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Calculation of LDL apoB.

Abstract：

OBJECTIVES:This study tests the validity of the Hattori formula to calculate LDL apoB based on plasma lipids and total apoB. METHODS:In 2178 patients in a tertiary care lipid clinic, LDL apoB calculated as suggested by Hattori et al. was compared to directly measured LDL apoB isolated by ultracentrifugation. RESULTS:In subjects with plasma triglycerides ≥ 3.0 mmol/L, there was considerable discordance between calculated and measured LDL apoB. In all others, the relation between measured LDL apoB and calculated LDL apoB could be expressed as LDL apoB = 0.86 [total apoB - 0.9 TC (mg/dL) + 0.09 HDL-C (mg/dL) - 0.08 TG (mg/dL)] - 7.0 (r > 0.91; P < 0.0001). CONCLUSIONS:Our results indicate that LDL apoB can be calculated with reasonable accuracy when triglycerides are <3.0 mmol/L. However, the calculation suggested by Hattori et al. should be corrected based on the regression demonstrated between calculated and measured LDL apoB in subjects with a plasma triglyceride <3.0 mmol/L.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Sniderman AD,Tremblay AJ,De Graaf J,Couture P

doi

10.1016/j.atherosclerosis.2014.03.012

subject

Has Abstract

pub_date

2014-06-01 00:00:00

pages

373-6

issue

2

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(14)00161-0

journal_volume

234

pub_type

杂志文章

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