Specific enrichment of 2-arachidonoyl-lysophosphatidylcholine in carotid atheroma plaque from type 2 diabetic patients.

abstract：:Collagenous components were extracted from bovine aorta by pepsin digestion. Differential salt precipitations separated the interstitial from the basement membrane (BM) collagens, and the latter were subsequently separated into three distinct types. Ion exchange chromatography, SDS-slab gel electrophoresis, cyanogen b...

journal_title：Atherosclerosis

authors： Leushner JR,Haust MD

更新日期：1984-01-01 00:00:00

abstract：OBJECTIVE:To investigate the association of the endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine (ADMA) and coronary endothelial function. METHODS AND RESULTS:In 289 patients with coronary artery disease we assessed coronary endothelium-dependent and -independent vascular responses to intracoro...

journal_title：Atherosclerosis

authors： Maas R,Quitzau K,Schwedhelm E,Spieker L,Rafflenbeul W,Steenpass A,Lüscher TF,Böger RH

更新日期：2007-03-01 00:00:00

abstract：:Heritability of plasma apolipoprotein (apo) A-I, apo B, and low density lipoprotein (LDL) subclasses and concordance for lipoprotein(a) excess were assessed in 109 monozygotic (MZ) and 113 dizygotic (DZ) twin pairs participating in the third examination of the National Heart, Lung, and Blood Institute Twin Study. The ...

journal_title：Atherosclerosis

authors： Lamon-Fava S,Jimenez D,Christian JC,Fabsitz RR,Reed T,Carmelli D,Castelli WP,Ordovas JM,Wilson PW,Schaefer EJ

更新日期：1991-11-01 00:00:00

abstract：:Sex differences in incidence and prevalence of and morbidity and mortality from cardiovascular disease are well documented. However, many studies examining the genetic basis for cardiovascular disease fail to consider sex as a variable in the study design, in part, because there is an inherent difficulty in studying t...

journal_title：Atherosclerosis

authors： Winham SJ,de Andrade M,Miller VM

更新日期：2015-07-01 00:00:00

abstract：:Using a simple, standardized denaturing gradient gel electrophoresis (DGGE) based mutation screening technique, a novel G-to-A mutation in the last base of the intron 12 splice acceptor site of the LDL receptor gene was found in 2 Danish families with familial hypercholesterolemia (FH). The mutation is shown to result...

journal_title：Atherosclerosis

authors： Nissen H,Hansen AB,Guldberg P,Petersen NE,Hansen TS,Hørder M

更新日期：1997-01-03 00:00:00

abstract：:There is clear evidence of lipoprotein oxidation in atherosclerotic lesions. Animal studies and observational prospective human cohort studies have been interpreted as supporting a role for antioxidants in the prevention of coronary heart disease (CHD). However, firm recommendations to take antioxidant supplements to ...

journal_title：Atherosclerosis

authors： Kritharides L,Stocker R

更新日期：2002-10-01 00:00:00

abstract：OBJECTIVES:In chronic kidney disease (CKD), high FGF23 concentrations are associated with left ventricular hypertrophy (LVH), cardiovascular events, and death. The associations of FGF23 with left ventricular mass (LVM) and LVH in the general population and the influence of CKD remains uncertain. METHODS:C-terminal pla...

journal_title：Atherosclerosis

authors： Jovanovich A,Ix JH,Gottdiener J,McFann K,Katz R,Kestenbaum B,de Boer IH,Sarnak M,Shlipak MG,Mukamal KJ,Siscovick D,Chonchol M

更新日期：2013-11-01 00:00:00

abstract：AIM:The aim of the study was to determine if a high salt meal containing 65 mmol Na causes a rise in sodium concentrations and a reduction in plasma nitrate/nitrite concentrations (an index of nitric oxide production). Secondary aims were to determine the effects of a high salt meal on augmentation index (AIx) a measur...

journal_title：Atherosclerosis

authors： Dickinson KM,Clifton PM,Burrell LM,Barrett PH,Keogh JB

更新日期：2014-01-01 00:00:00

abstract：:Oscillatory shear stress applied to the lining of blood vessels causes endothelial cell injury, one of the essential postulated prerequisites to the development of atherosclerosis. The purpose of this investigation was to study effects of shear stress on bovine aortic endothelial cells (BAEC), in vitro, for varying le...

journal_title：Atherosclerosis

authors： Skarlatos SI,Hollis TM

更新日期：1987-03-01 00:00:00

abstract：:Inflammatory cytokines, including tumor necrosis factor-alpha (TNF-alpha) have been implicated in atherogenesis. However, the precise role of TNF-alpha in atherogenesis is still unclear. To examine the effect of TNF-alpha on atherogenesis, we generated compound-deficient mice in apolipoprotein E (apoE) and TNF-alpha (...

journal_title：Atherosclerosis

authors： Ohta H,Wada H,Niwa T,Kirii H,Iwamoto N,Fujii H,Saito K,Sekikawa K,Seishima M

更新日期：2005-05-01 00:00:00

abstract：OBJECTIVE:P-selectin is a cellular adhesion molecule that has been shown to be crucial in development of coronary heart disease (CHD). We sought to determine the role of P-selectin on the risk of atherosclerosis in a large multi-ethnic population. METHODS:Data from the Multi-Ethnic Study of Atherosclerosis (MESA), inc...

journal_title：Atherosclerosis

authors： Bielinski SJ,Berardi C,Decker PA,Kirsch PS,Larson NB,Pankow JS,Sale M,de Andrade M,Sicotte H,Tang W,Hanson NQ,Wassel CL,Polak JF,Tsai MY

更新日期：2015-05-01 00:00:00

abstract：:Vitamin K is involved in the biosynthesis of a number of blood coagulation factors and bone proteins. It has been suggested that the vitamin K requirement of bone tissue is higher than that of the liver. Here we report that in rats very high doses of vitamin K affected neither the blood coagulation characteristics nor...

journal_title：Atherosclerosis

authors： Ronden JE,Groenen-van Dooren MM,Hornstra G,Vermeer C

更新日期：1997-07-11 00:00:00

abstract：:The metabolism in vitro of exogenous and endogenous arachidonic acid was studied in circulating blood monocytes obtained from control (control group) and cholesterol (0.5%)-fed (cholesterol group) rabbits. The production of superoxide anion (O2-), tissue plasminogen activator (t-PA) and adherence of monocytes were ass...

journal_title：Atherosclerosis

authors： Saito H,Salmon JA,Moncada S

更新日期：1986-08-01 00:00:00

abstract：:Selected normal human arteries and veins were solubilized with detergents, neutral salt buffers and organic solvents. Comparative sodium dodecyl sulphate polyacrylamide gels and thin layer chromatographic plates were developed and the patterns compared. The low molecular weight periodic acid--Schiff positive band seen...

journal_title：Atherosclerosis

authors： Moore CR,Gilbert DB

更新日期：1980-03-01 00:00:00

abstract：:Methodological differences and variations in health care regulations among countries often preclude direct comparisons of cost-effectiveness studies. A projected risk model was applied, designed to determine the economic value in the United States of pravastatin in the secondary prevention of coronary heart disease (C...

journal_title：Atherosclerosis

authors： Muls E,Van Ganse E,Closon MC

更新日期：1998-04-01 00:00:00

abstract：OBJECTIVE:Atherosclerosis is the main underlying cause of the majority of cardiovascular events. Although cardiovascular diseases (CVD) are a major challenge in both males and females, gender specific differences in the prevalence of CVD have been observed. This may indicate that there are differences in the developmen...

journal_title：Atherosclerosis

authors： van den Oord SCH,van der Burg J,Akkus Z,Bosch JG,van Domburg RT,Sijbrands EJG,van der Steen AFW,Schinkel AFL

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:The complement system is involved in the pathogenic course of SLE. These patients exhibit metabolic disturbances in lipoprotein metabolism characterized by a pro-inflammatory status and an accelerated atherosclerosis. The aim of this study is to investigate whether levels of the complement are associated to ...

journal_title：Atherosclerosis

authors： Parra S,Vives G,Ferré R,González M,Guardiola M,Ribalta J,Castro A

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVE:Recent studies have suggested that circulating malondialdehyde-modified low-density lipoprotein (MDA-LDL) is a useful marker for the identification of patients with coronary artery disease (CAD). However, the role of MDA-LDL in atherogenic mechanisms has not yet been fully determined. METHOD AND RESULTS:We i...

journal_title：Atherosclerosis

authors： Miyazaki T,Shimada K,Sato O,Kotani K,Kume A,Sumiyoshi K,Sato Y,Ohmura H,Watanabe Y,Mokuno H,Daida H

更新日期：2005-03-01 00:00:00

abstract：:Obesity is commonly associated with high rates of cardiovascular disease (CVD). Weight loss in obese subjects reduces risk factors for CVD but this response is not uniform. Genetic factors could be involved in this variability. The 360His polymorphism of apolipoproteinA-IV (apoA-IV) influences the lipid response to fa...

journal_title：Atherosclerosis

authors： Heilbronn LK,Noakes M,Morris AM,Kind KL,Clifton PM

更新日期：2000-05-01 00:00:00

abstract：:Protein synthesis in smooth muscle cells from normal and atherosclerotic rabbit aortas was studied. Cultures of cells from the third passage were incubated with [3H]proline and the synthesis rates of collagen and total protein measured from the radioactivities incorporated into protein-bound hydroxyproline and proline...

journal_title：Atherosclerosis

authors： Pietilä K,Nikkari T

更新日期：1980-09-01 00:00:00

abstract：:The importance of platelets for cardiovascular disease was established as early as the 19th century. Their therapeutic inhibition stands alongside the biggest achievements in medicine. Still, certain aspects of platelet pathophysiology remain unclear. This includes platelet resistance to antiplatelet therapy and the c...

journal_title：Atherosclerosis

authors： Gutmann C,Joshi A,Mayr M

更新日期：2020-08-01 00:00:00

abstract：:The rates of cholesterol synthesis from acetate were studied in freshly isolated peripheral blood lymphocytes in 41 age- and sex-matched subjects with essentially normal serum lipid profiles. Insulin binding to erythrocytes obtained from the same blood samples was also studied simultaneously. From the data on lymphocy...

journal_title：Atherosclerosis

authors： Sanghvi A,Virji MA,Warty V,Dimasi MJ

更新日期：1983-12-01 00:00:00

abstract：BACKGROUND AND AIMS:We aimed at developing a novel risk prediction model for death from cardiovascular disease (CVD) for Chinese individuals, based upon a large cohort from Taiwan. METHODS:This Chinese cohort came from Taiwan, with 381,963 individuals free from CVD, recruited from a private health surveillance program...

journal_title：Atherosclerosis

authors： Hu WS,Lee JH,Tsai MK,Wen CP

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND AND AIMS:We recently showed that miR-223-3p on high-density lipoproteins (HDL) is exported to endothelial cells, where it inhibits inflammation. However, the origin of miR-223-3p on HDL is unknown. We hypothesize that HDL-associated miR-223-3p originates in myeloid cells and is exported to HDL in a scavenger...

journal_title：Atherosclerosis

authors： Cuesta Torres LF,Zhu W,Öhrling G,Larsson R,Patel M,Wiese CB,Rye KA,Vickers KC,Tabet F

更新日期：2019-07-01 00:00:00

abstract：:The defects in the internal elastic lamina (IEL) have been proposed to be important for the migration of smooth muscle cells into the intima during atherosclerosis. We investigated the association of a genetic factor--apolipoprotein E (apoE) genotype--with the number of gaps in the IEL of the artery wall in 123 consec...

journal_title：Atherosclerosis

authors： Ilveskoski E,Järvinen O,Sisto T,Karhunen PJ,Laippala P,Lehtimäki T

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Oxidation of low-density lipoprotein (LDL) and oxidized LDL-mediated activation of the innate immune system have been recognized as early key events during the pathogenesis of atherosclerosis. Recent evidence identified eosinophils as a major source of enzymatic lipid oxidation and suggested a poten...

journal_title：Atherosclerosis

authors： Hofheinz K,Seibert F,Ackermann JA,Dietel B,Tauchi M,Oszvar-Kozma M,Kühn H,Schett G,Binder CJ,Krönke G

更新日期：2020-10-01 00:00:00

abstract：:Self-administration of anabolic-androgenic steroids to increase muscular strength and lean body mass has been used widely among athletes. Flow mediated dilatation (FMD) determined by ultrasound of the brachial artery is accepted as both an in vivo index of endothelial function and an indicator for future atheroscleros...

journal_title：Atherosclerosis

authors： Ebenbichler CF,Sturm W,Gänzer H,Bodner J,Mangweth B,Ritsch A,Sandhofer A,Lechleitner M,Föger B,Patsch JR

更新日期：2001-10-01 00:00:00

abstract：:The effect of guar (15.6 g/day), a dietary fibre, and simultaneous administration of bezafibrate (600 mg/day) during dietetic treatment on the plasma lipoproteins and apolipoproteins was investigated in 12 patients with familial hypercholesterolemia (corresponding to the HLP type IIa pattern). Either bezafibrate alone...

journal_title：Atherosclerosis

authors： Wirth A,Middelhoff G,Braeuning C,Schlierf G

更新日期：1982-12-01 00:00:00

abstract：OBJECTIVE:Recent studies have revealed that sequence variation on chromosome 9p21 is a major genetic determinant for coronary heart disease and stroke, however, the underlying mechanism remains unknown. This genomic region contains the gene encoding cyclin-dependent kinase 2A, a regulator of proliferation and different...

journal_title：Atherosclerosis

authors： Ye S,Willeit J,Xiao Q,Motterle A,Laxton RC,Oberhollenzer F,Kiechl S,Xu Q

更新日期：2010-02-01 00:00:00

abstract：:Oxidation of low density lipoprotein (LDL) is implicated in the pathogenesis of atherosclerosis. In this study the susceptibility to oxidation of LDL (from patients with atherosclerosis) is related to the progression of the disease. LDL were isolated from 37 patients with demonstrable atherosclerotic plaques. The susc...

journal_title：Atherosclerosis

authors： Andrews B,Burnand K,Paganga G,Browse N,Rice-Evans C,Sommerville K,Leake D,Taub N

更新日期：1995-01-06 00:00:00