Body fat distribution and cardiovascular risk in middle-aged people in southern Italy.

abstract：:It is still controversial whether circulating soluble form of receptor for AGE (sRAGE) is associated with atherosclerosis in diabetic patients. In this study, we enrolled 276 Japanese type 2 diabetic subjects without history of cardiovascular disease (CVD), assessed their baseline clinical and biochemical data includi...

journal_title：Atherosclerosis

authors： Fujisawa K,Katakami N,Kaneto H,Naka T,Takahara M,Sakamoto F,Irie Y,Miyashita K,Kubo F,Yasuda T,Matsuoka TA,Shimomura I

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND AND AIMS:Lipoprotein(a) (Lp(a)) is a causal risk factor for cardiovascular disorders including coronary heart disease and calcific aortic valve stenosis. Apolipoprotein(a) (apo(a)), the unique glycoprotein component of Lp(a), contains sequences homologous to plasminogen. Plasminogen activation is markedly ac...

journal_title：Atherosclerosis

authors： Romagnuolo R,Scipione CA,Bazzi ZA,Boffa MB,Koschinsky ML

更新日期：2018-08-01 00:00:00

abstract：UNLABELLED:This double blind randomized placebo controlled study assessed the effects of atorvastatin, estradiol and norethisterone, isolated and in combination, on the lipid profile and on vascular reactivity, in post-menopausal women with hypercholesterolemia and arterial hypertension. Ninety-four women aged 50-65 we...

journal_title：Atherosclerosis

authors： Faludi AA,Aldrighi JM,Bertolami MC,Saleh MH,Silva RA,Nakamura Y,Pereira IR,Abdalla DS,Ramires JA,Sousa JE

更新日期：2004-11-01 00:00:00

abstract：:The metabolism in vitro of exogenous and endogenous arachidonic acid was studied in circulating blood monocytes obtained from control (control group) and cholesterol (0.5%)-fed (cholesterol group) rabbits. The production of superoxide anion (O2-), tissue plasminogen activator (t-PA) and adherence of monocytes were ass...

journal_title：Atherosclerosis

authors： Saito H,Salmon JA,Moncada S

更新日期：1986-08-01 00:00:00

abstract：OBJECTIVE:To compare lipid-lowering efficacy of adding alirocumab to rosuvastatin versus other treatment strategies (NCT01730053). METHODS:Patients receiving baseline rosuvastatin regimens (10 or 20 mg) were randomized to: add-on alirocumab 75 mg every-2-weeks (Q2W) (1-mL subcutaneous injection via pre-filled pen); ad...

journal_title：Atherosclerosis

authors： Farnier M,Jones P,Severance R,Averna M,Steinhagen-Thiessen E,Colhoun HM,Du Y,Hanotin C,Donahue S

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Familial hypercholesterolemia (FH) was rarely diagnosed in Latvia before 2015, when the Latvian Registry of FH (LRFH) was established. Here, we report the first experience of the LRFH over three years (2015-2017). METHODS:The LRFH is an ongoing nationwide, dynamic, long-term prospective cohort. The...

journal_title：Atherosclerosis

authors： Latkovskis G,Saripo V,Gilis D,Nesterovics G,Upena-Roze A,Erglis A

更新日期：2018-10-01 00:00:00

abstract：:Simvastatin, an inhibitor of HMG CoA reductase, lowers the plasma total cholesterol and LDL-cholesterol concentration in familial hypercholesterolemic patients. The efficacy of the drug shows considerable inter-individual variation, however. In this study we have assessed the influence of certain LDL-receptor gene mut...

journal_title：Atherosclerosis

authors： Jeenah M,September W,Graadt van Roggen F,de Villiers W,Seftel H,Marais D

更新日期：1993-01-04 00:00:00

abstract：:A study conducted in 1953 by one of the authors (H.S.M. Uhl) reported that orally administered ethylenediamine tetraacetic acid (EDTA) both prevented the accumulation of cholesterol in the liver of cholesterol-fed rabbits and caused the removal of accumulated cholesterol from the liver. These observations were made in...

journal_title：Atherosclerosis

authors： Uhl HS,Dysko RC,St Clair RW

更新日期：1992-10-01 00:00:00

abstract：OBJECTIVE:The association of high-density lipoprotein particle (HDL-P) with atherosclerosis may be stronger than that of HDL-cholesterol (HDL-C) and independent of conventional cardiovascular risk factors. Whether associations persist in populations at low risk of coronary heart disease (CHD) remains unclear. This stud...

journal_title：Atherosclerosis

authors： Zaid M,Fujiyoshi A,Miura K,Abbott RD,Okamura T,Takashima N,Torii S,Saito Y,Hisamatsu T,Miyagawa N,Ohkubo T,Kadota A,Sekikawa A,Maegawa H,Nakamura Y,Mitsunami K,Ueshima H,SESSA Research group.

更新日期：2015-04-01 00:00:00

abstract：:Familial defective apolipoprotein B-100 (FDB) is a dominantly inherited disorder associated with hypercholesterolemia, in which substitution of the amino acid glutamine for arginine at position 3500 in the apoprotein B molecule results in LDL particles which bind poorly to the LDL receptor. To date, patients with FDB ...

journal_title：Atherosclerosis

authors： Schmidt EB,Illingworth DR,Bacon S,Mahley RW,Weisgraber KH

更新日期：1993-01-25 00:00:00

abstract：BACKGROUND:The complement system is involved in the pathogenic course of SLE. These patients exhibit metabolic disturbances in lipoprotein metabolism characterized by a pro-inflammatory status and an accelerated atherosclerosis. The aim of this study is to investigate whether levels of the complement are associated to ...

journal_title：Atherosclerosis

authors： Parra S,Vives G,Ferré R,González M,Guardiola M,Ribalta J,Castro A

更新日期：2012-11-01 00:00:00

abstract：:Recent evidence suggests that sterol 27-hydroxylase may play a role in cholesterol homeostasis and affect atherogenesis. The major objective of the study was to map and characterize the sterol 27-hydroxylase (CYP27) promoter region. Here we show that CYP27 gene has a TATA-less promoter and transcription initiates at a...

journal_title：Atherosclerosis

authors： Segev H,Honigman A,Rosen H,Leitersdorf E

更新日期：2001-06-01 00:00:00

abstract：OBJECTIVE:A direct correlation between blood glucose levels and the microvascular complications of diabetes is well established. However, the effects of hyperglycaemia on the vasa vasorum, a microvascular network which surrounds and supplies the walls of large arteries, is not known. The objective of this study is to i...

journal_title：Atherosclerosis

authors： Veerman KJ,Venegas-Pino DE,Shi Y,Khan MI,Gerstein HC,Werstuck GH

更新日期：2013-04-01 00:00:00

abstract：:Following injections of Evans blue (1-200 mg/kg) into rabbits, polyacrylamide gel disc electrophoresis showed that Evans blue binds to two protein fractions. The greater part was bound to albumin and the remainder to a plasma protein in the postalbumin fraction. Unbound Evans blue was present in each plasma sample ana...

journal_title：Atherosclerosis

authors： Lindner V,Heinle H

更新日期：1982-06-01 00:00:00

abstract：BACKGROUND:The CHA(2)DS(2)-VASc (congestive heart failure, hypertension, age ≥ 75 years (doubled), type 2 diabetes, previous stroke, transient ischemic attack, or thromboembolism (doubled), vascular disease, age 65-75 years, and sex category) score was published as a predictive scoring model for stroke in atrial fibril...

journal_title：Atherosclerosis

authors： Gary T,Belaj K,Hafner F,Hackl G,Froehlich H,Pilger E,Brodmann M

更新日期：2012-12-01 00:00:00

abstract：:Individuals who are physically fit or engage in regular physical activity have a lower incidence of cardiovascular disease and risk of mortality. We conducted a large-scale controlled trial of interventions to decrease cardiovascular risk factors, during which we assessed the effect of a workplace-based intervention p...

journal_title：Atherosclerosis

authors： Naito M,Nakayama T,Okamura T,Miura K,Yanagita M,Fujieda Y,Kinoshita F,Naito Y,Nakagawa H,Tanaka T,Ueshima H,HIPOP-OHP Research Group.

更新日期：2008-04-01 00:00:00

abstract：:Mevinolin (MK-803) is a potent inhibitor of HMG-CoA reductase. After a placebo run-in period, mevinolin 5,15 or 50 mg, or placebo was given twice daily for 7-11 days under double -blind conditions ot 4 groups of 6 normocholesterolemic male volunteers. After 7 days, mean serum cholesterol fell 14%, 25% and 24% on 5, 15...

journal_title：Atherosclerosis

authors： Tobert JA,Hitzenberger G,Kukovetz WR,Holmes IB,Jones KH

更新日期：1982-01-01 00:00:00

abstract：OBJECTIVE:Only a few studies have investigated the changes in carotid intima-media thickness (IMT) over time, and uncertainties remain on the underlying mechanisms linking depression and subclinical atherosclerosis. We carried out a prospective cohort study to evaluate whether depression is associated with changes in c...

journal_title：Atherosclerosis

authors： Pizzi C,Costa GM,Santarella L,Flacco ME,Capasso L,Bert F,Manzoli L

更新日期：2014-04-01 00:00:00

abstract：:Oxidized low-density lipoprotein (oxLDL) exhibits many atherogenic effects, including the promotion of monocyte recruitment to the arterial endothelium and the induction of scavenger receptor expression. However, while atherosclerosis involves chronic inflammation within the arterial intima, it is unclear whether oxLD...

journal_title：Atherosclerosis

authors： Kavanagh IC,Symes CE,Renaudin P,Nova E,Mesa MD,Boukouvalas G,Leake DS,Yaqoob P

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND AND AIMS:Low ankle-brachial index (ABI) is associated with increased mortality and an increased incidence of cardiovascular events. The purpose of this study was to investigate the value of borderline ABI in predicting clinical outcomes. METHODS AND RESULTS:The data were derived from the Shinken Database 20...

journal_title：Atherosclerosis

authors： Tanaka S,Kaneko H,Kano H,Matsuno S,Suzuki S,Takai H,Otsuka T,Uejima T,Oikawa Y,Nagashima K,Kirigaya H,Sagara K,Yajima J,Sawada H,Aizawa T,Yamashita T

更新日期：2016-07-01 00:00:00

abstract：OBJECTIVES:To examine whether serum concentrations of carotenoids are related to the risk of sudden cardiac death (SCD) in middle-aged men. METHODS:The study population consisted of 1031 Finnish men aged 46-65 years of the Kuopio Ischemic Heart Disease Risk Factor (KIHD) cohort. Serum concentrations of carotenoids wer...

journal_title：Atherosclerosis

authors： Karppi J,Laukkanen JA,Mäkikallio TH,Ronkainen K,Kurl S

更新日期：2013-01-01 00:00:00

abstract：:Several reports have suggested an association between lipid peroxidation and human carotid atherosclerosis, but few reports have demonstrated a link between lipid peroxidation and carotid plaques in humans. In this study, we investigated the relationship between clinical features, histopathological characteristics and...

journal_title：Atherosclerosis

authors： Nishi K,Uno M,Fukuzawa K,Horiguchi H,Shinno K,Nagahiro S

更新日期：2002-02-01 00:00:00

abstract：:Patients with homozygous familial hypercholesterolemia (FH), as a result of the increased levels and prolonged residence time of low density lipoprotein (LDL) in plasma, have a strong tendency toward accumulation of LDL-cholesterol in the arterial wall, causing premature atherosclerosis. This phenomenon may enhance pe...

journal_title：Atherosclerosis

authors： Napoli C,Postiglione A,Triggiani M,Corso G,Palumbo G,Carbone V,Ruocco A,Ambrosio G,Montefusco S,Malorni A,Condorelli M,Chiariello M

更新日期：1995-12-01 00:00:00

abstract：OBJECTIVE:Endothelial lipase (EL) is a new member of triacylglycerol lipase family that has been shown to decrease high-density lipoprotein (HDL) cholesterol levels leading to increased risk of atherosclerosis. Its expression is increased during inflammation and by inflammatory cytokines. Sulforaphane (SFN) is a natura...

journal_title：Atherosclerosis

authors： Kivelä AM,Mäkinen PI,Jyrkkänen HK,Mella-Aho E,Xia Y,Kansanen E,Leinonen H,Verma IM,Ylä-Herttuala S,Levonen AL

更新日期：2010-11-01 00:00:00

abstract：:Whether an association, causative or not, exists between the level of serum selenium and the risk of ischaemic heart disease (IHD) remains unsettled. We investigated the issue in a cohort of 3387 males aged 53-74 years (mean 63). Based on information about health status, life-style and socioeconomic factors given in a...

journal_title：Atherosclerosis

authors： Suadicani P,Hein HO,Gyntelberg F

更新日期：1992-09-01 00:00:00

abstract：BACKGROUND AND AIMS:Osteoporosis and coronary heart disease (CHD) are very common conditions among elderly people, and both represent a public health concern due to their prognostic consequences. Osteoporosis and CHD share many risk factors and pathophysiological mechanisms, such as calcification pathways. Clinical evi...

journal_title：Atherosclerosis

authors： Campos-Staffico AM,Freitas WM,Carvalho LSF,Coelho-Filho OR,Nadruz W Jr,Oliveira RB,Sposito AC,Brasilia Study on Healthy Aging and Brasilia Heart Study.

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVES:This study examined whether combined ultrasound assessment of plaque size and echolucency in the carotid artery had an additive effect for predicting coronary events in patients with coronary artery disease (CAD). Ultrasound assessment of either plaque size or echolucency of carotid artery provides prognosti...

journal_title：Atherosclerosis

authors： Hirano M,Nakamura T,Kitta Y,Sano K,Kodama Y,Kobayashi T,Fujioka D,Saito Y,Yano T,Watanabe K,Watanabe Y,Kawabata K,Obata JE,Kugiyama K

更新日期：2010-08-01 00:00:00

abstract：:We investigated the association between the multiple metabolic risk factors and cardiovascular and overall mortality among Korean men, a population with a low prevalence of obesity. This prospective cohort study involved 682,597 Korean men, aged 30-69 years at baseline (1992), who were initially without cancer or debi...

journal_title：Atherosclerosis

authors： Park HS,Cho SI,Song YM,Sung J

更新日期：2006-07-01 00:00:00

abstract：:Chylomicron catabolism in the bloodstream consists of lipolysis by lipoprotein lipase and uptake of remnants by the liver. In rats, triglyceride-rich emulsions can mimic chylomicron metabolism. To further validate this model in man, the emulsion was injected intravenously into fasting and into subjects previously fed ...

journal_title：Atherosclerosis

authors： Maranhão RC,Feres MC,Martins MT,Mesquita CH,Toffoletto O,Vinagre CG,Gianinni SD,Pileggi F

更新日期：1996-09-27 00:00:00

abstract：:The ontogenic development of lipoprotein lipase and liver triglyceride hydrolase was studied in the rat. The enzyme activity measured in extrahepatic tissues fulfilled the criteria of lipoprotein lipase from the onset of measurable activity, i.e. it was inhibited by protamine and 1 M NaCl and showed requirement for se...

journal_title：Atherosclerosis

authors： Chajek T,Stein O,Stein Y

更新日期：1977-04-01 00:00:00