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Betaine supplementation improves the atherogenic risk factor profile in a transgenic mouse model of hyperhomocysteinemia.

Abstract：

OBJECTIVE:To investigate the lipotropic action of betaine on plasma lipoproteins and tissue lipids. METHODS AND RESULTS:Adult mice, wild type (+/+) or heterozygous (+/-) for a disruption of the methylenetetrahydrofolate reductase (Mthfr) gene, were supplemented with betaine for 1 year and compared with mice on control diets. Outcome measures were plasma homocysteine and lipoprotein levels, aortic and liver morphology, and liver staining for 3-nitrotyrosine (oxidative stress marker) and Apolipoprotein A-I (ApoA-I). We also investigated short-term effects of supplemental betaine on plasma lipoproteins in Mthfr +/+ and +/- mice. Both genotypes showed significantly lower plasma homocysteine after long-term betaine supplementation, and lower plasma triglycerides and higher HDL-cholesterol after both short- and long-term betaine. Lipid accumulation in liver and aortic wall tended to be lower in Mthfr+/+ compared to Mthfr+/- mice and in betaine-supplemented compared to unsupplemented mice. Nitrotyrosine staining was higher and ApoA-I staining was lower in livers of Mthfr+/- compared to Mthfr+/+ mice. Betaine did not affect staining of nitrotyrosine but increased ApoA-I staining. A significant negative correlation was observed between plasma homocysteine and liver ApoA-I. CONCLUSIONS:Mild MTHFR deficiency in mice is associated with increased risk for atherosclerotic disease. Betaine has a lipotropic effect, which is associated with a reduction in homocysteine, an increase in ApoA-I and an amelioration of the atherogenic risk profile.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Schwahn BC,Wang XL,Mikael LG,Wu Q,Cohn J,Jiang H,Maclean KN,Rozen R

doi

10.1016/j.atherosclerosis.2007.06.030

subject

Has Abstract

pub_date

2007-12-01 00:00:00

pages

e100-7

issue

2

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(07)00403-0

journal_volume

195

pub_type

杂志文章

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