Association of pericoronary fat volume with atherosclerotic plaque burden in the underlying coronary artery: a segment analysis.

Abstract:

OBJECTIVE:We aimed to determine, whether the amount of local pericoronary fat volume is associated with the presence of plaque burden in the underlying coronary artery segment. METHODS:We assessed 311 coronary segments from ECG-gated contrast-enhanced dual-source computed tomography for presence of plaque as well as segmental pericoronary fat volume. For pericoronary fat evaluation, regions of interest were manually traced containing any fat surrounding a coronary artery segment, with the myocardial wall, the pericardial sac and other coronary segments as outer border. RESULTS:Per each doubling of pericoronary fat volume, we observed an 2.5-fold increase in the presence of plaque in the underlying coronary segment in unadjusted models (95% confidence interval [CI] 1.87-3.27, p<0.001), which remained after adjustment for traditional cardiovascular risk factors (odds ratio [OR] 3.07 [2.16-4.35], p<0.001) and when additionally accounting for overall pericardial fat volume (OR 2.68 [1.90-3.79], p<0.001). Associations were similar in all coronary artery segments and not related to the type of plaque (calcified or non-calcified, p<0.01 for all). CONCLUSION:Pericoronary fat is associated with atherosclerosis in the coronary arteries. Our results support the hypothesis that perivascular fat depots may function as a local endocrine risk factor in atherosclerosis development.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Mahabadi AA,Reinsch N,Lehmann N,Altenbernd J,Kälsch H,Seibel RM,Erbel R,Möhlenkamp S

doi

10.1016/j.atherosclerosis.2010.02.013

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

195-9

issue

1

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(10)00153-X

journal_volume

211

pub_type

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