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Platelet factors and the human vascular wall. Part 2. Such factors are not required for endothelial cell proliferation and migration.

Abstract：

:The effects of platelet factors on human umbilical venous endothelial cell DNA-synthesis at various serum concentrations were studied. While [3H]thymidine uptake of these cells was almost linearly related to the concentration of serum in the culture medium, no significant differences were found at any serum level between cultures treated with sera derived from either platelet-rich or platelet-poor plasma. The role of platelet factors in cellular migration into standardized mechanical "wounds" was also investigated following inhibition of the proliferative response by irradiation of endothelial monolayers. Repopulation of such "wounds" was not affected by platelet factors. We conclude that endothelial cells proliferate and migrate in vitro independently of platelet factors.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Thorgeirsson G,Robertson AL Jr

doi

10.1016/0021-9150(78)90168-5

subject

Has Abstract

pub_date

1978-10-01 00:00:00

pages

231-8

issue

2

eissn

0021-9150

issn

1879-1484

pii

0021-9150(78)90168-5

journal_volume

31

pub_type

杂志文章

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