Abstract：
:Plasma high density lipoproteins (HDL) and their major protein, apolipoprotein (apo) A-I, are deficient in homozygous Watanabe heritable hyperlipidemic (WHHL) rabbits. As the pathophysiology of subnormal HDL-apo A-I is unclear, we examined kinetic parameters of HDL-apo A-I in WHHL rabbits and normolipidemic Japanese White (control) rabbits. The total plasma mass of HDL-apo A-I was significantly smaller (P less than 0.01) in WHHL rabbits than in controls (less than one-third). Mean fractional catabolic rates (FCR) computed from the specific radioactivity decay curves of HDL-apo A-I were significantly greater (P less than 0.01) in WHHL rabbits than in controls (0.874 +/- 0.052 vs. 0.502 +/- 0.060/day, respectively). Mean synthetic rates of HDL-apo A-I were significantly lower (P less than 0.01) in WHHL rabbits than in controls (8.67 +/- 0.59 vs. 18.14 +/- 3.75 mg/kg body weight/day, respectively). We conclude that the deficiency of plasma HDL-apo A-I in the WHHL rabbits resulted from an increase in FCR and a decrease in apo A-I synthesis.
journal_name
Atherosclerosisjournal_title
Atherosclerosisauthors
Saku K,Yamamoto K,Sakai T,Yanagida T,Hidaka K,Sasaki J,Arakawa Kdoi
10.1016/0021-9150(89)90127-5subject
Has Abstractpub_date
1989-10-01 00:00:00pages
225-30issue
2-3eissn
0021-9150issn
1879-1484pii
0021-9150(89)90127-5journal_volume
79pub_type
杂志文章相关文献
ATHEROSCLEROSIS文献大全abstract：:We studied the functional role of N-linked sugar chains of apolipoprotein (apo) B-100 of low density lipoprotein (LDL) in cholesterol metabolism. The N-linked sugar chains of apo B-100 of LDL obtained from four homozygous Watanabe heritable hyperlipidemic (WHHL) rabbits were liberated by hydrazinolysis, followed by Na...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/0021-9150(94)90040-x
更新日期：1994-07-01 00:00:00
abstract：OBJECTIVE:The principal aim of this study was to determine whether the amount of visceral adipose tissue (VAT) is more related than subcutaneous adipose tissue (SAT) to atherosclerosis assessed by whole-body MRA (WBMRA). A further objective was to investigate whether traditional risk factors, inflammation, or adipokine...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2008.11.007
更新日期：2009-07-01 00:00:00
abstract：OBJECTIVE:Antiphospholipid antibodies are associated with increased risk of thrombosis, particularly as in antiphospholipid syndrome. This study aims to determine the acute effects of anticardiolipin antibodies on nitric oxide production and vascular function. METHODS:Ex vivo aortic rings from male Sprague Dawley rats...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2005.06.044
更新日期：2006-04-01 00:00:00
abstract：BACKGROUND AND AIMS:Mutations in the 5'-nucleotidase ecto (NT5E) gene that encodes CD73, a nucleotidase that converts AMP to adenosine, are linked to arterial calcification. However, the role of purinergic receptor signaling in the pathology of intimal calcification is not well understood. In this study, we examined wh...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2016.12.014
更新日期：2017-02-01 00:00:00
abstract：:Cardiovascular risk is increased in patients with diabetic nephropathy. The aim of this study was to examine the relative impacts of albuminuria and renal failure, the two important features of diabetic nephropathy, on potentially atherogenic lipoprotein changes in this condition. The subjects were 160 non-diabetic he...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/s0021-9150(00)00673-0
更新日期：2001-06-01 00:00:00
abstract：:We investigated the influence of fish oil on cholesterol induced atherosclerosis in rabbits. Group I, a control group was fed a cholesterol-free diet, group II was fed a diet supplemented with 1.5% cholesterol, group III received in addition to cholesterol supplementation a purified fish oil concentrate (Maxepa, 2 ml/...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/0021-9150(87)90081-5
更新日期：1987-01-01 00:00:00
abstract：:Inflammation is thought to play a central role in the etiology and outcome of atherosclerosis. Animal studies as well as in vitro and in vivo human studies suggest that host factors modulate the magnitude and extent of inflammatory responses. We investigated familial aggregation of three systemic markers of inflammati...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/s0021-9150(00)00586-4
更新日期：2001-02-15 00:00:00
abstract：OBJECTIVE:To investigate the effect of pioglitazone on endothelial and adipose tissue dysfunction in newly detected IGT patients with CAD. METHODS AND DESIGN:Participants (n=25) were randomized to treatment with either placebo or pioglitazone (30 mg/day) for 12 weeks. Before and after treatment we evaluated endothelia...
journal_title：Atherosclerosis
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.atherosclerosis.2010.12.021
更新日期：2011-03-01 00:00:00
abstract：:Endothelial cell lipotoxicity mediated by accumulation of free fatty acids is an early event in the pathogenesis of atherosclerosis. The energy-sensor AMP-activated protein kinase (AMPK) is a key regulator of endothelial cell lipid metabolism. To test the hypothesis that bradykinin (BK) regulates AMPK and fatty acid o...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2007.12.003
更新日期：2008-09-01 00:00:00
abstract：:Highly active antiretroviral therapy (HAART) has greatly extended the lives of people infected with the human immunodeficiency virus (HIV). This reduced risk of early death from opportunistic infections or other sequelae of HIV infection, however, means that other possible causes of death emerge. Myocardial infarction...
journal_title：Atherosclerosis
pub_type： 杂志文章,评审
doi：10.1016/j.atherosclerosis.2005.09.025
更新日期：2006-03-01 00:00:00
abstract：BACKGROUND:We sought to determine whether mitral annular calcification (MAC) predicts mortality and cardiac disease in a group of renal transplant candidates. METHODS:Hundred and forty patients were prospectively studied. All had echocardiography and coronary angiography. Significant coronary artery disease (CAD) was ...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2006.03.033
更新日期：2007-04-01 00:00:00
abstract：:Mast cells (MCs) contribute to atherogenesis by releasing pro-inflammatory mediators to activate vascular cells and other inflammatory cells. This study examined whether MC activation or stabilization affects diet-induced atherosclerosis in low-density lipoprotein receptor-deficient (Ldlr(-/-)) mice. When Ldlr(-/-) mi...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2013.05.025
更新日期：2013-08-01 00:00:00
abstract：BACKGROUND AND AIMS:Diabetic patients are at high risk of stroke and coronary artery disease. Recent data suggest that arachidonic acid metabolism is altered in diabetic conditions and that these alterations contribute to accelerated atherosclerosis. Little is known about how these alterations affect the metabolism and...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2016.05.004
更新日期：2016-08-01 00:00:00
abstract：BACKGROUND AND AIM:In the general population lipid-rich plaques are prone to rupture and healing of the plaque involves calcification. Patients undergoing hemodialysis have a severe derangement of mineral metabolism and calcification of the arterial tree may have different implications. METHODS:Between 2004 and 2005, ...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2016.03.034
更新日期：2016-07-01 00:00:00
abstract：:Vitamin K is involved in the biosynthesis of a number of blood coagulation factors and bone proteins. It has been suggested that the vitamin K requirement of bone tissue is higher than that of the liver. Here we report that in rats very high doses of vitamin K affected neither the blood coagulation characteristics nor...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/s0021-9150(97)00087-7
更新日期：1997-07-11 00:00:00
abstract：BACKGROUND:There is increasing evidence that renin-angiotensin system (RAS) may play a major role in the actively regulated fibrocalcific process in aortic valve stenosis (AS), but the gene expression or function of (pro)renin receptor ((P)RR), prorenin and renin or angiotensin converting enzyme 2(ACE2)/angiotensin-(1-...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2011.01.018
更新日期：2011-05-01 00:00:00
abstract：BACKGROUND AND AIMS:Clinical practice guidelines recommend specific statin doses for the primary and secondary prevention of cardiovascular disease. Little is known about how statin utilization and dosing have evolved over time in Hong Kong. The aim of this study was to describe trends in statin prevalence, initiation,...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2018.11.015
更新日期：2019-01-01 00:00:00
abstract：:Cholesterol lowering in both primary and secondary prevention has been clearly demonstrated to lower coronary morbidity and, in secondary prevention, to lower coronary mortality as well. Putative dangers of cholesterol lowering remain unproven. Population studies linking low cholesterol to noncoronary mortalities do n...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/0021-9150(94)90159-7
更新日期：1994-08-01 00:00:00
abstract：:Measurements of aortic length and circumference in 336 post-mortem specimens confirm earlier, neglected observations on the progressive increase in aortic size which occurs with advancing years. The increase is not related to atherosclerosis , or to hypertension and seems to be part of a true ageing process. The value...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/0021-9150(77)90162-9
更新日期：1977-08-01 00:00:00
abstract：:The offspring of type 2 diabetic patients are at elevated risk for type 2 diabetes and cardiovascular disease. The aim of our study was to characterize the role of various biomarkers of endothelial activation in a cohort of offspring of type 2 diabetic subjects and to assess the association of adhesion molecules with ...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2007.04.021
更新日期：2008-03-01 00:00:00
abstract：:The effects of atorvastatin (Lipitor) were evaluated in 40 patients with familial hypercholesterolemia (FH). Following a 6 week drug-free baseline period 20 male and 20 female patients were treated with atorvastatin 40 mg once daily (QD) for the initial 6 weeks increasing to 80 mg QD during the following 6 weeks. Ator...
journal_title：Atherosclerosis
pub_type： 临床试验,杂志文章
doi：10.1016/s0021-9150(99)00125-2
更新日期：1999-09-01 00:00:00
abstract：:We investigated the modulating effect of serum total triglycerides on the lipid composition of various lipoproteins, and on the response to gemfibrozil treatment. This placebo controlled study was conducted blind in 60 participants of the Helsinki Heart Study. An inverse relationship was observed between cholesterol c...
journal_title：Atherosclerosis
pub_type： 临床试验,杂志文章
doi：10.1016/0021-9150(90)90054-m
更新日期：1990-02-01 00:00:00
abstract：:Male and female rats kept on a long-term atherogenic regimen for periods up to 15 months developed marked atherosclerotic changes of cardiac valves in 100% of cases. The degree and the topography of valvular atherosclerotic plaques corresponded widely to that seen in human atherosclerotic valvular disease. The regular...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/0021-9150(77)90023-5
更新日期：1977-05-01 00:00:00
abstract：:Endothelium plays a pivotal role in the development of atherosclerosis. Endothelial dysfunction participates in the course of acute coronary event. Using high-resolution ultrasound technique, endothelial dysfunction has been demonstrated in patients with atherosclerosis and risk factors for coronary disease, such as h...
journal_title：Atherosclerosis
pub_type： 临床试验,杂志文章
doi：10.1016/s0021-9150(99)00288-9
更新日期：2000-03-01 00:00:00
abstract：BACKGROUND:Circulating endotoxin levels are associated with atherosclerosis. Moreover, ethnic differences in pro-inflammatory markers may be associated with ethnic differences in atherosclerotic and cardiovascular (CVD) and coronary heart disease (CHD) risk. OBJECTIVE AND METHODS:To investigate ethnic differences in c...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2008.06.018
更新日期：2009-04-01 00:00:00
abstract：:Interferon gamma (IFN-gamma) is an immunomodulatory and anti-microbial cytokine, which has a variety of proatherogenic effects. It has been reported that IFN-gamma can down-regulate ABCA1 expression. However, its mechanism is elusive. In the present study, we have investigated the effect of IFN-gamma on ABCA1 expressi...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2008.07.029
更新日期：2009-04-01 00:00:00
abstract：:Topographic distribution of atherosclerotic lesions of the aortic valve was investigated in rabbits on a 2%-cholesterol-enriched diet and related to distribution of intramural stress in the valve. Initially the lesions appeared at the base of the leaflet on the aortic face and with time spread further out into the lea...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/0021-9150(85)90108-x
更新日期：1985-06-01 00:00:00
abstract：:Inflammatory cytokine synthesis by monocyte-macrophages in the developing plaque represents an important amplification point in atherosclerotic disease progression. Here we have investigated whether the state of monocyte-macrophage differentiation can influence TNF alpha synthesis in response to scavenged modified low...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/s0021-9150(03)00285-5
更新日期：2003-10-01 00:00:00
abstract：OBJECTIVES:To explore the therapeutic potential of fibrates to attenuate premature atherosclerosis and cardiovascular disease in the atherogenic dyslipidemias typical of Type II diabetes, Metabolic Syndrome, and the Type IIB (mixed) lipid phenotype; such dyslipidemias frequently feature peripheral insulinoresistance. ...
journal_title：Atherosclerosis
pub_type： 杂志文章,评审
doi：10.1016/s0021-9150(03)00156-4
更新日期：2003-11-01 00:00:00
abstract：:Incubated human peripheral blood monocytes release a factor(s) which specifically stimulates homologous vascular smooth muscle (SMC) but not endothelial cells (EC) to proliferate in vitro. Conditioned medium from activated monocytes significantly (P less than 0.001) stimulated proliferation of SMC within 6 days of cul...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/0021-9150(81)90056-3
更新日期：1981-02-01 00:00:00
