Familial hypercholesterolemia in Canada: Initial results from the FH Canada national registry.


BACKGROUND AND AIMS:Familial hypercholesterolemia (FH) is under-diagnosed and under-treated in most of the world, including Canada. National registries play a key role in identifying patients with FH, understanding gaps in care, and advancing the science of FH to better treat these patients. METHODS:FH Canada has established a national registry across 19 academic sites acting as "hubs" in Canada to increase awareness and access to standard-of-care therapies. RESULTS:To-date, more than 3000 patients with FH have been entered into a secure, web-based database. Early outcomes of this initiative include a greater understanding of treatment gaps for patients with FH in Canada, the development of a new, simplified Canadian definition of FH, and tools to aid in the diagnosis of FH, including imputation of baseline levels of LDL cholesterol. CONCLUSIONS:As the national registry expands in size and scope, further learning will emerge with ultimate benefit for the diagnosis and treatment of FH in Canada.






Brunham LR,Ruel I,Khoury E,Hegele RA,Couture P,Bergeron J,Baass A,Dufour R,Francis GA,Cermakova L,Mancini GBJ,Brophy JM,Brisson D,Gaudet D,Genest J




Has Abstract


2018-10-01 00:00:00












  • Intramural stress as a causative factor in atherosclerotic lesions of the aortic valve.

    abstract::Topographic distribution of atherosclerotic lesions of the aortic valve was investigated in rabbits on a 2%-cholesterol-enriched diet and related to distribution of intramural stress in the valve. Initially the lesions appeared at the base of the leaflet on the aortic face and with time spread further out into the lea...


    pub_type: 杂志文章


    authors: Thubrikar MJ,Deck JD,Aouad J,Chen JM

    更新日期:1985-06-01 00:00:00

  • Oral exposure to acrolein exacerbates atherosclerosis in apoE-null mice.

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    authors: Srivastava S,Sithu SD,Vladykovskaya E,Haberzettl P,Hoetker DJ,Siddiqui MA,Conklin DJ,D'Souza SE,Bhatnagar A

    更新日期:2011-04-01 00:00:00

  • Quantitative trait locus on Chromosome 19 for circulating levels of intercellular adhesion molecule-1 in Mexican Americans.

    abstract::Circulating soluble intercellular adhesion molecule-1 (sICAM-1) is a biochemical marker of inflammation. We performed variance-components-based quantitative genetic analyses in SOLAR of sICAM-1 in 1170 individuals from Mexican American families in the San Antonio Family Heart Study. The trait is heritable (h(2)=0.50+/...


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    authors: Kent JW Jr,Mahaney MC,Comuzzie AG,Göring HH,Almasy L,Dyer TD,Cole SA,MacCluer JW,Blangero J

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  • Removal of fatty acid labelled cholesterol ester, phospholipid and triglyceride from atherosclerotic rabbit aorta in vitro.

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    authors: Hudson K,Day AJ,Horsch AK

    更新日期:1977-12-01 00:00:00

  • SCM-198 attenuates early atherosclerotic lesions in hypercholesterolemic rabbits via modulation of the inflammatory and oxidative stress pathways.

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    authors: Zhang Y,Guo W,Wen Y,Xiong Q,Liu H,Wu J,Zou Y,Zhu Y

    更新日期:2012-09-01 00:00:00

  • Plasma proprotein convertase subtilisin-kexin type 9 does not change during 24h insulin infusion in healthy subjects and type 2 diabetic patients.

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    pub_type: 杂志文章


    authors: Kappelle PJ,Lambert G,Dullaart RP

    更新日期:2011-02-01 00:00:00

  • 7-Ketocholesteryl-9-carboxynonanoate enhances the expression of ATP-binding cassette transporter A1 via CD36.

    abstract:BACKGROUND:CD36 signal transductions have been reported by a variety of lipid moiety of oxidized low-density lipoprotein (oxLDL), however, CD36 signal induced by 7-ketocholesteryl-9-carboxynonanoate (oxLig-1), a lipid moiety of oxLDL has not been elucidated. METHODS AND RESULTS:OxLig-1 leads to activation and recruitm...


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    authors: Li W,Wang D,Chi Y,Wang R,Zhang F,Ma G,Chen Z,Li J,Liu Z,Matsuura E,Liu Q

    更新日期:2013-01-01 00:00:00

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    authors: Tynan MB,Nicholls DP,Maguire SM,Steele IC,McMaster C,Moore R,Trimble ER,Pearce J

    更新日期:1995-10-01 00:00:00

  • Mitral annular calcification predicts mortality and coronary artery disease in end stage renal disease.

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    authors: Sharma R,Pellerin D,Gaze DC,Mehta RL,Gregson H,Streather CP,Collinson PO,Brecker SJ

    更新日期:2007-04-01 00:00:00

  • Effect of folic acid supplementation on the progression of carotid intima-media thickness: a meta-analysis of randomized controlled trials.

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    pub_type: 杂志文章,meta分析,评审


    authors: Qin X,Xu M,Zhang Y,Li J,Xu X,Wang X,Xu X,Huo Y

    更新日期:2012-06-01 00:00:00

  • Effect of dietary restriction on plasma cholesterol and cholesterol excretion in the White Carneau pigeon.

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    authors: Subbiah MT,Connelly PW

    更新日期:1976-09-01 00:00:00

  • Profound resolution of early atherosclerosis with conjugated linoleic acid.

    abstract::Conjugated linoleic acid (CLA) refers to a group of positional and geometric isomers of linoleic acid and has been shown to suppress the development of atherosclerosis in experimental models. However, the mechanism involved is unclear although it is believed it may act as a cyclooxygenase inhibitor or as an agonist of...


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    authors: Toomey S,Harhen B,Roche HM,Fitzgerald D,Belton O

    更新日期:2006-07-01 00:00:00

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    authors: George J,Afek A,Gilburd B,Levkovitz H,Shaish A,Goldberg I,Kopolovic Y,Wick G,Shoenfeld Y,Harats D

    更新日期:1998-05-01 00:00:00

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    abstract:BACKGROUND:The EPA/AA ratio has emerged as a predictor of mortality endpoints in cardiac disease; however, its prognostic value in peripheral artery disease (PAD) patients is unclear. We assessed the serum eicosapentaenoic acid (EPA) to arachidonic acid (AA) ratio in patients with PAD caused by femoropopliteal artery l...


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    authors: Hishikari K,Kimura S,Yamakami Y,Kojima K,Sagawa Y,Otani H,Sugiyama T,Kuwahara T,Hikita H,Takahashi A,Isobe M

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    authors: Schmidt EB,Illingworth DR,Bacon S,Mahley RW,Weisgraber KH

    更新日期:1993-01-25 00:00:00

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    authors: Leclercq A,Houard X,Loyau S,Philippe M,Sebbag U,Meilhac O,Michel JB

    更新日期:2007-03-01 00:00:00

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    authors: de la Llera Moya M,McGillicuddy FC,Hinkle CC,Byrne M,Joshi MR,Nguyen V,Tabita-Martinez J,Wolfe ML,Badellino K,Pruscino L,Mehta NN,Asztalos BF,Reilly MP

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    authors: Clay MA,Pyle DH,Rye KA,Vadas MA,Gamble JR,Barter PJ

    更新日期:2001-07-01 00:00:00

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    abstract::Epidemiological and clinical data demonstrate differences in atherosclerotic coronary heart disease prevalence between age-matched men and premenopausal women. Mechanisms underlying relative athero-susceptibility in men and athero-resistance in premenopausal women remain to be elucidated. Lack of informative animal mo...


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    authors: Herrera VL,Tsikoudakis A,Didishvili T,Ponce LR,Bagamasbad P,Gantz D,Herscovitz H,Van Tol A,Ruiz-Opazo N

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    pub_type: 杂志文章


    authors: Jayakumari N,Kurup PA

    更新日期:1979-05-01 00:00:00

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    pub_type: 杂志文章


    authors: Nordøy A,Aakvaag A,Thelle D

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    authors: Jeenah M,September W,Graadt van Roggen F,de Villiers W,Seftel H,Marais D

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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Lan T,Haywood J,Dawson PA

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    pub_type: 杂志文章


    authors: Tanigawa H,Miura S,Zhang B,Uehara Y,Matsuo Y,Fujino M,Sawamura T,Saku K

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    pub_type: 杂志文章


    authors: Turner ST,Peyser PA,Kardia SL,Bielak LF,Sheedy PF 3rd,Boerwinkle E,de Andrade M

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