Resialylation of sialic acid deficit vascular endothelium, circulating cells and macromolecules may counteract the development of atherosclerosis: a hypothesis.

abstract：BACKGROUND:Oxidation processes play an important role in atherogenesis. Bilirubin IXalpha is recognised as a potent antioxidant. In the present study, we assessed the role of elevated serum bilirubin levels in the prevention of ischemic heart disease (IHD). METHODS:The occurrence of IHD was determined in Gilbert syndr...

journal_title：Atherosclerosis

authors： Vítek L,Jirsa M,Brodanová M,Kalab M,Marecek Z,Danzig V,Novotný L,Kotal P

更新日期：2002-02-01 00:00:00

abstract：OBJECTIVE:Recent studies have suggested that circulating malondialdehyde-modified low-density lipoprotein (MDA-LDL) is a useful marker for the identification of patients with coronary artery disease (CAD). However, the role of MDA-LDL in atherogenic mechanisms has not yet been fully determined. METHOD AND RESULTS:We i...

journal_title：Atherosclerosis

authors： Miyazaki T,Shimada K,Sato O,Kotani K,Kume A,Sumiyoshi K,Sato Y,Ohmura H,Watanabe Y,Mokuno H,Daida H

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:Previous studies have indicated that sleep duration is associated with total mortality in a U-shaped fashion. The purpose of the current study was to examine the relationship between self-reported sleep duration and carotid artery atherosclerosis in a Japanese population. METHODS:In 2009-2010, a total of 24...

journal_title：Atherosclerosis

authors： Abe T,Aoki T,Yata S,Okada M

更新日期：2011-08-01 00:00:00

abstract：OBJECTIVE:Vasa vasorum (VV) have been implicated to play a role in the pathogenesis of atherosclerosis. This study was designed to describe the distribution of VV density in different vascular beds in humans and to investigate the association between VV density and the known distribution of atherosclerosis in human art...

journal_title：Atherosclerosis

authors： Hildebrandt HA,Gossl M,Mannheim D,Versari D,Herrmann J,Spendlove D,Bajanowski T,Malyar NM,Erbel R,Lerman LO,Lerman A

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:CD163 is a new potential scavenger receptor of Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) which elicits diverse biologic actions involved in atherosclerosis. We have analyzed the importance of TWEAK-CD163 interaction in atherosclerosis. METHODS:TWEAK and CD163 interaction was studied in cu...

journal_title：Atherosclerosis

authors： Moreno JA,Muñoz-García B,Martín-Ventura JL,Madrigal-Matute J,Orbe J,Páramo JA,Ortega L,Egido J,Blanco-Colio LM

更新日期：2009-11-01 00:00:00

abstract：:MGL-3196 is an oral, liver-targeted selective agonist for the thyroid hormone receptor-β (THR-β) that is being developed for the treatment of dyslipidemia. The safety profile and tolerability of THR-β agonist MGL-3196 was assessed in first-in humans studies, including a single ascending dose study (NCT01367873) in whi...

journal_title：Atherosclerosis

authors： Taub R,Chiang E,Chabot-Blanchet M,Kelly MJ,Reeves RA,Guertin MC,Tardif JC

更新日期：2013-10-01 00:00:00

abstract：:Coronary artery calcium (CAC) scanning is a reliable, noninvasive technique for estimating overall coronary plaque burden and for identifying risk for future cardiac events. Arthur Agatston and Warren Janowitz published the first technique for scoring CAC scans in 1990. Given the lack of available data correlating CAC...

journal_title：Atherosclerosis

authors： Alluri K,Joshi PH,Henry TS,Blumenthal RS,Nasir K,Blaha MJ

更新日期：2015-03-01 00:00:00

abstract：:Whole blood and plasma viscosity, red cell aggregability and deformability, and plasma fibrinogen have been compared between 20 patients with heterozygous familial hypercholesterolaemia (FH), without clinical arterial disease, and 20 age- and sex-matched controls. Plasma fibrinogen was elevated in FH, associated with ...

journal_title：Atherosclerosis

authors： Jay RH,Rampling MW,Betteridge DJ

更新日期：1990-12-01 00:00:00

abstract：:Whether cardiorespiratory fitness relates to early subclinical atherosclerotic vascular disease remains unknown. We investigated the relation of cardiorespiratory fitness to coronary artery calcification (CAC) in 2373 African-American and White young adults from the Coronary Artery Risk Development in Young Adults (CA...

journal_title：Atherosclerosis

authors： Lee CD,Jacobs DR Jr,Hankinson A,Iribarren C,Sidney S

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVE:Racial/ethnic differences in common carotid artery intima-media thickness (CIMT) and in risk factors associated with CIMT have been predominantly observed in middle-aged and older individuals. We aimed to characterize racial/ethnic differences CIMT and other cardiovascular risk factors in a healthy, young-adu...

journal_title：Atherosclerosis

authors： Breton CV,Wang X,Mack WJ,Berhane K,Lopez M,Islam TS,Feng M,Hodis HN,Künzli N,Avol E

更新日期：2011-08-01 00:00:00

abstract：:Changes in the concentration and composition of serum very low density lipoprotein (VLDL), low density lipoprotein (LDL) and high density lipoprotein (HDL) were studied in rabbits transferred from chow diet to cholesterol-free, semipurified diets containing casein or isolated soy protein. The fat and fibre content of ...

journal_title：Atherosclerosis

authors： Kurowska EM,Hrabek-Smith JM,Carroll KK

更新日期：1989-08-01 00:00:00

abstract：:Serum lipids, lipoprotein (a), plasminogen activator inhibitor and tissue plasminogen activator levels were measured in 260 subjects, constituting a cross-section sample of 30-60-year-old men and women. For Lp(a), there were positive correlations with age and cholesterol, but not with any of other measured parameters....

journal_title：Atherosclerosis

authors： Sundell IB,Nilsson TK,Hallmans G,Hellsten G,Dahlén GH

更新日期：1989-11-01 00:00:00

abstract：:Ultrasound measurements are both surrogate markers and risk factors for atherosclerosis end points. Carotid intima-media thickness (IMT) is most commonly used, but ultrasound can also define structures in higher spatial dimensions, such as total plaque area (TPA) and total plaque volume (TPV). Because there are minima...

journal_title：Atherosclerosis

authors： Al-Shali K,House AA,Hanley AJ,Khan HM,Harris SB,Mamakeesick M,Zinman B,Fenster A,Spence JD,Hegele RA

更新日期：2005-02-01 00:00:00

abstract：:The goal of the present study was to compare the allele frequency of four polymorphisms at the apo A-I C-III A-IV cluster gene locus-ApoA-I: XmnI and PstI; ApoC-III: SstI; ApoA-IV: XbaI-between male patients who had had a myocardial infarction (n= 614) and matched controls (n = 764). The association with a number of l...

journal_title：Atherosclerosis

authors： Kee F,Amouyel P,Fumeron F,Arveiler D,Cambou JP,Evans A,Cambien F,Fruchart JC,Ducimetière P,Dallongeville J

更新日期：1999-07-01 00:00:00

abstract：:Adhesion molecules and cytokines are involved in the pathogenesis of intimal injury in atherosclerosis but their relationship with endothelial function remains unclear. The objectives of this study were to examine the effects of atorvastatin on soluble adhesion molecules, interleukin-6 (IL-6) and brachial artery endot...

journal_title：Atherosclerosis

authors： Nawawi H,Osman NS,Annuar R,Khalid BA,Yusoff K

更新日期：2003-08-01 00:00:00

abstract：OBJECTIVE:Apolipoprotein E genotype (APOE) polymorphism affects lipid levels and coronary heart disease (CHD) risk. However, these associations may be modified by lifestyle factors. Therefore, we studied whether smoking, physical inactivity or overweight interact with APOE on cholesterol levels and CHD risk. METHODS:C...

journal_title：Atherosclerosis

authors： Gustavsson J,Mehlig K,Leander K,Strandhagen E,Björck L,Thelle DS,Lissner L,Blennow K,Zetterberg H,Nyberg F

更新日期：2012-02-01 00:00:00

abstract：OBJECTIVE:Serum adiponectin protects against incident ischemic heart disease (IHD). However, in patients with existing IHD, higher adiponectin levels are paradoxically associated with worse outcomes. We investigated this paradox by evaluating the relationship between adiponectin and cardiovascular events in patients wi...

journal_title：Atherosclerosis

authors： Beatty AL,Zhang MH,Ku IA,Na B,Schiller NB,Whooley MA

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Uric acid is frequently elevated in hypertension. In addition to renal and metabolic disturbances, lower limb ischemia might contribute to hyperuricemia among hypertensives complicated by peripheral arterial disease (PAD). OBJECTIVE:To test the hypothesis that uric acid status is related to lower limb funct...

journal_title：Atherosclerosis

authors： Langlois M,De Bacquer D,Duprez D,De Buyzere M,Delanghe J,Blaton V

更新日期：2003-05-01 00:00:00

abstract：:We have previously reported that plasma levels of remnant-like lipoprotein particles (RLP) significantly increased in sudden cardiac death cases with and without coronary atherosclerosis. In this study we have elucidated the major subset of proatherogenic RLP, containing both apoB-48 and apoB-100-carrying remnants, in...

journal_title：Atherosclerosis

authors： Nakajima K,Nakajima Y,Takeichi S,Fujita MQ

更新日期：2007-10-01 00:00:00

abstract：:Prolonged exposure of rats to cigarette smoke resulted in significant alterations in the metabolism of lipids. There was a significant increase in the concentration of cholesterol, triglycerides and phospholipids in most of the tissues, particularly the heart, aorta and lungs. Cholesterol, triglycerides and phospholip...

journal_title：Atherosclerosis

authors： Latha MS,Vijayammal PL,Kurup PA

更新日期：1988-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Serum γ-glutamyl transferase (GGT) levels are known to be positively associated with obesity. We aimed at verifying an association between baseline GGT levels and the development of obesity in Korean men. PATIENTS AND METHODS:This prospective cohort study was performed on 18,510 initially non-...

journal_title：Atherosclerosis

authors： Suh YJ,Park SK,Choi JM,Ryoo JH

更新日期：2013-04-01 00:00:00

abstract：RATIONALE:Lipoprotein lipase (LPL) X447 homozygotes are characterized by enhanced conversion of TRL apoB100. Here, we set out to investigate whether this LPL variant is also associated with enhanced apoB48 clearance. Therefore, we evaluated apoB48 kinetics in X447 homozygotes in the fed state by infusion of isotope L-[...

journal_title：Atherosclerosis

authors： Nierman MC,Rip J,Kuivenhoven JA,Sakai N,Kastelein JJ,de Sain-van der Velden MG,Stroes ES,Prinsen BH

更新日期：2007-10-01 00:00:00

abstract：:Oxidative stress is associated with many chronic diseases. In this review, we look at the role that oxidative stress may play in diabetes and related cardiovascular disease (CVD) and how oxidative damage may be measured in the plasma. Increased production of reactive oxygen species (ROS) has been implicated in the ini...

journal_title：Atherosclerosis

authors： Stephens JW,Khanolkar MP,Bain SC

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVE:To clarify the potential mechanisms by which oxidized low-density lipoprotein (oxLDL) could contribute to the progression of aortic valve stenosis (AVS). METHODS:We investigated a total of 46 stenotic and 20 control human aortic valves. The mRNA expression levels of scavenger receptor class A type 1 (SR-A1),...

journal_title：Atherosclerosis

authors： Syväranta S,Alanne-Kinnunen M,Oörni K,Oksjoki R,Kupari M,Kovanen PT,Helske-Suihko S

更新日期：2014-08-01 00:00:00

abstract：:The effectiveness of a new, almost l-thyroxine free preparation of d-thyroxine (Dynothel) was tested in 15 patients with Type IIa and 4 patients with Type IIb hyperlipoproteinemia. Eleven patients with Type IIa and 3 with Type IIb were responsive to treatment and showed an average 26% decrease in plasma TC. This decre...

journal_title：Atherosclerosis

authors： Rakow AD,Klor HU,Kuter E,Ditschuneit HH,Ditschuneit H

更新日期：1976-09-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to determine the relationship between brachial flow-mediated dilation (FMD) and carotid intima-media thickness (IMT) in a large multi-ethnic elderly cohort. BACKGROUND:Brachial flow-mediated dilation (FMD) is a physiologic measure and carotid IMT is an anatomic structural measure of...

journal_title：Atherosclerosis

authors： Yeboah J,Burke GL,Crouse JR,Herrington DM

更新日期：2008-04-01 00:00:00

abstract：OBJECTIVE:Transplant vasculopathy consists of neointima formation in graft vasculature resulting from vascular smooth muscle cell recruitment and proliferation. Variation in the severity of vasculopathy has been demonstrated. Genetic predisposition is suggested as a putative cause of this variation, although cellular m...

journal_title：Atherosclerosis

authors： Onuta G,van Ark J,Rienstra H,Boer MW,Klatter FA,Bruggeman CA,Zeebregts CJ,Rozing J,Hillebrands JL

更新日期：2010-04-01 00:00:00

abstract：:Diabetes mellitus is one of the major risk factors for coronary artery disease (CAD). A recent study reported that glimepiride, a new third-generation sulfonylurea, inhibited the formation of atheromatous plaques in high-cholesterol fed rabbits. However, the mechanism by which glimepiride induces atheroprotection rema...

journal_title：Atherosclerosis

authors： Ueba H,Kuroki M,Hashimoto S,Umemoto T,Yasu T,Ishikawa SE,Saito M,Kawakami M

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Evidence on the association between passive smoking and risk of aortic dissection or aneurysm is limited. This study aimed to investigate whether passive smoking increases risk of mortality from aortic dissection or aneurysm. METHODS:The Japan Collaborative Cohort (JACC) Study is a prospective comm...

journal_title：Atherosclerosis

authors： Kihara T,Yamagishi K,Iso H,Tamakoshi A,JACC Study Group.

更新日期：2017-08-01 00:00:00

abstract：:Collagenous components were extracted from bovine aorta by pepsin digestion. Differential salt precipitations separated the interstitial from the basement membrane (BM) collagens, and the latter were subsequently separated into three distinct types. Ion exchange chromatography, SDS-slab gel electrophoresis, cyanogen b...

journal_title：Atherosclerosis

authors： Leushner JR,Haust MD

更新日期：1984-01-01 00:00:00