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Asymmetrical dimethylarginine (ADMA) and coronary endothelial function in patients with coronary artery disease and mild hypercholesterolemia.

Abstract：

OBJECTIVE:To investigate the association of the endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine (ADMA) and coronary endothelial function. METHODS AND RESULTS:In 289 patients with coronary artery disease we assessed coronary endothelium-dependent and -independent vascular responses to intracoronary infusion of acetylcholine, adenosine, and nitroglycerin, respectively, and determined plasma ADMA and l-arginine concentrations by HPLC. After 6 months of treatment with either cerivastatin, nifedipine, cerivastatin+nifedipine, or placebo, coronary vascular function testing as well as ADMA and l-arginine determinations were repeated. We observed no correlation of plasma ADMA or l-arginine concentration and coronary response to acetylcholine, adenosine or nitroglycerin baseline, and no correlation of changes of ADMA or l-arginine plasma concentration with changes in coronary function (all r and rho<0.3, all p>0.05). CONCLUSION:At physiological plasma concentrations ADMA appears to have only little impact on coronary endothelial function.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Maas R,Quitzau K,Schwedhelm E,Spieker L,Rafflenbeul W,Steenpass A,Lüscher TF,Böger RH

doi

10.1016/j.atherosclerosis.2006.03.024

subject

Has Abstract

pub_date

2007-03-01 00:00:00

pages

211-9

issue

1

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(06)00167-5

journal_volume

191

pub_type

杂志文章

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