The influence of exercise on postprandial triacylglycerol metabolism.

Abstract:

:Trained people exhibit low plasma concentrations of triacylglcyeride (TAG) in both fasted and postprandial states. This mainly reflects enhanced uptake of TAG into skeletal muscle, via enhanced activity of lipoprotein lipase, the rate-limiting step in TAG removal. Endurance athletes possess a large, well-vascularised muscle mass and this may contribute through the increased availability of endothelial binding sites for LPL. However, each session of exercise stimulates a delayed increase in LPL activity so that prior exercise enhances uptake into muscle. Intramuscular TAG is one source of energy for muscular contraction so this may serve to replenish muscle nutrient stores which have been diminished by exercise. Regular, frequent aerobic exercise may oppose the atherogenic disturbances to lipoprotein metabolism evident during the postprandial period. It may also, by favouring the disposition of dietary fatty acids in muscle, improve the matching of fat oxidation to fat intake and hence help with maintenance of a desirable level of body fatness.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Hardman AE

doi

10.1016/s0021-9150(98)00225-1

subject

Has Abstract

pub_date

1998-12-01 00:00:00

pages

S93-100

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(98)00225-1

journal_volume

141 Suppl 1

pub_type

杂志文章,评审
  • Serum vitamin D, parathyroid hormone levels, and carotid atherosclerosis.

    abstract::Evidence suggests low vitamin D and elevated parathyroid hormone (PTH) concentrations may increase risk for cardiovascular disease. However, little is known about the association between vitamin D or PTH and subclinical atherosclerosis. This cross-sectional study included 654 community-dwelling older adults aged 55-96...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2009.05.030

    authors: Reis JP,von Mühlen D,Michos ED,Miller ER 3rd,Appel LJ,Araneta MR,Barrett-Connor E

    更新日期:2009-12-01 00:00:00

  • Oral exposure to acrolein exacerbates atherosclerosis in apoE-null mice.

    abstract:BACKGROUND:Acrolein is a dietary aldehyde that is present in high concentrations in alcoholic beverages and foods including cheese, donuts and coffee. It is also abundant in tobacco smoke, automobile exhaust and industrial waste and is generated in vivo during inflammation and oxidative stress. OBJECTIVES:The goal of ...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2011.01.001

    authors: Srivastava S,Sithu SD,Vladykovskaya E,Haberzettl P,Hoetker DJ,Siddiqui MA,Conklin DJ,D'Souza SE,Bhatnagar A

    更新日期:2011-04-01 00:00:00

  • Characterization of atherosclerosis in a patient with familial high-density lipoprotein deficiency.

    abstract::We describe the cardiovascular state of a 60-year-old homozygous patient with familial HDL deficiency (Tangier disease). The patient was examined by coronary angiography and intravascular ultrasound because of chest pain at rest and on exertion. We found a normal left ventricular function, moderately diffuse coronary ...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(94)90205-4

    authors: Walter M,Kerber S,Fechtrup C,Seedorf U,Breithardt G,Assmann G

    更新日期:1994-10-01 00:00:00

  • Induction of calcification in rabbit aortas by high cholesterol diets: roles of calcifiable vesicles in dystrophic calcification.

    abstract::Atherosclerotic calcification may weaken the aorta wall and thereby lead to rupture of the vessel. The mechanism whereby aortas undergo calcification remains unclear. Previous reports in this laboratory showed that, after 2 months of cholesterol-supplemental feeding, an increase in calcifiability of membrane vesicles ...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/s0021-9150(01)00623-2

    authors: Hsu HH,Camacho NC,Tawfik O,Sun F

    更新日期:2002-03-01 00:00:00

  • Effects of dietary intervention and n-3 PUFA supplementation on markers of gut-related inflammation and their association with cardiovascular events in a high-risk population.

    abstract:BACKGROUND & AIMS:Dysbiosis of the gut microbiota is associated with increased levels of circulating lipopolysaccharide (LPS) and subsequent activation of systemic inflammation. Diet is an important modulator of the gut microbiome. We aimed to investigate whether circulating markers of gut-related inflammation, LPS bin...

    journal_title:Atherosclerosis

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.atherosclerosis.2019.05.004

    authors: Awoyemi A,Trøseid M,Arnesen H,Solheim S,Seljeflot I

    更新日期:2019-07-01 00:00:00

  • Network analysis reveals a causal role of mitochondrial gene activity in atherosclerotic lesion formation.

    abstract:BACKGROUND AND AIMS:Mitochondrial damage and augmented production of reactive oxygen species (ROS) may represent an intermediate step by which hypercholesterolemia exacerbates atherosclerotic lesion formation. METHODS:To test this hypothesis, in mice with severe but genetically reversible hypercholesterolemia (i.e. th...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2017.10.019

    authors: Vilne B,Skogsberg J,Foroughi Asl H,Talukdar HA,Kessler T,Björkegren JLM,Schunkert H

    更新日期:2017-12-01 00:00:00

  • Sulforaphane inhibits restenosis by suppressing inflammation and the proliferation of vascular smooth muscle cells.

    abstract:OBJECTIVE:Sulforaphane, a naturally occurring organosulfur compound in broccoli, has chemopreventive properties in cancer. However, the effects of sulforaphane in vascular diseases have not been examined. We therefore aimed to investigate the effects of sulforaphane on vascular smooth muscle cell (VSMC) proliferation a...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2012.07.040

    authors: Kwon JS,Joung H,Kim YS,Shim YS,Ahn Y,Jeong MH,Kee HJ

    更新日期:2012-11-01 00:00:00

  • Reduced systemic inflammatory response to implantation of sirolimus-eluting stents in patients with stable coronary artery disease.

    abstract::Stent implantation causes significant injury to the vascular wall, resulting in inflammatory activation. Although sirolimus-eluting stents (SES) have anti-inflammatory properties, their effect on periprocedural systemic inflammatory response has not been sufficiently investigated. Eighty-one patients with stable coron...

    journal_title:Atherosclerosis

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.atherosclerosis.2006.08.029

    authors: Kochiadakis GE,Marketou ME,Arfanakis DA,Sfiridaki K,Skalidis EI,Igoumenidis NE,Hamilos MI,Kolyvaki S,Chlouverakis G,Kantidaki E,Castanas E,Vardas PE

    更新日期:2007-10-01 00:00:00

  • Bradykinin stimulates endothelial cell fatty acid oxidation by CaMKK-dependent activation of AMPK.

    abstract::Endothelial cell lipotoxicity mediated by accumulation of free fatty acids is an early event in the pathogenesis of atherosclerosis. The energy-sensor AMP-activated protein kinase (AMPK) is a key regulator of endothelial cell lipid metabolism. To test the hypothesis that bradykinin (BK) regulates AMPK and fatty acid o...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2007.12.003

    authors: Mount PF,Lane N,Venkatesan S,Steinberg GR,Fraser SA,Kemp BE,Power DA

    更新日期:2008-09-01 00:00:00

  • Acidic glycosaminoglycan, lipid and water contents in human coronary arterial branches.

    abstract::The acidic glycosaminoglycans (AGAG) of the human coronary arterial tree (the main left and right branches and their distal portions) were analyzed by enzymatic methods employing chondroitinases, hyaluronidase and heparitinase. The AGAG content of human coronary arteries was highest in the left branch, intermediate in...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(82)90171-x

    authors: Murata K,Yokoyama Y

    更新日期:1982-10-01 00:00:00

  • HbA1c is significantly associated with arterial stiffness but not with carotid atherosclerosis in a community-based population without type 2 diabetes: The Dong-gu study.

    abstract:OBJECTIVES:We examined the associations between HbA1c levels and various atherosclerotic vascular parameters among adults without diabetes from the general population. METHODS:A total of 6500 community-dwelling adults, who were free of type 2 diabetes and ≥50 years of age, were included. High-resolution B-mode ultraso...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2016.01.032

    authors: Lee YH,Shin MH,Choi JS,Rhee JA,Nam HS,Jeong SK,Park KS,Ryu SY,Choi SW,Kim BH,Oh GJ,Kweon SS

    更新日期:2016-04-01 00:00:00

  • Type 1 diabetes increases retention of low-density lipoprotein in the atherosclerosis-prone area of the murine aorta.

    abstract:BACKGROUND AND AIMS:Individuals with type 1 diabetes mellitus are at high risk of developing atherosclerotic cardiovascular disease, but the underlying mechanisms by which type 1 diabetes accelerates atherosclerosis remain unknown. Increased retention of low-density lipoprotein (LDL) in atherosclerosis-prone sites of t...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2017.05.019

    authors: Hagensen MK,Mortensen MB,Kjolby M,Stillits NL,Steffensen LB,Bentzon JF

    更新日期:2017-08-01 00:00:00

  • Serum β-carotene and the risk of sudden cardiac death in men: a population-based follow-up study.

    abstract:OBJECTIVES:To examine whether serum concentrations of carotenoids are related to the risk of sudden cardiac death (SCD) in middle-aged men. METHODS:The study population consisted of 1031 Finnish men aged 46-65 years of the Kuopio Ischemic Heart Disease Risk Factor (KIHD) cohort. Serum concentrations of carotenoids wer...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2012.10.077

    authors: Karppi J,Laukkanen JA,Mäkikallio TH,Ronkainen K,Kurl S

    更新日期:2013-01-01 00:00:00

  • Psychological stress impairs ischemia-induced neovascularization: Protective effect of fluoxetine.

    abstract:BACKGROUND:Psychological stress (PS) has been associated with the development of cardiovascular diseases and adverse long-term outcomes after ischemic events. However, the precise mechanisms involved are not completely understood. Here we investigated the effect of PS on ischemia-induced neovascularization, and the pot...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2015.06.010

    authors: Maingrette F,Dussault S,Dhahri W,Desjarlais M,Mathieu R,Turgeon J,Haddad P,Groleau J,Perez G,Rivard A

    更新日期:2015-08-01 00:00:00

  • Aortic glutathione metabolic status: time-dependent alterations in fat-fed rabbits.

    abstract::Little is known about the vascular metabolic status of glutathione (GSH), which is crucial in cell antioxidant protection, in experimental conditions like high-fat diet-induced atherosclerosis. This issue was, therefore, investigated in two groups of seven rabbits fed a 0.5% cholesterol-, 5% lard- and 5% peanut oil-en...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2003.11.014

    authors: Lapenna D,Pierdomenico SD,Ciofani G,Giamberardino MA,Cuccurullo F

    更新日期:2004-03-01 00:00:00

  • Comparison of the metabolism of [1,2,6,7-3H(N)]cholesteryl oleate, cholesteryl [9,10-3H]oleate, and cholesteryl [1-14C]oleate labeled lipoproteins in the rat.

    abstract::The intravascular metabolism of sterol labeled [1,2,6,7-3H(N)]cholesteryl oleate and acyl labeled cholesteryl [9,10-3H]oleate and cholesteryl [1-14C]oleate was compared in the rat, an animal species without plasma cholesteryl ester transfer activity (CETA). In a first series of studies, the metabolism of sterol labele...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(94)90125-2

    authors: Terpstra AH

    更新日期:1994-04-01 00:00:00

  • Genetic variation at the PCSK9 locus moderately lowers low-density lipoprotein cholesterol levels, but does not significantly lower vascular disease risk in an elderly population.

    abstract::Caucasian carriers of the T allele at R46L in the proprotein convertase subtilisin/kexin type 9 (PCSK9) locus have been reported to have 15% lower low-density lipoprotein (LDL) cholesterol (C) levels and 47% lower coronary heart disease (CHD) risk. Our objective was to examine two PCSK9 single nucleotide polymorphisms...

    journal_title:Atherosclerosis

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.atherosclerosis.2007.12.005

    authors: Polisecki E,Peter I,Robertson M,McMahon AD,Ford I,Packard C,Shepherd J,Jukema JW,Blauw GJ,Westendorp RG,de Craen AJ,Trompet S,Buckley BM,Murphy MB,Ordovas JM,Schaefer EJ,PROSPER Study Group.

    更新日期:2008-09-01 00:00:00

  • Rapid and substantial lowering of human serum cholesterol by mevinolin (MK-803), an inhibitor of hydroxymethylglutaryl-coenzyme A reductase.

    abstract::Mevinolin (MK-803) is a potent inhibitor of HMG-CoA reductase. After a placebo run-in period, mevinolin 5,15 or 50 mg, or placebo was given twice daily for 7-11 days under double -blind conditions ot 4 groups of 6 normocholesterolemic male volunteers. After 7 days, mean serum cholesterol fell 14%, 25% and 24% on 5, 15...

    journal_title:Atherosclerosis

    pub_type: 临床试验,杂志文章

    doi:10.1016/0021-9150(82)90070-3

    authors: Tobert JA,Hitzenberger G,Kukovetz WR,Holmes IB,Jones KH

    更新日期:1982-01-01 00:00:00

  • Physico-chemical properties of cholesterol-fed rabbit beta-VLDL are not affected by different dietary oils.

    abstract::Various oils have been used as vehicles for cholesterol in diets used to produce atherosclerosis in rabbits. Because such oils may affect the physico-chemical properties of the beta-VLDL produced in response to cholesterol feeding, we have studied the physico-chemical characteristics of beta-VLDL isolated from cholest...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(89)90107-x

    authors: Waugh DA,Tercyak AM,Small DM

    更新日期:1989-04-01 00:00:00

  • Augmented levels of CD44 in macrophages from atherosclerotic subjects: a possible IL-6-CD44 feedback loop?

    abstract::The cell-adhesion molecule CD44 likely participates in atherosclerosis development. We have shown previously that pro-inflammatory cytokines affect CD44 expression. Therefore, this work examined the role of elevated CD44 levels in human macrophages. Macrophages from human atherosclerotic subjects (n=15) showed elevate...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2006.03.020

    authors: Hägg D,Sjöberg S,Hultén LM,Fagerberg B,Wiklund O,Rosengren A,Carlsson LM,Borén J,Svensson PA,Krettek A

    更新日期:2007-02-01 00:00:00

  • New atherosclerosis risk factors in obese, hypertensive and diabetic children and adolescents.

    abstract:UNLABELLED:In the last few years it has been proved that risk factors for atherosclerosis are present in children and adolescents, and that already at this early age they are connected with anatomic, atheromatous changes in vessels. These changes can not be fully explained as occurring in young people exhibiting tradit...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/s0021-9150(03)00003-0

    authors: Glowinska B,Urban M,Koput A,Galar M

    更新日期:2003-04-01 00:00:00

  • Genome-wide meta-analysis identifies novel loci of plaque burden in carotid artery.

    abstract:BACKGROUND AND AIMS:Carotid artery plaque is an established marker of subclinical atherosclerosis and common patho-mechanisms with coronary artery disease (CAD) are hypothesized. We aimed to identify genetic variants associated with carotid plaque and to examine the potential shared genetic basis with CAD. METHODS:Aft...

    journal_title:Atherosclerosis

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.atherosclerosis.2017.02.018

    authors: Pott J,Burkhardt R,Beutner F,Horn K,Teren A,Kirsten H,Holdt LM,Schuler G,Teupser D,Loeffler M,Thiery J,Scholz M

    更新日期:2017-04-01 00:00:00

  • Anti-inflammatory agents in experimental atherosclerosis. Part 2. Failure of antihypertensive drugs to exacerbate atherosclerotic plaque formation.

    abstract::Hypertension is associated with an increased incidence of generalized vascular disease. Antihypertensive drug therapy, while decreasing overall mortality due to cerebral hemorrhage, myocardial hypertrophy or renal failure, paradoxically does not appear to reduce the incidence of coronary atherosclerosis. This study in...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(77)90143-5

    authors: Bailey JM,Randazzo R

    更新日期:1977-01-01 00:00:00

  • Angiotensin-converting enzyme gene polymorphism and common carotid stiffness. The Rotterdam study.

    abstract::The insertion/deletion (I/D) polymorphism of the ACE gene may be involved in structural arterial changes. Aim of the present study was to assess the relationship between the ACE I/D gene and vessel wall stiffness among older adults. The study was conducted within the Rotterdam study, a population-based cohort study in...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2004.01.012

    authors: Mattace-Raso FU,van der Cammen TJ,Sayed-Tabatabaei FA,van Popele NM,Asmar R,Schalekamp MA,Hofman A,van Duijn CM,Witteman JC

    更新日期:2004-05-01 00:00:00

  • Homocysteine content of lipoproteins in hypercholesterolemia.

    abstract::In order to study the connection between homocysteine and lipid metabolism in atherosclerosis, homocysteine was determined in lipoprotein fractions from men with hypercholesterolemia. All lipoprotein fractions contain a considerably higher level of homocysteine in hypercholesterolemia, compared to normolipemic men, va...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(91)90257-4

    authors: Olszewski AJ,McCully KS

    更新日期:1991-05-01 00:00:00

  • Prevention of oxLDL uptake leads to decreased atherosclerosis in hematopoietic NPC1-deficient Ldlr-/- mice.

    abstract:BACKGROUND AND AIMS:Atherosclerosis is a chronic inflammatory disease of medium and large vessels and is typically characterized by the predominant accumulation of low-density lipoprotein (LDL)-cholesterol inside macrophages that reside in the vessel walls. Previous studies clearly demonstrated an association specifica...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2016.10.038

    authors: Jeurissen MLJ,Walenbergh SMA,Houben T,Gijbels MJJ,Li J,Hendrikx T,Oligschlaeger Y,van Gorp PJ,Binder CJ,Donners MMPC,Shiri-Sverdlov R

    更新日期:2016-12-01 00:00:00

  • Increased lipid peroxidation as a mechanism of methionine-induced atherosclerosis in rabbits.

    abstract::Methionine is converted by the transmethylation/transsulfuration pathway to homocysteine which may exert atherogenic effects by several mechanisms, including lipid peroxidation. Therefore, the excessive dietary methionine may induce the development of atherosclerosis. To test this hypothesis, plasma and aortic thiobar...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(94)05516-l

    authors: Toborek M,Kopieczna-Grzebieniak E,Drózdz M,Wieczorek M

    更新日期:1995-06-01 00:00:00

  • Galectin-3 binding protein, coronary artery disease and cardiovascular mortality: Insights from the LURIC study.

    abstract:BACKGROUND AND AIMS:Galectin-3 binding protein (Gal-3BP) has been associated with inflammation and cancer, however, its role in coronary artery disease (CAD) and cardiovascular outcome remains unclear. METHODS:Gal-3BP plasma levels were measured by ELISA in 2922 individuals from the LURIC study (62.7 ± 10.6 years, 62....

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2017.03.031

    authors: Gleissner CA,Erbel C,Linden F,Domschke G,Akhavanpoor M,Helmes CM,Doesch AO,Kleber ME,Katus HA,Maerz W

    更新日期:2017-05-01 00:00:00

  • High-density lipoproteins induce miR-223-3p biogenesis and export from myeloid cells: Role of scavenger receptor BI-mediated lipid transfer.

    abstract:BACKGROUND AND AIMS:We recently showed that miR-223-3p on high-density lipoproteins (HDL) is exported to endothelial cells, where it inhibits inflammation. However, the origin of miR-223-3p on HDL is unknown. We hypothesize that HDL-associated miR-223-3p originates in myeloid cells and is exported to HDL in a scavenger...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2019.04.227

    authors: Cuesta Torres LF,Zhu W,Öhrling G,Larsson R,Patel M,Wiese CB,Rye KA,Vickers KC,Tabet F

    更新日期:2019-07-01 00:00:00

  • Influence of specific mutations at the LDL-receptor gene locus on the response to simvastatin therapy in Afrikaner patients with heterozygous familial hypercholesterolaemia.

    abstract::Simvastatin, an inhibitor of HMG CoA reductase, lowers the plasma total cholesterol and LDL-cholesterol concentration in familial hypercholesterolemic patients. The efficacy of the drug shows considerable inter-individual variation, however. In this study we have assessed the influence of certain LDL-receptor gene mut...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(93)90222-g

    authors: Jeenah M,September W,Graadt van Roggen F,de Villiers W,Seftel H,Marais D

    更新日期:1993-01-04 00:00:00