Familial hypercholesterolemia in Canada: Initial results from the FH Canada national registry.

abstract：:Topographic distribution of atherosclerotic lesions of the aortic valve was investigated in rabbits on a 2%-cholesterol-enriched diet and related to distribution of intramural stress in the valve. Initially the lesions appeared at the base of the leaflet on the aortic face and with time spread further out into the lea...

journal_title：Atherosclerosis

authors： Thubrikar MJ,Deck JD,Aouad J,Chen JM

更新日期：1985-06-01 00:00:00

abstract：BACKGROUND:Acrolein is a dietary aldehyde that is present in high concentrations in alcoholic beverages and foods including cheese, donuts and coffee. It is also abundant in tobacco smoke, automobile exhaust and industrial waste and is generated in vivo during inflammation and oxidative stress. OBJECTIVES:The goal of ...

journal_title：Atherosclerosis

authors： Srivastava S,Sithu SD,Vladykovskaya E,Haberzettl P,Hoetker DJ,Siddiqui MA,Conklin DJ,D'Souza SE,Bhatnagar A

更新日期：2011-04-01 00:00:00

abstract：:Circulating soluble intercellular adhesion molecule-1 (sICAM-1) is a biochemical marker of inflammation. We performed variance-components-based quantitative genetic analyses in SOLAR of sICAM-1 in 1170 individuals from Mexican American families in the San Antonio Family Heart Study. The trait is heritable (h(2)=0.50+/...

journal_title：Atherosclerosis

authors： Kent JW Jr,Mahaney MC,Comuzzie AG,Göring HH,Almasy L,Dyer TD,Cole SA,MacCluer JW,Blangero J

更新日期：2007-12-01 00:00:00

abstract：:An organ culture technique was used to investigate the removal of fatty acids incorporated into various lipid fractions in intimal segments of atherosclerotic rabbit aorta. Segments of aorta were pulse-labelled in vitro with [9,10-3H]oleic acid and [1-14C]linoleic acid for 24 h. The incubation medium was replaced with...

journal_title：Atherosclerosis

authors： Hudson K,Day AJ,Horsch AK

更新日期：1977-12-01 00:00:00

abstract：OBJECTIVE:To investigate SCM-198 (also known as "leonurine"), a compound in Herba leonuri, as well as its effect on the progression of atherosclerosis in hypercholesterolemic rabbits and underlying mechanisms. METHODS:Thirty New Zealand male White rabbits (5 groups, n = 6) were fed either a normal diet or a high-chole...

journal_title：Atherosclerosis

authors： Zhang Y,Guo W,Wen Y,Xiong Q,Liu H,Wu J,Zou Y,Zhu Y

更新日期：2012-09-01 00:00:00

abstract：PURPOSE:Proprotein convertase subtilisin-kexin type 9 (PCSK9) promotes low density lipoprotein (LDL) receptor degradation, thereby providing a key pathway for LDL metabolism. PCSK9 mRNA expression may be upregulated by insulin in murine models. Here we examined effects of exogenous hyperinsulinemia on plasma PCSK9 leve...

journal_title：Atherosclerosis

authors： Kappelle PJ,Lambert G,Dullaart RP

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:CD36 signal transductions have been reported by a variety of lipid moiety of oxidized low-density lipoprotein (oxLDL), however, CD36 signal induced by 7-ketocholesteryl-9-carboxynonanoate (oxLig-1), a lipid moiety of oxLDL has not been elucidated. METHODS AND RESULTS:OxLig-1 leads to activation and recruitm...

journal_title：Atherosclerosis

authors： Li W,Wang D,Chi Y,Wang R,Zhang F,Ma G,Chen Z,Li J,Liu Z,Matsuura E,Liu Q

更新日期：2013-01-01 00:00:00

abstract：:Dietary intervention is the first treatment step in management of hyperlipidaemia, but there are few objective criteria of compliance. Whether intensive dietary intervention would produce a detectable change in erythrocyte membrane fatty acid composition which could be used as a marker of compliance was examined in 31...

journal_title：Atherosclerosis

authors： Tynan MB,Nicholls DP,Maguire SM,Steele IC,McMaster C,Moore R,Trimble ER,Pearce J

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND:We sought to determine whether mitral annular calcification (MAC) predicts mortality and cardiac disease in a group of renal transplant candidates. METHODS:Hundred and forty patients were prospectively studied. All had echocardiography and coronary angiography. Significant coronary artery disease (CAD) was ...

journal_title：Atherosclerosis

authors： Sharma R,Pellerin D,Gaze DC,Mehta RL,Gregson H,Streather CP,Collinson PO,Brecker SJ

更新日期：2007-04-01 00:00:00

abstract：OBJECTIVES:We conducted a meta-analysis of relevant randomized trials to assess whether folic acid supplementation reduces the progression of atherosclerosis as measured by carotid intima-media thickness (CIMT). METHODS:This analysis included 2052 subjects from ten folic acid randomized trials with the change in CIMT ...

journal_title：Atherosclerosis

authors： Qin X,Xu M,Zhang Y,Li J,Xu X,Wang X,Xu X,Huo Y

更新日期：2012-06-01 00:00:00

abstract：:The effect of short-term dietary restriction on plasma cholesterol and cholesterol balance was examined in young While Carneau pigeons. Dietary restriction of 1 month increased plasma cholesterol significantly and subsequently decreased to initial levels at 3 months. The fecal excretion of neutral sterols was signific...

journal_title：Atherosclerosis

authors： Subbiah MT,Connelly PW

更新日期：1976-09-01 00:00:00

abstract：:Conjugated linoleic acid (CLA) refers to a group of positional and geometric isomers of linoleic acid and has been shown to suppress the development of atherosclerosis in experimental models. However, the mechanism involved is unclear although it is believed it may act as a cyclooxygenase inhibitor or as an agonist of...

journal_title：Atherosclerosis

authors： Toomey S,Harhen B,Roche HM,Fitzgerald D,Belton O

更新日期：2006-07-01 00:00:00

abstract：:The role of the immune system in modulating atherosclerosis has recently been the subject of intensive research. Several previous authors have put forward a paradigm of the autoimmune process occurring in the vicinity of the plaque. Two recent studies have shown that immunization of rabbits with homologous modified lo...

journal_title：Atherosclerosis

authors： George J,Afek A,Gilburd B,Levkovitz H,Shaish A,Goldberg I,Kopolovic Y,Wick G,Shoenfeld Y,Harats D

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND:The EPA/AA ratio has emerged as a predictor of mortality endpoints in cardiac disease; however, its prognostic value in peripheral artery disease (PAD) patients is unclear. We assessed the serum eicosapentaenoic acid (EPA) to arachidonic acid (AA) ratio in patients with PAD caused by femoropopliteal artery l...

journal_title：Atherosclerosis

authors： Hishikari K,Kimura S,Yamakami Y,Kojima K,Sagawa Y,Otani H,Sugiyama T,Kuwahara T,Hikita H,Takahashi A,Isobe M

更新日期：2015-04-01 00:00:00

abstract：:Familial defective apolipoprotein B-100 (FDB) is a dominantly inherited disorder associated with hypercholesterolemia, in which substitution of the amino acid glutamine for arginine at position 3500 in the apoprotein B molecule results in LDL particles which bind poorly to the LDL receptor. To date, patients with FDB ...

journal_title：Atherosclerosis

authors： Schmidt EB,Illingworth DR,Bacon S,Mahley RW,Weisgraber KH

更新日期：1993-01-25 00:00:00

abstract：:The pathological remodeling of the arterial wall in atherosclerosis involves protease activities, which play a major role in complications, through plaque rupture. Here, we investigated the release of active proteases by human carotid plaques in relation to (1) the degree of lesion complexity and (2) their compartment...

journal_title：Atherosclerosis

authors： Leclercq A,Houard X,Loyau S,Philippe M,Sebbag U,Meilhac O,Michel JB

更新日期：2007-03-01 00:00:00

abstract：OBJECTIVES:Inflammation may directly impair HDL functions, in particular reverse cholesterol transport (RCT), but limited data support this concept in humans. METHODS AND RESULTS:We employed low-dose human endotoxemia to assess the effects of inflammation on HDL and RCT-related parameters in vivo. Endotoxemia induced ...

journal_title：Atherosclerosis

authors： de la Llera Moya M,McGillicuddy FC,Hinkle CC,Byrne M,Joshi MR,Nguyen V,Tabita-Martinez J,Wolfe ML,Badellino K,Pruscino L,Mehta NN,Asztalos BF,Reilly MP

更新日期：2012-06-01 00:00:00

abstract：:We have used discoidal reconstituted high density lipoproteins (rHDL) containing apolipoprotein (apo) A-I and dimyristoyl phosphatidylcholine (DMPC) as a tool to investigate the time sequence of the HDL-mediated inhibition of vascular cell adhesion molecule (VCAM)-1 and E-selectin expression in cytokine-activated huma...

journal_title：Atherosclerosis

authors： Clay MA,Pyle DH,Rye KA,Vadas MA,Gamble JR,Barter PJ

更新日期：2001-07-01 00:00:00

abstract：:Epidemiological and clinical data demonstrate differences in atherosclerotic coronary heart disease prevalence between age-matched men and premenopausal women. Mechanisms underlying relative athero-susceptibility in men and athero-resistance in premenopausal women remain to be elucidated. Lack of informative animal mo...

journal_title：Atherosclerosis

authors： Herrera VL,Tsikoudakis A,Didishvili T,Ponce LR,Bagamasbad P,Gantz D,Herscovitz H,Van Tol A,Ruiz-Opazo N

更新日期：2004-11-01 00:00:00

abstract：:The effect of administering blackgram (Phaseolus mungo) fiber (isolated as neutral detergent residue) at the 30% dietary level has been studied with regard to lipid concentration in the tissues and that of biliary and fecal bile acids and sterols. Rats were fed a high fat-cholesterol diet and compared with those fed a...

journal_title：Atherosclerosis

authors： Jayakumari N,Kurup PA

更新日期：1979-05-01 00:00:00

abstract：:The serum concentrations of testosterone, androstenedione, oestradiol and total low polar oestrogens, mainly oestradiol and oestrone, were measured in 26 healthy male subjects. The subjects were divided into two groups each of them with low (less than 1.04 mmol/l) and high (greater than 1.56 mmol/l) levels of serum HD...

journal_title：Atherosclerosis

authors： Nordøy A,Aakvaag A,Thelle D

更新日期：1979-12-01 00:00:00

abstract：OBJECTIVE:The apolipoprotein E mimetic peptide Ac-hE18A-NH(2), capable of reducing plasma cholesterol and possessing anti-inflammatory properties, was compared with the well-studied anti-atherogenic apoA-I mimetic peptide 4F for reducing lesion formation in female apoE null mice with already existing lesions. METHODS ...

journal_title：Atherosclerosis

authors： Nayyar G,Garber DW,Palgunachari MN,Monroe CE,Keenum TD,Handattu SP,Mishra VK,Anantharamaiah GM

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Atherosclerosis starts early in life. We aimed to assess the dimension and progression of the intima-media thickness, a surrogate marker for early vascular aging, and its association with a broad palette of cardiovascular risk and lifestyle factors in a large cohort of healthy adolescents. METHODS:...

journal_title：Atherosclerosis

authors： Staudt A,Stock K,Gande N,Bernar B,Hochmayr C,Pechlaner R,Kiechl SJ,Geiger R,Griesmacher A,Anliker M,Kiechl S,Kiechl-Kohlendorfer U,Knoflach M,Early Vascular Ageing (EVA) Study Group.

更新日期：2020-07-01 00:00:00

abstract：:Simvastatin, an inhibitor of HMG CoA reductase, lowers the plasma total cholesterol and LDL-cholesterol concentration in familial hypercholesterolemic patients. The efficacy of the drug shows considerable inter-individual variation, however. In this study we have assessed the influence of certain LDL-receptor gene mut...

journal_title：Atherosclerosis

authors： Jeenah M,September W,Graadt van Roggen F,de Villiers W,Seftel H,Marais D

更新日期：1993-01-04 00:00:00

abstract：OBJECTIVE:Being the earliest step on the way to atherosclerosis, endothelial dysfunction is particularly escalated in diabetes. This study aimed at assessing endothelial dysfunction and blood pressure disturbances in young patients with type 1 diabetes mellitus (T1DM) and defining their interrelations. METHODS:The stu...

journal_title：Atherosclerosis

authors： Machnica L,Deja G,Polanska J,Czupryniak L,Szymanska-Garbacz E,Loba J,Jarosz-Chobot P

更新日期：2014-11-01 00:00:00

abstract：:The objective of this study was to examine frequency of familial defective apo-B-100 (FDB, R3500Q mutation) in probands with the phenotype of familial hypercholesterolemia (FH) and in the general population of 40-year-old subjects in Slovakia and to characterize their lipid and clinical criteria and to compare the fre...

journal_title：Atherosclerosis

authors： Gasparovic J,Basistová Z,Fábryová L,Wsólová L,Vohnout B,Raslová K,Slovak MED PED FH group.

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Statin is not beneficial for dialysis patients but moderate to high intensity statin is beneficial for patients after acute myocardial infarction (MI). The aim of this study was to evaluate the effect of moderate to high intensity statin on mortality, cardiovascular outcomes in dialysis patients aft...

journal_title：Atherosclerosis

authors： Chung CM,Lin MS,Chang CH,Cheng HW,Chang ST,Wang PC,Chang HY,Lin YS

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVE:Interruption of the enterohepatic circulation of bile acids induces hepatic bile acid synthesis, increases hepatic cholesterol demand, and increases clearance of apoB-containing lipoproteins in plasma. Based on these effects, bile acid sequestrants have been used for many years to treat hypercholesterolemia a...

journal_title：Atherosclerosis

authors： Lan T,Haywood J,Dawson PA

更新日期：2013-08-01 00:00:00

abstract：:Although the standard procedure for preparing extensively oxidized low-density lipoprotein (Ox-LDL) is to incubate it with 10muM CuSO(4) at 37 degrees C for 24h, it is not well known how important the degree of oxidation of LDL is for inducing cell signaling. Since Lox-1 (an Ox-LDL receptor) contributes to cell prolif...

journal_title：Atherosclerosis

authors： Tanigawa H,Miura S,Zhang B,Uehara Y,Matsuo Y,Fujino M,Sawamura T,Saku K

更新日期：2006-10-01 00:00:00

abstract：:We measured 381 genomewide markers and performed genetic linkage analyses in search of loci influencing coronary artery calcification (CAC), a measure of atherosclerosis determined by electron beam computed tomography, in 948 non-Hispanic white siblings (mean age [+/-standard deviation] = 59.6 +/- 9.9 years; 73.7% hyp...

journal_title：Atherosclerosis

authors： Turner ST,Peyser PA,Kardia SL,Bielak LF,Sheedy PF 3rd,Boerwinkle E,de Andrade M

更新日期：2006-04-01 00:00:00