Abstract:
OBJECTIVE:Peritoneal macrophages are used in many studies related to atherosclerosis. In situ, they are non-adherent and upon culturing, they adhere and function as scavengers of modified lipoproteins and dead apoptotic cells. They also produce growth factors, suggesting that they may provide life-supporting function as well. In this study, we propose that macrophage adherence plays a major role in their function and propose a novel concept that non-adherent macrophages are poor scavengers and may delay the process of apoptosis by secretion of growth factors. METHODS AND RESULTS:We analyzed non-adherent and adherent macrophages for changes in receptor expression, growth factor production and function by microarrays, real-time PCR, and western blot analyses. Our results indicate that adherent macrophages have increased expression of scavenger receptors as compared to fresh peritoneal cells. While genes for many growth factors were expressed in both non-adherent and adherent macrophages, the milk fat globule-epidermal growth factor 8 protein (MFG-E8) that recognizes and takes up apoptotic cells was specifically enhanced in non-adherent cells. Furthermore, early apoptotic endothelial cells demonstrated signs of delayed apoptosis when incubated in the presence of peritoneal lavage fluid that was shown to contain MFG-E8. Functional arrays indicated that peritoneal non-adherent macrophages represent a class of macrophages, distinct from either blood monocytes or adherent cultured macrophages. CONCLUSIONS:These results suggest that the adherence status of macrophages may play a major role in their functions.
journal_name
Atherosclerosisjournal_title
Atherosclerosisauthors
Selvarajan K,Moldovan L,Chandrakala AN,Litvinov D,Parthasarathy Sdoi
10.1016/j.atherosclerosis.2011.09.014subject
Has Abstractpub_date
2011-12-01 00:00:00pages
475-83issue
2eissn
0021-9150issn
1879-1484pii
S0021-9150(11)00918-Xjournal_volume
219pub_type
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