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"Low dose" colestipol in children, adolescents and young adults with familial hypercholesterolemia.

Abstract：

:The effect of colestipol on plasma lipids and lipoproteins was studied in children, adolescents and young adults with familial hypercholesterolemia. O.125 g or 0.25 g/kg body weight were given in randomized sequence for period of 4 weeks. Total cholesterol was lowered by 13 and 18% with the smaller and larger dose , respectively, and LDL cholesterol lowered by 15% with the smaller and 12% with the larger dose. HDL cholesterol rose by 18 an 32%. LDL composition before and during the study was abnormal due to a markedly reduced triglyceride content. "Low-dose" colestipol is less effective lowering total plasma and LDL cholesterol than conventional doses but may, due to very few side effects, by advantageously used in cases of familial hypercholesterolemia when plasma cholesterol levels after dietary management are only 15-20% above normal.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Schlierf G,Mrozik K,Heuck CC,Middelhoff G,Oster P,Riesen W,Schellenberg B

doi

10.1016/0021-9150(82)90077-6

subject

Has Abstract

pub_date

1982-01-01 00:00:00

pages

133-8

issue

1

eissn

0021-9150

issn

1879-1484

pii

0021-9150(82)90077-6

journal_volume

41

pub_type

临床试验,杂志文章,随机对照试验

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