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A concise review of non-alcoholic fatty liver disease.

Abstract：

:Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome and the incidence of which is rising rapidly due to the increasing epidemic of obesity in both adults and children. The initial accumulation of fat followed by subsequent inflammation is central to the development of liver damage, and is critically influenced by host factors including age, gender, presence of diabetes, genetic polymorphisms and more recently by the gut microbiome. An increasing body of data suggest that NAFLD is also an independent risk factor of cardiovascular disease, which remains the commonest cause of mortality in such patients. This review focusses on the pathogenesis of NAFLD, and the evolution of new approaches to the management and treatment of NAFLD.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Than NN,Newsome PN

doi

10.1016/j.atherosclerosis.2015.01.001

subject

Has Abstract

pub_date

2015-03-01 00:00:00

pages

192-202

issue

1

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(15)00030-1

journal_volume

239

pub_type

杂志文章,评审

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