Abstract：
:The goal of the present study was to compare the allele frequency of four polymorphisms at the apo A-I C-III A-IV cluster gene locus-ApoA-I: XmnI and PstI; ApoC-III: SstI; ApoA-IV: XbaI-between male patients who had had a myocardial infarction (n= 614) and matched controls (n = 764). The association with a number of lipid lipoprotein, apolipoprotein and lipoprotein particle variables was also assessed. Patients and subjects were recruited in Belfast, Lille, Strasbourg and Toulouse in the framework of the ECTIM study. In the control group, the frequencies of the different polymorphic alleles were homogeneous among recruitment centres suggesting the absence of any European North to South gradient for these cluster polymorphisms. There was no evidence for a significant difference in allelic distribution between cases and controls suggesting that apo A-I, C-III, A-IV gene cluster polymorphisms do not explain MI survival in this sample of European men. There was no statistically significant association between apo A-I C-III A-IV cluster gene polymorphisms and lipid, lipoprotein, apolipoprotein, and lipoprotein particle levels. In conclusion, in the ECTIM study, the apo A-I, C-III, A-IV gene cluster polymorphism is associated with neither circulating plasma variables nor MI survival.
journal_name
Atherosclerosisjournal_title
Atherosclerosisauthors
Kee F,Amouyel P,Fumeron F,Arveiler D,Cambou JP,Evans A,Cambien F,Fruchart JC,Ducimetière P,Dallongeville Jdoi
10.1016/s0021-9150(99)00066-0keywords:
subject
Has Abstractpub_date
1999-07-01 00:00:00pages
187-95issue
1eissn
0021-9150issn
1879-1484pii
S0021-9150(99)00066-0journal_volume
145pub_type
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