Brachial artery diameter as a marker for cardiovascular risk assessment: FMD-J study.

abstract：:Aging, which is an independent risk factor for heart disease, alters body fat mass and its function. Epicardial fat plays an important physiological and pathophysiological role on cardiac structure and function. This study investigated if aging altered the abundance of epicardial (EF) and abdominal fat (AF) derived me...

journal_title：Atherosclerosis

authors： Fei J,Cook C,Blough E,Santanam N

更新日期：2010-10-01 00:00:00

abstract：:The lecithin:cholesterol acyltransferase (LCAT) enzyme is responsible for the synthesis of cholesteryl esters in human plasma and plays a critical role in high density lipoprotein (HDL) metabolism. Genetic LCAT deficiency is a rare metabolic disorder characterized by low HDL cholesterol levels. This paper reviews the ...

journal_title：Atherosclerosis

authors： Calabresi L,Simonelli S,Gomaraschi M,Franceschini G

更新日期：2012-06-01 00:00:00

abstract：:In view of hypotheses suggesting mutagenesis is implicated in atherosclerosis, a total of 18 lipid extracts of human aortal tissues was examined by the standard Ames mutagenicity bioassay using Salmonella typhimurium or by a liquid modification thereof. One lipid extract of intimal-medial tissue contained detectable m...

journal_title：Atherosclerosis

authors： Johnson BH,Smith LL

更新日期：1984-12-01 00:00:00

abstract：:Prolonged exposure of rats to cigarette smoke resulted in significant alterations in the metabolism of lipids. There was a significant increase in the concentration of cholesterol, triglycerides and phospholipids in most of the tissues, particularly the heart, aorta and lungs. Cholesterol, triglycerides and phospholip...

journal_title：Atherosclerosis

authors： Latha MS,Vijayammal PL,Kurup PA

更新日期：1988-04-01 00:00:00

abstract：:This prospective randomized trial was designed to elucidate clinically the effect of fluvastatin on inhibiting oxidation of the low density lipoprotein (LDL) and improving the vascular endothelial function as well as its lipid-lowering effects, in comparison with pravastatin. Of 64 consecutive dyslipidemic patients, 4...

journal_title：Atherosclerosis

authors： Inoue T,Hayashi M,Takayanagi K,Morooka S

更新日期：2002-02-01 00:00:00

abstract：:Ghrelin, the endogenous ligand for the GH secretagogue receptor, is produced by the oxyntic cells of the stomach and is involved in the regulation of energy balance. However, an increasing number of direct ghrelin cardiovascular effects, and, among them, high ghrelin binding in atherosclerotic coronary arteries, are b...

journal_title：Atherosclerosis

authors： Rossi F,Bertone C,Petricca S,Santiemma V

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND AND AIMS:There is increasing awareness that the intestinal microbiome plays an important role in human health. We investigated its role in the burden of carotid atherosclerosis, measured by ultrasound as total plaque area. METHODS:Multiple regression with traditional risk factors was used to identify three ...

journal_title：Atherosclerosis

authors： Bogiatzi C,Gloor G,Allen-Vercoe E,Reid G,Wong RG,Urquhart BL,Dinculescu V,Ruetz KN,Velenosi TJ,Pignanelli M,Spence JD

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND AND AIMS:Diabetic patients are at high risk of stroke and coronary artery disease. Recent data suggest that arachidonic acid metabolism is altered in diabetic conditions and that these alterations contribute to accelerated atherosclerosis. Little is known about how these alterations affect the metabolism and...

journal_title：Atherosclerosis

authors： Ménégaut L,Masson D,Abello N,Denimal D,Truntzer C,Ducoroy P,Lagrost L,Pais de Barros JP,Athias A,Petit JM,Martin L,Steinmetz E,Kretz B

更新日期：2016-08-01 00:00:00

abstract：:In order to obtain information about the developmental mechanisms of restenosis after angioplasty, we investigated an association between the expression of platelet-derived growth factors (PDGFs) and neointimal cell accumulation in rabbit femoral arteries subjected to balloon angioplasty. Northern analysis demonstrate...

journal_title：Atherosclerosis

authors： Uchida K,Sasahara M,Morigami N,Hazama F,Kinoshita M

更新日期：1996-07-01 00:00:00

abstract：:Activation of the renin-angiotensin-aldosterone system plays an important role in the pathogenesis of endothelial dysfunction and atherosclerosis. Studies evaluating the effect of AT1-receptor blockers on endothelial dysfunction in patients with coronary artery disease (CAD) revealed mixed results. Studies addressing ...

journal_title：Atherosclerosis

authors： Warnholtz A,Ostad MA,Heitzer T,Thuneke F,Fröhlich M,Tschentscher P,Schwedhelm E,Böger R,Meinertz T,Munzel T

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:Cholesteryl ester transfer protein (CETP) mediates the transfer of neutral lipids between lipoproteins. The role of CETP in atherogenesis is controversial. To better understand the relationships between plasma CETP levels, lipoproteins and atherosclerosis, we assessed these parameters in patients with an enh...

journal_title：Atherosclerosis

authors： de Grooth GJ,Smilde TJ,Van Wissen S,Klerkx AH,Zwinderman AH,Fruchart JC,Kastelein JJ,Stalenhoef AF,Kuivenhoven JA

更新日期：2004-04-01 00:00:00

abstract：:Several reports have shown that lipoprotein(a) is associated with ischemic diseases. Two characteristics might explain this association. Firstly, Lp(a) is an LDL-like lipoprotein which may be implicated in the atherosclerotic process and secondly, Lp(a) possesses an additional apolipoprotein(a) whose structure is clos...

journal_title：Atherosclerosis

authors： Delplanque B,Beaumont V,Lemort N,Beaumont JL

更新日期：1993-05-01 00:00:00

abstract：OBJECTIVE:We used cardiac surgery as a model of acute inflammatory response to evaluate the role of the inflammatory mediators in influencing the number of circulating endothelial progenitor cells (EPCs). METHODS:In 38 coronary artery by-pass grafting (CABG) [28M/10F] and in 54 valvular [28M/26F] patients the numbers ...

journal_title：Atherosclerosis

authors： Cesari F,Caporale R,Marcucci R,Caciolli S,Stefano PL,Capalbo A,Macchi C,Vannucci M,Gensini GF,Abbate R,Gori AM

更新日期：2008-07-01 00:00:00

abstract：:We have used DNA and protein polymorphisms for the third complement component (C3) to assess the potential of DNA markers in the diagnosis and study of familial hypercholesterolaemia (FH), and to confirm the reported linkage between FH and C3. The inheritance of FH and the C3 gene has been studied in 10 families by co...

journal_title：Atherosclerosis

authors： Humphries SE,Donald JA,McFadden JJ,Shull S,Williamson R,Jowett NI,Galton DJ,Julsrud JO,Berg K,Heiberg A

更新日期：1984-09-01 00:00:00

abstract：:Five homozygous patients with familial hypercholesterolemia (FH) are described. Their serum cholesterol levels were between 603 and 907 mg/dl, with an average of 714 mg/dl. The mean value of serum cholesterol levels of the obligate heterozygous parents was 270 mg/dl. In the patient group, 87% of the serum cholesterol ...

journal_title：Atherosclerosis

authors： Cai HJ,Fan LM,Huang MG,Chen XY,Liu GQ,Chen Q

更新日期：1985-11-01 00:00:00

abstract：OBJECTIVES:We tested the hypothesis that working shifts is related to atherosclerosis and myocardial infarction. BACKGROUND:The number of shift workers is continuously increasing. Shift work is discussed to be related with cardiovascular heart disease. METHODS:A total of 2510 subjects recruited for the population-bas...

journal_title：Atherosclerosis

authors： Haupt CM,Alte D,Dörr M,Robinson DM,Felix SB,John U,Völzke H

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:Epicardial adipose tissue (EAT) mass correlates with metabolic syndrome and coronary artery disease (CAD). However, little is known about the expression of genes involved in triglyceride (TG) storage and mobilization in EAT. We therefore analyzed the expression of genes involved in fat mobilization in EAT in...

journal_title：Atherosclerosis

authors： Jaffer I,Riederer M,Shah P,Peters P,Quehenberger F,Wood A,Scharnagl H,März W,Kostner KM,Kostner GM

更新日期：2012-01-01 00:00:00

abstract：:Apolipoprotein F (ApoF) is a sialoglycoprotein that is a component of the HDL and LDL fractions of human serum. We sought to test the hypothesis that ApoF plays an important role in atherosclerosis in mice by modulating lipoprotein function. Atherosclerosis was assessed in male low density lipoprotein receptor knockou...

journal_title：Atherosclerosis

authors： Lagor WR,Fields DW,Bauer RC,Crawford A,Abt MC,Artis D,Wherry EJ,Rader DJ

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:The CHA(2)DS(2)-VASc (congestive heart failure, hypertension, age ≥ 75 years (doubled), type 2 diabetes, previous stroke, transient ischemic attack, or thromboembolism (doubled), vascular disease, age 65-75 years, and sex category) score was published as a predictive scoring model for stroke in atrial fibril...

journal_title：Atherosclerosis

authors： Gary T,Belaj K,Hafner F,Hackl G,Froehlich H,Pilger E,Brodmann M

更新日期：2012-12-01 00:00:00

abstract：:Cholesteryl esters (CE) exchange between lipoproteins through the action of cholesteryl ester transfer protein (CETP). Situations at high risk for atherosclerosis are often accompanied by an accelerated net mass CE transfer (CET) from high density lipoproteins (HDL) to very low (VLDL) and low density lipoproteins (LDL...

journal_title：Atherosclerosis

authors： Elchebly M,Porokhov B,Pulcini T,Berthezène F,Ponsin G

更新日期：1996-06-01 00:00:00

abstract：OBJECTIVE:Limited evidence suggests NT-proBNP improves prediction of coronary heart disease (CHD) events but further data are needed, especially in people without pre-existing CHD and in women. METHODS:We measured NT-proBNP in serum from 162 women with incident CHD events and 1226 controls (60-79 years) in a case-cont...

journal_title：Atherosclerosis

authors： Sattar N,Welsh P,Sarwar N,Danesh J,Di Angelantonio E,Gudnason V,Davey Smith G,Ebrahim S,Lawlor DA

更新日期：2010-03-01 00:00:00

abstract：OBJECTIVE:Genetic variation in CC-chemokine receptor-2 (CCR2) and -5 (CCR5), and their common haplotypes, acting through inflammatory responses, may affect atherosclerosis and risk of coronary heart disease (CHD). METHOD AND RESULTS:We examined seven common variants in the CCR2 and CCR5 loci and risk of CHD among wome...

journal_title：Atherosclerosis

authors： Pai JK,Kraft P,Cannuscio CC,Manson JE,Rexrode KM,Albert CM,Hunter D,Rimm EB

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVES:Compare carotid plaque morphology of acute symptomatic, recently symptomatic and asymptomatic patients (groups 1, 2 and 3 respectively) with carotid artery disease using high resolution magnetic resonance imaging (MRI), to identify high-risk plaque characteristics best associated with risk of recurrent throm...

journal_title：Atherosclerosis

authors： Sadat U,Weerakkody RA,Bowden DJ,Young VE,Graves MJ,Li ZY,Tang TY,Gaunt ME,Hayes PD,Gillard JH

更新日期：2009-12-01 00:00:00

abstract：:Previous studies in mouse models showed that 12/15lipoxygenase (12/15LO) gene disruption diminishes atherosclerosis. Pharmacologic suppression of thromboxane (Tx) A(2) biosynthesis or blockade of its receptor also reduces the development of the disease in the same models. We tested the hypothesis that simultaneous gen...

journal_title：Atherosclerosis

authors： Tang L,Ding T,Praticò D

更新日期：2008-08-01 00:00:00

abstract：:Adhesion molecules and cytokines are involved in the pathogenesis of intimal injury in atherosclerosis but their relationship with endothelial function remains unclear. The objectives of this study were to examine the effects of atorvastatin on soluble adhesion molecules, interleukin-6 (IL-6) and brachial artery endot...

journal_title：Atherosclerosis

authors： Nawawi H,Osman NS,Annuar R,Khalid BA,Yusoff K

更新日期：2003-08-01 00:00:00

abstract：:Sixty-two subjects from 23 families were evaluated by serum lipid analyses and tissue culture biochemistry in skin fibroblasts. In 53 cases from 19 families with proven familial hypercholesterolemia (FHC), fibroblast cultures were successful. In 45 of these cases (85%) the clinical diagnosis of hyper- or normocholeste...

journal_title：Atherosclerosis

authors： Keller C,Harders-Spengel K,Spengel F,Wieczorek A,Wolfram G,Zöllner N

更新日期：1981-04-01 00:00:00

abstract：:Administration of ursodeoxycholic acid (UDCA) has been shown to decrease serum total and low density lipoprotein (LDL) cholesterol in hypercholesterolemic patients with primary biliary cirrhosis. Results of previous studies prompted us to postulate that the cholesterol-lowering effect of UDCA may be due, at least in p...

journal_title：Atherosclerosis

authors： Ceryak S,Bouscarel B,Malavolti M,Robins SJ,Caslow KL,Fromm H

更新日期：2000-11-01 00:00:00

abstract：:Interferon gamma (IFN-gamma) is an immunomodulatory and anti-microbial cytokine, which has a variety of proatherogenic effects. It has been reported that IFN-gamma can down-regulate ABCA1 expression. However, its mechanism is elusive. In the present study, we have investigated the effect of IFN-gamma on ABCA1 expressi...

journal_title：Atherosclerosis

authors： Hao XR,Cao DL,Hu YW,Li XX,Liu XH,Xiao J,Liao DF,Xiang J,Tang CK

更新日期：2009-04-01 00:00:00

abstract：:We investigated the effect of transmembrane form of tumor necrosis factor-alpha (TNF) on atherosclerosis in mice. We compared the development of early atherosclerotic lesions in the aortic sinus of (1) TNF-deficient mice that express only a non-cleavable transmembrane form of TNF (tmTNF), (2) wild-type (WT) C57BL/6 mi...

journal_title：Atherosclerosis

authors： Canault M,Peiretti F,Mueller C,Kopp F,Morange P,Rihs S,Portugal H,Juhan-Vague I,Nalbone G

更新日期：2004-02-01 00:00:00

abstract：:Human serum paraoxonase (PON1) is an HDL-associated enzyme involved in the protection of lipoproteins from oxidation. A polymorphism at position 192 (Gln/Arg) influences its activity in a substrate-dependent manner. The aim of the present study was to evaluate, in vivo, the contribution of the PON1-192 polymorphism to...

journal_title：Atherosclerosis

authors： Gnasso A,Motti C,Irace C,Di Gennaro I,Pujia A,Leto E,Ciamei M,Crivaro A,Bernardini S,Federici G,Cortese C

更新日期：2002-10-01 00:00:00