Effects of estrogens on lipoprotein metabolism and cardiovascular disease in women.

abstract：UNLABELLED:Previous studies have suggested altered triglyceride (TG) storage in patients with abdominal obesity and blood lipid disorders. OBJECTIVE:We hypothesized that women with abdominal obesity and a dysmetabolic profile have low DGAT activity in their abdominal fat compartments. METHODS:Paired omental (OM) and ...

journal_title：Atherosclerosis

authors： Côté JA,Nadeau M,Leboeuf M,Blackburn L,Tchernof A

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:the extracellular matrix (ECM) is an important determinant of plaque instability. Since tissue transglutaminase (tTG) and elafin act as stabilizing factors, they might play a crucial role in the pathogenesis of acute coronary syndrome. We examined their expression in human coronary arteries and the regulatio...

journal_title：Atherosclerosis

authors： Sumi Y,Inoue N,Azumi H,Seno T,Okuda M,Hirata K,Kawashima S,Hayashi Y,Itoh H,Yokoyama M

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND AND AIMS:South Asians are at increased risk for cardiovascular disease (CVD). Aortic valve calcium (AVC) is associated with CVD risk and aortic stenosis. Elevated Lp(a) is a heritable risk factor for CVD and AVC. AVC prevalence and its association with Lp(a) have not been studied in South Asians. METHODS:Am...

journal_title：Atherosclerosis

authors： Makshood M,Joshi PH,Kanaya AM,Ayers C,Budoff M,Tsai MY,Blaha M,Michos ED,Post WS

更新日期：2020-11-01 00:00:00

abstract：:Several reports have shown that lipoprotein(a) is associated with ischemic diseases. Two characteristics might explain this association. Firstly, Lp(a) is an LDL-like lipoprotein which may be implicated in the atherosclerotic process and secondly, Lp(a) possesses an additional apolipoprotein(a) whose structure is clos...

journal_title：Atherosclerosis

authors： Delplanque B,Beaumont V,Lemort N,Beaumont JL

更新日期：1993-05-01 00:00:00

abstract：:The formation of atherosclerotic lesions requires the migration of vascular smooth muscle cells from the media into the intima of the artery and their proliferation. These events, which are preceded and accompanied by inflammation, are modulated by integrin receptors linking vascular smooth muscle cells to extracellul...

journal_title：Atherosclerosis

authors： Barillari G,Albonici L,Incerpi S,Bogetto L,Pistritto G,Volpi A,Ensoli B,Manzari V

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND AND AIM:Hypercholesterolaemia is a major risk factor for atherosclerosis. Cholesterol is modulated by genetic and environmental factors. An important regulatory pathway is controlled by the sterol-regulatory element-binding proteins (SREBPs) and the SREBP cleavage-activating protein (SCAP). Both SREBP-2 and ...

journal_title：Atherosclerosis

authors： Durst R,Jansen A,Erez G,Bravdo R,Butbul E,Ben Avi L,Shpitzen S,Lotan C,Leitersdorf E,Defesche J,Friedlander Y,Meiner V,Miserez AR

更新日期：2006-12-01 00:00:00

abstract：:A marked reduction of serum cholesterol was obtained by treatment with probucol in heterozygous as well as in homozygous cases of familial hypercholesterolemia. A strict dietary regimen (low-fat, low-calories) intensified the hypocholesterolemic effect of the drug. The drug was also useful in diminishing the rebound o...

journal_title：Atherosclerosis

authors： Yamamoto A,Matsuzawa Y,Kishino B,Hayashi R,Hirobe K,Kikkawa T

更新日期：1983-08-01 00:00:00

abstract：OBJECTIVE:Although C-reactive protein (CRP) and albuminuria are well-documented cardiovascular risk markers, the functional implications of these biomarkers and their combination on functional disability and metabolic risks in patients with cardiovascular disease (CVD) are unknown. METHODS:Data were from 1403 adults (...

journal_title：Atherosclerosis

authors： Kuo HK,Al Snih S,Kuo YF,Raji MA

更新日期：2012-06-01 00:00:00

abstract：:Neutrophils have been implicated in ischaemic heart disease, unstable angina pectoris and acute myocardial infarction. Alterations in dietary levels of specific 18- and 20-carbon polyunsaturated fatty acids have significant clinical benefits in cardiovascular disease. However, to date there has been no concerted effor...

journal_title：Atherosclerosis

authors： Bates EJ,Ferrante A,Smithers L,Poulos A,Robinson BS

更新日期：1995-08-01 00:00:00

abstract：:Oxidized low-density lipoprotein (oxLDL) exhibits many atherogenic effects, including the promotion of monocyte recruitment to the arterial endothelium and the induction of scavenger receptor expression. However, while atherosclerosis involves chronic inflammation within the arterial intima, it is unclear whether oxLD...

journal_title：Atherosclerosis

authors： Kavanagh IC,Symes CE,Renaudin P,Nova E,Mesa MD,Boukouvalas G,Leake DS,Yaqoob P

更新日期：2003-06-01 00:00:00

abstract：UNLABELLED:Pentraxin 3 (PTX3) is an acute phase protein strongly expressed by advanced atherosclerotic lesions. We investigated (a) PTX3 expression and secretion in subcutaneous adipose tissue (SAT) and omental visceral adipose tissue (VAT) obtained from 21 obese (37.4+/-8.15 yr) and 10 normal weight subjects (43.7+/-1...

journal_title：Atherosclerosis

authors： Alberti L,Gilardini L,Zulian A,Micheletto G,Peri G,Doni A,Mantovani A,Invitti C

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVE:Carotid intima-media thickness (IMT) is a measure of arterial thickening and a risk predictor for myocardial infarction and stroke. It is unclear whether IMT also predicts atrial fibrillation (AF). We explored the association between IMT and incidence of first AF hospitalization in a population-based cohort. ...

journal_title：Atherosclerosis

authors： Adamsson Eryd S,Östling G,Rosvall M,Persson M,Smith JG,Melander O,Hedblad B,Engström G

更新日期：2014-04-01 00:00:00

abstract：UNLABELLED:Inflammation plays an important role in atherosclerosis and the genesis of acute coronary syndromes, i.e., atheromatous plaque disruption. Neutrophil count and C-reactive protein (CRP) levels are markers of ongoing inflammation and predictors of cardiovascular risk. We sought to assess whether these inflamma...

journal_title：Atherosclerosis

authors： Avanzas P,Arroyo-Espliguero R,Cosín-Sales J,Quiles J,Zouridakis E,Kaski JC

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND AND AIMS:We examined whether the inflammation resolution mediator lipoxin A4 (LXA4) inhibits foam cell formation and oxidized low-density lipoprotein (oxLDL)-induced apoptotic signaling in macrophages and the role of circulating/local LXA4 biosynthesis in atherogenesis. METHODS:LXA4 levels were measured by ...

journal_title：Atherosclerosis

authors： Mai J,Liu W,Fang Y,Zhang S,Qiu Q,Yang Y,Wang X,Huang T,Zhang H,Xie Y,Lin M,Chen Y,Wang J

更新日期：2018-11-01 00:00:00

abstract：:Although calcific aortic stenosis is a very common disease with major adverse cardiovascular events and healthcare costs, there are no effective medical interventions to delay or halt its progression. Cardiometabolic risk factors, including smoking and male sex, are linked to aortic stenosis. Emerging studies have ide...

journal_title：Atherosclerosis

authors： Cho KI,Sakuma I,Sohn IS,Jo SH,Koh KK

更新日期：2018-10-01 00:00:00

abstract：:Some baboons accumulate appreciable amounts of large apoE-rich HDLs (HDL(1)) which are similar to those reported in humans with several different dyslipoproteinemias. We estimated HDL(1) cholesterol concentrations by gradient gel electrophoresis of serum samples obtained from 634 pedigreed baboons fed with three diets...

journal_title：Atherosclerosis

authors： Rainwater DL,Kammerer CM,Cox LA,Rogers J,Carey KD,Dyke B,Mahaney MC,McGill HC Jr,VandeBerg JL

更新日期：2002-08-01 00:00:00

abstract：:Vascular smooth muscle cell (VSMC) migration and proliferation are critical events in the development of neointima following vascular injury. In this study, we found that CD9 is constitutively expressed in the VSMC of the neointima of injured carotid arteries. The in vitro migration and proliferation of human coronary...

journal_title：Atherosclerosis

authors： Kotha J,Zhang C,Longhurst CM,Lu Y,Jacobs J,Cheng Y,Jennings LK

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:In coronary artery disease (CAD), concomitant peripheral arterial disease (PAD) entails more severe coronary atherosclerosis. We investigated whether the inflammatory status of affected limbs impairs coronary artery endothelial function (CAEF). METHODS:We measured the neutrophil myeloperoxidase content (NMP...

journal_title：Atherosclerosis

authors： Brevetti G,Piscione F,Cirillo P,Galasso G,Schiano V,Barbato E,Scopacasa F,Chiariello M

更新日期：2008-12-01 00:00:00

abstract：:Lipoprotein dynamics are complex during the postprandial state. A significant rise in chylomicron concentration is associated with increased competition for LPL with VLDL particles. This results in an increased concentration of large VLDL. The concentration of small VLDL is reduced as a result of diminished conversion...

journal_title：Atherosclerosis

authors： Hugh P,Barrett R

更新日期：1998-12-01 00:00:00

abstract：:The number of low density platelets was found to be increased in patients with hypercholesterolemia, as compared with the number in controls. The percentage increase of the low density platelet subpopulation was even more pronounced in patients with hypercholesterolemia when compared with that in patients suffering fr...

journal_title：Atherosclerosis

authors： Opper C,Clement C,Schwarz H,Krappe J,Steinmetz A,Schneider J,Wesemann W

更新日期：1995-03-01 00:00:00

abstract：OBJECTIVES:Pyrophosphate (PPi) is a potent inhibitor of ectopic mineralization but its role during aortic valve calcification is not known. METHODS:Anti-calcific effect of PPi was investigated by using an in vitro model of serum-driven calcification of collagen sponges and decellularized porcine aortic valve leaflets....

journal_title：Atherosclerosis

authors： Rattazzi M,Bertacco E,Iop L,D'Andrea S,Puato M,Buso G,Causin V,Gerosa G,Faggin E,Pauletto P

更新日期：2014-12-01 00:00:00

abstract：:Methionine is converted by the transmethylation/transsulfuration pathway to homocysteine which may exert atherogenic effects by several mechanisms, including lipid peroxidation. Therefore, the excessive dietary methionine may induce the development of atherosclerosis. To test this hypothesis, plasma and aortic thiobar...

journal_title：Atherosclerosis

authors： Toborek M,Kopieczna-Grzebieniak E,Drózdz M,Wieczorek M

更新日期：1995-06-01 00:00:00

abstract：:The present study is the first work to evaluate thrombin-, ADP-, and collagen-induced platelet aggregation in laboratory rats receiving alimentation with the parenterally-administered lipid emulsion, Lipofundin-S, in doses sufficient to induce early atherosclerotic changes in the aorta. The aggregometry parameters of ...

journal_title：Atherosclerosis

authors： Saladino CF,Fox RL,Yeh Q,Karpowicz F,Feffer SE,Jonas EA

更新日期：1987-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Previous epidemiological studies have shown positive associations between serum calcium concentration and risk of cardiovascular disease (CVD), but results differ by definition of CVD. We examined the association of circulating calcium with incident and fatal CVD, myocardial infarction (MI), and str...

journal_title：Atherosclerosis

authors： Rohrmann S,Garmo H,Malmström H,Hammar N,Jungner I,Walldius G,Van Hemelrijck M

更新日期：2016-08-01 00:00:00

abstract：:Patients with homozygous familial hypercholesterolemia (FH), as a result of the increased levels and prolonged residence time of low density lipoprotein (LDL) in plasma, have a strong tendency toward accumulation of LDL-cholesterol in the arterial wall, causing premature atherosclerosis. This phenomenon may enhance pe...

journal_title：Atherosclerosis

authors： Napoli C,Postiglione A,Triggiani M,Corso G,Palumbo G,Carbone V,Ruocco A,Ambrosio G,Montefusco S,Malorni A,Condorelli M,Chiariello M

更新日期：1995-12-01 00:00:00

abstract：OBJECTIVE:We examined the risk of cardiovascular disease, stroke, ischaemic heart disease, and diabetes with the metabolic syndrome according to the new harmonised definition and its components using a national longitudinal data set from an Asian population. METHODS:Data of 9791 men and women aged 20+ from 1998 and 20...

journal_title：Atherosclerosis

authors： Khang YH,Cho SI,Kim HR

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:The relative expression levels of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs), key regulators in remodeling of extracellular matrix, are considered to play a pivotal role in the development of abdominal aortic aneurysm (AAA). However, few data exist regarding quantita...

journal_title：Atherosclerosis

authors： Higashikata T,Yamagishi M,Sasaki H,Minatoya K,Ogino H,Ishibashi-Ueda H,Hao H,Nagaya N,Tomoike H,Sakamoto A

更新日期：2004-12-01 00:00:00

abstract：OBJECTIVE:Pravastatin has been reported to elevate circulating adiponectin levels in patients with various insulin resistant state, hypertension, coronary artery disease, and hypercholesterolemia. This study aimed to evaluate whether pravastatin increase serum total and high molecular weight adiponectin levels and impr...

journal_title：Atherosclerosis

authors： Kim JH,Lee MR,Shin JA,Lee SS,Lee JM,You SJ,Yoon KH,Chang SA

更新日期：2013-04-01 00:00:00

abstract：:Endothelial lipase (EL), a new member of the triacylglycerol lipase gene family, is a key enzyme in HDL metabolism. The EL expression pattern in humans was reported to be unique and complementary to that documented for lipoprotein lipase. The regulatory elements responsible for the tissue-specific EL expression are no...

journal_title：Atherosclerosis

authors： Broedl UC,Jin W,Marchadier D,Secreto A,Rader DJ

更新日期：2005-08-01 00:00:00

abstract：:The association between serum selenium concentration and a number of coronary heart disease risk factors is studied in 364 males from southern Italy participating in the Olivetti Heart Study. Selenium correlates positively and significantly with serum cholesterol (r = 0.120; P = 0.022), and this positive association p...

journal_title：Atherosclerosis

authors： Jossa F,Trevisan M,Krogh V,Farinaro E,Giumetti D,Fusco G,Galasso R,Panico S,Frascatore S,Mellone C

更新日期：1991-04-01 00:00:00