Abstract:
:Cholesterol lowering in both primary and secondary prevention has been clearly demonstrated to lower coronary morbidity and, in secondary prevention, to lower coronary mortality as well. Putative dangers of cholesterol lowering remain unproven. Population studies linking low cholesterol to noncoronary mortalities do not demonstrate cause-and-effect relations. In fact, based on current studies, the opposite is more likely to be the case. Neither gender nor age should automatically exclude persons from cholesterol screening. Drug intervention, however, should be used conservatively, particularly in young adults and the elderly. Drugs should be used only after diet and lifestyle interventions have failed. The evidence linking high blood cholesterol to coronary atherosclerosis and cholesterol lowering to its prevention is broad-based and definitive. Concerns about cholesterol lowering and spontaneously low cholesterols should be pursued but should not interfere with the implementation of current public policies to reduce the still heavy burden of atherosclerosis in Western society.
journal_name
Atherosclerosisjournal_title
Atherosclerosisauthors
LaRosa JCdoi
10.1016/0021-9150(94)90159-7subject
Has Abstractpub_date
1994-08-01 00:00:00pages
S137-41eissn
0021-9150issn
1879-1484pii
0021-9150(94)90159-7journal_volume
108 Supplpub_type
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