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Dectin-1 deficiency does not affect atherosclerosis development in mice.

Abstract：

OBJECTIVE:Recent data suggest the involvement of dectin-1 in atherosclerosis through regulation of local reactive oxygen species production. The aim of the current study was to assess the effect of dectin-1 deficiency on atherosclerotic plaque development. METHODS:Using immunohistochemistry dectin-1 expression was observed on foamy macrophages in atherosclerotic lesions in mice. Following lethal irradiation LDLR(-/-) mice were reconstituted with bone marrow from either wild type or dectin-1(-/-) mice. After recovery, mice were fed a high fat diet for 9 weeks and atherosclerotic lesions were analyzed. RESULTS AND CONCLUSION:Overall, we found no significant differences in plaque size or severity between the groups. Also no differences were observed in granulocyte or macrophage composition of the plaques or in the ability to produce reactive oxygen species by macrophages from both groups. Dectin-1 is dispensable for the development of atherosclerotic lesions in mice.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Szilagyi K,Gijbels MJ,van der Velden S,Heinsbroek SE,Kraal G,de Winther MP,van den Berg TK

doi

10.1016/j.atherosclerosis.2015.02.005

subject

Has Abstract

pub_date

2015-04-01 00:00:00

pages

318-21

issue

2

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(15)00092-1

journal_volume

239

pub_type

杂志文章

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