specimens were available for six of the individuals. Each bifurcation was removed intact and included ...

journal_title：Atherosclerosis

authors： Masawa N,Glagov S,Zarins CK

更新日期：1994-06-01 00:00:00

abstract：:Familial combined hyperlipidemia (FCHL) is one of the most common inherited lipid disorders. Resistance of adipocytes to the effects of acylation stimulating protein (ASP) may contribute to ineffective triglyceride synthesis and thereby prolonged postprandial lipemia and increased fatty acid flux to the liver seen in ...

journal_title：Atherosclerosis

authors： Ylitalo K,Porkka KV,Meri S,Nuotio I,Suurinkeroinen L,Vakkilainen J,Pajukanta P,Viikari JS,Peltonen L,Ehnholm C,Taskinen MR

更新日期：1997-03-21 00:00:00

abstract：:High density lipoprotein cholesterol (HDL-C) is a primary risk factor for cardiovascular disease. Apolipoprotein A-1 (apoA1) is the major HDL-associated apolipoprotein. The -75G/A single nucleotide polymorphism (SNP) in the apolipoprotein A1 gene (APOA1) promoter has been reported to be associated with HDL-C concentra...

journal_title：Atherosclerosis

authors： Ruaño G,Seip RL,Windemuth A,Zöllner S,Tsongalis GJ,Ordovas J,Otvos J,Bilbie C,Miles M,Zoeller R,Visich P,Gordon P,Angelopoulos TJ,Pescatello L,Moyna N,Thompson PD

更新日期：2006-03-01 00:00:00

abstract：:To determine whether high prevalence of small dense low-density lipoprotein (LDL) in non-insulin-dependent diabetes (NIDDM) with nephropathy is directly associated with kidney damage, we measured LDL particle size by non-denaturing 2-16% gradient polyacrylamide gel electrophoresis in non-diabetic patients with primary...

journal_title：Atherosclerosis

authors： Hirano T,Oi K,Sakai S,Kashiwazaki K,Adachi M,Yoshino G

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Collagen synthesis in vascular smooth muscle cells (VSMCs) is very important in atherosclerosis, as it affects plaque stability. In this study, we aim to assess whether miR-124-3p is involved in the collagen synthesis process in VSMCs and the role it might play in atherosclerotic development. METHO...

journal_title：Atherosclerosis

authors： Chen W,Yu F,Di M,Li M,Chen Y,Zhang Y,Liu X,Huang X,Zhang M

更新日期：2018-10-01 00:00:00

abstract：:The relationship of fetal plasma cholesterol levels to aortic free and esterified cholesterol concentration was determined in the rabbit during gestation. Plasma cholesterol levels (mg/dl) in early fetuses were markedly high and decreased at term. While aortic free cholesterol content increased with fetal age, cholest...

journal_title：Atherosclerosis

authors： Cayatte AJ,Subbiah MT

更新日期：1989-04-01 00:00:00

abstract：UNLABELLED:Previous studies have suggested altered triglyceride (TG) storage in patients with abdominal obesity and blood lipid disorders. OBJECTIVE:We hypothesized that women with abdominal obesity and a dysmetabolic profile have low DGAT activity in their abdominal fat compartments. METHODS:Paired omental (OM) and ...

journal_title：Atherosclerosis

authors： Côté JA,Nadeau M,Leboeuf M,Blackburn L,Tchernof A

更新日期：2014-03-01 00:00:00

abstract：:The differences in the fatty acid spectra of serum samples obtained from vegetarians (62 females, 40 males) and non-vegetarians (70 females, 38 males) were evaluated in a matched-pair study design. This study population made it possible to examine 48 female and 31 male pairs whose age difference did not exceed 3 years...

journal_title：Atherosclerosis

authors： Melchert HU,Limsathayourat N,Mihajlović H,Eichberg J,Thefeld W,Rottka H

更新日期：1987-05-01 00:00:00