当前位置： SCI文献检索 > ATHEROSCLEROSIS期刊下所有文献 > Galectin-3 binding protein, coronary artery disease and cardiovascular mortality: Insights from the LURIC study.

Galectin-3 binding protein, coronary artery disease and cardiovascular mortality: Insights from the LURIC study.

Abstract：

BACKGROUND AND AIMS:Galectin-3 binding protein (Gal-3BP) has been associated with inflammation and cancer, however, its role in coronary artery disease (CAD) and cardiovascular outcome remains unclear. METHODS:Gal-3BP plasma levels were measured by ELISA in 2922 individuals from the LURIC study (62.7 ± 10.6 years, 62.7% male). All-cause and cardiovascular mortality was assessed by Kaplan-Meier analysis and Cox proportional hazards regression. Causal involvement of Gal-3BP was tested for by Mendelian randomization. Gal-3BP effects on human monocyte-derived macrophages were assessed in vitro. RESULTS:During 8.8 ± 3.0 years, 866 individuals died, 654 of cardiovascular causes. There was a significant increase in all-cause and cardiovascular mortality with increasing Gal-3BP quintiles. After thorough adjustment, all-cause mortality remained significantly increased in the fifth Gal-3BP quintile (HRQ5 1.292 (1.030-1.620), p = 0.027); cardiovascular mortality remained increased in Gal-3BP quintiles two to five (HRQ51.433 (1.061-1.935, p = 0.019). Gal-3BP levels were not associated with diagnosis and extent of coronary artery disease. In addition, Mendelian randomization did not show a direct causal relationship between Gal-3BP levels and mortality. Gal-3BP levels were, however, independently associated with markers of metabolic and inflammatory distress. In vitro, Gal-3BP induced a pro-inflammatory response in human monocyte-derived macrophages. Adding Gal-3BP levels to the ESC score improved risk assessment in patients with ESC SCORE-based risk >5% (p = 0.010). CONCLUSIONS:In a large clinical cohort of CAD patients, Gal-3BP levels are independently associated with all-cause and cardiovascular mortality. The underlying mechanisms may likely involve metabolic and inflammatory distress. To further evaluate the potential clinical value of Gal-3BP, prospective studies are needed.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Gleissner CA,Erbel C,Linden F,Domschke G,Akhavanpoor M,Helmes CM,Doesch AO,Kleber ME,Katus HA,Maerz W

doi

10.1016/j.atherosclerosis.2017.03.031

subject

Has Abstract

pub_date

2017-05-01 00:00:00

pages

121-129

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(17)30133-8

journal_volume

260

pub_type

杂志文章

相关文献

ATHEROSCLEROSIS文献大全
  • Association of TNF-alpha serum levels and TNFA promoter polymorphisms with risk of myocardial infarction.

    abstract：:Elevated levels of tumor necrosis factor-alpha (TNF-alpha), and presence of polymorphisms of the TNFA gene have been implicated in cardiovascular disease pathogenesis. We explored the relationship between polymorphisms in the TNFA gene (-1031C/T, -863C/A -857T/C, -308G/A, -238G/A), protein levels of TNF-alpha and thei...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2005.09.022

    authors： Bennet AM,van Maarle MC,Hallqvist J,Morgenstern R,Frostegård J,Wiman B,Prince JA,de Faire U

    更新日期：2006-08-01 00:00:00

  • Effect of KC-9432, a new hypolipidemic compound, on high density lipoprotein cholesterol in rats.

    abstract：:KC-9432 (a new hypolipidemic compound, alpha-[p-(p-chlorobenzoyl) phenoxy-alpha-cyclohexyl acetic acid ethyl ester) was studied in rats for its effect on plasma lipid and lipoprotein levels. KC-9432 was particularly effective in hyperlipidemia in rats fed with a diet containing 2% cholesterol and 1% sodium cholate. Th...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(80)90097-0

    authors： Seri K,Sato R,Hamazaki Y,Yamamoto T,Ishiyama N

    更新日期：1980-09-01 00:00:00

  • Oxidized cholesterol in oxidized low density lipoprotein may be responsible for the inhibition of LPS-induced nitric oxide production in macrophages.

    abstract：:Previous work has shown that oxidized low density lipoprotein (Ox-LDL) inhibited lipopolysacchride (LPS)-induced nitric oxide (NO) production in macrophages. In this paper, the role of different components of Ox-LDL in the inhibitory effect was studied by measuring nitrite in media. Ox-LDL inhibited LPS-induced NO pro...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(97)00185-8

    authors： Liu SX,Chen Y,Zhou M,Wan J

    更新日期：1998-01-01 00:00:00

  • Carotid atherosclerosis in chronic renal failure-the central role of increased plaque burden.

    abstract：:Studies on carotid artery atherosclerosis have been performed in order to understand the high risk for cardiovascular disease in chronic renal failure (CRF). The purpose of this study was to evaluate the extent and nature of carotid artery atherosclerosis in patients with CRF. Of the 135 patients with CRF (52 +/- 11 y...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2003.08.010

    authors： Leskinen Y,Lehtimäki T,Loimaala A,Lautamatti V,Kallio T,Huhtala H,Salenius JP,Saha H

    更新日期：2003-12-01 00:00:00

  • Correlation between cholesterol content in circulating immune complexes and atherogenic properties of CHD patients' serum manifested in cell culture.

    abstract：:Blood serum of most patients with coronary heart disease (CHD) caused a 2-5-fold increase in the total cholesterol content of smooth muscle cells cultured from unaffected human aortic intima, i.e. possessed an atherogenic potential manifested in culture. Removal of immunoglobulins G and M from an atherogenic serum bro...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(90)90065-q

    authors： Tertov VV,Orekhov AN,Sayadyan KS,Serebrennikov SG,Kacharava AG,Lyakishev AA,Smirnov VN

    更新日期：1990-04-01 00:00:00

  • Sterol-regulatory-element binding protein inhibits upstream stimulatory factor-stimulated hepatic lipase gene expression.

    abstract：:Hepatic lipase (HL) not only plays an important role in plasma lipoprotein transport, but may also affect intracellular lipid metabolism. We hypothesize that HL expression is regulated as an integral part of intracellular lipid homeostasis. Addition of oleate (1 mM) to HepG2 cells increased HL secretion to 134+/-14% o...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2004.10.027

    authors： Botma GJ,van Deursen D,Vieira D,van Hoek M,Jansen H,Verhoeven AJ

    更新日期：2005-03-01 00:00:00

  • Type 1 diabetes increases retention of low-density lipoprotein in the atherosclerosis-prone area of the murine aorta.

    abstract：BACKGROUND AND AIMS:Individuals with type 1 diabetes mellitus are at high risk of developing atherosclerotic cardiovascular disease, but the underlying mechanisms by which type 1 diabetes accelerates atherosclerosis remain unknown. Increased retention of low-density lipoprotein (LDL) in atherosclerosis-prone sites of t...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2017.05.019

    authors： Hagensen MK,Mortensen MB,Kjolby M,Stillits NL,Steffensen LB,Bentzon JF

    更新日期：2017-08-01 00:00:00

  • The genetic effect of the apoprotein AV gene on the serum triglyceride level in Japanese.

    abstract：:The newly identified apoprotein AV (apoAV) gene was suggested to have a significant effect on triglyceride (TG) metabolism in Caucasians. We studied the genetic effect of this gene on serum TG in a Japanese population. Participants (481 male and 412 female) were recruited at a health examination. A T/C single nucleoti...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(02)00252-6

    authors： Nabika T,Nasreen S,Kobayashi S,Masuda J

    更新日期：2002-12-01 00:00:00

  • Impact of evolocumab treatment on low-density lipoprotein cholesterol levels in heterozygous familial hypercholesterolemic patients withdrawing from regular apheresis.

    abstract：BACKGROUND AND AIMS:Low-density lipoprotein (LDL) apheresis has been used to treat refractory hyperlipidemia such as familial hypercholesterolemia (FH). Evolocumab, a proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor used in clinical settings, can reduce LDL cholesterol (LDL-C) levels by >70%. Therefore, ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.atherosclerosis.2017.09.011

    authors： Kawashiri MA,Nohara A,Higashikata T,Tada H,Nakanishi C,Okada H,Konno T,Sakata K,Hayashi K,Inazu A,Mabuchi H,Yamagishi M

    更新日期：2017-10-01 00:00:00

  • Cross-sectional association of soluble thrombomodulin with mild peripheral artery disease; the ARIC study. Atherosclerosis Risk in Communities.

    abstract：:Thrombomodulin, an endothelial membrane glycoprotein, is an essential part of the protein C anti-coagulant pathway. It may also have a role in the regulation of fibrinolysis. We carried out a cross-sectional study to assess the association of soluble thrombomodulin (sTM) with peripheral artery disease (PAD) in a strat...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(00)00729-2

    authors： Salomaa V,Matei C,Aleksic N,Sansores-Garcia L,Folsom AR,Juneja H,Park E,Wu KK

    更新日期：2001-08-01 00:00:00

  • C/EBPβ in bone marrow is essential for diet induced inflammation, cholesterol balance, and atherosclerosis.

    abstract：BACKGROUND AND OBJECTIVE:Atherosclerosis is both a chronic inflammatory disease and a lipid metabolism disorder. C/EBPβ is well documented for its role in the development of hematopoietic cells and integration of lipid metabolism. However, C/EBPβ's role in atherosclerotic progression has not been examined. We assessed ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2016.03.040

    authors： Rahman SM,Baquero KC,Choudhury M,Janssen RC,de la Houssaye BA,Sun M,Miyazaki-Anzai S,Wang S,Moustaid-Moussa N,Miyazaki M,Friedman JE

    更新日期：2016-07-01 00:00:00

  • Additive anti-atherogenic effect of thromboxane receptor antagonism with 12/15lipoxygenase gene disruption in apolipoprotein E-deficient mice.

    abstract：:Previous studies in mouse models showed that 12/15lipoxygenase (12/15LO) gene disruption diminishes atherosclerosis. Pharmacologic suppression of thromboxane (Tx) A(2) biosynthesis or blockade of its receptor also reduces the development of the disease in the same models. We tested the hypothesis that simultaneous gen...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2007.11.038

    authors： Tang L,Ding T,Praticò D

    更新日期：2008-08-01 00:00:00

  • NT-proBNP is associated with coronary heart disease risk in healthy older women but fails to enhance prediction beyond established risk factors: results from the British Women's Heart and Health Study.

    abstract：OBJECTIVE:Limited evidence suggests NT-proBNP improves prediction of coronary heart disease (CHD) events but further data are needed, especially in people without pre-existing CHD and in women. METHODS:We measured NT-proBNP in serum from 162 women with incident CHD events and 1226 controls (60-79 years) in a case-cont...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2009.09.016

    authors： Sattar N,Welsh P,Sarwar N,Danesh J,Di Angelantonio E,Gudnason V,Davey Smith G,Ebrahim S,Lawlor DA

    更新日期：2010-03-01 00:00:00

  • Enhanced apoB48 metabolism in lipoprotein lipase X447 homozygotes.

    abstract：RATIONALE:Lipoprotein lipase (LPL) X447 homozygotes are characterized by enhanced conversion of TRL apoB100. Here, we set out to investigate whether this LPL variant is also associated with enhanced apoB48 clearance. Therefore, we evaluated apoB48 kinetics in X447 homozygotes in the fed state by infusion of isotope L-[...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2006.08.038

    authors： Nierman MC,Rip J,Kuivenhoven JA,Sakai N,Kastelein JJ,de Sain-van der Velden MG,Stroes ES,Prinsen BH

    更新日期：2007-10-01 00:00:00

  • Impact of treatment strategies on outcomes in patients with stable coronary artery disease and type 2 diabetes mellitus according to presenting angina severity: A pooled analysis of three federally-funded randomized trials.

    abstract：BACKGROUND AND AIMS:The impact of treatment strategies on outcomes in patients with stable coronary artery disease (CAD) and type 2 diabetes mellitus (T2DM) according to presenting angina has not been rigorously assessed. METHODS:We performed a patient-level pooled-analysis (n = 5027) of patients with stable CAD and T...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2018.04.005

    authors： Mancini GBJ,Boden WE,Brooks MM,Vlachos H,Chaitman BR,Frye R,Bittner V,Hartigan PM,Dagenais GR

    更新日期：2018-10-01 00:00:00

  • High serum level of lutein may be protective against early atherosclerosis: the Beijing atherosclerosis study.

    abstract：OBJECTIVE:We investigated whether early atherosclerosis before calcified plaque appeared as assessed by carotid intima-media thickness (IMT) was associated with levels of the major carotenoids, and assessed the associations among these serum carotenoids, carotid IMT, and arterial stiffness. METHODS:The case-control st...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2011.08.006

    authors： Zou Z,Xu X,Huang Y,Xiao X,Ma L,Sun T,Dong P,Wang X,Lin X

    更新日期：2011-12-01 00:00:00

  • Multiple metabolic risk factors and total and cardiovascular mortality in men with low prevalence of obesity.

    abstract：:We investigated the association between the multiple metabolic risk factors and cardiovascular and overall mortality among Korean men, a population with a low prevalence of obesity. This prospective cohort study involved 682,597 Korean men, aged 30-69 years at baseline (1992), who were initially without cancer or debi...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2005.08.027

    authors： Park HS,Cho SI,Song YM,Sung J

    更新日期：2006-07-01 00:00:00

  • Atherosclerotic lesion development and Toll like receptor 2 and 4 responsiveness.

    abstract：BACKGROUND:Toll like receptors (TLR) have been recognized for their role in atherosclerotic lesion development and progression. Endogenous TLR ligands that are also expressed in atherosclerotic tissues have been shown to promote atherosclerosis in mice. Since repetitive stimulation of TLR induces an attenuated inflamma...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2007.08.004

    authors： Schoneveld AH,Hoefer I,Sluijter JP,Laman JD,de Kleijn DP,Pasterkamp G

    更新日期：2008-03-01 00:00:00

  • Baseline and on-statin treatment lipoprotein(a) levels for predicting cardiovascular events in patients with familial hypercholesterolemia.

    abstract：BACKGROUND AND AIMS:Lipoprotein(a) [Lp(a)] has been considered as a causal risk factor for cardiovascular disease (CVD) in the general population and levels vary in different ethnicities. However, no systemic analysis is currently available regarding the relation of plasma Lp(a) levels to cardiovascular events (CVEs) i...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2019.10.010

    authors： Cao YX,Jin JL,Guo YL,Sun D,Liu HH,Wu NQ,Xu RX,Zhu CG,Liu G,Dong Q,Sun J,Li JJ

    更新日期：2019-12-01 00:00:00

  • Endothelial function in conduit and resistance arteries in men with coronary disease.

    abstract：:The aims of this study were to determine whether non-invasive measurement of endothelial function in conduit arteries reflects that of subcutaneous resistance arteries measured in vitro and to examine whether there is an endothelial dysfunction also in resistance arteries in patients with a previous myocardial infarct...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2005.03.025

    authors： Agewall S,Henareh L,Kublickiene K

    更新日期：2006-01-01 00:00:00

  • Placental maternal and fetal vascular circulation in healthy non-obese and metabolically healthy obese pregnant women.

    abstract：BACKGROUND AND AIMS:We investigated placental histopathology for lesions that are associated with maternal and fetal circulation abnormalities in obese pregnant women with and without metabolic alterations. METHODS:332 pregnant women were divided into three groups: Group 1 included 163 non-obese metabolically healthy ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2017.03.006

    authors： Bar J,Kovo M,Schraiber L,Shargorodsky M

    更新日期：2017-05-01 00:00:00

  • Metformin-induced changes in serum lipids, lipoproteins, and apoproteins in non-insulin-dependent diabetes mellitus.

    abstract：:Forty patients with NIDDM and hyperlipoproteinemia were selected for a 12-week double-blind placebo-controlled trial to study the effects of metformin on lipoprotein concentration and composition. A significant decrease occurred in VLDL-apo B and all lipid components of VLDL, indicating a decreased number of circulati...

    journal_title：Atherosclerosis

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0021-9150(90)90148-c

    authors： Schneider J,Erren T,Zöfel P,Kaffarnik H

    更新日期：1990-05-01 00:00:00

  • Resialylation of sialic acid deficit vascular endothelium, circulating cells and macromolecules may counteract the development of atherosclerosis: a hypothesis.

    abstract：:Deficit sialylation of vascular endothelium, circulating cells and macromolecules has been associated with the development of atherosclerosis. On the other hand, an elevated serum level of sialic acid is a long-lasting marker of atherosclerosis and complications from atherosclerosis. One may speculate that the inverse...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2007.03.011

    authors： Lindberg G

    更新日期：2007-06-01 00:00:00

  • High-sensitivity cardiac troponin T in patients with intermittent claudication and its relation with cardiovascular events and all-cause mortality--the CAVASIC Study.

    abstract：BACKGROUND:Serum concentrations of high-sensitivity cardiac troponin T (hs-cTnT) are elevated in various diseases. The role of this marker in peripheral arterial disease (PAD) has not been fully investigated. METHODS:Hs-cTnT was measured in the CAVASIC Study, a male cohort of 235 patients diagnosed with intermittent c...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2014.10.097

    authors： Pohlhammer J,Kronenberg F,Rantner B,Stadler M,Peric S,Hammerer-Lercher A,Klein-Weigel P,Fraedrich G,Kollerits B

    更新日期：2014-12-01 00:00:00

  • Relation of plasma high-density lipoprotein cholesterol to lipoprotein-lipase activity in adipose tissue and skeletal muscle of man.

    abstract：:Lipoprotein-lipase activity (LPL) was measured in biopsies of adipose tissue and skeletal muscle of normal human subjects, and the results were related to concentrations of cholesterol and triglycerides in plasma lipoproteins. Adipose-tissue LPL activity was significantly higher in females than in males, whereas no se...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(78)90178-8

    authors： Nikkilä EA,Taskinen MR,Kekki M

    更新日期：1978-04-01 00:00:00

  • Comparison between the hypercholesterolaemia in rabbits induced by semipurified diets containing either cholesterol or casein.

    abstract：:Rabbits were fed a semipurified diet containing soy protein for 4 weeks and subsequently transferred to a semipurified diet containing soy protein plus cholesterol (2 g/kg), or a semipurified diet containing casein as protein source. One group of rabbits was fed the soy protein diet throughout the entire experimental ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(82)90055-7

    authors： Scholz KE,Beynen AC,West CE

    更新日期：1982-07-01 00:00:00

  • Evidence of a major locus for lipoprotein lipase (LPL) activity in addition to a pleiotropic locus for both LPL and fasting insulin: results from the HERITAGE Family Study.

    abstract：:A major gene hypothesis for heparin releasable plasma lipoprotein lipase (PH-LPL) activity was assessed using segregation analyses of data on 495 members in 98 normolipidemic sedentary families of Caucasian descent who participated in the HERITAGE Family Study. Segregation analyses were performed on PH-LPL adjusted fo...

    journal_title：Atherosclerosis

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/s0021-9150(98)00324-4

    authors： Hong Y,Rice T,Després JP,Gagnon J,Nadeau A,Bergeron J,Pérusse L,Bouchard C,Leon AS,Skinner JS,Wilmore JH,Rao DC

    更新日期：1999-06-01 00:00:00

  • Effects of oils rich in eicosapentaenoic and docosahexaenoic acids on the oxidizability and thrombogenicity of low-density lipoprotein.

    abstract：:Consumption of oily fish and fish oils is associated with protection against cardiovascular disease. Paradoxically, long-chain polyunsaturated fatty acids present in low-density lipoprotein (LDL) are suggested to be susceptible to oxidation. It is not clear whether eicosapentaenoic acid (EPA) and docosahexaenoic acid ...

    journal_title：Atherosclerosis

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.atherosclerosis.2004.04.004

    authors： Mesa MD,Buckley R,Minihane AM,Yaqoob P

    更新日期：2004-08-01 00:00:00

  • Cholesteryl ester cycle in cultured hepatoma cells.

    abstract：:The existence of a cholesteryl ester cycle in cultured Fu5AH hepatoma cells was documented and factors affecting the rate of turnover of the cholesteryl ester cycle in this cell line were explored. The influence of the physical state of the lipid inclusion in which the cholesteryl esters are stored could be addressed ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(87)90250-4

    authors： Glick JM,Adelman SJ,Rothblat GH

    更新日期：1987-04-01 00:00:00

  • Association of pericoronary fat volume with atherosclerotic plaque burden in the underlying coronary artery: a segment analysis.

    abstract：OBJECTIVE:We aimed to determine, whether the amount of local pericoronary fat volume is associated with the presence of plaque burden in the underlying coronary artery segment. METHODS:We assessed 311 coronary segments from ECG-gated contrast-enhanced dual-source computed tomography for presence of plaque as well as s...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2010.02.013

    authors： Mahabadi AA,Reinsch N,Lehmann N,Altenbernd J,Kälsch H,Seibel RM,Erbel R,Möhlenkamp S

    更新日期：2010-07-01 00:00:00