The dyslipoproteinemias of diabetes.

abstract：:We examined the interactive effect of oxidized low density lipoprotein (LDL) and ascorbic acid on collagen production in cultured smooth muscle cells (SMCs). Porcine aortic SMCs were incubated with 50-200 micrograms/ml of human LDL with/without 5 microM Cu2+ for 24 h. Collagen production was assayed by successive salt...

journal_title：Atherosclerosis

authors： Jimi S,Saku K,Uesugi N,Sakata N,Takebayashi S

更新日期：1995-07-01 00:00:00

abstract：:A soluble form of endoglin (sEng) is known to be an extracellular domain of the full-length membrane endoglin, which is elevated during various pathological conditions related to vascular endothelium. In the current review, we tried to summarize a possible role of soluble endoglin in cardiovascular pathologies, focusi...

journal_title：Atherosclerosis

authors： Rathouska J,Jezkova K,Nemeckova I,Nachtigal P

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVE:Genomewide association studies (GWAS), conventional association studies and the characterization of families with ApoA5 deficiency have shown that variation in the apolipoprotein A5 (APOA5) gene is associated with plasma triglyceride levels. The aim of this study was to determine the frequency of rare variant...

journal_title：Atherosclerosis

authors： Evans D,Aberle J,Beil FU

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Risk factors of cardiovascular disease such as lipid aberrations, hypertension, abdominal adiposity and elevations in systemic inflammation, are prominent aetiologies in hyperlipidemia. Supplementation with n-3 PUFA is associated with a reduction in cardiovascular events through its hypotriglyceridemic, anti...

journal_title：Atherosclerosis

authors： Micallef MA,Garg ML

更新日期：2009-06-01 00:00:00

abstract：:Lipoprotein dynamics are complex during the postprandial state. A significant rise in chylomicron concentration is associated with increased competition for LPL with VLDL particles. This results in an increased concentration of large VLDL. The concentration of small VLDL is reduced as a result of diminished conversion...

journal_title：Atherosclerosis

authors： Hugh P,Barrett R

更新日期：1998-12-01 00:00:00

abstract：OBJECTIVE:Pravastatin has been reported to elevate circulating adiponectin levels in patients with various insulin resistant state, hypertension, coronary artery disease, and hypercholesterolemia. This study aimed to evaluate whether pravastatin increase serum total and high molecular weight adiponectin levels and impr...

journal_title：Atherosclerosis

authors： Kim JH,Lee MR,Shin JA,Lee SS,Lee JM,You SJ,Yoon KH,Chang SA

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVE:The cluster of differentiation-1d (CD1d) recognizes and presents the lipid antigens to NK-T lymphocytes. Atherosclerotic lesions contain atherogenic lipids, mainly cholesterol and its oxides. Peroxisome proliferator-activated receptor-γ (PPARγ) is also known to exist in atherosclerotic lesions, participating ...

journal_title：Atherosclerosis

authors： Rosales C,Tang D,Geng YJ

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Evidence suggests that delayed re-endothelialization is responsible for in-stent thrombosis. Probucol inhibits neointimal thickening in animals via enhanced re-endothelialization and is the only oral drug that consistently inhibits restenosis after coronary angioplasty in humans. Here, we examined the effect...

journal_title：Atherosclerosis

authors： Tanous D,Bräsen JH,Choy K,Wu BJ,Kathir K,Lau A,Celermajer DS,Stocker R

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND AND AIMS:Using a nationwide epidemiological database, we aimed to clarify the association of fasting plasma glucose (FPG) with subsequent cardiovascular disease (CVD) risk among young adults. METHODS AND RESULTS:Medical records of 1,180,062 young adults (20-49 years old) without a prior history of CVD and w...

journal_title：Atherosclerosis

authors： Kaneko H,Itoh H,Kiriyama H,Kamon T,Fujiu K,Morita K,Michihata N,Jo T,Takeda N,Morita H,Yasunaga H,Komuro I

更新日期：2021-01-16 00:00:00

abstract：:Collagens (types I and III) are among the strongest thrombus-forming components of the vascular subendothelium. We compared the thrombogenic effects of four collagen-containing advanced atherosclerotic lesions with those of purified types I and III collagen fibers. Cell-free homogenates from the human plaques effectiv...

journal_title：Atherosclerosis

authors： Cosemans JM,Kuijpers MJ,Lecut C,Loubele ST,Heeneman S,Jandrot-Perrus M,Heemskerk JW

更新日期：2005-07-01 00:00:00

abstract：:In the French Canadian population six mutations appear to be responsible for about 85% of FH cases. Two of these mutations are large deletions. The most prevalent deletion is a >15 kb deletion of the promoter and first exon; the second, a 5 kb deletion that removes exons 2 and 3. The high frequency of these deletions ...

journal_title：Atherosclerosis

authors： Bernier L,Boulet L,Roy M,Dufour R,Larivière F,Davignon J

更新日期：2008-03-01 00:00:00

abstract：:The association between serum selenium concentration and a number of coronary heart disease risk factors is studied in 364 males from southern Italy participating in the Olivetti Heart Study. Selenium correlates positively and significantly with serum cholesterol (r = 0.120; P = 0.022), and this positive association p...

journal_title：Atherosclerosis

authors： Jossa F,Trevisan M,Krogh V,Farinaro E,Giumetti D,Fusco G,Galasso R,Panico S,Frascatore S,Mellone C

更新日期：1991-04-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome and the incidence of which is rising rapidly due to the increasing epidemic of obesity in both adults and children. The initial accumulation of fat followed by subsequent inflammation is central to the development of liver...

journal_title：Atherosclerosis

authors： Than NN,Newsome PN

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVES:Inflammation may directly impair HDL functions, in particular reverse cholesterol transport (RCT), but limited data support this concept in humans. METHODS AND RESULTS:We employed low-dose human endotoxemia to assess the effects of inflammation on HDL and RCT-related parameters in vivo. Endotoxemia induced ...

journal_title：Atherosclerosis

authors： de la Llera Moya M,McGillicuddy FC,Hinkle CC,Byrne M,Joshi MR,Nguyen V,Tabita-Martinez J,Wolfe ML,Badellino K,Pruscino L,Mehta NN,Asztalos BF,Reilly MP

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Astaxanthin has been reported to improve dyslipidemia and metabolic syndrome in animals, but such effects in humans are not well known. METHODS:Placebo-controlled astaxanthin administration at doses of 0, 6, 12, 18 mg/day for 12 weeks was randomly allocated to 61 non-obese subjects with fasting serum trigly...

journal_title：Atherosclerosis

authors： Yoshida H,Yanai H,Ito K,Tomono Y,Koikeda T,Tsukahara H,Tada N

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND AND AIMS:The impact of treatment strategies on outcomes in patients with stable coronary artery disease (CAD) and type 2 diabetes mellitus (T2DM) according to presenting angina has not been rigorously assessed. METHODS:We performed a patient-level pooled-analysis (n = 5027) of patients with stable CAD and T...

journal_title：Atherosclerosis

authors： Mancini GBJ,Boden WE,Brooks MM,Vlachos H,Chaitman BR,Frye R,Bittner V,Hartigan PM,Dagenais GR

更新日期：2018-10-01 00:00:00

abstract：:Human aortic aneurysm is commonly characterized by the presence of advanced atherosclerosis associated with variable chronic adventitial inflammation. Histological examination of human aortic aneurysmal specimens revealed the presence of plasma cells and lymphoid aggregates in media and adventitia of the vessels. Immu...

journal_title：Atherosclerosis

authors： Yen HC,Lee FY,Chau LY

更新日期：1997-11-01 00:00:00

abstract：:High-density lipoproteins (HDL) have several antiatherogenic actions, including the ability to sequester cellular cholesterol, to protect low-density lipoproteins from oxidation and to inhibit platelet aggregation. An early event in atherogenesis is the adhesion and recruitment of blood monocytes, a process mediated b...

journal_title：Atherosclerosis

authors： Stannard AK,Khan S,Graham A,Owen JS,Allen SP

更新日期：2001-01-01 00:00:00

abstract：:Although it has been widely acknowledged that endothelial injury is an important contributing factor to the pathogenesis of atherosclerosis, and may even represent an initiating event, morphologic documentation of its occurrence both in humans and animals has been difficult to obtain. However, electrical stimulation o...

journal_title：Atherosclerosis

authors： Gutstein WH

更新日期：1988-03-01 00:00:00

abstract：:The offspring of type 2 diabetic patients are at elevated risk for type 2 diabetes and cardiovascular disease. The aim of our study was to characterize the role of various biomarkers of endothelial activation in a cohort of offspring of type 2 diabetic subjects and to assess the association of adhesion molecules with ...

journal_title：Atherosclerosis

authors： Ruotsalainen E,Vauhkonen I,Salmenniemi U,Pihlajamäki J,Punnonen K,Kainulainen S,Jalkanen S,Salmi M,Laakso M

更新日期：2008-03-01 00:00:00

abstract：:The effects of the artificial triglyceride-phospholipid emulsion (10% intralipid) on HDL subfraction were studied in vivo. After a 14-h fast, subjects received intralipid via a 4-h infusion. Serum lipoproteins were analyzed before and at 4 and 6 h after the start of the infusion. At 4-h the following acute changes by ...

journal_title：Atherosclerosis

authors： Sakuma N,Lin C,Matsumoto Y,Ikeuchi R,Ichikawa T,Hirata H,Noguchi Y,Fujinami T

更新日期：1988-11-01 00:00:00

abstract：:The relationships among platelet membrane fluidity, arterial thrombosis tendency, and platelet aggregation and prostanoid formation were investigated after feeding rats diets enriched in (n-6) or (n-3) polyunsaturated fatty acids. For at least 8 weeks, rats were fed a control diet containing 5 energy % (en%) sunflower...

journal_title：Atherosclerosis

authors： Rand ML,Hennissen AA,Hornstra G

更新日期：1986-12-01 00:00:00

abstract：BACKGROUND AND AIMS:There is some evidence of a cross-sectional, and possibly causal, relationship of lipid levels with leukocyte counts in mice and humans. This study investigates the cross-sectional and longitudinal relationship of blood lipid and lipoprotein levels with leukocyte counts in the UK Biobank cohort. ME...

journal_title：Atherosclerosis

authors： Tucker B,Sawant S,McDonald H,Rye KA,Patel S,Ong KL,Cochran BJ

更新日期：2020-12-21 00:00:00

abstract：BACKGROUND:Dyslipidemia has been linked to vascular complications of Type 1 diabetes (T1DM). We investigated the prospective associations of nuclear magnetic resonance-determined lipoprotein subclass profiles (NMR-LSP) and conventional lipid profiles with carotid intima-media thickness (IMT) in T1DM. METHODS:NMR-LSP a...

journal_title：Atherosclerosis

authors： Basu A,Jenkins AJ,Zhang Y,Stoner JA,Klein RL,Lopes-Virella MF,Garvey WT,Lyons TJ,DCCT\/EDIC Research Group.

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Mutations in the LDL receptor gene are the major cause of familial hypercholesterolaemia (FH) but it has been previously shown that the simple finding of a variation in the coding sequence of the LDLR does not confirm that it is the actual cause of FH. The pathogenicity of five missense alterations in the LD...

journal_title：Atherosclerosis

authors： Silva S,Alves AC,Patel D,Malhó R,Soutar AK,Bourbon M

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Metabolic syndrome (MS) is associated with dyslipidemia, and insulin resistance (IR) may be a main determinant of this dyslipidemia. OBJECTIVE:To determine how lipoprotein particle concentration and size are related to MS and IR in a population-based sample of Alaska Eskimos. DESIGN:Participants underwent ...

journal_title：Atherosclerosis

authors： Rivellese AA,Patti L,Kaufman D,Zhu J,Annuzzi G,Vaccaro O,Ebbesson SO,Howard WJ,Riccardi G,Howard BV

更新日期：2008-10-01 00:00:00

abstract：:Oxidant signalling and lipoprotein oxidation may play important roles in atherosclerotic lesion development. Given coincident localization of 15-lipoxygenase (15-LO), stereospecific products of 15-LO and epitopes of modified LDL in atherosclerotic lesions, we hypothesized that inhibition of 15-LO by PD146176, an inhib...

journal_title：Atherosclerosis

authors： Bocan TM,Rosebury WS,Mueller SB,Kuchera S,Welch K,Daugherty A,Cornicelli JA

更新日期：1998-02-01 00:00:00

abstract：:The molecular mechanisms underlying the atherogenic activity of cigarette smoke have yet to be fully elucidated. In the present study, genome-wide microarray analysis was performed on endothelial cells exposed to an aqueous cigarette smoke extract (CSE) for 3, 7, and 24 h, to obtain a better insight into how smoking m...

journal_title：Atherosclerosis

authors： Henderson B,Csordas A,Backovic A,Kind M,Bernhard D,Wick G

更新日期：2008-12-01 00:00:00

abstract：UNLABELLED:This double blind randomized placebo controlled study assessed the effects of atorvastatin, estradiol and norethisterone, isolated and in combination, on the lipid profile and on vascular reactivity, in post-menopausal women with hypercholesterolemia and arterial hypertension. Ninety-four women aged 50-65 we...

journal_title：Atherosclerosis

authors： Faludi AA,Aldrighi JM,Bertolami MC,Saleh MH,Silva RA,Nakamura Y,Pereira IR,Abdalla DS,Ramires JA,Sousa JE

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:Psychological stress (PS) has been associated with the development of cardiovascular diseases and adverse long-term outcomes after ischemic events. However, the precise mechanisms involved are not completely understood. Here we investigated the effect of PS on ischemia-induced neovascularization, and the pot...

journal_title：Atherosclerosis

authors： Maingrette F,Dussault S,Dhahri W,Desjarlais M,Mathieu R,Turgeon J,Haddad P,Groleau J,Perez G,Rivard A

更新日期：2015-08-01 00:00:00