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Coronary artery disease in heterozygous familial hypercholesterolemia.

Abstract：

:Serum lipids, lipoproteins and Achilles tendon thickness in 52 patients with heterozygous familial hypercholesterolemia (FH) were investigated in order to clarify what are the important factors for the development of coronary artery disease (CAD) in heterozygous FH patients. There were no significant differences in the average concentration of total cholesterol and triglyceride between the patients with and those without CAD. The HDL cholesterol (HDL-C) level was significantly lower in patients with CAD than in those without, and the HDL-C value was within the normal range in most of the patients with heterozygous FH, if not associated with CAD. Although most of the males aged over 50 years had CAD and a decreased level of HDL-C, many of the aged females were without signs of CAD. The HDL-C value of heterozygous FH patients with CAD was significantly lower compared with the age-matched group without CAD. The Achilles tendon was thicker in patients with CAD than in those without CAD, both for males and females, although it was less closely correlated with the incidence of CAD than HDL-C or the atherogenic index. A forecast concerning the development of CAD in heterozygous FH may be possible if we consider multiple parameters, such as HDL-C, atherogenic index, Achilles tendon thickness, etc.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Hirobe K,Matsuzawa Y,Ishikawa K,Tarui S,Yamamoto A,Nambu S,Fujimoto K

doi

10.1016/0021-9150(82)90114-9

subject

Has Abstract

pub_date

1982-08-01 00:00:00

pages

201-10

issue

2

eissn

0021-9150

issn

1879-1484

pii

0021-9150(82)90114-9

journal_volume

44

pub_type

杂志文章

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