当前位置： SCI文献检索 > ATHEROSCLEROSIS期刊下所有文献 > Platelet membrane collagen receptor glycoprotein VI polymorphism is associated with coronary thrombosis and fatal myocardial infarction in middle-aged men.

Platelet membrane collagen receptor glycoprotein VI polymorphism is associated with coronary thrombosis and fatal myocardial infarction in middle-aged men.

Abstract：

:Glycoprotein VI is a platelet collagen receptor binding to subendothelial collagen after a rupture of an atherosclerotic plaque. The GPVI gene is polymorphic with several SNPs and the T13254C polymorphism predicting amino acid substitution (serine to proline) has been associated with the risk of MI in a preliminary study. We studied the association of the GPVI T13254C with fatal myocardial infarction (MI) and coronary artery disease among the 300 men of the Helsinki Sudden Death Study (HSDS). Genotype frequencies were 77.9% for TT, 20.7% for CT and 1.4% for CC. We found a significant association (P = 0.02) between the C-allele carriers (CT or CC) and coronary thrombosis (OR 2.5, 95% CI: 1.05-6.2). There was also a tendency (P = 0.07) for an association between the C-allele and acute myocardial infarction (AMI) (OR 2.2). The average area of complicated coronary lesions was also significantly (P = 0.01) larger in carriers compared to non-carriers of the C-allele. Our findings support previous results on the role of this GPVI polymorphism, or another linked polymorphism, as a possible predictor of the risk of coronary thrombosis.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Ollikainen E,Mikkelsson J,Perola M,Penttilä A,Karhunen PJ

doi

10.1016/j.atherosclerosis.2004.03.021

keywords:

subject

Has Abstract

pub_date

2004-09-01 00:00:00

pages

95-9

issue

1

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(04)00214-X

journal_volume

176

pub_type

杂志文章

相关文献

ATHEROSCLEROSIS文献大全
  • Coronary flow reserve is impaired in patients with aortic valve calcification.

    abstract：BACKGROUND:Calcific aortic valve disease is an active and progressive condition. Data indicate that aortic valve calcification (AVC) is associated with endothelial dysfunction and accepted as a manifestation of atherosclerosis. Coronary flow reserve (CFR) determined by transthoracic echocardiography has been introduced...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2007.07.036

    authors： Bozbas H,Pirat B,Yildirir A,Simşek V,Sade E,Eroglu S,Atar I,Altin C,Demirtas S,Ozin B,Muderrisoglu H

    更新日期：2008-04-01 00:00:00

  • Inflammation modulates human HDL composition and function in vivo.

    abstract：OBJECTIVES:Inflammation may directly impair HDL functions, in particular reverse cholesterol transport (RCT), but limited data support this concept in humans. METHODS AND RESULTS:We employed low-dose human endotoxemia to assess the effects of inflammation on HDL and RCT-related parameters in vivo. Endotoxemia induced ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2012.02.032

    authors： de la Llera Moya M,McGillicuddy FC,Hinkle CC,Byrne M,Joshi MR,Nguyen V,Tabita-Martinez J,Wolfe ML,Badellino K,Pruscino L,Mehta NN,Asztalos BF,Reilly MP

    更新日期：2012-06-01 00:00:00

  • Hyperglycaemia is associated with impaired vasa vasorum neovascularization and accelerated atherosclerosis in apolipoprotein-E deficient mice.

    abstract：OBJECTIVE:A direct correlation between blood glucose levels and the microvascular complications of diabetes is well established. However, the effects of hyperglycaemia on the vasa vasorum, a microvascular network which surrounds and supplies the walls of large arteries, is not known. The objective of this study is to i...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2013.01.018

    authors： Veerman KJ,Venegas-Pino DE,Shi Y,Khan MI,Gerstein HC,Werstuck GH

    更新日期：2013-04-01 00:00:00

  • Complement system and small HDL particles are associated with subclinical atherosclerosis in SLE patients.

    abstract：BACKGROUND:The complement system is involved in the pathogenic course of SLE. These patients exhibit metabolic disturbances in lipoprotein metabolism characterized by a pro-inflammatory status and an accelerated atherosclerosis. The aim of this study is to investigate whether levels of the complement are associated to ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2012.08.029

    authors： Parra S,Vives G,Ferré R,González M,Guardiola M,Ribalta J,Castro A

    更新日期：2012-11-01 00:00:00

  • Maternal inheritance of familial hypercholesterolemia caused by the V408M low-density lipoprotein receptor mutation increases mortality.

    abstract：OBJECTIVE:Fetal exposure to maternal hypercholesterolemia increases the extent of fatty-streak formation in fetal aortas as well as the rate of progression, and may therefore increase coronary heart disease (CHD) risk later in life. We hypothesized that the risk of CHD in untreated individuals with familial hypercholes...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2011.08.039

    authors： Versmissen J,Botden IP,Huijgen R,Oosterveer DM,Defesche JC,Heil TC,Muntz A,Langendonk JG,Schinkel AF,Kastelein JJ,Sijbrands EJ

    更新日期：2011-12-01 00:00:00

  • Exclusive expression of transmembrane TNF-alpha in mice reduces the inflammatory response in early lipid lesions of aortic sinus.

    abstract：:We investigated the effect of transmembrane form of tumor necrosis factor-alpha (TNF) on atherosclerosis in mice. We compared the development of early atherosclerotic lesions in the aortic sinus of (1) TNF-deficient mice that express only a non-cleavable transmembrane form of TNF (tmTNF), (2) wild-type (WT) C57BL/6 mi...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2003.10.004

    authors： Canault M,Peiretti F,Mueller C,Kopp F,Morange P,Rihs S,Portugal H,Juhan-Vague I,Nalbone G

    更新日期：2004-02-01 00:00:00

  • Evaluation of coronary features of HIV patients presenting with ACS: The CUORE, a multicenter study.

    abstract：BACKGROUND AND AIMS:The risk of recurrence of myocardial infarction (MI) in HIV patients presenting with acute coronary syndrome (ACS) is well known, but there is limited evidence about potential differences in coronary plaques compared to non-HIV patients. METHODS:In this multicenter case-control study, HIV patients ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.atherosclerosis.2018.05.001

    authors： Peyracchia M,De Lio G,Montrucchio C,Omedè P,d'Ettore G,Calcagno A,Vullo V,Cerrato E,Pennacchi M,Sardella G,Manga P,GrossoMarra W,Vullo F,Fedele F,Biondi-Zoccai G,Moretti C,Vachiat A,Bonora S,Rinaldi M,Mancone M,D'

    更新日期：2018-07-01 00:00:00

  • Relationship between plasma coenzyme Q10, asymmetric dimethylarginine and arterial stiffness in patients with phenotypic or genotypic familial hypercholesterolemia on long-term statin therapy.

    abstract：OBJECTIVE:We investigated whether statin-treated heterozygous familial hypercholesterolemic (FH) patients have lower plasma coenzyme Q(10) (CoQ(10)) levels than low-density lipoprotein receptor (LDLR) mutation negative FH patients on equivalent statin doses, and whether lower CoQ(10) concentrations are associated with ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2011.04.034

    authors： Young JM,Molyneux SL,Reinheimer AM,Florkowski CM,Frampton CM,Scott RS,George PM

    更新日期：2011-09-01 00:00:00

  • Endogenous sex hormones impact the progression of subclinical atherosclerosis in women during the menopausal transition.

    abstract：OBJECTIVE:To determine whether endogenous sex hormones (estradiol (E2), testosterone (T), sex hormone binding globulin (SHBG), and follicle stimulating hormone (FSH)) are longitudinally associated with progression of atherosclerosis among women at midlife. METHODS:249 Pre- or early peri-menopausal women (42-57 years) ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2012.07.025

    authors： El Khoudary SR,Wildman RP,Matthews K,Thurston RC,Bromberger JT,Sutton-Tyrrell K

    更新日期：2012-11-01 00:00:00

  • Association of descending thoracic aortic plaque with brain atrophy and white matter hyperintensities: The Framingham Heart Study.

    abstract：BACKGROUND AND AIMS:Aortic atherosclerosis is an aggregate marker of vascular risk factor exposure and has been associated with intracranial atherosclerosis and stroke. We hypothesized that atherosclerosis of the descending aorta (DAo) could be a risk marker for brain aging and injury. METHODS:We evaluated 1527 partic...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2017.06.919

    authors： Aparicio HJ,Petrea RE,Massaro JM,Manning WJ,Oyama-Manabe N,Beiser AS,Kase CS,D'Agostino RB,Wolf PA,Vasan RS,DeCarli C,O'Donnell CJ,Seshadri S

    更新日期：2017-10-01 00:00:00

  • Homocysteine content of lipoproteins in hypercholesterolemia.

    abstract：:In order to study the connection between homocysteine and lipid metabolism in atherosclerosis, homocysteine was determined in lipoprotein fractions from men with hypercholesterolemia. All lipoprotein fractions contain a considerably higher level of homocysteine in hypercholesterolemia, compared to normolipemic men, va...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(91)90257-4

    authors： Olszewski AJ,McCully KS

    更新日期：1991-05-01 00:00:00

  • Oxidative stress, inflammation, and markers of cardiovascular health.

    abstract：OBJECTIVE:To investigate associations of a oxidative balance score (OBS) with blood levels of total cholesterol, low-density lipoprotein- (LDL)-cholesterol, high-density lipoprotein- (HDL) cholesterol and triglycerides, and biomarkers of inflammation (serum C-reactive protein [CRP], albumin and venous total white blood...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2015.08.032

    authors： Lakkur S,Judd S,Bostick RM,McClellan W,Flanders WD,Stevens VL,Goodman M

    更新日期：2015-11-01 00:00:00

  • The relationship between cholesteryl ester transfer protein levels and risk factor profile in patients with familial hypercholesterolemia.

    abstract：BACKGROUND:Cholesteryl ester transfer protein (CETP) mediates the transfer of neutral lipids between lipoproteins. The role of CETP in atherogenesis is controversial. To better understand the relationships between plasma CETP levels, lipoproteins and atherosclerosis, we assessed these parameters in patients with an enh...

    journal_title：Atherosclerosis

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.atherosclerosis.2003.11.020

    authors： de Grooth GJ,Smilde TJ,Van Wissen S,Klerkx AH,Zwinderman AH,Fruchart JC,Kastelein JJ,Stalenhoef AF,Kuivenhoven JA

    更新日期：2004-04-01 00:00:00

  • Human triglyceride-rich lipoprotein apo E kinetics and its relationship to LDL apo B-100 metabolism.

    abstract：:Apolipoprotein (apo) E is a multifunctional protein that can act as a ligand for lipoprotein receptors. The receptor-mediated clearance of the triglyceride-rich lipoproteins (TRL) chylomicrons and VLDL from plasma is, in part, dependent on apo E. Enrichment of VLDL with apo E is thought to enhance receptor-mediated cl...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(00)00589-x

    authors： Millar JS,Lichtenstein AH,Ordovas JM,Dolnikowski GG,Schaefer EJ

    更新日期：2001-04-01 00:00:00

  • Effects of oils rich in eicosapentaenoic and docosahexaenoic acids on the oxidizability and thrombogenicity of low-density lipoprotein.

    abstract：:Consumption of oily fish and fish oils is associated with protection against cardiovascular disease. Paradoxically, long-chain polyunsaturated fatty acids present in low-density lipoprotein (LDL) are suggested to be susceptible to oxidation. It is not clear whether eicosapentaenoic acid (EPA) and docosahexaenoic acid ...

    journal_title：Atherosclerosis

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.atherosclerosis.2004.04.004

    authors： Mesa MD,Buckley R,Minihane AM,Yaqoob P

    更新日期：2004-08-01 00:00:00

  • beta-very low density lipoprotein enhances inducible nitric oxide synthase expression in cytokine-stimulated vascular smooth muscle cells.

    abstract：:beta-very low-density lipoprotein (beta-VLDL), a collective term for VLDL and chylomicron remnants, has recently shown to potently promote the development of atherosclerosis. However, the effects of beta-VLDL on the accumulation of nitric oxide (NO) and the expression of inducible NO synthase (iNOS) in vascular smooth...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(01)00727-4

    authors： Takahashi M,Takahashi S,Shimpo M,Naito A,Ogata Y,Kobayashi E,Ikeda U,Shimada K

    更新日期：2002-06-01 00:00:00

  • Evaluation of anti-atherosclerotic activities of PPAR-α, PPAR-γ, and LXR agonists in hyperlipidemic atherosclerosis-susceptible F(1)B hamsters.

    abstract：BACKGROUND:Fenofibrate, a PPAR-α agonist and rosiglitazone, a PPAR-γ agonist, reduce triglycerides and fatty acids in humans and in animal disease models. The efficacy of PPAR-α agonists in mouse model of human atherosclerosis disease has shown mixed results, and efficacy of PPAR-γ and liver X receptor (LXR) agonists h...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2010.10.033

    authors： Srivastava RA

    更新日期：2011-01-01 00:00:00

  • Impact of treatment strategies on outcomes in patients with stable coronary artery disease and type 2 diabetes mellitus according to presenting angina severity: A pooled analysis of three federally-funded randomized trials.

    abstract：BACKGROUND AND AIMS:The impact of treatment strategies on outcomes in patients with stable coronary artery disease (CAD) and type 2 diabetes mellitus (T2DM) according to presenting angina has not been rigorously assessed. METHODS:We performed a patient-level pooled-analysis (n = 5027) of patients with stable CAD and T...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2018.04.005

    authors： Mancini GBJ,Boden WE,Brooks MM,Vlachos H,Chaitman BR,Frye R,Bittner V,Hartigan PM,Dagenais GR

    更新日期：2018-10-01 00:00:00

  • Impact of HIV and highly active antiretroviral therapy on leukocyte adhesion molecules, arterial inflammation, dyslipidemia, and atherosclerosis.

    abstract：:Highly active antiretroviral therapy (HAART) has greatly extended the lives of people infected with the human immunodeficiency virus (HIV). This reduced risk of early death from opportunistic infections or other sequelae of HIV infection, however, means that other possible causes of death emerge. Myocardial infarction...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,评审

    doi：10.1016/j.atherosclerosis.2005.09.025

    authors： Fisher SD,Miller TL,Lipshultz SE

    更新日期：2006-03-01 00:00:00

  • Cholesterol vehicle in experimental atherosclerosis. Part 15. Randomized butter and randomized lard.

    abstract：:Randomized lard and butter oil were conpared with native lard and butter oil for their effects on cholesterol-induced atherosclerosis in rabbits. In each experiment there was also a group fed corn oil. The diets contained 2% cholesterol and 6% fat and were fed for eight weeks. Randomization of either butter or lard ha...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(77)90043-0

    authors： Kritchevsky D,Tepper SA

    更新日期：1977-07-01 00:00:00

  • Effect of folic acid supplementation on the progression of carotid intima-media thickness: a meta-analysis of randomized controlled trials.

    abstract：OBJECTIVES:We conducted a meta-analysis of relevant randomized trials to assess whether folic acid supplementation reduces the progression of atherosclerosis as measured by carotid intima-media thickness (CIMT). METHODS:This analysis included 2052 subjects from ten folic acid randomized trials with the change in CIMT ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.atherosclerosis.2011.12.007

    authors： Qin X,Xu M,Zhang Y,Li J,Xu X,Wang X,Xu X,Huo Y

    更新日期：2012-06-01 00:00:00

  • An investigation of the role of lecithin:cholesterol acyltransferase and triglyceride-rich lipoproteins in the metabolism of pre-beta high density lipoproteins.

    abstract：:Small high density lipoproteins (HDL) with pre-beta electrophoretic mobility (pre-beta HDL) have recently been shown to be the primary acceptor of cholesterol from cultured cells. We studied the metabolism of these particles by incubating serum at 37 degrees C in the presence and absence of active lecithin: cholestero...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(91)90005-n

    authors： Neary R,Bhatnagar D,Durrington P,Ishola M,Arrol S,Mackness M

    更新日期：1991-07-01 00:00:00

  • Lipid-lowering therapy with fluvastatin inhibits oxidative modification of low density lipoprotein and improves vascular endothelial function in hypercholesterolemic patients.

    abstract：:This prospective randomized trial was designed to elucidate clinically the effect of fluvastatin on inhibiting oxidation of the low density lipoprotein (LDL) and improving the vascular endothelial function as well as its lipid-lowering effects, in comparison with pravastatin. Of 64 consecutive dyslipidemic patients, 4...

    journal_title：Atherosclerosis

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0021-9150(01)00585-8

    authors： Inoue T,Hayashi M,Takayanagi K,Morooka S

    更新日期：2002-02-01 00:00:00

  • Race and sex-based disparities associated with carotid endarterectomy in the Atherosclerosis Risk in Communities (ARIC) study.

    abstract：BACKGROUND AND AIMS:The indications for carotid endarterectomy (CEA) are well established. The aim of the current study was to investigate sex and race-based disparities in the incidence of CEA after adjusting for carotid artery stenosis risk factors. METHODS:We conducted a prospective cohort analysis of 14,492 black ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2019.10.019

    authors： Hicks CW,Daya NR,Black JH 3rd,Matsushita K,Selvin E

    更新日期：2020-01-01 00:00:00

  • Is inflammation prior to renal transplantation predictive for cardiovascular and renal outcomes?

    abstract：OBJECTIVES:Markers of non-specific inflammation, such as C-reactive protein (CRP) or leukocyte count are increased in end-stage renal disease patients. Recent studies have shown positive associations between inflammatory markers and cardiovascular mortality in kidney transplant recipients, but these analyses had been l...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2010.01.004

    authors： Krüger B,Walberer A,Debler J,Böger CA,Farkas S,Reinhold SW,Obed A,Schlitt HJ,Fischereder M,Banas B,Krämer BK

    更新日期：2010-06-01 00:00:00

  • A specific 15-lipoxygenase inhibitor limits the progression and monocyte-macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit.

    abstract：:Oxidant signalling and lipoprotein oxidation may play important roles in atherosclerotic lesion development. Given coincident localization of 15-lipoxygenase (15-LO), stereospecific products of 15-LO and epitopes of modified LDL in atherosclerotic lesions, we hypothesized that inhibition of 15-LO by PD146176, an inhib...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(97)00204-9

    authors： Bocan TM,Rosebury WS,Mueller SB,Kuchera S,Welch K,Daugherty A,Cornicelli JA

    更新日期：1998-02-01 00:00:00

  • Characterization of LncRNA expression profile and identification of novel LncRNA biomarkers to diagnose coronary artery disease.

    abstract：BACKGROUND AND AIMS:Dysregulation of long non-coding RNAs (lncRNAs) has been proven to be involved in the pathogenesis of coronary artery disease (CAD). However, it remains to be extensively explored. Thus, the present study aims to study expression patterns, biological functions, and diagnostic value of lncRNAs in CAD...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2018.06.866

    authors： Li L,Wang L,Li H,Han X,Chen S,Yang B,Hu Z,Zhu H,Cai C,Chen J,Li X,Huang J,Gu D

    更新日期：2018-08-01 00:00:00

  • The association of serum lipid and lipoprotein levels with total and differential leukocyte counts: Results of a cross-sectional and longitudinal analysis of the UK Biobank.

    abstract：BACKGROUND AND AIMS:There is some evidence of a cross-sectional, and possibly causal, relationship of lipid levels with leukocyte counts in mice and humans. This study investigates the cross-sectional and longitudinal relationship of blood lipid and lipoprotein levels with leukocyte counts in the UK Biobank cohort. ME...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2020.12.016

    authors： Tucker B,Sawant S,McDonald H,Rye KA,Patel S,Ong KL,Cochran BJ

    更新日期：2020-12-21 00:00:00

  • Treatment of familial hypercholesterolemia with a combination of bezafibrate and guar.

    abstract：:The effect of guar (15.6 g/day), a dietary fibre, and simultaneous administration of bezafibrate (600 mg/day) during dietetic treatment on the plasma lipoproteins and apolipoproteins was investigated in 12 patients with familial hypercholesterolemia (corresponding to the HLP type IIa pattern). Either bezafibrate alone...

    journal_title：Atherosclerosis

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0021-9150(82)90230-1

    authors： Wirth A,Middelhoff G,Braeuning C,Schlierf G

    更新日期：1982-12-01 00:00:00

  • Lipoprotein particle distribution and size, insulin resistance, and metabolic syndrome in Alaska Eskimos: the GOCADAN study.

    abstract：BACKGROUND:Metabolic syndrome (MS) is associated with dyslipidemia, and insulin resistance (IR) may be a main determinant of this dyslipidemia. OBJECTIVE:To determine how lipoprotein particle concentration and size are related to MS and IR in a population-based sample of Alaska Eskimos. DESIGN:Participants underwent ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2007.12.041

    authors： Rivellese AA,Patti L,Kaufman D,Zhu J,Annuzzi G,Vaccaro O,Ebbesson SO,Howard WJ,Riccardi G,Howard BV

    更新日期：2008-10-01 00:00:00