Abstract:
:Arterial specimens were obtained from 12 patients during arterial repair surgery and 3 patients during nephrectomy following a bolus injection of autologous radio-iodinated very low density lipoprotein (VLDL) up to 30 h before surgery. Radioactivity in apoprotein B (apo B) was determined in lipoprotein fractions isolated from saline extracts of washed intima in the density ranges less than 1.006 g/ml, 1.006-1.019 g/ml and 1.019-1.063 g/ml [intimal VLDL, intermediate-(IDL) and low density lipoprotein (LDL), respectively]. Specific radioactivity of apo B was measured in corresponding plasma protein fractions. In atheromatous intima, minimum influx rates of VLDL-apo B [12.1 +/- 4.3 (SEM) ng . cm-1 . h-1] and IDL-apo B (13.6 +/- 5.1) over 24 h were significantly higher than fluxes of VLDL-apo B (1.2 +/- 0.34) and IDL-apo B (1.4 +/- 1.1) into normal intima (P less than 0.05). Minimum influx rate of LDL-apo B was also significantly higher in atheromatous intima (196 +/- 39) compared with normal intima (25.8 +/- 13.5, P less than 0.01) and was 16-18 fold higher than corresponding VLDL- and IDL-apo B fluxes in both types of intima. Collagenase digestion of intimal samples after saline extraction yielded further significant mass of VLDL but this fraction had little radioactivity compared with saline extractable VLDL.
journal_name
Atherosclerosisjournal_title
Atherosclerosisauthors
Nicoll A,Duffield R,Lewis Bdoi
10.1016/0021-9150(81)90073-3subject
Has Abstractpub_date
1981-05-01 00:00:00pages
229-42issue
2eissn
0021-9150issn
1879-1484pii
0021-9150(81)90073-3journal_volume
39pub_type
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