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Metabolic studies on the hypolipidaemic effect of guar gum.

Abstract：

:The hypolipidaemic effect of guar gum (30 g/day) was examined in a double blind placebo-controlled crossover study in 9 patients with primary hyperlipidaemia. The treatment periods were of six weeks duration. Cholesterol levels in low density lipoprotein (LDL) were decreased by 11.5% and in intermediate density lipoprotein (IDL) by 10.7%. Plasma cholesterol levels were reduced by 9.6% (P less than 0.05). Kinetic studies using autologous 125I-labelled LDL showed a decrease of 21.6% in plasma LDL apo B pool size (P less than 0.05) that resulted from a 39.1% increase in its fractional rate of catabolism. The kinetic effects of guar gum on LDL metabolism appear similar to that of bile acid binding resins in that LDL apo B fractional catabolism is greatly increased while there is a slight increase in production rate.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Turner PR,Tuomilehto J,Happonen P,La Ville AE,Shaikh M,Lewis B

doi

10.1016/0021-9150(90)90021-a

subject

Has Abstract

pub_date

1990-03-01 00:00:00

pages

145-50

issue

2

eissn

0021-9150

issn

1879-1484

pii

0021-9150(90)90021-A

journal_volume

81

pub_type

临床试验,杂志文章,随机对照试验

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