Antiplatelet agent cilostazol potentiates adipocyte differentiation of 3T3-L1 cells.

abstract：OBJECTIVE:A direct correlation between blood glucose levels and the microvascular complications of diabetes is well established. However, the effects of hyperglycaemia on the vasa vasorum, a microvascular network which surrounds and supplies the walls of large arteries, is not known. The objective of this study is to i...

journal_title：Atherosclerosis

authors： Veerman KJ,Venegas-Pino DE,Shi Y,Khan MI,Gerstein HC,Werstuck GH

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND AND AIMS:The risk of recurrence of myocardial infarction (MI) in HIV patients presenting with acute coronary syndrome (ACS) is well known, but there is limited evidence about potential differences in coronary plaques compared to non-HIV patients. METHODS:In this multicenter case-control study, HIV patients ...

journal_title：Atherosclerosis

authors： Peyracchia M,De Lio G,Montrucchio C,Omedè P,d'Ettore G,Calcagno A,Vullo V,Cerrato E,Pennacchi M,Sardella G,Manga P,GrossoMarra W,Vullo F,Fedele F,Biondi-Zoccai G,Moretti C,Vachiat A,Bonora S,Rinaldi M,Mancone M,D'

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Results from prospective studies evaluating the relationship between elevated lipoprotein-associated phospholipase A2 (Lp-PLA2) activity and incident peripheral arterial disease (PAD) have been mixed. We investigated whether higher Lp-PLA2 levels are associated with increased risk of incident PAD an...

journal_title：Atherosclerosis

authors： Garg PK,Norby FL,Polfus LM,Boerwinkle E,Gibbs RA,Grove ML,Folsom AR,Garimella PS,Matsushita K,Hoogeveen RC,Ballantyne CM

更新日期：2018-01-01 00:00:00

abstract：:The insertion/deletion (I/D) polymorphism of the ACE gene may be involved in structural arterial changes. Aim of the present study was to assess the relationship between the ACE I/D gene and vessel wall stiffness among older adults. The study was conducted within the Rotterdam study, a population-based cohort study in...

journal_title：Atherosclerosis

authors： Mattace-Raso FU,van der Cammen TJ,Sayed-Tabatabaei FA,van Popele NM,Asmar R,Schalekamp MA,Hofman A,van Duijn CM,Witteman JC

更新日期：2004-05-01 00:00:00

abstract：:Elevated fibrinogen levels after coronary balloon angioplasty have been reported to be useful in predicting restenosis. Therefore, we sought to evaluate the relationship between preprocedural fibrinogen levels and the 6-12-month outcomes of patients undergoing coronary stenting. Plasma levels of fibrinogen were measur...

journal_title：Atherosclerosis

authors： Otsuka M,Hayashi Y,Ueda H,Imazu M,Kohno N

更新日期：2002-10-01 00:00:00

abstract：:To clarify age-related and lipid-related hemostatic abnormalities in the elderly, we measured the plasma levels of active PAI-1 antigen (aPAI-1), tPA-PAI-1 complex (TPC), plasminogen, alpha 2-plasmin inhibitor (alpha 2-PI), plasmin-alpha 2-PI complex (PIC), and D-dimer, together with the plasma levels of fibrinogen, f...

journal_title：Atherosclerosis

authors： Kario K,Matsuo T

更新日期：1993-11-01 00:00:00

abstract：:The present study is the first work to evaluate thrombin-, ADP-, and collagen-induced platelet aggregation in laboratory rats receiving alimentation with the parenterally-administered lipid emulsion, Lipofundin-S, in doses sufficient to induce early atherosclerotic changes in the aorta. The aggregometry parameters of ...

journal_title：Atherosclerosis

authors： Saladino CF,Fox RL,Yeh Q,Karpowicz F,Feffer SE,Jonas EA

更新日期：1987-07-01 00:00:00

abstract：:Degranulated mast cells are present in the human arterial intima. After degranulation of rat serosal mast cells, the secreted neutral serine protease chymase remains bound to the heparin proteoglycan matrix of the exocytosed granules, forming granule remnants. Addition of granule remnants to human aortic intimal fluid...

journal_title：Atherosclerosis

authors： Lindstedt L,Lee M,Kovanen PT

更新日期：2001-03-01 00:00:00

abstract：:Diabetes mellitus is one of the major risk factors for coronary artery disease (CAD). A recent study reported that glimepiride, a new third-generation sulfonylurea, inhibited the formation of atheromatous plaques in high-cholesterol fed rabbits. However, the mechanism by which glimepiride induces atheroprotection rema...

journal_title：Atherosclerosis

authors： Ueba H,Kuroki M,Hashimoto S,Umemoto T,Yasu T,Ishikawa SE,Saito M,Kawakami M

更新日期：2005-11-01 00:00:00

abstract：:Familial defective apolipoprotein B-100 (FDB) is a dominantly inherited disorder associated with hypercholesterolemia, in which substitution of the amino acid glutamine for arginine at position 3500 in the apoprotein B molecule results in LDL particles which bind poorly to the LDL receptor. To date, patients with FDB ...

journal_title：Atherosclerosis

authors： Schmidt EB,Illingworth DR,Bacon S,Mahley RW,Weisgraber KH

更新日期：1993-01-25 00:00:00

abstract：:It has been shown that triglyceride levels are one of the determinants of factor VII levels. In this study we have simultaneously evaluated, in a group of 102 healthy individuals, the different forms of factor VII, namely factor VII mass, factor VII coagulant activity, activated factor VII double-chain form and factor...

journal_title：Atherosclerosis

authors： Negri M,Arigliano PL,Talamini G,Carlini S,Manzato F,Bonadonna G

更新日期：1993-02-01 00:00:00

abstract：:Small high density lipoproteins (HDL) with pre-beta electrophoretic mobility (pre-beta HDL) have recently been shown to be the primary acceptor of cholesterol from cultured cells. We studied the metabolism of these particles by incubating serum at 37 degrees C in the presence and absence of active lecithin: cholestero...

journal_title：Atherosclerosis

authors： Neary R,Bhatnagar D,Durrington P,Ishola M,Arrol S,Mackness M

更新日期：1991-07-01 00:00:00

abstract：:Since VLDL and LDL are involved in atherogenesis, their response to dietary modification was studied in 15 normal male prisoners. A 3-month reference diet (P/S ratio 0.3, daily cholesterol intake 370 mg) was compared with a modified fat diet (P/S 1.0, 250 mg) given for further 3 months. The decrement in serum choleste...

journal_title：Atherosclerosis

authors： Weisweiler P,Drosner M,Janetschek P,Schwandt P

更新日期：1983-12-01 00:00:00

abstract：BACKGROUND:Recent failures of clinical trials promoting HDL-elevating therapies have prompted research groups to focus on its functional activity in disease. Endothelial effects of HDL can be measured with in vitro cell assays. The reproducibility and biological relevance of these assays have not been explored both in ...

journal_title：Atherosclerosis

authors： O'Neill F,McLoughlin E,Riwanto M,Manz J,Adler A,Sutill E,Khan T,Haywood R,Kay CW,D'Aiuto F,Charakida M,Landmesser U,Deanfield J

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVES:Inflammation may directly impair HDL functions, in particular reverse cholesterol transport (RCT), but limited data support this concept in humans. METHODS AND RESULTS:We employed low-dose human endotoxemia to assess the effects of inflammation on HDL and RCT-related parameters in vivo. Endotoxemia induced ...

journal_title：Atherosclerosis

authors： de la Llera Moya M,McGillicuddy FC,Hinkle CC,Byrne M,Joshi MR,Nguyen V,Tabita-Martinez J,Wolfe ML,Badellino K,Pruscino L,Mehta NN,Asztalos BF,Reilly MP

更新日期：2012-06-01 00:00:00

abstract：:The effects of niceritrol, a nicotinic acid derivative, on the levels of HDL-cholesterol (HDL-Ch) and a mixture of VLDL- and LDL-Ch (VLDL- + LDL-Ch) were studied in hyperlipidemic patients. Serum total cholesterol (sTC) and serum triglyceride (sTG) were significantly reduced during niceritrol administration. Lipoprote...

journal_title：Atherosclerosis

authors： Kibata M,Ishida M,Asano K,Uehara H,Saito K,Fuchimoto T,Ugaki K,Murakami H,Matoba K,Kotakemori Y,Shirai K,Yoshioka H,Nanba M,Yasuda M,Ishizaki M,Kitagawa N,Ikejiri K,Inohara R,Lee BJ,Saino S,Sakado J,Matuzaka H,

更新日期：1980-11-01 00:00:00

abstract：:Investigations to date have demonstrated that the underlying etiology, causes and burden of stroke may be different for women and men. However, data regarding sex differences among young cerebral ischemic stroke patients remains scarce. We conducted this study in 669 young Chinese adults with acute ischemic stroke as ...

journal_title：Atherosclerosis

authors： Zhang B,Pu S,Zhang W,Yang N,Shen G,Yin J,Yi Y,Gao Q,Gao C

更新日期：2011-06-01 00:00:00

abstract：:The effect of methyl prednisolone and colchicine on the development of both the early proliferative and advanced atherosclerotic lesion in swine aorta was studied. In order to accelerate the development of atherosclerosis, the abdominal aortic endothelium was partially denuded by a balloon before the animals were plac...

journal_title：Atherosclerosis

authors： Lee WM,Morrison ES,Scott RF,Lee KT,Kroms M

更新日期：1976-11-01 00:00:00

abstract：:The hydrolysis of lipoprotein triglycerides is catalyzed by lipoprotein lipase (LPL), an enzyme found in many tissues. We have examined tissue LPL activity (LPLA) in rats with experimentally-induced hyperthyroidism. In younger, lighter rats, hyperthyroidism was accompanied by a decrease in LPL in adipose tissue wherea...

journal_title：Atherosclerosis

authors： Wilson DE,Jubiz W,Flowers CM,Carlile SI,Adolf AM

更新日期：1977-03-01 00:00:00

abstract：BACKGROUND:Evidence suggests that delayed re-endothelialization is responsible for in-stent thrombosis. Probucol inhibits neointimal thickening in animals via enhanced re-endothelialization and is the only oral drug that consistently inhibits restenosis after coronary angioplasty in humans. Here, we examined the effect...

journal_title：Atherosclerosis

authors： Tanous D,Bräsen JH,Choy K,Wu BJ,Kathir K,Lau A,Celermajer DS,Stocker R

更新日期：2006-12-01 00:00:00

abstract：OBJECTIVE:High homocysteine level is a risk factor for atherosclerosis and has been associated with lacunar infarcts (LIs), white matter lesions (WML) and cognitive dysfunction. It is unclear whether homocysteine is associated with cerebral small vessel disease (cSVD) on top of pre-existent atherosclerosis. We evaluate...

journal_title：Atherosclerosis

authors： Kloppenborg RP,Nederkoorn PJ,van der Graaf Y,Geerlings MI

更新日期：2011-06-01 00:00:00

abstract：:Dietary linoleate was effective to increase LDL fluidity in adult men but did not significantly influence VLDL or HDL fluidities. Lipoproteins were isolated ultracentrifugally from plasma of sixteen healthy, free living male volunteers consuming controlled diets formulated from typical U.S.A. foods to have 35 energy %...

journal_title：Atherosclerosis

authors： Berlin E,Judd JT,Marshall MW,Kliman PG

更新日期：1987-08-01 00:00:00

abstract：:The role of prostaglandin I2 (PGI2) in the control of DNA synthesis during the cell cycle was investigated in cultured rabbit aortic smooth muscle cells (SMC). SMC at confluency in the G0 state reached the S phase about 16 h after stimulation with serum, as judged by measurement of [3H]thymidine incorporation into DNA...

journal_title：Atherosclerosis

authors： Morisaki N,Kanzaki T,Motoyama N,Saito Y,Yoshida S

更新日期：1988-06-01 00:00:00

abstract：:Preclinical and clinical data on atorvastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, indicate that it has superior activity in treating a variety of dyslipidemic disorders characterized by elevations in low-density lipoprotein cholesterol (LDL-C) and/or triglycerides. Results for p...

journal_title：Atherosclerosis

authors： Bakker-Arkema RG,Best J,Fayyad R,Heinonen TM,Marais AD,Nawrocki JW,Black DM

更新日期：1997-05-01 00:00:00

abstract：:Animal models are used extensively in the ongoing investigation of a possible causal link between Chlamydia pneumoniae infection and conditions such as asthma and cardiovascular disease. Respiratory infections have been studied in monkeys, while mouse and rabbit models have been used to study both respiratory and card...

journal_title：Atherosclerosis

authors： Saikku P,Laitinen K,Leinonen M

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND:Autosomal dominant hypercholesterolemia (ADH) is caused by mutations in the low density lipoprotein receptor (LDLR), its ligand apoB (APOB) or proprotein convertase subtilisin/kexin type 9 (PCSK9) genes. Yet DNA sequencing does not identify mutations in these genes in a significant number of cases, suggestin...

journal_title：Atherosclerosis

authors： Awan Z,Choi HY,Stitziel N,Ruel I,Bamimore MA,Husa R,Gagnon MH,Wang RH,Peloso GM,Hegele RA,Seidah NG,Kathiresan S,Genest J

更新日期：2013-12-01 00:00:00

abstract：:The mechanisms of inflammation responsible for the myocardial tissue damage seen after an acute myocardial infarction (AMI) have not been clearly identified. Recent lines of evidence, demonstrating depressed sera levels of individual complement components in patients after myocardial infarction, have suggested involve...

journal_title：Atherosclerosis

authors： Langlois PF,Gawryl MS

更新日期：1988-03-01 00:00:00

abstract：:The present study focused on the role of blood flow in the formation of focal intimal hyperplasia in vein grafts, as well as the development of an engineering approach that can be used to eliminate disturbed blood flow and prevent blood flow-related focal intimal hyperplasia. A rat vein graft model was constructed by ...

journal_title：Atherosclerosis

authors： Liu SQ

更新日期：1998-10-01 00:00:00

abstract：OBJECTIVE:Elevated leukocyte count is a classic marker of systemic inflammation. This study examined whether the leukocyte count is associated with incidence of coronary events (CE) and stroke during a long follow-up period. METHODS:A total of 17,131 men and 2932 women, aged 27-61 years, without history of cardiovascu...

journal_title：Atherosclerosis

authors： Li C,Engström G,Hedblad B

更新日期：2010-04-01 00:00:00

abstract：:VPS10P domain receptors are a unique class of sorting receptors that direct intracellular transport of target proteins in neurons and that play central roles in neurodegenerative processes. Surprisingly, genome-wide association studies now implicate the very same receptors in cardiovascular and metabolic disturbances....

journal_title：Atherosclerosis

authors： Schmidt V,Willnow TE

更新日期：2016-02-01 00:00:00