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Experimental atherosclerosis of the heart valves in rats following a long-term atherogenic regimen.

Abstract：

:Male and female rats kept on a long-term atherogenic regimen for periods up to 15 months developed marked atherosclerotic changes of cardiac valves in 100% of cases. The degree and the topography of valvular atherosclerotic plaques corresponded widely to that seen in human atherosclerotic valvular disease. The regular topography of atherosclerotic valvular lesions was believed to be primarily due to differences in blood pressure as occurring during cardiac performance. Histologically, there was a striking contrast between the uniform composition of atheromatous plaques as found on the valves and the variability in composition of aortic atheromas.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Záhor Z,Czabanová V

doi

10.1016/0021-9150(77)90023-5

subject

Has Abstract

pub_date

1977-05-01 00:00:00

pages

49-57

issue

1

eissn

0021-9150

issn

1879-1484

pii

0021-9150(77)90023-5

journal_volume

27

pub_type

杂志文章

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