当前位置： SCI文献检索 > ATHEROSCLEROSIS期刊下所有文献 > The effect of renal hypertension on the regional deposition of cholesterol and phospholipid in the aorta of normally- and cholesterol-fed rabbits.

The effect of renal hypertension on the regional deposition of cholesterol and phospholipid in the aorta of normally- and cholesterol-fed rabbits.

Abstract：

:The effect of renal hypertension on dry defatted tissue mass and lipid accumulation in different segments of the aortic intima was studied in both normally-fed and cholesterol-fed rabbits. In normally-fed rabbits hypertension caused an increase in intimal dry weight in the aorta. The increase was greatest in the lower thoracic intimal segment but was not significant in the aortic arch. The increase in tissue mass was not influenced by the addition of cholesterol to the diet and no regression of the increased tissue mass occurred when a 4-week period of hypertension was followed by a 4-week period of normotension. Hypertension did not increase the intimal cholesterol or phospholipid concentrations in normally-fed rabbits, suggesting that an observed increase in lipid content represented the cellular component of the intimal hypertrophy. Hypertension in cholesterol-fed animals caused preferential lipid accumulation in the lower thoracic segment, an effect that was independent of the total intimal cholesterol level. Intimal cholesterol, cholesterol ester and phospholipid were all increased. When a 4-week period of normotension and cholesterol feeding was preceded by a 4-week period of hypertension with normal feeding the amount of cholesterol deposited did not exceed that of the normotensive control, suggesting either that hypertension increased intimal permeability to lipid only in the presence of hypercholesterolaemia, or that healing of damaged intima had occurred before hypercholesterolaemia was fully established.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Bretherton KN,Day AJ,Skinner SL

doi

10.1016/0021-9150(75)90030-1

keywords:

subject

Has Abstract

pub_date

1975-11-01 00:00:00

pages

517-32

issue

3

eissn

0021-9150

issn

1879-1484

pii

0021-9150(75)90030-1

journal_volume

22

pub_type

杂志文章

相关文献

ATHEROSCLEROSIS文献大全
  • Impact of fibrate therapy on plasma plasminogen activator inhibitor-1: a systematic review and meta-analysis of randomized controlled trials.

    abstract：OBJECTIVE:The aim of this systematic review was to perform a meta-analysis of randomized controlled trials (RCTs) examining the efficacy of fibrate therapy in reducing plasma concentration or activity of plasminogen activator inhibitor 1 (PAI-1). METHODS:Scopus and MEDLINE databases were searched (up to October 15, 20...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.atherosclerosis.2015.03.016

    authors： Sahebkar A,Simental-Mendía LE,Watts GF,Golledge J

    更新日期：2015-05-01 00:00:00

  • The effects of diet and lovastatin on regression of fatty streak lesions and on hepatic and intestinal mRNA levels for the LDL receptor and HMG CoA reductase in F1B hamsters.

    abstract：:This study examined the effects of lovastatin supplementation (25 mg/kg per day) in conjunction with an atherogenic diet (10% coconut oil (w/w), 0.05% cholesterol) on regression of pre-existing foam cells and on hepatic and intestinal LDL receptor and HMG CoA reductase mRNA levels. F1B hamsters fed the atherogenic die...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(97)00302-x

    authors： Pitman WA,Osgood DP,Smith D,Schaefer EJ,Ordovas JM

    更新日期：1998-05-01 00:00:00

  • Dietary linoleate increases fluidity and influences chemical composition of plasma low density lipoprotein in adult men.

    abstract：:Dietary linoleate was effective to increase LDL fluidity in adult men but did not significantly influence VLDL or HDL fluidities. Lipoproteins were isolated ultracentrifugally from plasma of sixteen healthy, free living male volunteers consuming controlled diets formulated from typical U.S.A. foods to have 35 energy %...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(87)90065-7

    authors： Berlin E,Judd JT,Marshall MW,Kliman PG

    更新日期：1987-08-01 00:00:00

  • Effects of dietary saturated, monounsaturated and n-3 fatty acids on fasting lipoproteins, LDL size and post-prandial lipid metabolism in healthy subjects.

    abstract：BACKGROUND:The influence of the quality of dietary fat on some aspects of lipid metabolism-i.e. lipoprotein concentrations, post-prandial lipids and LDL size-is not completely understood, especially in healthy individuals. OBJECTIVES:Aim of this study was to evaluate the effects of different types of dietary fat (mono...

    journal_title：Atherosclerosis

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0021-9150(02)00424-0

    authors： Rivellese AA,Maffettone A,Vessby B,Uusitupa M,Hermansen K,Berglund L,Louheranta A,Meyer BJ,Riccardi G

    更新日期：2003-03-01 00:00:00

  • Increased atherosclerosis following treatment with a dual PPAR agonist in the ApoE knockout mouse.

    abstract：OBJECTIVE:Recent reports have suggested that dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonists are associated with adverse cardiovascular events. This study aimed to investigate the actions of the non-thiazolidinedione PPARalpha/gamma agonist, compound 3q, on plaque development in the apolipop...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2006.11.021

    authors： Calkin AC,Allen TJ,Lassila M,Tikellis C,Jandeleit-Dahm KA,Thomas MC

    更新日期：2007-11-01 00:00:00

  • One-year treatment with exenatide vs. insulin glargine: effects on postprandial glycemia, lipid profiles, and oxidative stress.

    abstract：OBJECTIVE:The objective of the present study was to investigate the effects of one-year treatment with exenatide or Insulin Glargine, followed by a 5-week off-drug period, on postprandial lipidaemia, glycaemia and measures of oxidative stress. METHODS:Sixty-nine metformin-treated patients with type 2 diabetes were ran...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.atherosclerosis.2010.04.024

    authors： Bunck MC,Cornér A,Eliasson B,Heine RJ,Shaginian RM,Wu Y,Yan P,Smith U,Yki-Järvinen H,Diamant M,Taskinen MR

    更新日期：2010-09-01 00:00:00

  • The therapeutic gap--compliance with medication and guidelines.

    abstract：:Hospitals, clinics and cardiologists have a significant impact on prescribing in general practice. Physicians in primary care rank hospital recommendations as one of the most important sources of information on new drugs. However, recent surveys of coronary heart disease (CHD) prevention paint a depressing picture abo...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(99)00253-1

    authors： Feely J

    更新日期：1999-09-09 00:00:00

  • Eosinophils count and periprocedural myocardial infarction in patients undergoing percutaneous coronary interventions.

    abstract：BACKGROUND:Eosinophils have been involved in a wide spectrum of pro-inflammatory and pro-thrombotic conditions, with the development of cardiovascular complications in a significant proportion of hypereosinophilic patients. However, no study has so far evaluated the impact of eosinophils levels on periprocedural myocar...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2014.06.023

    authors： Verdoia M,Schaffer A,Barbieri L,Sinigaglia F,Marino P,Suryapranata H,De Luca G,Novara Atherosclerosis Study Group (NAS).

    更新日期：2014-09-01 00:00:00

  • The clinical importance of serum γ-glutamyltransferase level as an early predictor of obesity development in Korean men.

    abstract：BACKGROUND AND OBJECTIVE:Serum γ-glutamyl transferase (GGT) levels are known to be positively associated with obesity. We aimed at verifying an association between baseline GGT levels and the development of obesity in Korean men. PATIENTS AND METHODS:This prospective cohort study was performed on 18,510 initially non-...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2013.01.029

    authors： Suh YJ,Park SK,Choi JM,Ryoo JH

    更新日期：2013-04-01 00:00:00

  • Plaque microstructures in patients with coronary artery disease who achieved very low low-density lipoprotein cholesterol levels.

    abstract：OBJECTIVE:Lowering low-density lipoprotein cholesterol (LDL-C) with statins reduces cardiovascular events and slows plaque progression. While this therapeutic approach has been reported to favorably modify plaque composition, this is not well characterized in humans. Also, the benefit of achieving LDL-C levels below cu...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2015.08.005

    authors： Kataoka Y,Hammadah M,Puri R,Duggal B,Uno K,Kapadia SR,Murat Tuzcu E,Nissen SE,Nicholls SJ

    更新日期：2015-10-01 00:00:00

  • Antiatherothrombotic effects of nicotinic acid.

    abstract：:Cardiovascular event reduction in hypercholesterolemic subjects appropriately emphasizes the prominent role of statin therapy; however, niacin (nicotinic acid) is also an effective lipid-altering agent that prevents atherosclerosis and reduces cardiovascular events. Niacin has multifarious lipoprotein and anti-atherot...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,评审

    doi：10.1016/j.atherosclerosis.2003.07.003

    authors： Rosenson RS

    更新日期：2003-11-01 00:00:00

  • Association of arterial stiffness and diabetes with triglycerides-to-HDL cholesterol ratio for Japanese men: the Nagasaki Islands Study.

    abstract：OBJECTIVE:Although many studies have reported that elevated serum triglycerides to high-density lipoprotein cholesterol (TG-HDL) ratios constitute a risk for insulin resistance and increased arterial stiffness, no study has clarified as yet the association, in terms of the TG-HDL ratio, between diabetes and increased a...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2013.03.021

    authors： Shimizu Y,Nakazato M,Sekita T,Kadota K,Yamasaki H,Takamura N,Aoyagi K,Maeda T

    更新日期：2013-06-01 00:00:00

  • Prevalence and risk factors for cerebral infarction and carotid artery stenosis in peripheral arterial disease.

    abstract：OBJECTIVE:The purpose of the study was to examine the prevalence and risk factors for cerebral infarction (CI) and carotid artery stenosis (CAS) in patients with peripheral arterial disease (PAD) compared with normal controls. METHOD:A cross-sectional analysis was performed in 857 subjects (PAD: 543, controls: 314). C...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2012.05.019

    authors： Araki Y,Kumakura H,Kanai H,Kasama S,Sumino H,Ichikawa A,Ito T,Iwasaki T,Takayama Y,Ichikawa S,Fujita K,Nakashima K,Minami K,Kurabayashi M

    更新日期：2012-08-01 00:00:00

  • CD1d serves as a surface receptor for oxidized cholesterol induction of peroxisome proliferator-activated receptor-γ.

    abstract：OBJECTIVE:The cluster of differentiation-1d (CD1d) recognizes and presents the lipid antigens to NK-T lymphocytes. Atherosclerotic lesions contain atherogenic lipids, mainly cholesterol and its oxides. Peroxisome proliferator-activated receptor-γ (PPARγ) is also known to exist in atherosclerotic lesions, participating ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2015.01.004

    authors： Rosales C,Tang D,Geng YJ

    更新日期：2015-03-01 00:00:00

  • Effects of estrogens on lipoprotein metabolism and cardiovascular disease in women.

    abstract：:Estrogen use is associated with protection from cardiovascular disease in postmenopausal women. This benefit appears to be magnified among women with pre-existing heart disease. The possible bias of intrinsically better health in women using estrogen has not been ruled out in observational studies. Therefore, two doub...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,评审

    doi：10.1016/0021-9150(94)05379-w

    authors： Knopp RH,Zhu X,Bonet B

    更新日期：1994-10-01 00:00:00

  • Tissue n-3 and n-6 fatty acids and risk for coronary heart disease events.

    abstract：BACKGROUND:Tissue proportions of long chain n-6 [especially arachidonic acid (AA)] and n-3 fatty acids [FA; eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) acids], or some ratio of these may be markers of risk for coronary heart disease (CHD). The purpose of this paper is to evaluate the published associatio...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,评审

    doi：10.1016/j.atherosclerosis.2007.03.018

    authors： Harris WS,Poston WC,Haddock CK

    更新日期：2007-07-01 00:00:00

  • Variants in the cholesterol ester transfer protein and lipoprotein lipase genes are predictors of plasma cholesterol response to dietary change.

    abstract：:There are no definitive explanations as to why individuals with hypercholesterolemia, a major cardiovascular risk factor, respond differently to dietary change. Fifty five free-living individuals completed a double crossover trial with two dietary regimens, a high saturated fat diet (providing 21% energy from saturate...

    journal_title：Atherosclerosis

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0021-9150(99)00490-6

    authors： Wallace AJ,Mann JI,Sutherland WH,Williams S,Chisholm A,Skeaff CM,Gudnason V,Talmud PJ,Humphries SE

    更新日期：2000-10-01 00:00:00

  • Carotid and femoral atherosclerotic plaques show different morphology.

    abstract：OBJECTIVE:Results of endovascular repair vary according to the arterial bed. We hypothesized that these differences may be related to the plaque features. To explore this hypothesis, we designed a prospective study that compared carotid and femoral atheroma. METHODS AND RESULTS:Patients that underwent femoral or carot...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2011.02.004

    authors： Herisson F,Heymann MF,Chétiveaux M,Charrier C,Battaglia S,Pilet P,Rouillon T,Krempf M,Lemarchand P,Heymann D,Gouëffic Y

    更新日期：2011-06-01 00:00:00

  • Carotid plaque, compared with carotid intima-media thickness, more accurately predicts coronary artery disease events: a meta-analysis.

    abstract：OBJECTIVES:We conducted the meta-analysis to compare the diagnostic accuracies of carotid plaque and carotid intima-media thickness (CIMT) measured by B-mode ultrasonography for the prediction of coronary artery disease (CAD) events. METHODS:Two reviewers independently searched electronic databases to identify relevan...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.atherosclerosis.2011.06.044

    authors： Inaba Y,Chen JA,Bergmann SR

    更新日期：2012-01-01 00:00:00

  • Aging, smooth muscle cells and vascular pathobiology: implications for atherosclerosis.

    abstract：:Epidemiological and autopsy studies suggest a close link between aging and the clinical manifestation of atherosclerosis. Several experiments show increased arterial susceptibility to atherogenetic stimuli in aged subjects. All together, these findings support the concept that aging represents an independent atherogen...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,评审

    doi：10.1016/j.atherosclerosis.2006.01.018

    authors： Orlandi A,Bochaton-Piallat ML,Gabbiani G,Spagnoli LG

    更新日期：2006-10-01 00:00:00

  • Serum complement and familial combined hyperlipidemia.

    abstract：:Familial combined hyperlipidemia (FCHL) is one of the most common inherited lipid disorders. Resistance of adipocytes to the effects of acylation stimulating protein (ASP) may contribute to ineffective triglyceride synthesis and thereby prolonged postprandial lipemia and increased fatty acid flux to the liver seen in ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(96)06054-6

    authors： Ylitalo K,Porkka KV,Meri S,Nuotio I,Suurinkeroinen L,Vakkilainen J,Pajukanta P,Viikari JS,Peltonen L,Ehnholm C,Taskinen MR

    更新日期：1997-03-21 00:00:00

  • The Crataegus extract WS 1442 inhibits balloon catheter-induced intimal hyperplasia in the rat carotid artery by directly influencing PDGFR-beta.

    abstract：OBJECTIVE:Effective systemic drugs against restenosis upon percutaneous transluminal coronary angioplasty (PTCA) are largely lacking. Polyphenols have been suggested to ameliorate post-angioplasty restenosis. Hawthorn (Crataegus spp.) extracts, which are among the most frequently used herbal medicinal products against ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2010.04.003

    authors： Fürst R,Zirrgiebel U,Totzke F,Zahler S,Vollmar AM,Koch E

    更新日期：2010-08-01 00:00:00

  • Association of plasma intermediate density lipoproteins with atherogenic intimal proliferative activity in abdominal aortas of hyperlipidemic swine.

    abstract：:In an earlier study of swine fed hyperlipidemic (HL) diets containing either butter or corn oil we found wide differences in atherogenic intimal proliferative responses among the swine, especially in the corn oil group, that could not be entirely accounted for by differences in serum cholesterol levels. We hypothesize...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(85)90068-1

    authors： Kim DN,Geourzoung SM,Schmee J,Lee KT,Thomas WA

    更新日期：1985-12-01 00:00:00

  • Pomegranate juice (PJ) consumption antioxidative properties on mouse macrophages, but not PJ beneficial effects on macrophage cholesterol and triglyceride metabolism, are mediated via PJ-induced stimulation of macrophage PON2.

    abstract：OBJECTIVE:To examine whether the beneficial effects of PJ consumption by mice on their macrophages are mediated via PJ-induced increment in serum paraoxonase 1 (PON1) activity and/or in macrophage PON2 expression. METHODS AND RESULTS:We performed studies in peritoneal macrophages (MPM) from C57BL/6 control mice, or fr...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2010.04.039

    authors： Rosenblat M,Volkova N,Aviram M

    更新日期：2010-09-01 00:00:00

  • Dectin-1 deficiency does not affect atherosclerosis development in mice.

    abstract：OBJECTIVE:Recent data suggest the involvement of dectin-1 in atherosclerosis through regulation of local reactive oxygen species production. The aim of the current study was to assess the effect of dectin-1 deficiency on atherosclerotic plaque development. METHODS:Using immunohistochemistry dectin-1 expression was obs...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2015.02.005

    authors： Szilagyi K,Gijbels MJ,van der Velden S,Heinsbroek SE,Kraal G,de Winther MP,van den Berg TK

    更新日期：2015-04-01 00:00:00

  • Prostanoid and isoprostanoid pathways in atherogenesis.

    abstract：:Atherosclerosis is a chronic inflammatory disease of the vasculature that is influenced by multiple factors and involves a complex interplay between some components of the bloodstream and the arterial wall. Among different circulating factors implicated in atherogenesis there is a large group of bioactive lipids calle...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,评审

    doi：10.1016/j.atherosclerosis.2008.04.037

    authors： Praticò D

    更新日期：2008-11-01 00:00:00

  • Cerivastatin: pharmacology of a novel synthetic and highly active HMG-CoA reductase inhibitor.

    abstract：:The pyridine derivative cerivastatin is a new entirely synthetic and enantiomerically pure inhibitor of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase. As a sodium salt cerivastatin is present in the active, open ring form. Cerivastatin inhibited the membrane-bound (non-solubilized) HMG-CoA reductase of the native...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(97)00188-3

    authors： Bischoff H,Angerbauer R,Bender J,Bischoff E,Faggiotto A,Petzinna D,Pfitzner J,Porter MC,Schmidt D,Thomas G

    更新日期：1997-11-01 00:00:00

  • Three-dimensional ultrasound imaging for the evaluation of carotid atherosclerosis.

    abstract：INTRODUCTION:Emerging data suggests that 3-dimensional (D) ultrasound (US) may provide us with a new tool for the identification of the vulnerable carotid plaque. METHODS:A systematic review of the PubMed, Scopus and Cochrane databases regarding the reproducibility and effectiveness of 3D US in evaluation of carotid p...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,评审

    doi：10.1016/j.atherosclerosis.2011.05.006

    authors： Makris GC,Lavida A,Griffin M,Geroulakos G,Nicolaides AN

    更新日期：2011-12-01 00:00:00

  • Chymase bound to heparin is resistant to its natural inhibitors and capable of proteolyzing high density lipoproteins in aortic intimal fluid.

    abstract：:Degranulated mast cells are present in the human arterial intima. After degranulation of rat serosal mast cells, the secreted neutral serine protease chymase remains bound to the heparin proteoglycan matrix of the exocytosed granules, forming granule remnants. Addition of granule remnants to human aortic intimal fluid...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(00)00544-x

    authors： Lindstedt L,Lee M,Kovanen PT

    更新日期：2001-03-01 00:00:00

  • Clinicopathological significance of lipid peroxidation in carotid plaques.

    abstract：:Several reports have suggested an association between lipid peroxidation and human carotid atherosclerosis, but few reports have demonstrated a link between lipid peroxidation and carotid plaques in humans. In this study, we investigated the relationship between clinical features, histopathological characteristics and...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(01)00583-4

    authors： Nishi K,Uno M,Fukuzawa K,Horiguchi H,Shinno K,Nagahiro S

    更新日期：2002-02-01 00:00:00