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Detection of rupture-prone atherosclerotic plaques by time-resolved laser-induced fluorescence spectroscopy.

Abstract：

OBJECTIVE:Plaque with dense inflammatory cells, including macrophages, thin fibrous cap and superficial necrotic/lipid core is thought to be prone-to-rupture. We report a time-resolved laser-induced fluorescence spectroscopy (TR-LIFS) technique for detection of such markers of plaque vulnerability in human plaques. METHODS:The autofluorescence of carotid plaques (65 endarterectomy patients) induced by a pulsed laser (337 nm, 0.7 ns) was measured from 831 distinct areas. The emission was resolved spectrally (360-550 nm range) and temporally (0.3 ns resolution) using a prototype fiber-optic TR-LIFS apparatus. Lesions were evaluated microscopically and quantified as to the % of different components (fibrous cap, necrotic core, inflammatory cells, foam cells, mature and degraded collagen, elastic fibers, calcification, and smooth muscle cell of the vessel wall). RESULTS:We determined that the spectral intensities and time-dependent parameters at discrete emission wavelengths (1) allow for discrimination (sensitivity >81%, specificity >94%) of various compositional and pathological features associated with plaque vulnerability including infiltration of macrophages into intima and necrotic/lipid core under a thin fibrous cap, and (2) show a linear correlation with plaque biochemical content: elastin (P<0.008), collagen (P<0.02), inflammatory cells (P<0.003), necrosis (P<0.004). CONCLUSION:Our results demonstrate the feasibility of TR-LIFS as a method for the identification of markers of plaque vulnerability. Current findings enable future development of TR-LIFS-based clinical devices for rapid investigation of atherosclerotic plaques and detection of those at high-risk.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Marcu L,Jo JA,Fang Q,Papaioannou T,Reil T,Qiao JH,Baker JD,Freischlag JA,Fishbein MC

doi

10.1016/j.atherosclerosis.2008.08.035

subject

Has Abstract

pub_date

2009-05-01 00:00:00

pages

156-64

issue

1

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(08)00595-9

journal_volume

204

pub_type

杂志文章

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