Familial hypercholesterolemia in Canada: Initial results from the FH Canada national registry.


BACKGROUND AND AIMS:Familial hypercholesterolemia (FH) is under-diagnosed and under-treated in most of the world, including Canada. National registries play a key role in identifying patients with FH, understanding gaps in care, and advancing the science of FH to better treat these patients. METHODS:FH Canada has established a national registry across 19 academic sites acting as "hubs" in Canada to increase awareness and access to standard-of-care therapies. RESULTS:To-date, more than 3000 patients with FH have been entered into a secure, web-based database. Early outcomes of this initiative include a greater understanding of treatment gaps for patients with FH in Canada, the development of a new, simplified Canadian definition of FH, and tools to aid in the diagnosis of FH, including imputation of baseline levels of LDL cholesterol. CONCLUSIONS:As the national registry expands in size and scope, further learning will emerge with ultimate benefit for the diagnosis and treatment of FH in Canada.






Brunham LR,Ruel I,Khoury E,Hegele RA,Couture P,Bergeron J,Baass A,Dufour R,Francis GA,Cermakova L,Mancini GBJ,Brophy JM,Brisson D,Gaudet D,Genest J




Has Abstract


2018-10-01 00:00:00












  • Common carotid intima-media thickness in patients with peripheral arterial disease or abdominal aortic aneurysm: the SMART study. Second Manifestations of ARTerial disease.

    abstract::Evidence is emerging that the contribution of atherosclerosis to the development of abdominal aortic aneurysm may differ from that of other manifestations of arterial disease. B-mode ultrasound may be helpful in understanding the characteristics and factors that contribute to the development of different manifestation...


    pub_type: 杂志文章


    authors: Simons PC,Algra A,Bots ML,Banga JD,Grobbee DE,van der Graaf Y

    更新日期:1999-10-01 00:00:00

  • Galectin-3 binding protein plasma levels are associated with long-term mortality in coronary artery disease independent of plaque morphology.

    abstract:BACKGROUND AND AIMS:Galectin-3 binding protein (Gal-3BP) is a secreted protein associated with inflammation and carotid atherosclerosis. We hypothesized that high Gal-3BP levels may indicate unfavorable plaque morphology and outcome in coronary artery disease (CAD). METHODS:Gal-3BP plasma levels were measured by ELISA...


    pub_type: 杂志文章


    authors: Gleissner CA,Erbel C,Linden F,Domschke G,Akhavanpoor M,Doesch AO,Buss SJ,Giannitsis E,Katus HA,Korosoglou G

    更新日期:2016-08-01 00:00:00

  • Brain microangiopathy and macroangiopathy share common risk factors and biomarkers.

    abstract:AIMS:Besides carotid or cardiac embolism, stroke can occur via microangiopathy (small arterial disease [SAD]) and macroangiopathy (intracranial atherosclerotic stroke [ICAS]) of the intracranial vasculature. There have been efforts to identify risk factors specific to microangiopathy and macroangiopathy, including vasc...


    pub_type: 杂志文章


    authors: Bang OY,Chung JW,Ryoo S,Moon GJ,Kim GM,Chung CS,Lee KH

    更新日期:2016-03-01 00:00:00

  • Erythrocyte membrane n-3 fatty acid levels and carotid atherosclerosis in Chinese men and women.

    abstract:OBJECTIVE:Prospective studies have supported the beneficial effects of n-3 fatty acid consumption on cardiac deaths, but limited data focused on atherosclerosis. We investigated the associations between n-3 fatty acids in erythrocytes and atherosclerosis in middle-aged and older Chinese. METHODS:847 subjects (285 men ...


    pub_type: 杂志文章


    authors: Dai XW,Zhang B,Wang P,Chen CG,Chen YM,Su YX

    更新日期:2014-01-01 00:00:00

  • High-density lipoproteins induce miR-223-3p biogenesis and export from myeloid cells: Role of scavenger receptor BI-mediated lipid transfer.

    abstract:BACKGROUND AND AIMS:We recently showed that miR-223-3p on high-density lipoproteins (HDL) is exported to endothelial cells, where it inhibits inflammation. However, the origin of miR-223-3p on HDL is unknown. We hypothesize that HDL-associated miR-223-3p originates in myeloid cells and is exported to HDL in a scavenger...


    pub_type: 杂志文章


    authors: Cuesta Torres LF,Zhu W,Öhrling G,Larsson R,Patel M,Wiese CB,Rye KA,Vickers KC,Tabet F

    更新日期:2019-07-01 00:00:00

  • Remnant-like particles accelerate endothelial progenitor cells senescence and induce cellular dysfunction via an oxidative mechanism.

    abstract::Remnant-like particles (RLPs) are closely associated with coronary heart disease and can induce endothelial dysfunction through oxidative mechanisms. Many risk factors accelerate the onset of endothelial progenitor cells (EPCs) senescence via increased oxidative stress. In this study, we investigated the effect of RLP...


    pub_type: 杂志文章


    authors: Liu L,Wen T,Zheng XY,Yang DG,Zhao SP,Xu DY,Lü GH

    更新日期:2009-02-01 00:00:00

  • Correlates of endothelial function and the peak systolic blood pressure response to a graded maximal exercise test.

    abstract:PURPOSE:An elevated systolic blood pressure (SBP) response to a graded maximal exercise stress test (GEST) may be a predictor of endothelial dysfunction and hypertension. We examined relationships among the GEST peak SBP response and indicators of endothelial function. METHODS:Men (n=48, 43.7±1.4 yr) with high BP (145...


    pub_type: 杂志文章


    authors: Olson KM,Augeri AL,Seip RL,Tsongalis GJ,Thompson PD,Pescatello LS

    更新日期:2012-05-01 00:00:00

  • Utility of high resolution MR imaging to assess carotid plaque morphology: a comparison of acute symptomatic, recently symptomatic and asymptomatic patients with carotid artery disease.

    abstract:OBJECTIVES:Compare carotid plaque morphology of acute symptomatic, recently symptomatic and asymptomatic patients (groups 1, 2 and 3 respectively) with carotid artery disease using high resolution magnetic resonance imaging (MRI), to identify high-risk plaque characteristics best associated with risk of recurrent throm...


    pub_type: 杂志文章


    authors: Sadat U,Weerakkody RA,Bowden DJ,Young VE,Graves MJ,Li ZY,Tang TY,Gaunt ME,Hayes PD,Gillard JH

    更新日期:2009-12-01 00:00:00

  • CD1d serves as a surface receptor for oxidized cholesterol induction of peroxisome proliferator-activated receptor-γ.

    abstract:OBJECTIVE:The cluster of differentiation-1d (CD1d) recognizes and presents the lipid antigens to NK-T lymphocytes. Atherosclerotic lesions contain atherogenic lipids, mainly cholesterol and its oxides. Peroxisome proliferator-activated receptor-γ (PPARγ) is also known to exist in atherosclerotic lesions, participating ...


    pub_type: 杂志文章


    authors: Rosales C,Tang D,Geng YJ

    更新日期:2015-03-01 00:00:00

  • The long-term effect of dietary supplementation with fish lipid concentrate on serum lipids, bleeding time, platelets and angina.

    abstract::The effect of a fish lipid concentrate rich in eicosapentaenoic acid was studied in 107 subjects for periods up to 2 years. Ninety-two had heart disease or hyper-lipidaemia and 15 had no history of heart disease. Serum triglyceride levels were rapidly reduced, cholesterol fell more slowly but high density lipoprotein ...


    pub_type: 杂志文章


    authors: Saynor R,Verel D,Gillott T

    更新日期:1984-01-01 00:00:00

  • Effects of medication, treatment, and behavioral beliefs on intentions to take medication in patients with familial hypercholesterolemia.

    abstract:BACKGROUND AND AIMS:Although familial hypercholesterolemia (FH) can be effectively managed using cholesterol-lowering medication, patients often fall short of complete treatment adherence. Identifying the psychological factors associated with self-regulation of FH medication is important to inform interventions to maxi...


    pub_type: 杂志文章,多中心研究


    authors: Hagger MS,Hardcastle SJ,Hu M,Kwok S,Lin J,Nawawi HM,Pang J,Santos RD,Soran H,Su TC,Tomlinson B,Watts GF

    更新日期:2018-10-01 00:00:00

  • Apolipoprotein C-III, a strong discriminant of coronary risk in men and a determinant of the metabolic syndrome in both genders.

    abstract:AIMS:Apolipoprotein C-III (apoC-III) has been recognized as a useful marker of triglyceride-rich lipoproteins (TRLs) metabolism and proposed as an indicator of prognosis for coronary risk in healthy subjects. We studied cross-sectionally in a population having low cholesterol levels, but a high prevalence of the metabo...


    pub_type: 杂志文章


    authors: Onat A,Hergenç G,Sansoy V,Fobker M,Ceyhan K,Toprak S,Assmann G

    更新日期:2003-05-01 00:00:00

  • Anti-inflammatory and recycling properties of an apolipoprotein mimetic peptide, Ac-hE18A-NH(2).

    abstract::Apolipoprotein E (apoE) exerts prominent anti-inflammatory effects and undergoes recycling by target cells. We previously reported that the peptide Ac-hE18A-NH(2), composed of the receptor binding domain (LRKLRKRLLR) of apoE covalently linked to the Class A amphipathic peptide 18A, dramatically lowers plasma cholester...


    pub_type: 杂志文章


    authors: Datta G,White CR,Dashti N,Chaddha M,Palgunachari MN,Gupta H,Handattu SP,Garber DW,Anantharamaiah GM

    更新日期:2010-01-01 00:00:00

  • Fenofibrate induces plaque regression in hypercholesterolemic atherosclerotic rabbits: in vivo demonstration by high-resolution MRI.

    abstract:INTRODUCTION:Fenofibrate has shown to reduce major cardiovascular events and slow angiographic progression of coronary atherosclerosis. The postulated mechanism of action is via the activation of peroxisomal proliferator-activated receptor-alpha (PPAR-alpha), a nuclear transcription factor that controls a variety of ce...


    pub_type: 杂志文章


    authors: Corti R,Osende J,Hutter R,Viles-Gonzalez JF,Zafar U,Valdivieso C,Mizsei G,Fallon JT,Fuster V,Badimon JJ

    更新日期:2007-01-01 00:00:00

  • Cell cycle-dependent inhibition of DNA synthesis by prostaglandin I2 in cultured rabbit aortic smooth muscle cells.

    abstract::The role of prostaglandin I2 (PGI2) in the control of DNA synthesis during the cell cycle was investigated in cultured rabbit aortic smooth muscle cells (SMC). SMC at confluency in the G0 state reached the S phase about 16 h after stimulation with serum, as judged by measurement of [3H]thymidine incorporation into DNA...


    pub_type: 杂志文章


    authors: Morisaki N,Kanzaki T,Motoyama N,Saito Y,Yoshida S

    更新日期:1988-06-01 00:00:00

  • Formation of atherosclerotic lesions is independent of eosinophils in male mice.

    abstract:BACKGROUND AND AIMS:Oxidation of low-density lipoprotein (LDL) and oxidized LDL-mediated activation of the innate immune system have been recognized as early key events during the pathogenesis of atherosclerosis. Recent evidence identified eosinophils as a major source of enzymatic lipid oxidation and suggested a poten...


    pub_type: 杂志文章


    authors: Hofheinz K,Seibert F,Ackermann JA,Dietel B,Tauchi M,Oszvar-Kozma M,Kühn H,Schett G,Binder CJ,Krönke G

    更新日期:2020-10-01 00:00:00

  • Combination therapy of statin with flavonoids rich extract from chokeberry fruits enhanced reduction in cardiovascular risk markers in patients after myocardial infraction (MI).

    abstract:UNLABELLED:Recent studies have shown, that chronic flavonoids treatment improves vascular function and cardiovascular remodeling by decreasing superoxide anion production as well as by increasing NO realize from endothelial cells. A progressive decrease in systolic blood pressure and reduction of low-density lipoprotei...


    pub_type: 杂志文章,随机对照试验


    authors: Naruszewicz M,Laniewska I,Millo B,Dłuzniewski M

    更新日期:2007-10-01 00:00:00

  • Impaired adaptive vascular growth in hypercholesterolemic rabbit.

    abstract::Occlusive arterial disease stimulates compensatory growth of pre-existent and new arterial channels which help to maintain organ perfusion. Previous studies characterizing compensatory or collateral vascular growth have been performed in normocholesterolemic animals. Because hyperlipidemic states alter vascular regula...


    pub_type: 杂志文章


    authors: Bucay M,Nguy J,Barrios R,Chen CH,Henry PD

    更新日期:1998-08-01 00:00:00

  • Impact of attenuated-signal plaque observed by intravascular ultrasound on vessel response after drug-eluting stent implantation.

    abstract:BACKGROUND AND AIMS:The aim of this study was to investigate the impact of attenuated-signal plaque (ASP) observed by intravascular ultrasound (IVUS) on vessel response after drug-eluting stent implantation. METHODS:Data were derived from the IVUS cohort of the J-DESsERT trial comparing paclitaxel- and sirolimus-eluti...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Kitahara H,Waseda K,Sakamoto K,Yamada R,Huang CC,Nakatani D,Sakata K,Kawarada O,Yock PG,Matsuyama Y,Yokoi H,Nakamura M,Muramatsu T,Nanto S,Fitzgerald PJ,Honda Y

    更新日期:2017-04-01 00:00:00

  • The age- and sex-specific composition of atherosclerotic plaques in vascular surgery patients.

    abstract:BACKGROUND AND AIMS:The sex- and age-related differences in the composition of iliofemoral atherosclerotic plaques are largely unknown. Therefore, the aim of the current study is to gain insight into plaque composition across strata of age and sex in a large cohort of vascular surgery patients. METHODS:Peripheral athe...


    pub_type: 杂志文章


    authors: de Bakker M,Timmerman N,van Koeverden ID,de Kleijn DPV,de Borst GJ,Pasterkamp G,Boersma E,den Ruijter HM

    更新日期:2020-10-01 00:00:00

  • Dose-response effect of single and combined clofibrate (Atromidin) and niceritrol (Perycit) treatment on serum lipids and lipoproteins in type II hyperlipoproteinaemia.

    abstract::The dose-response effects of clofibrate and niceritrol on serum cholesterol and triglycerides (TG) were studied in 29 patients with Type IIa and IIb hyperlipoproteinaemia. In 17 patients, clofibrate and niceritrol were then given as combined treatment, and the effects of this combination on serum lipoproteins were stu...


    pub_type: 临床试验,杂志文章


    authors: Olsson AG,Orö L,Rössner S

    更新日期:1975-07-01 00:00:00

  • Involvement of potassium channels in the protective effect of 17beta-estradiol on hypercholesterolemic rabbit carotid artery.

    abstract::The involvement of endothelium-derived hyperpolarizing factor (EDHF) in the protective effect of 17beta-estradiol was investigated on the phenylephrine-precontracted carotid artery from cholesterol fed rabbits. Animals were fed for 8 weeks as follows: control group, standard chow; (control+estradiol) group, standard c...


    pub_type: 杂志文章


    authors: Ghanam K,Ea-Kim L,Javellaud J,Oudart N

    更新日期:2000-09-01 00:00:00

  • APOE p.Leu167del mutation in familial hypercholesterolemia.

    abstract:BACKGROUND:Autosomal dominant hypercholesterolemia (ADH) is caused by mutations in the low density lipoprotein receptor (LDLR), its ligand apoB (APOB) or proprotein convertase subtilisin/kexin type 9 (PCSK9) genes. Yet DNA sequencing does not identify mutations in these genes in a significant number of cases, suggestin...


    pub_type: 杂志文章


    authors: Awan Z,Choi HY,Stitziel N,Ruel I,Bamimore MA,Husa R,Gagnon MH,Wang RH,Peloso GM,Hegele RA,Seidah NG,Kathiresan S,Genest J

    更新日期:2013-12-01 00:00:00

  • Metaformin: an antiatherosclerotic agent modifying very low density lipoproteins in rabbits.

    abstract::The composition of very low density lipoproteins (VLDL: d less than 1.019) of New Zealand male rabbits reciving cholesterol (2 g/day) and metformin (135 mg/kg/day) is investigated. These rabbits, while showing only a slight reduction of plasma cholesterol levels, as compared to cholesterol-fed (h.c.) animals, show a m...


    pub_type: 杂志文章


    authors: Sirtori CR,Catapano A,Ghiselli GC,Innocenti AL,Rodriguez J

    更新日期:1977-01-01 00:00:00

  • Lovastatin therapy in familial dysbetalipoproteinemia: effects on kinetics of apolipoprotein B.

    abstract::Familial dysbetalipoproteinemia is characterized by hyperlipidemia, increases in beta-migrating, very low density lipoproteins (beta-VLDL), and homozygosity for apolipoprotein E2 (apo E2). In this study, 3 patients with familial dysbetalipoproteinemia were treated with lovastatin, and kinetics for apolipoprotein B (ap...


    pub_type: 杂志文章


    authors: Vega GL,East C,Grundy SM

    更新日期:1988-03-01 00:00:00

  • Pulse wave velocity is associated with early clinical outcome after ischemic stroke.

    abstract:BACKGROUND AND PURPOSES:Pulse wave analysis (PWV), a marker of aortic stiffness, has independent predictive value for cardiovascular morbidity and mortality in both healthy and high-risk populations, especially fatal stroke, and for long-term functional stroke prognosis. Whether arterial stiffness and wave reflection a...


    pub_type: 杂志文章


    authors: Gąsecki D,Rojek A,Kwarciany M,Kowalczyk K,Boutouyrie P,Nyka W,Laurent S,Narkiewicz K

    更新日期:2012-12-01 00:00:00

  • Changes in aortic endothelial gene expressions and relaxation responses following chronic short-term insulin treatment in diabetic rats.

    abstract::The purpose of the present study was to examine the relationship between the changes in the expressions of several mRNAs and changes in endothelial function in streptozotocin-induced diabetic and chronic short-term insulin-treated rats. Aortas from later-stage (10 week) diabetics, but not those from their insulin-trea...


    pub_type: 杂志文章


    authors: Kobayashi T,Oishi K,Hayashi Y,Matsumoto T,Kamata K

    更新日期:2006-03-01 00:00:00

  • Plasma MR-proANP levels are associated with carotid intima-media thickness in the general community: the KORA F4 study.

    abstract:OBJECTIVE:Subjects with metabolic syndrome (MetS) and individuals with type 2 diabetes are at high risk for vascular complications. Hormones acting on vascular endothelium may be involved in the atherogenic process associated with metabolic disorders. The objective of this study was to determine the correlation of pro-...


    pub_type: 杂志文章


    authors: Then C,Kowall B,Lechner A,Meisinger C,Heier M,Koenig W,Peters A,Thiery J,Rathmann W,Seissler J

    更新日期:2013-10-01 00:00:00

  • Alterations in composition and concentration of lipoproteins and elevated cholesteryl ester transfer in non-insulin-dependent diabetes mellitus (NIDDM).

    abstract::Cholesteryl esters (CE) exchange between lipoproteins through the action of cholesteryl ester transfer protein (CETP). Situations at high risk for atherosclerosis are often accompanied by an accelerated net mass CE transfer (CET) from high density lipoproteins (HDL) to very low (VLDL) and low density lipoproteins (LDL...


    pub_type: 杂志文章


    authors: Elchebly M,Porokhov B,Pulcini T,Berthezène F,Ponsin G

    更新日期:1996-06-01 00:00:00

  • To statin or to non-statin in coronary disease--considering absolute risk is the answer.

    abstract::The newest guidelines for treating people with coronary artery disease (CAD) suggest benefit from statin-induced LDL cholesterol lowering regardless of baseline LDL cholesterol level. These guidelines were based on recent clinical trials that showed statistically significant statin-induced relative risk reductions (RR...


    pub_type: 杂志文章,评审


    authors: Rembold CM

    更新日期:2007-11-01 00:00:00