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The use of polymorphic DNA and protein markers for the third complement component for determining linkage of familial hypercholesterolaemia.

Abstract：

:We have used DNA and protein polymorphisms for the third complement component (C3) to assess the potential of DNA markers in the diagnosis and study of familial hypercholesterolaemia (FH), and to confirm the reported linkage between FH and C3. The inheritance of FH and the C3 gene has been studied in 10 families by combining information from both the protein and DNA polymorphisms. Our results confirm that the C3 gene is loosely linked to the gene causing FH (lod score maximum of 2.0) at a recombination distance of 0.15. When these results are combined with previously published data the overall lod score maximum is 4.75 at a recombination distance of 0.2, meaning that the two genes will be inherited together in only about 80% of children. These results confirm that the gene that causes familial hypercholesterolaemia is linked to C3 and is therefore on chromosome 19, but C3 is not close enough to be used as a diagnostic marker.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Humphries SE,Donald JA,McFadden JJ,Shull S,Williamson R,Jowett NI,Galton DJ,Julsrud JO,Berg K,Heiberg A

doi

10.1016/0021-9150(84)90056-x

subject

Has Abstract,Author List Incomplete

pub_date

1984-09-01 00:00:00

pages

267-78

issue

3

eissn

0021-9150

issn

1879-1484

pii

0021-9150(84)90056-X

journal_volume

52

pub_type

杂志文章

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