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ACE inhibition with perindopril and biomarkers of atherosclerosis and thrombosis: results from the PERTINENT study.

Abstract：

:The PERTINENT study measured biomarkers of atherosclerosis and thrombosis in a stable coronary artery disease population from EUROPA receiving ACE inhibition with perindopril 8 mg/day or placebo. Biomarkers of inflammation, C-reactive protein (CRP), fibrinogen, and tumor necrosis factor-alpha (TNF-alpha), and a biomarker of thrombosis, D-dimer, were measured at baseline and 1 year. CRP was recorded in 1157 patients; fibrinogen, TNF-alpha, and D-dimer in 291 patients. There was no significant effect of treatment on CRP or fibrinogen. In contrast, there were significant reductions in TNF-alpha (27.60-25.20 pg/mL; P<0.05) and D-dimer (0.24-0.18 microg/mL; P<0.05) with perindopril over 1 year. Survival analysis of the prognostic significance of baseline CRP failed to detect a significant role for the prediction of cardiovascular events over 4 years (lower versus higher tertile: 1.54; 95% confidence interval 0.88-2.68; P=0.16). In conclusion, in the PERTINENT trial, we observed significant effects of ACE inhibition on biomarkers of the atherothrombotic complications (D-dimer) and the proinflammatory cytokine TNF-alpha, but not on biomarkers of inflammation associated with atherosclerosis (CRP and fibrinogen).

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Ceconi C,Fox KM,Remme WJ,Simoons ML,Deckers JW,Bertrand M,Parrinello G,Kluft C,Blann A,Cokkinos D,Ferrari R

doi

10.1016/j.atherosclerosis.2008.08.042

subject

Has Abstract

pub_date

2009-05-01 00:00:00

pages

273-5

issue

1

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(08)00611-4

journal_volume

204

pub_type

杂志文章,多中心研究,随机对照试验

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