The effect of renal hypertension on the regional deposition of cholesterol and phospholipid in the aorta of normally- and cholesterol-fed rabbits.


:The effect of renal hypertension on dry defatted tissue mass and lipid accumulation in different segments of the aortic intima was studied in both normally-fed and cholesterol-fed rabbits. In normally-fed rabbits hypertension caused an increase in intimal dry weight in the aorta. The increase was greatest in the lower thoracic intimal segment but was not significant in the aortic arch. The increase in tissue mass was not influenced by the addition of cholesterol to the diet and no regression of the increased tissue mass occurred when a 4-week period of hypertension was followed by a 4-week period of normotension. Hypertension did not increase the intimal cholesterol or phospholipid concentrations in normally-fed rabbits, suggesting that an observed increase in lipid content represented the cellular component of the intimal hypertrophy. Hypertension in cholesterol-fed animals caused preferential lipid accumulation in the lower thoracic segment, an effect that was independent of the total intimal cholesterol level. Intimal cholesterol, cholesterol ester and phospholipid were all increased. When a 4-week period of normotension and cholesterol feeding was preceded by a 4-week period of hypertension with normal feeding the amount of cholesterol deposited did not exceed that of the normotensive control, suggesting either that hypertension increased intimal permeability to lipid only in the presence of hypercholesterolaemia, or that healing of damaged intima had occurred before hypercholesterolaemia was fully established.






Bretherton KN,Day AJ,Skinner SL





Has Abstract


1975-11-01 00:00:00














  • Comparison of various lipid, lipoprotein, and bilirubin combinations as risk factors for predicting coronary artery disease.

    abstract::Studies were performed to determine if serum bilirubin, when combined with various lipid and lipoprotein risk factors, enhances our ability to predict coronary artery disease (CAD). This hypothesis was tested in a retrospective study of 644 middle-aged males who had undergone coronary angiography. The traditional risk...


    pub_type: 杂志文章


    authors: Schwertner HA,Fischer JR Jr

    更新日期:2000-06-01 00:00:00

  • Lovastatin therapy in familial dysbetalipoproteinemia: effects on kinetics of apolipoprotein B.

    abstract::Familial dysbetalipoproteinemia is characterized by hyperlipidemia, increases in beta-migrating, very low density lipoproteins (beta-VLDL), and homozygosity for apolipoprotein E2 (apo E2). In this study, 3 patients with familial dysbetalipoproteinemia were treated with lovastatin, and kinetics for apolipoprotein B (ap...


    pub_type: 杂志文章


    authors: Vega GL,East C,Grundy SM

    更新日期:1988-03-01 00:00:00

  • Simvastatin-induced decrease in the transfer of cholesterol esters from high density lipoproteins to very low and low density lipoproteins in normolipidemic subjects.

    abstract::Hyperlipidemic patients often have an accelerated esterified cholesterol transfer (ECT) from high density lipoproteins (HDL) to very low (VLDL) and low density lipoproteins (LDL). We investigated the effect of simvastatin on ECT in twelve normolipidemic subjects. After 6 weeks of simvastatin administration, ECT was de...


    pub_type: 杂志文章


    authors: Ahnadi CE,Berthezène F,Ponsin G

    更新日期:1993-03-01 00:00:00

  • Effects of fenofibrate on lipoproteins, vasomotor function, and serological markers of inflammation, plaque stabilization, and hemostasis.

    abstract::We investigated the effects of fenofibrate, peroxisome proliferator-activated receptors (PPARs) agonist, on endothelial function in patients with hypertriglyceridemia. We administered placebo or fenofibrate 200 mg daily to 25 patients with hypertriglyceridemia for 8 weeks. This study was randomized, double-blind, plac...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kon Koh K,Yeal Ahn J,Hwan Han S,Kyu Jin D,Sik Kim H,Cheon Lee K,Kyun Shin E,Sakuma I

    更新日期:2004-06-01 00:00:00

  • Effect of ursodeoxycholic acid on hepatic LDL binding and uptake in dietary hypercholesterolemic hamsters.

    abstract::Administration of ursodeoxycholic acid (UDCA) has been shown to decrease serum total and low density lipoprotein (LDL) cholesterol in hypercholesterolemic patients with primary biliary cirrhosis. Results of previous studies prompted us to postulate that the cholesterol-lowering effect of UDCA may be due, at least in p...


    pub_type: 杂志文章


    authors: Ceryak S,Bouscarel B,Malavolti M,Robins SJ,Caslow KL,Fromm H

    更新日期:2000-11-01 00:00:00

  • Statin eligibility and cardiovascular risk burden assessed by coronary artery calcium score: comparing the two guidelines in a large Korean cohort.

    abstract:OBJECTIVE:To investigate the statin eligibility and the predictabilities for cardiovascular disease between AHA/ACC and ATPIII guidelines, comparing those results to concomitant coronary artery calcium scores (CACS) in a large cohort of Korean individuals who met statin-eligibility criteria. METHODS:Among 19,920 parti...


    pub_type: 杂志文章


    authors: Rhee EJ,Park SE,Oh HG,Park CY,Oh KW,Park SW,Blankstein R,Plutzky J,Lee WY

    更新日期:2015-05-01 00:00:00

  • Dietary linoleate increases fluidity and influences chemical composition of plasma low density lipoprotein in adult men.

    abstract::Dietary linoleate was effective to increase LDL fluidity in adult men but did not significantly influence VLDL or HDL fluidities. Lipoproteins were isolated ultracentrifugally from plasma of sixteen healthy, free living male volunteers consuming controlled diets formulated from typical U.S.A. foods to have 35 energy %...


    pub_type: 杂志文章


    authors: Berlin E,Judd JT,Marshall MW,Kliman PG

    更新日期:1987-08-01 00:00:00

  • Transcriptional regulation of the human sterol 27-hydroxylase gene (CYP27) and promoter mapping.

    abstract::Recent evidence suggests that sterol 27-hydroxylase may play a role in cholesterol homeostasis and affect atherogenesis. The major objective of the study was to map and characterize the sterol 27-hydroxylase (CYP27) promoter region. Here we show that CYP27 gene has a TATA-less promoter and transcription initiates at a...


    pub_type: 杂志文章


    authors: Segev H,Honigman A,Rosen H,Leitersdorf E

    更新日期:2001-06-01 00:00:00

  • Enhanced macromolecular permeability of aortic endothelial cells in association with mitosis.

    abstract::Experiments were performed on thoracic aortae of 12 male Sprague-Dawley [corrected] rats to determine the statistical frequency of isolated leaks to Evans blue-albumin (EBA) conjugate at the level of individual cells and to assess the relationship of such leaks to the cell turnover process. Fluorescence microscopy was...


    pub_type: 杂志文章


    authors: Lin SJ,Jan KM,Schuessler G,Weinbaum S,Chien S

    更新日期:1988-10-01 00:00:00

  • Imbalanced gp130 signalling in ApoE-deficient mice protects against atherosclerosis.

    abstract:OBJECTIVE:Interleukin (IL)-6 is a key modulator of the acute phase response (APR), and while both are implicated in atherosclerosis, the pathological role of specific IL-6 signalling cascades is ill-defined. Since IL-6 employs the cytokine receptor gp130 to primarily activate the STAT3 pathway, here we evaluate whether...


    pub_type: 杂志文章


    authors: Jones GW,McLeod L,Kennedy CL,Bozinovski S,Najdovska M,Jenkins BJ

    更新日期:2015-02-01 00:00:00

  • Hepatic gene expression profiling reveals perturbed calcium signaling in a mouse model lacking both LDL receptor and Apobec1 genes.

    abstract::Atherosclerosis is a complex disease that gene and environment interaction influences the progression of atherosclerotic lesion development. Our laboratory used mice lacking both the low density lipoprotein (LDL) receptor and Apobec1 genes (LDLR-/-Apobec1-/-, designated LDb) to investigate gene-gene interaction and th...


    pub_type: 杂志文章


    authors: Dutta R,Singh U,Li TB,Fornage M,Teng BB

    更新日期:2003-07-01 00:00:00

  • Lifibrol enhances the low density lipoprotein apolipoprotein B-100 turnover in patients with hypercholesterolemia and mixed hyperlipidemia.

    abstract::Lifibrol (4-(4'-tert-butylphenyl)-1-(4'carboxyphenoxy)-2-butanol), a new hypocholesterolemic drug, effectively reduces total cholesterol (CH), low density lipoprotein (LDL)-CH, and apolipoprotein (apo) B in experimental animals and in humans. The impact of Lifibrol on the metabolism of apoB-100 containing lipoproteins...


    pub_type: 临床试验,杂志文章


    authors: Winkler K,Schäfer JR,Klima B,Nuber C,Sattler A,Friedrich I,Köster W,Steinmetz A,Wieland H,März W

    更新日期:1999-05-01 00:00:00

  • Relationship between the geometry and quantitative morphology of the left anterior descending coronary artery.

    abstract::The well established 'systemic' risk factors for atherosclerosis can explain only half of the variability in its occurrence. To account for some of the remaining variability, it was suggested that certain geometric features of atherosclerosis-prone segments ('geometric risk factors') can increase the likelihood of dis...


    pub_type: 杂志文章


    authors: Friedman MH,Baker PB,Ding Z,Kuban BD

    更新日期:1996-09-06 00:00:00

  • Chemokine receptor expression on infiltrating lymphocytes from abdominal aortic aneurysms: role of CXCR4-CXCL12 in lymphoid recruitment.

    abstract::This is a study to define the profile of chemokine receptors expressed on isolated infiltrating lymphocytes in human abdominal aortic aneurysms (AAAs), and to examine their role in lymphoid recruitment. AAA T-lymphocytes were CXCR4-positive, CCR7-negative and partially CXCR3 and CCR5-positive. Functionally, AAA T-cell...


    pub_type: 杂志文章


    authors: Ocaña E,Pérez-Requena J,Bohórquez JC,Brieva JA,Rodríguez C

    更新日期:2008-10-01 00:00:00

  • DNA polymorphisms of the apolipoprotein genes--their use in the investigation of the genetic component of hyperlipidaemia and atherosclerosis.

    abstract::DNA probes for all eight of the major apolipoprotein genes are now available. The chromosomal location, the basic structure and in many cases the nucleotide sequences of the normal genes are known. Common DNA polymorphisms of all of the genes have been detected. These have been been used in a number of ways to investi...


    pub_type: 杂志文章,评审


    authors: Humphries SE

    更新日期:1988-08-01 00:00:00

  • Genetic and pharmacological inhibition of the 5-lipoxygenase/leukotriene pathway in atherosclerotic lesion development in ApoE deficient mice.

    abstract::The 5-lipoxygenase (5-LO) catalyzed formation of leukotriene (LT) lipid mediators is a pathway contributing to inflammatory events in asthma and more recently has been associated with cardiovascular disease. However, the relative impact of this pathway in atherogenesis has been controversial and a variety of mixed res...


    pub_type: 杂志文章


    authors: Cao RY,St Amand T,Gräbner R,Habenicht AJ,Funk CD

    更新日期:2009-04-01 00:00:00

  • Contribution of apolipoprotein(a) size, pentanucleotide TTTTA repeat and C/T(+93) polymorphisms of the apo(a) gene to regulation of lipoprotein(a) plasma levels in a population of young European Caucasians.

    abstract::Several studies indicate that the inter-individual variation in plasma concentrations of lipoprotein(a) (Lp(a)) is mainly under genetic control. To define the effect of three DNA polymorphisms on apolipoprotein(a) (apo(a)) expression, we have determined plasma Lp(a) concentrations, apo(a) isoform size, KpnI allele siz...


    pub_type: 杂志文章


    authors: Valenti K,Aveynier E,Leauté S,Laporte F,Hadjian AJ

    更新日期:1999-11-01 00:00:00

  • Prevalence Of familial hypercholeSTerolaemia (FH) in Italian Patients with coronary artERy disease: The POSTER study.

    abstract:BACKGROUND AND AIMS:Familial hypercholesterolaemia (FH) is a powerful risk factor for cardiovascular (CV) events. High levels of low-density lipoprotein cholesterol (LDL-C) since birth are linked to the early onset of atherosclerotic disease. A genetic mutation determining FH is present in about one subject out of 250;...


    pub_type: 杂志文章


    authors: Gulizia MM,Maggioni AP,Abrignani MG,Bilato C,Mangiacapra F,Sanchez FA,Piovaccari G,Montagna L,Marini M,De Biasio M,Averna M,Casula M,Colivicchi F,Fabbri G,Lucci D,Zampoleri V,Catapano AL,POSTER Investigators.

    更新日期:2020-09-01 00:00:00

  • Seropositivity for anti-Borrelia IgG antibody is independently associated with carotid atherosclerosis.

    abstract:BACKGROUND:Various infectious agents are associated with atherosclerosis. This analysis was performed to investigate relation between seropositivity for anti-Borrelia IgG and carotid atherosclerosis. METHODS:The cross-sectional Study of Health in Pomerania was conducted in a general community living in a region with e...


    pub_type: 杂志文章


    authors: Völzke H,Wolff B,Lüdemann J,Guertler L,Kramer A,John U,Felix SB

    更新日期:2006-01-01 00:00:00

  • Postprandial effects of a high salt meal on serum sodium, arterial stiffness, markers of nitric oxide production and markers of endothelial function.

    abstract:AIM:The aim of the study was to determine if a high salt meal containing 65 mmol Na causes a rise in sodium concentrations and a reduction in plasma nitrate/nitrite concentrations (an index of nitric oxide production). Secondary aims were to determine the effects of a high salt meal on augmentation index (AIx) a measur...


    pub_type: 杂志文章,随机对照试验


    authors: Dickinson KM,Clifton PM,Burrell LM,Barrett PH,Keogh JB

    更新日期:2014-01-01 00:00:00

  • High-density lipoproteins induce miR-223-3p biogenesis and export from myeloid cells: Role of scavenger receptor BI-mediated lipid transfer.

    abstract:BACKGROUND AND AIMS:We recently showed that miR-223-3p on high-density lipoproteins (HDL) is exported to endothelial cells, where it inhibits inflammation. However, the origin of miR-223-3p on HDL is unknown. We hypothesize that HDL-associated miR-223-3p originates in myeloid cells and is exported to HDL in a scavenger...


    pub_type: 杂志文章


    authors: Cuesta Torres LF,Zhu W,Öhrling G,Larsson R,Patel M,Wiese CB,Rye KA,Vickers KC,Tabet F

    更新日期:2019-07-01 00:00:00

  • The protective effect of resveratrol on vascular aging by modulation of the renin-angiotensin system.

    abstract:BACKGROUND AND AIMS:This study evaluated the effects of resveratrol on arterial aging and the renin-angiotensin system (RAS) in mice and vascular smooth muscle cells (VSMCs). METHODS:Aging mice were divided into control and resveratrol groups. Histological changes, inflammation, oxidative stress, RAS components, and t...


    pub_type: 杂志文章


    authors: Kim EN,Kim MY,Lim JH,Kim Y,Shin SJ,Park CW,Kim YS,Chang YS,Yoon HE,Choi BS

    更新日期:2018-03-01 00:00:00

  • The influence of exercise on postprandial triacylglycerol metabolism.

    abstract::Trained people exhibit low plasma concentrations of triacylglcyeride (TAG) in both fasted and postprandial states. This mainly reflects enhanced uptake of TAG into skeletal muscle, via enhanced activity of lipoprotein lipase, the rate-limiting step in TAG removal. Endurance athletes possess a large, well-vascularised ...


    pub_type: 杂志文章,评审


    authors: Hardman AE

    更新日期:1998-12-01 00:00:00

  • Newly developed reconstituted high-density lipoprotein containing sphingosine-1-phosphate induces endothelial tube formation.

    abstract::Reconstituted high-density lipoprotein (rHDL) has been shown to produce a rapid regression of atherosclerosis in animal models and humans. Sphingosine-1-phosphate (S1P), which is a bioactive lipid in HDL, plays a role in mitogenesis, endothelial cell motility, and cell survival, as well as organization and differentia...


    pub_type: 杂志文章


    authors: Matsuo Y,Miura S,Kawamura A,Uehara Y,Rye KA,Saku K

    更新日期:2007-09-01 00:00:00

  • Associations between IgG antibody to oral organisms and carotid intima-medial thickness in community-dwelling adults.

    abstract:AIMS:The aims of this study are to describe the relationships between IgG antibodies to 17 oral organisms and atherosclerosis as indexed by carotid intima-medial wall thickness (IMT) and to evaluate the role of smoking. METHODS AND RESULTS:Our study is based on a subset of participants in the Atherosclerosis Risk in C...


    pub_type: 杂志文章


    authors: Beck JD,Eke P,Lin D,Madianos P,Couper D,Moss K,Elter J,Heiss G,Offenbacher S

    更新日期:2005-12-01 00:00:00

  • ATP binding cassette A1 (ABCA1) mediates microparticle formation during high-density lipoprotein (HDL) biogenesis.

    abstract:BACKGROUND AND AIMS:Micro-particles (MP) are secreted by various cells. Their biological roles in health and in disease remain unknown. Here we describe formation of MP in the process of ABCA1-dependent cholesterol efflux in different cell types. METHODS:The ATP-binding cassette transporter, subfamily A, member 1 (ABC...


    pub_type: 杂志文章


    authors: Hafiane A,Genest J

    更新日期:2017-02-01 00:00:00

  • Changes in very low and low density lipoproteins with dietary fat modification.

    abstract::Since VLDL and LDL are involved in atherogenesis, their response to dietary modification was studied in 15 normal male prisoners. A 3-month reference diet (P/S ratio 0.3, daily cholesterol intake 370 mg) was compared with a modified fat diet (P/S 1.0, 250 mg) given for further 3 months. The decrement in serum choleste...


    pub_type: 杂志文章


    authors: Weisweiler P,Drosner M,Janetschek P,Schwandt P

    更新日期:1983-12-01 00:00:00

  • Race differences in the response of postheparin plasma lipoprotein lipase and hepatic lipase activities to endurance exercise training in men: results from the HERITAGE Family Study.

    abstract::Endurance exercise training is known to produce favorable changes in the metabolic profile including reduced plasma triglyceride (TG) and increased high-density lipoprotein (HDL) cholesterol concentrations. These metabolic improvements are likely to contribute to the reduced coronary heart disease (CHD) risk often obs...


    pub_type: 杂志文章


    authors: Bergeron J,Couillard C,Després JP,Gagnon J,Leon AS,Rao DC,Skinner JS,Wilmore JH,Bouchard C

    更新日期:2001-12-01 00:00:00

  • A neutralizing antibody against DKK1 does not reduce plaque formation in classical murine models of atherosclerosis: Is the therapeutic potential lost in translation?

    abstract:BACKGROUND AND AIMS:Clinical interventions targeting nonlipid risk factors are needed given the high residual risk of atherothrombotic events despite effective control of dyslipidemia. Dickkopf-1 (DKK1) plays a lipid-independent role in vascular pathophysiology but its involvement in atherosclerosis development and its...


    pub_type: 杂志文章


    authors: Rakipovski G,Rolin B,Barascuk N,Lund HE,Bjørn Bonde MF,Djordjevic D,Wulff-Larsen PG,Petersen M,Kirk RK,Hultman K,Manfe V,Blume N,Zahn S,Lengquist M,Maegdefessel L,Hovingh GK,Conde-Knape K,Hedin U,Matic L,Nyberg M

    更新日期:2020-12-01 00:00:00

  • Cardiorespiratory fitness and coronary artery calcification in young adults: The CARDIA Study.

    abstract::Whether cardiorespiratory fitness relates to early subclinical atherosclerotic vascular disease remains unknown. We investigated the relation of cardiorespiratory fitness to coronary artery calcification (CAC) in 2373 African-American and White young adults from the Coronary Artery Risk Development in Young Adults (CA...


    pub_type: 杂志文章


    authors: Lee CD,Jacobs DR Jr,Hankinson A,Iribarren C,Sidney S

    更新日期:2009-03-01 00:00:00