Abstract:
BACKGROUND AND AIMS:Carbohydrates and fat intake have both been linked to development of atherosclerosis. We examined associations between glycemic index (GI) and fat intake with carotid atherosclerosis. METHODS:The Atherosclerosis Risk in Communities (ARIC) cohort enrolled participants during the period 1987-1989 and the Carotid MRI sub-study occurred between 2004 and 2006 (1672 participants attending both visits). Measures of carbohydrate quality (usual GI), fat intake (total, polyunsaturated and saturated) and overall dietary quality index (DASH Diet Score) were derived from a 66-item food frequency questionnaire administered at baseline. Trained readers measured lipid core presence and maximum wall thickness. Using multivariate logistic regression, we determined the odds of lipid core presence by quintile (Q) of energy-adjusted dietary components. Restricted cubic spline models were used to examine non-linear associations between dietary components and maximum wall thickness. RESULTS:Mean daily polyunsaturated fat intake was 5 g (SD 1.4). GI and polyunsaturated fat intake had a nonlinear relationship with maximum wall thickness. Low (1-4 g) and high (6-12 g) polyunsaturated fat intake were associated with a statistically significant decreased odds of lipid core presence compared to intake in a majority of participants (OR Q5 vs. Q2-4: 0.64, 95% CI 0.42 to 0.98; OR Q1 vs. Q2-4: 0.64, 95% CI 0.42, 0.96), however, the association with lipid core was attenuated by adjustment for maximum wall thickness, hypertension, hyperlipidemia, and diabetes. CONCLUSIONS:GI and polyunsaturated fat intake were not associated with high-risk plaque features, such as lipid core presence, independent of traditional vascular risk factors.
journal_name
Atherosclerosisjournal_title
Atherosclerosisauthors
Dearborn JL,Qiao Y,Guallar E,Steffen LM,Gottesman RF,Zhang Y,Wasserman BAdoi
10.1016/j.atherosclerosis.2016.05.024subject
Has Abstractpub_date
2016-08-01 00:00:00pages
361-366eissn
0021-9150issn
1879-1484pii
S0021-9150(16)30201-5journal_volume
251pub_type
杂志文章相关文献
ATHEROSCLEROSIS文献大全abstract:OBJECTIVES:Urinary cystatin C (u-CysC) is a new biomarker for acute tubular kidney dysfunction and may also indicate chronic tubular dysfunction. Chronic kidney disease is an important cardiovascular risk factor, however it is not known if u-CysC is a risk marker for cardiovascular death. METHODS:The association betwe...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2014.02.020
更新日期:2014-05-01 00:00:00
abstract::The ATP-binding cassette transporters, ABCA1 and ABCG1, are LXR-target genes that participate in the removal of cholesterol from lipid-laden macrophages, a crucial anti-atherogenic mechanism. Statins are currently the most efficacious therapy for the treatment of hypercholesterolemia and cardiovascular disease. We and...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2007.03.030
更新日期:2008-01-01 00:00:00
abstract::We have previously reported that mouse peritoneal macrophages have three types of modified low density lipoprotein (LDL) receptors. One is specific for acetylated LDL (Ac-LDL), the second is for oxidized LDL (Ox-LDL), and the third recognizes both (Arai, H. et al. (1989) Biochem. Biophys. Res. Commun. 159, 1375-1382)....
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(93)90098-f
更新日期:1993-06-01 00:00:00
abstract::Vitamin K is involved in the biosynthesis of a number of blood coagulation factors and bone proteins. It has been suggested that the vitamin K requirement of bone tissue is higher than that of the liver. Here we report that in rats very high doses of vitamin K affected neither the blood coagulation characteristics nor...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/s0021-9150(97)00087-7
更新日期:1997-07-11 00:00:00
abstract:BACKGROUND AND AIMS:Atherosclerosis is a chronic inflammatory disease, and recent studies have shown that infection at remote sites can contribute to the progression of atherosclerosis in hyperlipidemic mouse models. In this report, we tested the hypothesis that genital Chlamydia infection could accelerate the onset an...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2019.09.021
更新日期:2019-11-01 00:00:00
abstract::Studies were performed to determine if serum bilirubin, when combined with various lipid and lipoprotein risk factors, enhances our ability to predict coronary artery disease (CAD). This hypothesis was tested in a retrospective study of 644 middle-aged males who had undergone coronary angiography. The traditional risk...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/s0021-9150(99)00387-1
更新日期:2000-06-01 00:00:00
abstract::Diabetes mellitus is one of the major risk factors for coronary artery disease (CAD). A recent study reported that glimepiride, a new third-generation sulfonylurea, inhibited the formation of atheromatous plaques in high-cholesterol fed rabbits. However, the mechanism by which glimepiride induces atheroprotection rema...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2005.01.055
更新日期:2005-11-01 00:00:00
abstract::We previously reported linkage for plasma levels of high-density lipoprotein cholesterol (HDL-C) on 15q21 in Caucasian families from the National Heart, Lung, and Blood Institute Family Heart Study (NHLBI FHS). Hepatic lipase gene (LIPC), which has a major role in lipoprotein metabolism, resides within the linkage reg...
journal_title:Atherosclerosis
pub_type: 杂志文章,多中心研究
doi:10.1016/j.atherosclerosis.2008.09.007
更新日期:2009-05-01 00:00:00
abstract::Oxidant signalling and lipoprotein oxidation may play important roles in atherosclerotic lesion development. Given coincident localization of 15-lipoxygenase (15-LO), stereospecific products of 15-LO and epitopes of modified LDL in atherosclerotic lesions, we hypothesized that inhibition of 15-LO by PD146176, an inhib...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/s0021-9150(97)00204-9
更新日期:1998-02-01 00:00:00
abstract::High density lipoprotein (HDL) was fractionated by ion exchange column chromatography using a continuous NaCl gradient of 0.06--0.13 M. It was found that, on the basic C apoprotein content, HDL is comprised of 3 subfractions. All 3 subfractions contain apo A-I and apo A-II but the apo A-I/apo A-II ratio is different i...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(79)90034-0
更新日期:1979-08-01 00:00:00
abstract::The efficacy and safety of bezafibrate were evaluated in 83 patients with type IIa, IIb, or IV hyperlipoproteinemia. Following a 12- to 14-week placebo period on a coronary-prudent diet (Period 1), patients were assigned randomly to receive either bezafibrate 600 mg/day or placebo, plus diet in a double-blind, 12-week...
journal_title:Atherosclerosis
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0021-9150(92)90007-4
更新日期:1992-01-01 00:00:00
abstract::The effect of immunological injury upon the early in vivo changes in aortic connective tissue metabolism was studied. It was found that a single antigen (bovine serum albumin), when administered in multiple doses, activated collagen synthesis and increased the rate of lgycosaminoglycan synthesis in the arterial wall. ...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(79)90003-0
更新日期:1979-04-01 00:00:00
abstract::Rabbits were fed a semipurified diet containing soy protein for 4 weeks and subsequently transferred to a semipurified diet containing soy protein plus cholesterol (2 g/kg), or a semipurified diet containing casein as protein source. One group of rabbits was fed the soy protein diet throughout the entire experimental ...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(82)90055-7
更新日期:1982-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:It is recognized that arteries can enlarge to compensate atherosclerosis. The role of diameter enlargement of unaffected arteries is not well known. We hypothesized that brachial and common carotid arteries diameters were larger in subjects with carotid atherosclerosis compared to subjects withou...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2006.11.040
更新日期:2008-01-01 00:00:00
abstract::Exercise affects lipoprotein metabolism and apolipoprotein E (Apo E) genotype may alter changes in lipoprotein subclasses that occur with exercise. The present study examined the effects of Apo E genotype (APOE) on the response of lipoprotein subclass concentrations to long-term exercise. A prospective longitudinal st...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2005.06.050
更新日期:2006-09-01 00:00:00
abstract::The relationship of fetal plasma cholesterol levels to aortic free and esterified cholesterol concentration was determined in the rabbit during gestation. Plasma cholesterol levels (mg/dl) in early fetuses were markedly high and decreased at term. While aortic free cholesterol content increased with fetal age, cholest...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(89)90096-8
更新日期:1989-04-01 00:00:00
abstract::Arterial specimens were obtained from 12 patients during arterial repair surgery and 3 patients during nephrectomy following a bolus injection of autologous radio-iodinated very low density lipoprotein (VLDL) up to 30 h before surgery. Radioactivity in apoprotein B (apo B) was determined in lipoprotein fractions isola...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(81)90073-3
更新日期:1981-05-01 00:00:00
abstract::Familial ligand-defective apolipoprotein (apo) B-100 (FDB) is an autosomal codominant disorder which may give rise to hypercholesterolaemia. It is caused by the substitution of glutamine for arginine at codon 3500 of the apo B gene (apo B R3500Q), resulting in decreased binding of low density lipoprotein (LDL) to the ...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/s0021-9150(96)06029-7
更新日期:1997-03-21 00:00:00
abstract::This study sought to examine the association between cigarette smoking and serum bilirubin antioxidant concentrations in 715 middle-aged men undergoing coronary angiography. The study involved 153 current smokers, 251 who quit smoking and 311 who never smoked. Serum bilirubin concentrations were divided into the follo...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/s0021-9150(97)00232-3
更新日期:1998-02-01 00:00:00
abstract::Endothelium-derived relaxing and contracting factors play an important role in atherosclerosis, re-stenosis and graft survival. Internal thoracic artery (ITA) and saphenous vein (SV) are used as conduit vessels in coronary artery bypass graft surgery (CABG). The long-term graft patency rate is higher with ITA than SV....
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/s0021-9150(97)00114-7
更新日期:1997-08-01 00:00:00
abstract::The enhanced production of endothelin-1 (ET-1) in atherosclerotic arteries may be related to increased activity of the endothelin converting enzyme (ECE) which converts big ET-1 to ET-1. The purpose of the present study was to investigate whether the vasoconstrictor activity of big ET-1 is altered as a result of incre...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/s0021-9150(01)00564-0
更新日期:2002-01-01 00:00:00
abstract::Vascular calcification is associated with increased risk of cardiovascular events that are the most common cause of death in patients with end-stage renal disease. Clinical and experimental studies indicate that hyperphosphatemia is a risk factor for vascular calcification and cardiovascular mortality in these patient...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2007.11.031
更新日期:2008-08-01 00:00:00
abstract:OBJECTIVE:Previous studies indicate an association between marathon running and premature atherosclerosis. Retinal vessel diameter alterations, in particular narrower arterioles and wider venules, reflect early stages of atherosclerosis, but the influence of marathon on the retinal microcirculation is unknown. METHODS...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2011.08.052
更新日期:2011-12-01 00:00:00
abstract::Data relating to the effects of calcium channel blockers on experimental atherosclerosis in rabbits are inconsistent with most studies finding no effect on either serum lipids or atherosclerosis. We have administered flordipine (5, 15 or 45 mg/kg/day) for 10 weeks to rabbits fed 1% cholesterol and 4% corn oil. At no l...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(88)90292-4
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVE:To study the influence of polyvascular atherothrombotic disease on stroke patient prognosis, its relation with inflammatory markers, and to analyze the progression of atherothrombotic disease. METHODS:MITICO is a multi-centered prospective observational study recruiting non-anticoagulated ischemic stroke pat...
journal_title:Atherosclerosis
pub_type: 杂志文章,多中心研究
doi:10.1016/j.atherosclerosis.2009.07.041
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVE:In addition to being a risk marker for cardiovascular disease, recent data suggests that C-reactive protein (CRP) induces endothelial dysfunction and promotes oxidative stress. We evaluated the effects of two conformers of CRP (pentameric, or native [nCRP], versus monomeric, or modified [mCRP]) on vessel func...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2007.06.013
更新日期:2007-12-01 00:00:00
abstract::In symptom-free subjects, exercise tolerance testing (ETT) has a doubtful utility for detecting latent coronary heart disease (CHD) because of frequent false positives, but it may be valuable for predicting future CHD. To clarify the latter question, we calculated CHD incidence associated with presence or absence of E...
journal_title:Atherosclerosis
pub_type: 杂志文章,评审
doi:10.1016/j.atherosclerosis.2008.12.034
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND:Heterozygous familial hypercholesterolemia (heFH) is a common autosomal dominant hereditary disorder caused by mutations in the LDL-receptor gene that lead to elevated plasma levels of low-density lipoprotein-cholesterol (LDL-c). Robust lowering of LDL-c levels is essential for risk reduction of premature ca...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2009.09.014
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:Calcific aortic valve disease is an active and progressive condition. Data indicate that aortic valve calcification (AVC) is associated with endothelial dysfunction and accepted as a manifestation of atherosclerosis. Coronary flow reserve (CFR) determined by transthoracic echocardiography has been introduced...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2007.07.036
更新日期:2008-04-01 00:00:00
abstract::Heritability of plasma apolipoprotein (apo) A-I, apo B, and low density lipoprotein (LDL) subclasses and concordance for lipoprotein(a) excess were assessed in 109 monozygotic (MZ) and 113 dizygotic (DZ) twin pairs participating in the third examination of the National Heart, Lung, and Blood Institute Twin Study. The ...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(91)90191-5
更新日期:1991-11-01 00:00:00