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Rapid and substantial lowering of human serum cholesterol by mevinolin (MK-803), an inhibitor of hydroxymethylglutaryl-coenzyme A reductase.

Abstract：

:Mevinolin (MK-803) is a potent inhibitor of HMG-CoA reductase. After a placebo run-in period, mevinolin 5,15 or 50 mg, or placebo was given twice daily for 7-11 days under double -blind conditions ot 4 groups of 6 normocholesterolemic male volunteers. After 7 days, mean serum cholesterol fell 14%, 25% and 24% on 5, 15 and 50 mg, respectively, which was significantly greater than the fall on placebo (4%) in the case of the two higher doses (P less than 0.01). Serum triglycerides did not change significantly. Mevinolin was generally well-tolerated and there were no serious adverse effects.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Tobert JA,Hitzenberger G,Kukovetz WR,Holmes IB,Jones KH

doi

10.1016/0021-9150(82)90070-3

subject

Has Abstract

pub_date

1982-01-01 00:00:00

pages

61-5

issue

1

eissn

0021-9150

issn

1879-1484

pii

0021-9150(82)90070-3

journal_volume

41

pub_type

临床试验,杂志文章

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