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Effect of low-dose probucol therapy on LDL oxidation and the plasma lipoprotein profile in male volunteers.

Abstract：

:The effect of 4 months of low-dose probucol treatment (250 mg/day) on LDL oxidation and on plasma-HDL cholesterol was studied in a prospective, double-blind, randomized, placebo-controlled trial involving 26 male volunteers. LDL samples isolated at baseline and at 4 months were subjected to in vitro tests of LDL oxidation, involving copper-catalyzed, time-course experiments. For the placebo group, LDL oxidation did not significantly change over the 4-month period. However, in the probucol group, LDL oxidation was significantly inhibited at 4 months, as evidenced by assays measuring conjugated diene formation, lipid peroxide production and altered electrophoretic mobility of oxidized LDL. In fact, in the probucol group the 'lag-phase' of oxidation was prolonged 2.7-fold. Neither probucol nor placebo had a significant effect on plasma HDL-cholesterol: in the probucol group HDL-cholesterol fell from 37.7 +/- 7.4 mg/dl to 34.2 +/- 8.3 mg/dl (percentage decrease -8.9), while in the placebo group plasma HDL-cholesterol levels were 42.4 +/- 8.3 mg/dl and 40.9 +/- 7.0 mg/dl at baseline and 4 months (percentage decrease -2.7). Therefore, a low dose of probucol (250 mg/day) given daily seems to afford protection against the oxidative modification of LDL, and does not appear to exert any substantial effect on the plasma lipoprotein profile.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Cristol LS,Jialal I,Grundy SM

doi

10.1016/0021-9150(92)90046-j

keywords:

subject

Has Abstract

pub_date

1992-11-01 00:00:00

pages

11-20

issue

1

eissn

0021-9150

issn

1879-1484

pii

0021-9150(92)90046-J

journal_volume

97

pub_type

临床试验,杂志文章,随机对照试验

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