当前位置： SCI文献检索 > ATHEROSCLEROSIS期刊下所有文献 > Placental maternal and fetal vascular circulation in healthy non-obese and metabolically healthy obese pregnant women.

Placental maternal and fetal vascular circulation in healthy non-obese and metabolically healthy obese pregnant women.

Abstract：

BACKGROUND AND AIMS:We investigated placental histopathology for lesions that are associated with maternal and fetal circulation abnormalities in obese pregnant women with and without metabolic alterations. METHODS:332 pregnant women were divided into three groups: Group 1 included 163 non-obese metabolically healthy (NOMH), Group 2 106 obese metabolically healthy (OMH), and Group 3 63 obese metabolically abnormal (OMA) subjects, respectively. RESULTS:Fetal vascular supply (FVS) abnormalities and Willous maturation defect (WMD) rate were higher in obese subjects without metabolic abnormalities, compared to NOMH subjects (p < 0.021 and p < 0.018, respectively). In the logistic regression analysis, obesity emerged as a significant independent predictor of FVS abnormalities (OR 1.54, 95% CI 1.193-1.992, p = 0.001) and WMD (OR 2.004, 95% CI 1.173-3.422, p = 0.011). Although maternal vascular supply (MVS) abnormalities differed significantly across groups (31%, 38% and 54% respectively, p < 0.005), in the logistic regression analysis, obesity was not significantly associated with MVS abnormalities. CONCLUSIONS:We demonstrated that obesity, per se, is associated with an increased rate of placental vascular supply abnormalities and has a more adverse effect on fetal vascular circulation than on maternal vascular supply.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Bar J,Kovo M,Schraiber L,Shargorodsky M

doi

10.1016/j.atherosclerosis.2017.03.006

subject

Has Abstract

pub_date

2017-05-01 00:00:00

pages

63-66

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(17)30096-5

journal_volume

260

pub_type

杂志文章

相关文献

ATHEROSCLEROSIS文献大全
  • Polyunsaturated fats, carbohydrates and carotid disease: The Atherosclerosis Risk in Communities (ARIC) Carotid MRI study.

    abstract：BACKGROUND AND AIMS:Carbohydrates and fat intake have both been linked to development of atherosclerosis. We examined associations between glycemic index (GI) and fat intake with carotid atherosclerosis. METHODS:The Atherosclerosis Risk in Communities (ARIC) cohort enrolled participants during the period 1987-1989 and...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2016.05.024

    authors： Dearborn JL,Qiao Y,Guallar E,Steffen LM,Gottesman RF,Zhang Y,Wasserman BA

    更新日期：2016-08-01 00:00:00

  • The effect of hormone replacement therapy on arterial distensibility and compliance in perimenopausal women: a 2-year randomised trial.

    abstract：:A single centre randomised placebo-controlled trial was performed to assess the 2-year effects of hormone replacement therapy compared to placebo on mechanical arterial properties in 99 perimenopausal women recruited from the general population. The trial was double-blind with respect to a sequential combined regimen ...

    journal_title：Atherosclerosis

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0021-9150(99)00438-4

    authors： Westendorp IC,de Kleijn MJ,Bots ML,Bak AA,Planellas J,Coelingh Bennink HJ,Hofman A,Grobbee DE,Witteman JC

    更新日期：2000-09-01 00:00:00

  • Anti-inflammatory and recycling properties of an apolipoprotein mimetic peptide, Ac-hE18A-NH(2).

    abstract：:Apolipoprotein E (apoE) exerts prominent anti-inflammatory effects and undergoes recycling by target cells. We previously reported that the peptide Ac-hE18A-NH(2), composed of the receptor binding domain (LRKLRKRLLR) of apoE covalently linked to the Class A amphipathic peptide 18A, dramatically lowers plasma cholester...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2009.07.019

    authors： Datta G,White CR,Dashti N,Chaddha M,Palgunachari MN,Gupta H,Handattu SP,Garber DW,Anantharamaiah GM

    更新日期：2010-01-01 00:00:00

  • Endothelial dysfunction in hypercholesterolemia is improved by L-arginine administration: possible role of oxidative stress.

    abstract：:Hypercholesterolemia impairs endothelial function. However, the production/release of nitric oxide from the hypercholesterolemic aorta is reported to be enhanced rather than impaired in animal studies. L-arginine improves endothelial function in hypercholesterolemic subjects. The goal of the present study was to inves...

    journal_title：Atherosclerosis

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0021-9150(01)00671-2

    authors： Kawano H,Motoyama T,Hirai N,Kugiyama K,Yasue H,Ogawa H

    更新日期：2002-04-01 00:00:00

  • A novel antioxidant 3,7-dihydroxy-isoflav-3-ene (DHIF) inhibits neointimal hyperplasia after vessel injury attenuating reactive oxygen species and nuclear factor-kappaB signaling.

    abstract：:Reactive oxygen species (ROS) contribute to neointimal smooth muscle proliferation by yet to be defined mechanisms. We examined the effects of a novel isoflavone 3,7-dihydroxy-isoflav-3-ene (DHIF) on development of neointimal lesions in relation to ROS elevations and cell signaling in injured arteries. Carotid arterie...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2008.09.005

    authors： Kanellakis P,Pomilio G,Walker C,Husband A,Huang JL,Nestel P,Agrotis A,Bobik A

    更新日期：2009-05-01 00:00:00

  • Epicardial adipose tissue thickness is a predictor for plaque vulnerability in patients with significant coronary artery disease.

    abstract：:The aim of this study is to assess the relationship of epicardial adipose tissue (EAT) and plaque vulnerability. We consecutively enrolled 82 patients with coronary artery disease (CAD). A symptom-related vessel was imaged by virtual histology intravascular ultrasound (VH-IVUS). In 60 out of 82 patients, all three ves...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2012.11.001

    authors： Park JS,Choi SY,Zheng M,Yang HM,Lim HS,Choi BJ,Yoon MH,Hwang GS,Tahk SJ,Shin JH

    更新日期：2013-01-01 00:00:00

  • Effect of dietary restriction on plasma cholesterol and cholesterol excretion in the White Carneau pigeon.

    abstract：:The effect of short-term dietary restriction on plasma cholesterol and cholesterol balance was examined in young While Carneau pigeons. Dietary restriction of 1 month increased plasma cholesterol significantly and subsequently decreased to initial levels at 3 months. The fecal excretion of neutral sterols was signific...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(76)90143-x

    authors： Subbiah MT,Connelly PW

    更新日期：1976-09-01 00:00:00

  • Upregulation of cholesterol synthesis after acute myocardial infarction--is cholesterol a positive acute phase reactant?

    abstract：:Acute myocardial infarction is associated with profound alterations in the plasma lipoprotein profile. The mechanism of these alterations is not clear, and both cholesterol biosynthesis up- and downregulation could possibly be a consequence of acute myocardial infarction. We determined plasma lipids, lipoproteins, apo...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(98)00242-1

    authors： Pfohl M,Schreiber I,Liebich HM,Häring HU,Hoffmeister HM

    更新日期：1999-02-01 00:00:00

  • Lovastatin maintains nitric oxide--but not EDHF-mediated endothelium-dependent relaxation in the hypercholesterolemic rabbit carotid artery.

    abstract：:The endothelium contributes to the regulation of vascular tone by producing nitric oxide (NO) and the endothelium-derived hyperpolarising factor (EDHF). In hypercholesterolemia, endothelium-dependent relaxation is impaired but can be restored by treatment with lovastatin (LOVAS). We investigated the effects of LOVAS o...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(98)00197-x

    authors： Brandes RP,Behra A,Lebherz C,Böger RH,Bode-Böger SM,Mügge A

    更新日期：1999-01-01 00:00:00

  • Atorvastatin increases low-density lipoprotein size and enhances high-density lipoprotein cholesterol concentration in male, but not in female patients with familial hypercholesterolemia.

    abstract：:The effects of atorvastatin (Lipitor) were evaluated in 40 patients with familial hypercholesterolemia (FH). Following a 6 week drug-free baseline period 20 male and 20 female patients were treated with atorvastatin 40 mg once daily (QD) for the initial 6 weeks increasing to 80 mg QD during the following 6 weeks. Ator...

    journal_title：Atherosclerosis

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0021-9150(99)00125-2

    authors： Hoogerbrugge N,Jansen H

    更新日期：1999-09-01 00:00:00

  • Prevention of oxLDL uptake leads to decreased atherosclerosis in hematopoietic NPC1-deficient Ldlr-/- mice.

    abstract：BACKGROUND AND AIMS:Atherosclerosis is a chronic inflammatory disease of medium and large vessels and is typically characterized by the predominant accumulation of low-density lipoprotein (LDL)-cholesterol inside macrophages that reside in the vessel walls. Previous studies clearly demonstrated an association specifica...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2016.10.038

    authors： Jeurissen MLJ,Walenbergh SMA,Houben T,Gijbels MJJ,Li J,Hendrikx T,Oligschlaeger Y,van Gorp PJ,Binder CJ,Donners MMPC,Shiri-Sverdlov R

    更新日期：2016-12-01 00:00:00

  • Expression of long pentraxin PTX3 in human adipose tissue and its relation with cardiovascular risk factors.

    abstract：UNLABELLED:Pentraxin 3 (PTX3) is an acute phase protein strongly expressed by advanced atherosclerotic lesions. We investigated (a) PTX3 expression and secretion in subcutaneous adipose tissue (SAT) and omental visceral adipose tissue (VAT) obtained from 21 obese (37.4+/-8.15 yr) and 10 normal weight subjects (43.7+/-1...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2008.05.015

    authors： Alberti L,Gilardini L,Zulian A,Micheletto G,Peri G,Doni A,Mantovani A,Invitti C

    更新日期：2009-02-01 00:00:00

  • Impact of gender on the density of intraplaque neovascularization: a quantitative contrast-enhanced ultrasound study.

    abstract：OBJECTIVE:Atherosclerosis is the main underlying cause of the majority of cardiovascular events. Although cardiovascular diseases (CVD) are a major challenge in both males and females, gender specific differences in the prevalence of CVD have been observed. This may indicate that there are differences in the developmen...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2013.12.054

    authors： van den Oord SCH,van der Burg J,Akkus Z,Bosch JG,van Domburg RT,Sijbrands EJG,van der Steen AFW,Schinkel AFL

    更新日期：2014-04-01 00:00:00

  • Vascular NAD(P)H oxidase mediates endothelial dysfunction in basilar arteries from Otsuka Long-Evans Tokushima Fatty (OLETF) rats.

    abstract：:We examined the responses of basilar arteries taken from Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a type 2 diabetes model. Both the nitric oxide (NO)-mediated relaxation and the cyclic 3',5'-guanosine monophosphate (cGMP) production elicited by acetylcholine (ACh) were much weaker in OLETF rats than in age-matc...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2006.06.005

    authors： Matsumoto T,Kobayashi T,Wachi H,Seyama Y,Kamata K

    更新日期：2007-05-01 00:00:00

  • Carotid plaque, compared with carotid intima-media thickness, more accurately predicts coronary artery disease events: a meta-analysis.

    abstract：OBJECTIVES:We conducted the meta-analysis to compare the diagnostic accuracies of carotid plaque and carotid intima-media thickness (CIMT) measured by B-mode ultrasonography for the prediction of coronary artery disease (CAD) events. METHODS:Two reviewers independently searched electronic databases to identify relevan...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.atherosclerosis.2011.06.044

    authors： Inaba Y,Chen JA,Bergmann SR

    更新日期：2012-01-01 00:00:00

  • Functional relevance of tetraspanin CD9 in vascular smooth muscle cell injury phenotypes: a novel target for the prevention of neointimal hyperplasia.

    abstract：:Vascular smooth muscle cell (VSMC) migration and proliferation are critical events in the development of neointima following vascular injury. In this study, we found that CD9 is constitutively expressed in the VSMC of the neointima of injured carotid arteries. The in vitro migration and proliferation of human coronary...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2008.07.036

    authors： Kotha J,Zhang C,Longhurst CM,Lu Y,Jacobs J,Cheng Y,Jennings LK

    更新日期：2009-04-01 00:00:00

  • Molecular role of Cx37 in advanced atherosclerosis: a micro-array study.

    abstract：:Recently, we showed that connexin37 (Cx37) protects against early atherosclerotic lesion development by regulating monocyte adhesion. The expression of this gap junction protein is altered in mouse and human atherosclerotic lesions; it is increased in macrophages newly recruited to the lesions and disappears from the ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2009.02.020

    authors： Derouette JP,Wong C,Burnier L,Morel S,Sutter E,Galan K,Brisset AC,Roth I,Chadjichristos CE,Kwak BR

    更新日期：2009-09-01 00:00:00

  • Oxidative structural modifications of low density lipoprotein in homozygous familial hypercholesterolemia.

    abstract：:Patients with homozygous familial hypercholesterolemia (FH), as a result of the increased levels and prolonged residence time of low density lipoprotein (LDL) in plasma, have a strong tendency toward accumulation of LDL-cholesterol in the arterial wall, causing premature atherosclerosis. This phenomenon may enhance pe...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(95)05612-2

    authors： Napoli C,Postiglione A,Triggiani M,Corso G,Palumbo G,Carbone V,Ruocco A,Ambrosio G,Montefusco S,Malorni A,Condorelli M,Chiariello M

    更新日期：1995-12-01 00:00:00

  • Increasing levels of TNFalpha are associated with increased brain perfusion.

    abstract：OBJECTIVE:Recent reports of animal models have shown that growth factors have stimulating effect on brain perfusion via the development of blood vessels. However, studies on the effect of growth factors on brain perfusion in humans are lacking. The aim of our study was to prospectively investigate in humans the relatio...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2006.11.041

    authors： van Laar PJ,van Raamt AF,van der Grond J,Mali WPTM,van der Graaf Y,Hendrikse J,SMART Study Group.

    更新日期：2008-01-01 00:00:00

  • Effect of sarpogrelate, a selective 5-HT2A receptor antagonist, on characteristics of coronary artery disease in patients with type 2 diabetes.

    abstract：BACKGROUND AND AIMS:Sarpogrelate, a 5-hydroxytryptamine type 2A antagonist, is a potential antiplatelet agent. We performed a randomized study to evaluate the effect of sarpogrelate on vascular health in Korean patients with diabetes. METHODS:Forty diabetic patients aged 58.6 ± 6.8 years with 10-75% coronary artery st...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.atherosclerosis.2016.12.011

    authors： Lee DH,Chun EJ,Hur JH,Min SH,Lee JE,Oh TJ,Kim KM,Jang HC,Han SJ,Kang DK,Kim HJ,Lim S

    更新日期：2017-02-01 00:00:00

  • MicroRNA-27a/b regulates cellular cholesterol efflux, influx and esterification/hydrolysis in THP-1 macrophages.

    abstract：RATIONALE:Macrophage cholesterol homeostasis maintenance is the result of a balance between influx, endogenous synthesis, esterification/hydrolysis and efflux. Excessive accumulation of cholesterol leads to foam cell formation, which is the major pathology of atherosclerosis. Previous studies have shown that miR-27 (mi...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2014.02.008

    authors： Zhang M,Wu JF,Chen WJ,Tang SL,Mo ZC,Tang YY,Li Y,Wang JL,Liu XY,Peng J,Chen K,He PP,Lv YC,Ouyang XP,Yao F,Tang DP,Cayabyab FS,Zhang DW,Zheng XL,Tian GP,Tang CK

    更新日期：2014-05-01 00:00:00

  • Comparison of the metabolism of [1,2,6,7-3H(N)]cholesteryl oleate, cholesteryl [9,10-3H]oleate, and cholesteryl [1-14C]oleate labeled lipoproteins in the rat.

    abstract：:The intravascular metabolism of sterol labeled [1,2,6,7-3H(N)]cholesteryl oleate and acyl labeled cholesteryl [9,10-3H]oleate and cholesteryl [1-14C]oleate was compared in the rat, an animal species without plasma cholesteryl ester transfer activity (CETA). In a first series of studies, the metabolism of sterol labele...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(94)90125-2

    authors： Terpstra AH

    更新日期：1994-04-01 00:00:00

  • Identification and characterization of new gain-of-function mutations in the PCSK9 gene responsible for autosomal dominant hypercholesterolemia.

    abstract：BACKGROUND:The identification of mutations in PCSK9 (proprotein convertase subtilisin kexin9) in autosomal dominant hypercholesterolemia (ADH), has revealed the existence of a new player in cholesterol homeostasis. PCSK9 has been shown to enhance the degradation of the LDL receptor (LDLR) at the cell surface. Gain-of-f...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2012.04.006

    authors： Abifadel M,Guerin M,Benjannet S,Rabès JP,Le Goff W,Julia Z,Hamelin J,Carreau V,Varret M,Bruckert E,Tosolini L,Meilhac O,Couvert P,Bonnefont-Rousselot D,Chapman J,Carrié A,Michel JB,Prat A,Seidah NG,Boileau C

    更新日期：2012-08-01 00:00:00

  • Long-term use of statins reduces the risk of hospitalization for dementia.

    abstract：BACKGROUND:Dementia is a major public health problem because of its high prevalence in elderly individuals, particularly in the growing category of subjects aged 80 years or more. There is accumulating evidence that cholesterol may be implicated in the pathogenesis of dementia, and this has led us to assess the relatio...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2013.07.009

    authors： Corrao G,Ibrahim B,Nicotra F,Zambon A,Merlino L,Pasini TS,Catapano AL,Mancia G

    更新日期：2013-10-01 00:00:00

  • Deficiency of receptor-associated protein attenuates angiotensin II-induced atherosclerosis in hypercholesterolemic mice without influencing abdominal aortic aneurysms.

    abstract：OBJECTIVE:Receptor-associated protein (RAP) was initially described as a regulator of low density lipoprotein receptor-related protein 1 (LRP1), but is now known to regulate many proteins. Since the direct effects of RAP on vascular pathologies have not been studied, this study determined whether RAP deficiency influen...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2011.11.013

    authors： Wang S,Subramanian V,Lu H,Howatt DA,Moorleghen JJ,Charnigo R,Cassis LA,Daugherty A

    更新日期：2012-02-01 00:00:00

  • Palmitic acid promotes endothelial progenitor cells apoptosis via p38 and JNK mitogen-activated protein kinase pathways.

    abstract：OBJECTIVE:Recent studies have demonstrated that palmitic acid (PA) could regulate endothelial progenitor cells (EPCs) function (migration, proliferation, survival and angiogenesis) via various signal pathways, but the effect of PA on EPCs apoptosis and associated mechanisms are still elusive. METHODS:The human EPCs we...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2009.10.032

    authors： Jiang H,Liang C,Liu X,Jiang Q,He Z,Wu J,Pan X,Ren Y,Fan M,Li M,Wu Z

    更新日期：2010-05-01 00:00:00

  • Expression and regulation of 12/15-lipoxygenases in human primary macrophages.

    abstract：OBJECTIVES:Atherosclerosis is a chronic disease characterized by two main features, lipid retention and inflammation. The 12/15-lipoxygenases play a two-faced role in atherosclerosis with pro-inflammatory effects through oxidation of LDL and anti-inflammatory effects through lipid mediator synthesis. In cells involved ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2012.07.022

    authors： Wuest SJ,Crucet M,Gemperle C,Loretz C,Hersberger M

    更新日期：2012-11-01 00:00:00

  • Usefulness of lipoprotein ratios in assessing carotid atherosclerosis in Japanese type 2 diabetic patients.

    abstract：OBJECTIVE:It is indicated that total/HDL cholesterol and LDL/HDL cholesterol ratios have more predictive power for cardiovascular disease compared to classic lipid parameters. However, there have been few reports about the usefulness of these indices for the assessment of early stage atherosclerosis in Japanese type 2 ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2010.10.035

    authors： Katakami N,Kaneto H,Osonoi T,Saitou M,Takahara M,Sakamoto F,Yamamoto K,Yasuda T,Matsuoka TA,Matsuhisa M,Yamasaki Y,Shimomura I

    更新日期：2011-02-01 00:00:00

  • Separate impact of metabolic syndrome and altered glucose tolerance on early markers of vascular injuries.

    abstract：OBJECTIVE:We investigated the separate impact of metabolic syndrome (MS) and altered glucose tolerance on early markers of vascular injuries. METHODS:Intima-media thickness (IMT) and pulse wave analysis (PWA), were evaluated in 132 overweight or obese subjects, with (MS(+)) or without (MS(-)) MS; subjects were further...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2012.05.008

    authors： Di Pino A,Alagona C,Piro S,Calanna S,Spadaro L,Palermo F,Urbano F,Purrello F,Rabuazzo AM

    更新日期：2012-08-01 00:00:00

  • CD59 (homologous restriction factor 20), a plasma membrane protein that protects against complement C5b-9 attack, in human atherosclerotic lesions.

    abstract：:Blood cells express a cell membrane protein, termed homologous restriction factor 20 (HRF20) and identical to CD59, that can inhibit complement C5b-9 insertion into their membranes. In this report, we investigated by immunohistochemistry whether CD59 was present on cells in human atherosclerotic lesions since membrano...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(92)90060-t

    authors： Seifert PS,Roth I,Schmiedt W,Oelert H,Okada N,Okada H,Bhakdi S

    更新日期：1992-10-01 00:00:00