Association between nutrient intake and peripheral artery disease: results from the InCHIANTI study.

Abstract:

BACKGROUND:Little is known about the relationship between dietary patterns and peripheral arterial disease (PAD). Our aim was to estimate the association between nutrient intake and diagnosis of PAD. METHODS AND RESULTS:We assessed the nutrient intake of 1251 home-dwelling subjects enrolled in the InCHIANTI study, mean age 68 years (S.D.: 15). We explored the relationship between nutrient intake, obtained through the European Prospective Investigation into Cancer and Nutrition (EPIC) questionnaire, and PAD, defined as an ankle-brachial index (ABI)<0.90. After adjustment for potential confounders, we found a reduction of the risk of having an ABI<0.90 associated with vegetable lipid intake>or=34.4 g/day (OR: 0.39; 95% CI: 0.16-0.97), Vitamin E intake>or=7.726 mg/day (OR: 0.37; 95% CI 0.16-0.84) and higher serum HDL cholesterol concentration (OR: 0.76; 95% CI: 0.63-0.92 for 10mg/dl increase). Age (OR: 1.11; 95% CI 1.07-1.14 for 1 year increase), smoking (OR: 1.03; 95% CI: 1.01-1.04 for 10 packs/year increase) and pulse pressure (OR: 1.11; 95% CI: 1.03-1.19 for 5 mmHg increase) were associated with an increased risk of PAD. CONCLUSIONS:A higher intake of vegetable lipids, Vitamin E and higher concentrations of serum HDL cholesterol characterize subjects free from PAD. Prospective studies are needed to verify whether this dietary pattern and/or interventions aimed at increasing HDL cholesterol exert some protective effect against PAD.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Antonelli-Incalzi R,Pedone C,McDermott MM,Bandinelli S,Miniati B,Lova RM,Lauretani F,Ferrucci L

doi

10.1016/j.atherosclerosis.2005.07.016

keywords:

subject

Has Abstract

pub_date

2006-05-01 00:00:00

pages

200-6

issue

1

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(05)00474-0

journal_volume

186

pub_type

杂志文章,多中心研究,随机对照试验
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    pub_type: 临床试验,杂志文章,随机对照试验

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    pub_type: 杂志文章,评审

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    pub_type: 杂志文章,多中心研究

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    pub_type: 临床试验,杂志文章

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    更新日期:2014-05-01 00:00:00

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    pub_type: 杂志文章

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    更新日期:1983-12-01 00:00:00

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    更新日期:1989-04-01 00:00:00

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    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(80)90230-0

    authors: Hajjar DP,Smith SC

    更新日期:1980-06-01 00:00:00

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    pub_type: 杂志文章,评审

    doi:10.1016/j.atherosclerosis.2011.02.010

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    更新日期:2011-04-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1016/0021-9150(78)90041-2

    authors: Rössner S

    更新日期:1978-09-01 00:00:00