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Leukocyte count is associated with incidence of coronary events, but not with stroke: a prospective cohort study.

Abstract：

OBJECTIVE:Elevated leukocyte count is a classic marker of systemic inflammation. This study examined whether the leukocyte count is associated with incidence of coronary events (CE) and stroke during a long follow-up period. METHODS:A total of 17,131 men and 2932 women, aged 27-61 years, without history of cardiovascular disease (CVD), were enrolled. Incidence of CE and stroke was studied in relation to leukocyte concentrations over a mean follow-up of 24 years. RESULTS:During the follow-up period, 2600 CE and 1333 stroke events occurred. After risk factor adjustments, leukocyte concentrations in the highest quartile (vs. lowest, >7.0 vs. <4.7 x 10(9)cells/L) were associated with CE in men (HR: 1.31, 95%CI: 1.16-1.48, trend p<0.001), but not significantly in women (HR: 1.46, CI: 0.87-2.46, trend p=0.13). The increased incidence remained significant after adjustments for plasma fibrinogen in a sub-group of 6018 men (HR: 1.31, CI: 1.08-1.60). The association between leukocytes and CE was most pronounced in younger men (aged 27-46) and men without hypertension. In younger men, high leukocytes were associated with early CE (within 10 years of follow-up) and late CE (>10 years of follow-up). In older men (46-61 years), leukocytes were not associated with CE after more than 10 years of follow-up. The leukocyte count was not associated with incidence of stroke. CONCLUSION:Elevated leukocyte count in men is associated with increased incidence of CE, but not with stroke. The increased risk persisted after more than 10 years of follow-up in younger, but not in older men.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Li C,Engström G,Hedblad B

doi

10.1016/j.atherosclerosis.2009.09.029

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

545-50

issue

2

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(09)00782-5

journal_volume

209

pub_type

杂志文章

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