Leukocyte count is an independent predictor for risk of acute myocardial infarction in middle-aged Japanese men.

abstract：OBJECTIVE:To analyze the possible role of arachidonic acid (AA) in macrophage cholesterol biosynthesis and in PON2 expression. METHODS AND RESULTS:We used peritoneal macrophages (MPM) from the 6-DS KO mice that were fed a diet without or with AA. Macrophage cholesterol biosynthesis rate and HMGCoA-reductase mRNA level...

journal_title：Atherosclerosis

authors： Rosenblat M,Volkova N,Roqueta-Rivera M,Nakamura MT,Aviram M

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:Although obesity is a risk factor for cardiovascular disease and mortality, several studies have reported that patients with obesity who have suffered acute myocardial infarction or have undergone percutaneous coronary intervention (PCI) have better clinical outcomes than their normal weight counterparts. We ...

journal_title：Atherosclerosis

authors： Sohn GH,Kim EK,Hahn JY,Song YB,Yang JH,Chang SA,Lee SC,Choe YH,Choi SH,Choi JH,Lee SH,Oh JK,Gwon HC

更新日期：2014-08-01 00:00:00

abstract：:A recent study has suggested that symptoms of chronic bronchitis predict the risk of coronary disease independently of the known major cardiovascular risk factors. High serum levels of lipoprotein(a) (Lp(a)) have also been considered as an independent risk factor for coronary heart disease. Therefore, the aim of the p...

journal_title：Atherosclerosis

authors： Basili S,Ferroni P,Vieri M,Cardelli P,Ceci F,Paradiso M,Labbadia G,Gazzaniga PP,Cordova C,Alessandri C

更新日期：1999-12-01 00:00:00

abstract：:Whether an association, causative or not, exists between the level of serum selenium and the risk of ischaemic heart disease (IHD) remains unsettled. We investigated the issue in a cohort of 3387 males aged 53-74 years (mean 63). Based on information about health status, life-style and socioeconomic factors given in a...

journal_title：Atherosclerosis

authors： Suadicani P,Hein HO,Gyntelberg F

更新日期：1992-09-01 00:00:00

abstract：:High serum concentrations of soluble adhesion molecules are present in diabetics, but whether similar levels are present in patients with impaired glucose tolerance (IGT) is unclear. We measured serum concentrations of soluble intercellular adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (sVCAM-1), an...

journal_title：Atherosclerosis

authors： Matsumoto K,Miyake S,Yano M,Ueki Y,Tominaga Y

更新日期：2000-10-01 00:00:00

abstract：RATIONALE:Obstructive sleep apnea results in nocturnal intermittent hypoxia (IH) as a main trigger for cardiovascular morbidity, including atherosclerosis. IH induces hemodynamic, hormono-metabolic and also immuno-inflammatory alterations that could differentially contribute to atherosclerosis. Our study aimed at exami...

journal_title：Atherosclerosis

authors： Arnaud C,Poulain L,Lévy P,Dematteis M

更新日期：2011-12-01 00:00:00

abstract：INTRODUCTION:Fenofibrate has shown to reduce major cardiovascular events and slow angiographic progression of coronary atherosclerosis. The postulated mechanism of action is via the activation of peroxisomal proliferator-activated receptor-alpha (PPAR-alpha), a nuclear transcription factor that controls a variety of ce...

journal_title：Atherosclerosis

authors： Corti R,Osende J,Hutter R,Viles-Gonzalez JF,Zafar U,Valdivieso C,Mizsei G,Fallon JT,Fuster V,Badimon JJ

更新日期：2007-01-01 00:00:00

abstract：:Previous studies from this laboratory have shown that degradation of heparan sulphate proteoglycan by both living macrophages and macrophage lysosomal heparanase induces phenotypic change of vascular smooth muscle cells (SMC) from a high volume fraction of myofilaments (V(v)myo) to a low V(v)myo [Campbell et al. Exp C...

journal_title：Atherosclerosis

authors： Fitzgerald M,Hayward IP,Thomas AC,Campbell GR,Campbell JH

更新日期：1999-07-01 00:00:00

abstract：OBJECTIVE:The association of high-density lipoprotein particle (HDL-P) with atherosclerosis may be stronger than that of HDL-cholesterol (HDL-C) and independent of conventional cardiovascular risk factors. Whether associations persist in populations at low risk of coronary heart disease (CHD) remains unclear. This stud...

journal_title：Atherosclerosis

authors： Zaid M,Fujiyoshi A,Miura K,Abbott RD,Okamura T,Takashima N,Torii S,Saito Y,Hisamatsu T,Miyagawa N,Ohkubo T,Kadota A,Sekikawa A,Maegawa H,Nakamura Y,Mitsunami K,Ueshima H,SESSA Research group.

更新日期：2015-04-01 00:00:00

abstract：:A synergistic interaction between the insertion/deletion (I/D) polymorphism within the angiotensin-converting enzyme (ACE) gene and an A/C transversion at nucleotide position 1166 within the angiotensin II sub-type 1 receptor (AT1R) gene on risk of myocardial infarction has been reported. The risk associated with the ...

journal_title：Atherosclerosis

authors： Steeds RP,Wardle A,Smith PD,Martin D,Channer KS,Samani NJ

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVE:To investigate the hypothesis that COMP can influence the morphology, stability and size of murine atherosclerotic lesions. METHODS:ApoE- and ApoE/COMP-knockout mice were fed a high-fat diet to develop atherosclerotic plaques at lesion sites of three different types; inflammatory and fibrous plaques induced ...

journal_title：Atherosclerosis

authors： Bond AR,Hultgårdh-Nilsson A,Knutsson A,Jackson CL,Rauch U

更新日期：2014-10-01 00:00:00

abstract：:Low density lipoprotein (LDL) and high density lipoprotein (HDL3) were tested for their ability to induce inositol phospholipid turnover and inositol phosphate production in bovine aortic endothelial cells (BAEC). The production of inositol phosphates following hydrolysis of the phosphoinositides was demonstrated by t...

journal_title：Atherosclerosis

authors： Myers DE,Fidge NH,Stanton H,Larkins RG

更新日期：1992-01-01 00:00:00

abstract：:The cysteine protease cathepsin L is one of the most potent mammalian elastases and collagenases, widely expressed at basal levels in most tested tissues and cell types, and regulated by pro-inflammatory stimuli. The inflammatory arterial diseases abdominal aortic aneurysm (AAA) and atherosclerosis involve extensive v...

journal_title：Atherosclerosis

authors： Liu J,Sukhova GK,Yang JT,Sun J,Ma L,Ren A,Xu WH,Fu H,Dolganov GM,Hu C,Libby P,Shi GP

更新日期：2006-02-01 00:00:00

abstract：:Studies on carotid artery atherosclerosis have been performed in order to understand the high risk for cardiovascular disease in chronic renal failure (CRF). The purpose of this study was to evaluate the extent and nature of carotid artery atherosclerosis in patients with CRF. Of the 135 patients with CRF (52 +/- 11 y...

journal_title：Atherosclerosis

authors： Leskinen Y,Lehtimäki T,Loimaala A,Lautamatti V,Kallio T,Huhtala H,Salenius JP,Saha H

更新日期：2003-12-01 00:00:00

abstract：OBJECTIVE:Although many studies have reported that elevated serum triglycerides to high-density lipoprotein cholesterol (TG-HDL) ratios constitute a risk for insulin resistance and increased arterial stiffness, no study has clarified as yet the association, in terms of the TG-HDL ratio, between diabetes and increased a...

journal_title：Atherosclerosis

authors： Shimizu Y,Nakazato M,Sekita T,Kadota K,Yamasaki H,Takamura N,Aoyagi K,Maeda T

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND AND AIMS:Although familial hypercholesterolemia (FH) can be effectively managed using cholesterol-lowering medication, patients often fall short of complete treatment adherence. Identifying the psychological factors associated with self-regulation of FH medication is important to inform interventions to maxi...

journal_title：Atherosclerosis

authors： Hagger MS,Hardcastle SJ,Hu M,Kwok S,Lin J,Nawawi HM,Pang J,Santos RD,Soran H,Su TC,Tomlinson B,Watts GF

更新日期：2018-10-01 00:00:00

abstract：:Oxidant signalling and lipoprotein oxidation may play important roles in atherosclerotic lesion development. Given coincident localization of 15-lipoxygenase (15-LO), stereospecific products of 15-LO and epitopes of modified LDL in atherosclerotic lesions, we hypothesized that inhibition of 15-LO by PD146176, an inhib...

journal_title：Atherosclerosis

authors： Bocan TM,Rosebury WS,Mueller SB,Kuchera S,Welch K,Daugherty A,Cornicelli JA

更新日期：1998-02-01 00:00:00

abstract：:Early stages of atherosclerosis are commonly noted in youth. The present study was designed to examine the effects of lifestyle modification in 19 overweight children (age 8-17) who were placed on a high-fiber, low-fat diet in a 2-week residential program where food was provided ad libitum and daily exercise (2-2.5h) ...

journal_title：Atherosclerosis

authors： Roberts CK,Chen AK,Barnard RJ

更新日期：2007-03-01 00:00:00

abstract：OBJECTIVE:Effective systemic drugs against restenosis upon percutaneous transluminal coronary angioplasty (PTCA) are largely lacking. Polyphenols have been suggested to ameliorate post-angioplasty restenosis. Hawthorn (Crataegus spp.) extracts, which are among the most frequently used herbal medicinal products against ...

journal_title：Atherosclerosis

authors： Fürst R,Zirrgiebel U,Totzke F,Zahler S,Vollmar AM,Koch E

更新日期：2010-08-01 00:00:00

abstract：:The beneficial therapeutic effects of raising HDL cholesterol are proving difficult to confirm in humans. The evaluation of antiatherogenic functions of HDL is an important area of research which includes the role of HDL in reverse cholesterol transport (RCT), especially macrophage-specific RCT, and its antioxidant an...

journal_title：Atherosclerosis

authors： Escolà-Gil JC,Rotllan N,Julve J,Blanco-Vaca F

更新日期：2009-10-01 00:00:00

abstract：:In type 2 diabetics, the progression of atherosclerosis is more rapid than the general population and 80% of these patients will die of an atherosclerotic event. Since in these patients hyperglycemia per se confers increased risk for cardiovascular disease (CVD), the presence of even borderline-high-risk LDL-C signals...

journal_title：Atherosclerosis

authors： Baliarsingh S,Beg ZH,Ahmad J

更新日期：2005-10-01 00:00:00

abstract：OBJECTIVE:To investigate the association of the endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine (ADMA) and coronary endothelial function. METHODS AND RESULTS:In 289 patients with coronary artery disease we assessed coronary endothelium-dependent and -independent vascular responses to intracoro...

journal_title：Atherosclerosis

authors： Maas R,Quitzau K,Schwedhelm E,Spieker L,Rafflenbeul W,Steenpass A,Lüscher TF,Böger RH

更新日期：2007-03-01 00:00:00

abstract：:The 5-lipoxygenase (5-LO) catalyzed formation of leukotriene (LT) lipid mediators is a pathway contributing to inflammatory events in asthma and more recently has been associated with cardiovascular disease. However, the relative impact of this pathway in atherogenesis has been controversial and a variety of mixed res...

journal_title：Atherosclerosis

authors： Cao RY,St Amand T,Gräbner R,Habenicht AJ,Funk CD

更新日期：2009-04-01 00:00:00

abstract：:Circulating soluble intercellular adhesion molecule-1 (sICAM-1) is a biochemical marker of inflammation. We performed variance-components-based quantitative genetic analyses in SOLAR of sICAM-1 in 1170 individuals from Mexican American families in the San Antonio Family Heart Study. The trait is heritable (h(2)=0.50+/...

journal_title：Atherosclerosis

authors： Kent JW Jr,Mahaney MC,Comuzzie AG,Göring HH,Almasy L,Dyer TD,Cole SA,MacCluer JW,Blangero J

更新日期：2007-12-01 00:00:00

abstract：:Several studies have reported that elevated plasma levels of total homocysteine (tHcy) are related to an increased risk of cardiovascular disease. Only a few studies have looked at the effect of cysteine, another amino thiol, on cardiovascular disease risk. Therefore, in the present case-control study we compared plas...

journal_title：Atherosclerosis

authors： van den Brandhof WE,Haks K,Schouten EG,Verhoef P

更新日期：2001-08-01 00:00:00

abstract：:The interaction of mouse peritoneal and human pericardial macrophages with lipoprotein (LP)-antibody (Ab) immune complex isolated from the serum of ischemic heart disease (IHD) patients has been studied. It is shown that the Ab of the autoimmune complex belongs to IgG class, and the antigen is the LP with d less than ...

journal_title：Atherosclerosis

authors： Klimov AN,Denisenko AD,Vinogradov AG,Nagornev VA,Pivovarova YI,Sitnikova OD,Pleskov VM

更新日期：1988-11-01 00:00:00

abstract：:Subendothelial cells (SEC) were obtained from the inner intimal layer of adult human aorta by collagenase treatment. SEC were identified in primary culture either as smooth muscle cells by staining with FITC-labeled antisera against human smooth muscle myosin or as macrophages, foam cells and contaminating endothelial...

journal_title：Atherosclerosis

authors： Babaev VR,Antonov AS,Zacharova OS,Romanov YA,Krushinsky AV,Tsibulsky VP,Shirinsky VP,Repin VS,Smirnov VN

更新日期：1988-05-01 00:00:00

abstract：BACKGROUND AND AIMS:Atherosclerosis develops with age and is partially controlled by genetics. Research to date has identified common variants with small effects on atherosclerosis related traits. We aimed to use family-based genome-wide linkage analysis to identify chromosomal regions potentially harboring rare varian...

journal_title：Atherosclerosis

authors： Kuipers AL,Wojczynski MK,Barinas-Mitchell E,Minster RL,Wang L,Feitosa MF,Kulminski A,Thyagarajan B,Lee JH,Province MA,Newman AB,Zmuda JM,Long-Life Family Study.

更新日期：2019-12-01 00:00:00

abstract：:The heavy and light subfractions of low density lipoprotein (LDL) were bound to the same extent and with the same affinity by the LDL receptors of cultured human fibroblasts, both when assayed at 4 degrees C and when assayed at 37 degrees C. They were also degraded similarly by the low affinity, LDL-receptor-mediated ...

journal_title：Atherosclerosis

authors： Knight BL,Thompson GR,Soutar AK

更新日期：1986-03-01 00:00:00

abstract：:In the process of screening apolipoprotein (apo) E genotypes in a population of subjects with lipid abnormalities, we have identified five subjects (one homozygote and four heterozygotes) with an abnormal 109 base pairs band following apo E restriction isotyping of amplified DNA with the restriction endonuclease CfoI....

journal_title：Atherosclerosis

authors： Pocovi M,Cenarro A,Civeira F,Myers RH,Casao E,Esteban M,Ordovas JM

更新日期：1996-04-26 00:00:00