Abstract:
:Elevated levels of tumor necrosis factor-alpha (TNF-alpha), and presence of polymorphisms of the TNFA gene have been implicated in cardiovascular disease pathogenesis. We explored the relationship between polymorphisms in the TNFA gene (-1031C/T, -863C/A -857T/C, -308G/A, -238G/A), protein levels of TNF-alpha and their association to myocardial infarction (MI) using a sample of 1213 post-MI patients and 1561 healthy controls. MI risk was higher among men with elevated TNF-alpha levels, with the highest compared to the lowest TNF-alpha quartile giving a 70% risk increase (OR [95% CI]: 1.7 [1.1; 2.6]). Obese subjects who also had elevated TNF-alpha levels were at even higher risk for MI (OR [95% CI]: 3.4 [2.1; 5.6]). Higher TNF-alpha levels were seen among smokers (but not among non-smokers) carrying the -857T allele. Furthermore, a rare haplotype occurred more frequently among the cases than the controls. Elevated TNF-alpha levels are associated with increased MI risk. Obese subjects with elevated TNF-a levels, and carriers of polymorphisms in or near TNFA are particularly susceptible to the hazards of smoking, results which may have implications for cardiovascular preventive measures.
journal_name
Atherosclerosisjournal_title
Atherosclerosisauthors
Bennet AM,van Maarle MC,Hallqvist J,Morgenstern R,Frostegård J,Wiman B,Prince JA,de Faire Udoi
10.1016/j.atherosclerosis.2005.09.022keywords:
subject
Has Abstractpub_date
2006-08-01 00:00:00pages
408-14issue
2eissn
0021-9150issn
1879-1484pii
S0021-9150(05)00637-4journal_volume
187pub_type
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