Abstract:
:Atherosclerosis is considered a chronic inflammatory disease of the arterial wall. Recently, compelling evidence has arisen for the role of monocytes and neutrophils and a particular protein complex that resides within these cells - the NLRP3 inflammasome - in atherosclerosis-associated inflammation. It is now also known that cholesterol crystals are present through all stages of atherosclerosis and can activate the NLRP3 inflammasome within these inflammatory cells to produce interleukin 1β and interleukin 18 - key mediators in the inflammatory cascade that drive plaque progression and instability. In this review, we describe the role of monocytes/macrophages and neutrophils in atherosclerosis, outline mechanisms of activation of the NLRP3 inflammasome in the setting of atherosclerosis-associated inflammation and discuss potential therapies that specifically target the NLRP3 inflammasome and/or its downstream mediators in atherosclerosis, with a particular focus on the emerging role of colchicine.
journal_name
Atherosclerosisjournal_title
Atherosclerosisauthors
Martínez GJ,Celermajer DS,Patel Sdoi
10.1016/j.atherosclerosis.2017.12.027subject
Has Abstractpub_date
2018-02-01 00:00:00pages
262-271eissn
0021-9150issn
1879-1484pii
S0021-9150(17)31456-9journal_volume
269pub_type
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