当前位置： SCI文献检索 > ATHEROSCLEROSIS期刊下所有文献 > Arteriosclerosis in the African elephant: Part 2. Medial sclerosis.

Arteriosclerosis in the African elephant: Part 2. Medial sclerosis.

Abstract：

SUMMARY:A type of spontaneous arteriosclerosis, described as medial sclerosis and quite distinct from atherosclerosis, was found in the aortas, coronary arteries and aortic branch arteries of free-living elephants (Loxodonta africana) in Uganda and Kenya. The lesions took the form of calcified fibrotic plaques in the inner tunica media. The calcification appeared to commence in the internal elastic lamina and was associated with atrophy of medial smooth muscle fibres and their replacement by fibrous tissue. In the aorta, medial sclerosis was found to be associated with aortic dilatation, decreased wall thickness and decreased extensibility. These changes were shown to result in substantial increases in the tangential stresses carried by the tissues of the aorta and coronary arteries. As with atherosclerosis, medial sclerosis increased progressively with age; and the approximate involvement of the aorta at different ages could be predicted from linear regression equations. There was no difference in the severity of lesions between male and female animals. Biochemically, the lesions of medial sclerosis were associated with decreased amounts of elastin and increased amounts of collagen in arterial walls. Arterial tissue showing medial calcification always contained less than 30% elastin by weight. In addition, the severity of medial sclerosis in individual elephants was found to be positively correlated with the concentration of calcium in their sera. The pathogenesis of these lesions is discussed and it is suggested that mechanical stress, medial anoxia and high serum calcium levels all contribute to the aetiology of medial sclerosis.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

McCullagh KG

doi

10.1016/0021-9150(75)90093-3

keywords:

subject

Has Abstract

pub_date

1975-01-01 00:00:00

pages

37-59

issue

1

eissn

0021-9150

issn

1879-1484

pii

0021-9150(75)90093-3

journal_volume

21

pub_type

杂志文章

相关文献

ATHEROSCLEROSIS文献大全
  • Accurate quantification of atherosclerotic plaque volume by 3D vascular ultrasound using the volumetric linear array method.

    abstract：INTRODUCTION:Direct quantification of atherosclerotic plaque volume by three-dimensional vascular ultrasound (3DVUS) is more reproducible than 2DUS-based three-dimensional (2D/3D) techniques that generate pseudo-3D volumes from summed 2D plaque areas; however, its accuracy has not been reported. We aimed to determine 3...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2016.03.002

    authors： López-Melgar B,Fernández-Friera L,Sánchez-González J,Vilchez JP,Cecconi A,Mateo J,Peñalvo JL,Oliva B,García-Ruiz JM,Kauffman S,Jiménez-Borreguero LJ,Ruiz-Cabello J,Fernández-Ortiz A,Ibáñez B,Fuster V

    更新日期：2016-05-01 00:00:00

  • Effects of dietary sunflowerseed oil and marine oil on platelet membrane fluidity, arterial thrombosis, and platelet responses in rats.

    abstract：:The relationships among platelet membrane fluidity, arterial thrombosis tendency, and platelet aggregation and prostanoid formation were investigated after feeding rats diets enriched in (n-6) or (n-3) polyunsaturated fatty acids. For at least 8 weeks, rats were fed a control diet containing 5 energy % (en%) sunflower...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(86)90101-2

    authors： Rand ML,Hennissen AA,Hornstra G

    更新日期：1986-12-01 00:00:00

  • Relation of N-glycosylation of apolipoprotein B-100 to cellular metabolism of low density lipoprotein.

    abstract：:We studied the functional role of N-linked sugar chains of apolipoprotein (apo) B-100 of low density lipoprotein (LDL) in cholesterol metabolism. The N-linked sugar chains of apo B-100 of LDL obtained from four homozygous Watanabe heritable hyperlipidemic (WHHL) rabbits were liberated by hydrazinolysis, followed by Na...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(94)90040-x

    authors： Fujioka Y,Taniguchi T,Ishikawa Y,Shiomi M,Yokoyama M

    更新日期：1994-07-01 00:00:00

  • Kinetics of HDL-apo A-I in the WHHL rabbit, an animal model of familial hypercholesterolemia.

    abstract：:Plasma high density lipoproteins (HDL) and their major protein, apolipoprotein (apo) A-I, are deficient in homozygous Watanabe heritable hyperlipidemic (WHHL) rabbits. As the pathophysiology of subnormal HDL-apo A-I is unclear, we examined kinetic parameters of HDL-apo A-I in WHHL rabbits and normolipidemic Japanese W...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(89)90127-5

    authors： Saku K,Yamamoto K,Sakai T,Yanagida T,Hidaka K,Sasaki J,Arakawa K

    更新日期：1989-10-01 00:00:00

  • [Aortic development and ageing in the rat aorta -- Comparative histochemical and histoenzymological study (author's transl)].

    abstract：:A comparative study was made of 36 aortic enzyme activities (E.A.) and 6 macromelecular substances at different stages of ontogenesis in 49 male rats. In the foetal aorta (19th day) the E.Z. were moderate or weak and restricted to a few metabolic pathways: glycolysis, diaphorases, esterolysis of some nucleotides and g...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(75)90065-9

    authors： Hadjiisky P,Renais J,Scebat L

    更新日期：1975-07-01 00:00:00

  • Ethnic and sex differences in circulating endotoxin levels: A novel marker of atherosclerotic and cardiovascular risk in a British multi-ethnic population.

    abstract：BACKGROUND:Circulating endotoxin levels are associated with atherosclerosis. Moreover, ethnic differences in pro-inflammatory markers may be associated with ethnic differences in atherosclerotic and cardiovascular (CVD) and coronary heart disease (CHD) risk. OBJECTIVE AND METHODS:To investigate ethnic differences in c...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2008.06.018

    authors： Miller MA,McTernan PG,Harte AL,Silva NF,Strazzullo P,Alberti KG,Kumar S,Cappuccio FP

    更新日期：2009-04-01 00:00:00

  • Impaired adaptive vascular growth in hypercholesterolemic rabbit.

    abstract：:Occlusive arterial disease stimulates compensatory growth of pre-existent and new arterial channels which help to maintain organ perfusion. Previous studies characterizing compensatory or collateral vascular growth have been performed in normocholesterolemic animals. Because hyperlipidemic states alter vascular regula...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(98)00073-2

    authors： Bucay M,Nguy J,Barrios R,Chen CH,Henry PD

    更新日期：1998-08-01 00:00:00

  • The NLRP3 inflammasome and the emerging role of colchicine to inhibit atherosclerosis-associated inflammation.

    abstract：:Atherosclerosis is considered a chronic inflammatory disease of the arterial wall. Recently, compelling evidence has arisen for the role of monocytes and neutrophils and a particular protein complex that resides within these cells - the NLRP3 inflammasome - in atherosclerosis-associated inflammation. It is now also kn...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,评审

    doi：10.1016/j.atherosclerosis.2017.12.027

    authors： Martínez GJ,Celermajer DS,Patel S

    更新日期：2018-02-01 00:00:00

  • Nuclear magnetic resonance-determined lipoprotein subclasses and carotid intima-media thickness in type 1 diabetes.

    abstract：BACKGROUND:Dyslipidemia has been linked to vascular complications of Type 1 diabetes (T1DM). We investigated the prospective associations of nuclear magnetic resonance-determined lipoprotein subclass profiles (NMR-LSP) and conventional lipid profiles with carotid intima-media thickness (IMT) in T1DM. METHODS:NMR-LSP a...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2015.10.106

    authors： Basu A,Jenkins AJ,Zhang Y,Stoner JA,Klein RL,Lopes-Virella MF,Garvey WT,Lyons TJ,DCCT\/EDIC Research Group.

    更新日期：2016-01-01 00:00:00

  • Impact of CD14++CD16+ monocytes on coronary plaque vulnerability assessed by optical coherence tomography in coronary artery disease patients.

    abstract：BACKGROUND AND AIMS:This study examined the impact of CD14++CD16+ monocytes on coronary plaque vulnerability, as assessed by optical coherence tomography (OCT), and investigated their association with daily glucose fluctuation. Although increased CD14++CD16+ monocyte levels have been reported to increase cardiovascular...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2018.01.010

    authors： Yamamoto H,Yoshida N,Shinke T,Otake H,Kuroda M,Sakaguchi K,Hirota Y,Toba T,Takahashi H,Terashita D,Uzu K,Tahara N,Shinkura Y,Kuroda K,Nagasawa Y,Nagano Y,Tsukiyama Y,Yanaka KI,Emoto T,Sasaki N,Yamashita T,Ogawa

    更新日期：2018-02-01 00:00:00

  • Modulation of endothelial progenitor cell number and function with n-3 polyunsaturated fatty acids.

    abstract：:Endothelial dysfunction is pivotal in atherosclerosis. Endothelial progenitor cells (EPC) predict cardiovascular events and could serve as a cellular biomarker of endothelial function. Epidemiological studies suggest the benefits of omega 3 polyunsaturated fatty acids (n-3 PUFA), mainly docosahexaenoic acid (DHA) and ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2013.02.036

    authors： Devaraj S,Chien A,Rao B,Chen X,Jialal I

    更新日期：2013-05-01 00:00:00

  • Di-oleoyl phosphatidylcholine (PC-18:1) stimulates paraoxonase 1 (PON1) enzymatic and biological activities: in vitro and in vivo studies.

    abstract：OBJECTIVE:Paraoxonase 1 (PON1) is a high-density lipoprotein (HDL)-associated enzyme which possess anti-atherogenic properties. Our aim was to analyze the effect of HDL phospholipids on HDL-associated paraoxonase (PON1) catalytic and biological activities. METHODS AND RESULTS:In HDL isolated from di-oleoyl-phosphatidy...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2008.05.016

    authors： Efrat M,Rosenblat M,Mahmood S,Vaya J,Aviram M

    更新日期：2009-02-01 00:00:00

  • Low density lipoprotein metabolism by cultured skin fibroblasts from atherosclerotic patients.

    abstract：:The aim of this study was to determine whether an abnormality in low density lipoprotein (LDL) metabolism could be demonstrated in fibroblasts cultured from normolipidaemic subjects with atherosclerosis. Seventeen male subjects aged 30-55 years with normal plasma lipid concentrations were divided into 2 groups on the ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(82)90148-4

    authors： Behrman RG,Wynn V

    更新日期：1982-04-01 00:00:00

  • Identification of a blood-based 12-gene signature that predicts the severity of coronary artery stenosis: An integrative approach based on gene network construction, Support Vector Machine algorithm, and multi-cohort validation.

    abstract：BACKGROUND AND AIMS:We aimed to identify a blood-based gene expression score (GES) to predict the severity of coronary artery stenosis in patients with known or suspected coronary artery disease (CAD) by integrative use of gene network construction, Support Vector Machine (SVM) algorithm, and multi-cohort validation. ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.atherosclerosis.2019.10.001

    authors： Wang XB,Cui NH,Liu X,Ming L

    更新日期：2019-12-01 00:00:00

  • Oxidized cholesterol in oxidized low density lipoprotein may be responsible for the inhibition of LPS-induced nitric oxide production in macrophages.

    abstract：:Previous work has shown that oxidized low density lipoprotein (Ox-LDL) inhibited lipopolysacchride (LPS)-induced nitric oxide (NO) production in macrophages. In this paper, the role of different components of Ox-LDL in the inhibitory effect was studied by measuring nitrite in media. Ox-LDL inhibited LPS-induced NO pro...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(97)00185-8

    authors： Liu SX,Chen Y,Zhou M,Wan J

    更新日期：1998-01-01 00:00:00

  • Socioeconomic and ethnic differences in use of lipid-lowering drugs after deregulation of simvastatin in the UK: the Whitehall II prospective cohort study.

    abstract：BACKGROUND:We examined socioeconomic and ethnic differences in use of lipid-lowering drugs after deregulation of simvastatin in the UK for adults with moderate or high risk of coronary heart disease. METHODS:3631 participants in the Whitehall II cohort study (mean age 62.7 years, 91% white) were informed of their risk...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2010.12.012

    authors： Forde I,Chandola T,Raine R,Marmot MG,Kivimaki M

    更新日期：2011-03-01 00:00:00

  • Evaluation of sCD163 and sTWEAK in patients with stable peripheral arterial disease and association with disease severity as well as long-term mortality.

    abstract：BACKGROUND AND AIMS:The TNF-superfamily member sTWEAK and its scavenger receptor sCD163 are potentially involved in pathophysiological processes of atherosclerosis. In patients with peripheral arterial disease, previous research has shown that sTWEAK and the sCD163/sTWEAK ratio were independently associated with long t...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2020.11.026

    authors： Mrak D,Zierfuss B,Höbaus C,Herz CT,Pesau G,Schernthaner GH

    更新日期：2021-01-01 00:00:00

  • Protein content and composition of human high density lipoprotein subfractions.

    abstract：:High density lipoprotein (HDL) was fractionated by ion exchange column chromatography using a continuous NaCl gradient of 0.06--0.13 M. It was found that, on the basic C apoprotein content, HDL is comprised of 3 subfractions. All 3 subfractions contain apo A-I and apo A-II but the apo A-I/apo A-II ratio is different i...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(79)90034-0

    authors： Rubenstein B

    更新日期：1979-08-01 00:00:00

  • Predictive value of preprocedural fibrinogen concerning coronary stenting.

    abstract：:Elevated fibrinogen levels after coronary balloon angioplasty have been reported to be useful in predicting restenosis. Therefore, we sought to evaluate the relationship between preprocedural fibrinogen levels and the 6-12-month outcomes of patients undergoing coronary stenting. Plasma levels of fibrinogen were measur...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(02)00177-6

    authors： Otsuka M,Hayashi Y,Ueda H,Imazu M,Kohno N

    更新日期：2002-10-01 00:00:00

  • Pregnancy-associated plasma protein-A (PAPP-A) and cardiovascular risk.

    abstract：:The search for markers to improve risk prediction for individuals at risk of developing serious cardiovascular events is ongoing. New markers of coronary artery disease progression have been identified in recent years, among which, circulating levels of pregnancy-associated plasma protein-A (PAPP-A) offer an interesti...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,评审

    doi：10.1016/j.atherosclerosis.2008.07.042

    authors： Consuegra-Sanchez L,Fredericks S,Kaski JC

    更新日期：2009-04-01 00:00:00

  • Coronary artery disease in heterozygous familial hypercholesterolemia.

    abstract：:Serum lipids, lipoproteins and Achilles tendon thickness in 52 patients with heterozygous familial hypercholesterolemia (FH) were investigated in order to clarify what are the important factors for the development of coronary artery disease (CAD) in heterozygous FH patients. There were no significant differences in th...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(82)90114-9

    authors： Hirobe K,Matsuzawa Y,Ishikawa K,Tarui S,Yamamoto A,Nambu S,Fujimoto K

    更新日期：1982-08-01 00:00:00

  • Differential expression of nonmuscle myosin II isoforms in human atherosclerotic plaque.

    abstract：:Intimal proliferation and functional changes involving vascular smooth muscle cells are key events in the development of atherosclerosis, including restenosis after percutaneous transluminal angioplasty. Nonmuscle myosin (NMM) is required for cytokinesis and has been shown in cultures of vascular smooth muscle cells t...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(96)06047-9

    authors： Nikol S,Murakami N,Pickering JG,Kearney M,Leclerc G,Höfling B,Isner JM,Weir L

    更新日期：1997-04-01 00:00:00

  • Associations between retinal microvascular structure and the severity and extent of coronary artery disease.

    abstract：OBJECTIVE:Microvascular mechanisms are increasingly recognized as being involved in a significant proportion of coronary artery disease (CAD) cases, but their exact contribution or role is unclear. We aimed to define the association between retinal microvascular signs and both CAD extent and severity. METHODS:1120 par...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2014.06.018

    authors： Gopinath B,Chiha J,Plant AJ,Thiagalingam A,Burlutsky G,Kovoor P,Liew G,Mitchell P

    更新日期：2014-09-01 00:00:00

  • Association of the insertion/deletion gene polymorphism of the apolipoprotein B signal peptide with myocardial infarction.

    abstract：:The Del allele of the apolipoprotein B (apoB) signal peptide (SP) insertion/deletion (Ins/Del) polymorphism has been shown to be associated with elevated plasma levels of apoB, cholesterol and low density lipoprotein. It was the aim of the present study to analyse the relation of this gene variation to the risk of cor...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(98)00161-0

    authors： Gardemann A,Ohly D,Fink M,Katz N,Tillmanns H,Hehrlein FW,Haberbosch W

    更新日期：1998-11-01 00:00:00

  • Relationship between cholesteryl ester transfer activity and high density lipoprotein composition in hyperlipidemic patients.

    abstract：:Cholesteryl ester transfer from solid-phase bound HDL to endogenous plasma HDL or VLDL/LDL was determined in 50 patients with primary disorders of lipid metabolism and 27 normolipidemic subjects. Transfer to the plasma HDL pool was significantly reduced in familial hypercholesterolemia, familial combined hyperlipidemi...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(89)90080-4

    authors： Sparks DL,Frohlich J,Lacko AG,Pritchard PH

    更新日期：1989-06-01 00:00:00

  • Sleep duration is significantly associated with carotid artery atherosclerosis incidence in a Japanese population.

    abstract：BACKGROUND:Previous studies have indicated that sleep duration is associated with total mortality in a U-shaped fashion. The purpose of the current study was to examine the relationship between self-reported sleep duration and carotid artery atherosclerosis in a Japanese population. METHODS:In 2009-2010, a total of 24...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2011.02.029

    authors： Abe T,Aoki T,Yata S,Okada M

    更新日期：2011-08-01 00:00:00

  • The density of calcified plaques and the volume of calcium predict mortality in hemodialysis patients.

    abstract：BACKGROUND AND AIM:In the general population lipid-rich plaques are prone to rupture and healing of the plaque involves calcification. Patients undergoing hemodialysis have a severe derangement of mineral metabolism and calcification of the arterial tree may have different implications. METHODS:Between 2004 and 2005, ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2016.03.034

    authors： Bellasi A,Ferramosca E,Ratti C,Block G,Raggi P

    更新日期：2016-07-01 00:00:00

  • Administration of natural astaxanthin increases serum HDL-cholesterol and adiponectin in subjects with mild hyperlipidemia.

    abstract：BACKGROUND:Astaxanthin has been reported to improve dyslipidemia and metabolic syndrome in animals, but such effects in humans are not well known. METHODS:Placebo-controlled astaxanthin administration at doses of 0, 6, 12, 18 mg/day for 12 weeks was randomly allocated to 61 non-obese subjects with fasting serum trigly...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.atherosclerosis.2009.10.012

    authors： Yoshida H,Yanai H,Ito K,Tomono Y,Koikeda T,Tsukahara H,Tada N

    更新日期：2010-04-01 00:00:00

  • Effects of doxazosin, an alpha 1-adrenergic inhibitor, on plasma lipid and lipoprotein levels, low density lipoprotein metabolism and cholesterol absorption in cynomolgus monkeys.

    abstract：:The mechanism(s) by which doxazosin, an alpha 1 inhibitor, regulates plasma low density lipoprotein cholesterol (LDL-C) and apolipoprotein B (apo B) levels were investigated in 'normocholesterolemic' (average total cholesterol (TC) of 218 mg/dl) and 'hypercholesterolemic' (average TC of 350 mg/dl) cynomolgus monkeys. ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(93)90268-y

    authors： Stucchi AF,Vespa DB,Terpstra AH,Nicolosi RJ

    更新日期：1993-11-01 00:00:00

  • Coronary CT angiography versus standard of care strategies to evaluate patients with potential coronary artery disease; effect on long term clinical outcomes.

    abstract：BACKGROUND:Previous studies have shown that computed tomography coronary angiography (CTA) in patients with suspected coronary artery disease (CAD) predicts short term adverse events. However, there is no current data on whether identifying atherosclerosis on CTA impacts outcomes. We performed a case-control study to a...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2014.09.038

    authors： Budoff MJ,Liu S,Chow D,Flores F,Hsieh B,Gebow D,DeFrance T,Ahmadi N

    更新日期：2014-12-01 00:00:00